Reactivity of selected markers of innate and adaptive immunity in rabbits experimentally infected with antigenic variants of RHD (Lagovirus europaeus/GI.1a) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-10-29

AUTHORS

Paulina Niedźwiedzka-Rystwej, Beata Tokarz-Deptuła, Wiesław Deptuła

ABSTRACT

Lagovirus europaeus/GI.1 causes a fatal viral condition in rabbits characterized by acute viral hepatitis and disseminated intravascular coagulation. Due to rapid viral and environmental changes variants (Lagovirus europaeus/GI.1a and GI.2) have appeared and few immunological studies were performed. The aim of the study was to determine innate and adaptive immunity parameters in rabbits infected with six Lagovirus europeus/GI.1a viruses. To achieve the goal several methods were used, i.e. cytometry, microscopy, biochemical and cytochemical tests, spectrophotometry. The results show that three immunotypes exists among the studied strains and they differ in innate (mainly) and adaptive immunity, partly depending on hemagglutination. The peak of changes is 24 h post infection in phagocytosis markers of polymorphonuclear cells and CD8+ T cells. Lagovirus europaeus/GI.1a strains differ from Lagovirus europaeus/GI.1 in terms of immunological response based on our previous work concerning the same parameters in immunological response against this disease. More... »

PAGES

233-242

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11259-021-09851-x

DOI

http://dx.doi.org/10.1007/s11259-021-09851-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1142247412

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34713305


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197 schema:name Institute of Biology, University of Szczecin, Felczaka 3c, 71-412, Szczecin, Poland
198 rdf:type schema:Organization
 




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