Supplementing transglucosidase with a high-fiber diet for prevention of postprandial hyperglycemia in streptozotocin-induced diabetic dogs View Full Text


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Article Info

DATE

2010-02-18

AUTHORS

Toshinori Sako, Akihiro Mori, Peter Lee, Hiroshi Goto, Hiroko Fukuta, Hitomi Oda, Kaori Saeki, Yohei Miki, Yuki Makino, Katsumi Ishioka, Hisashi Mizutani, Yuzo Kojima, Satoshi Koikeda, Toshiro Arai

ABSTRACT

Indigestible oligosaccharides have been shown to normalize blood glucose and insulin concentration thereby promoting good health and preventing diseases, such as diabetes. Transglucosidase (TG, α-glucosidase, enzyme code (EC) 3.2.1.20) is an enzyme capable of converting starch to oligosaccharides, such as iso-malto-oligosaccharides from maltose, via the action of amylase. The aim of this study was to evaluate whether oral administration of TG with maltose or dextrin is capable of reducing post-prandial serum glucose concentration in experimentally streptozotocin (STZ)-induced diabetic dogs fed on a high-fiber diet. Five healthy and five STZ-induced diabetic dogs were employed in this study. TG supplementation with dextrin or maltose had no detrimental effect in healthy dogs. In fact, TG and dextrin exhibited a flatlined serum glucose pattern, while reducing mean post-prandial serum insulin and glucose concentration as compared to control diet alone. When TG supplementation was tested in STZ-induced diabetic dogs under the context of a high fiber diet, a 13.8% and 23.9% reduction in mean glucose concentration for TG with maltose and dextrin, respectively was observed. Moreover, TG with dextrin resulted in a 13% lower mean post-prandial glucose concentration than TG with maltose, suggesting that dextrin may be a more efficient substrate than maltose when used at the same concentration (1 g/kg). Our results indicate that TG supplementation with diet can lead to lower postprandial glucose levels versus diet alone. However, the efficacy of TG supplementation may depend on the type of diet it is supplemented with. As such, TG administration may be useful for preventing the progression of diabetes mellitus and in its management in dogs. More... »

PAGES

161-172

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11259-010-9342-0

DOI

http://dx.doi.org/10.1007/s11259-010-9342-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051177698

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20165914


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24 schema:description Indigestible oligosaccharides have been shown to normalize blood glucose and insulin concentration thereby promoting good health and preventing diseases, such as diabetes. Transglucosidase (TG, α-glucosidase, enzyme code (EC) 3.2.1.20) is an enzyme capable of converting starch to oligosaccharides, such as iso-malto-oligosaccharides from maltose, via the action of amylase. The aim of this study was to evaluate whether oral administration of TG with maltose or dextrin is capable of reducing post-prandial serum glucose concentration in experimentally streptozotocin (STZ)-induced diabetic dogs fed on a high-fiber diet. Five healthy and five STZ-induced diabetic dogs were employed in this study. TG supplementation with dextrin or maltose had no detrimental effect in healthy dogs. In fact, TG and dextrin exhibited a flatlined serum glucose pattern, while reducing mean post-prandial serum insulin and glucose concentration as compared to control diet alone. When TG supplementation was tested in STZ-induced diabetic dogs under the context of a high fiber diet, a 13.8% and 23.9% reduction in mean glucose concentration for TG with maltose and dextrin, respectively was observed. Moreover, TG with dextrin resulted in a 13% lower mean post-prandial glucose concentration than TG with maltose, suggesting that dextrin may be a more efficient substrate than maltose when used at the same concentration (1 g/kg). Our results indicate that TG supplementation with diet can lead to lower postprandial glucose levels versus diet alone. However, the efficacy of TG supplementation may depend on the type of diet it is supplemented with. As such, TG administration may be useful for preventing the progression of diabetes mellitus and in its management in dogs.
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32 STZ-induced diabetic dogs
33 TG administration
34 TG supplementation
35 Tg
36 action
37 action of amylase
38 administration
39 aim
40 amylase
41 blood glucose
42 concentration
43 context
44 detrimental effects
45 dextrin
46 diabetes
47 diabetes mellitus
48 diabetic dogs
49 diet
50 disease
51 dogs
52 effect
53 efficacy
54 efficient substrate
55 enzyme
56 fact
57 fiber diet
58 glucose
59 glucose concentration
60 glucose levels
61 glucose patterns
62 good health
63 health
64 healthy dogs
65 high-fiber diet
66 hyperglycemia
67 indigestible oligosaccharides
68 insulin
69 insulin concentrations
70 levels
71 lower mean post-prandial glucose concentration
72 lower postprandial glucose levels
73 maltose
74 management
75 mean glucose concentration
76 mean post-prandial glucose concentration
77 mean post-prandial serum insulin
78 mellitus
79 oligosaccharides
80 oral administration
81 patterns
82 post-prandial glucose concentrations
83 post-prandial serum glucose concentration
84 post-prandial serum insulin
85 postprandial glucose levels
86 postprandial hyperglycemia
87 prevention
88 progression
89 reduction
90 results
91 same concentration
92 serum glucose concentration
93 serum glucose pattern
94 serum insulin
95 starch
96 streptozotocin
97 study
98 substrate
99 supplementation
100 transglucosidase
101 type of diet
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