Effect of glimepiride and nateglinide on serum insulin and glucose concentration in healthy cats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-09-02

AUTHORS

A. Mori, P. Lee, T. Yamashita, Y. Nishimaki, H. Oda, K. Saeki, Y. Miki, H. Mizutani, K. Ishioka, T. Honjo, T. Arai, T. Sako

ABSTRACT

Glimepiride and nateglinide are two common oral hypoglycemic agents currently being used with humans suffering from Type 2 diabetes mellitus. Neither drug has been tested with cats thus far and it is currently unknown whether either of these drugs exert any effect in cats or not. The objective of this study was to determine the effect of glimepiride and nateglinide on glucose and insulin responses in healthy control cats, in order to determine their potential use in diabetic cats. The intravenous glucose tolerance tests was carried out since it is an excellent test for evaluating pancreatic β-cell function for insulin secretion. Alterations in the insulin secretion pattern can be perceived as the earliest sign of β-cell dysfunction in many species, including cats. Nateglinide demonstrated a quick action/short duration type effect with serum glucose nadiring and insulin response peaking at 60 and 20 minutes, respectively. Alternatively, glimepiride is medium-to-long acting with serum glucose nadiring and insulin response peaking at 180 minutes and 60 minutes, respectively. Nateglinide’s potency was evident allowing it to induce a 1.5–2 higher preliminary insulin peak (3.7 ± 1.1 pg/ml) than glimepiride’s (2.5 ± 0.1 pg/ml), albeit only for a short period of time. Because glimepiride and nateglinide have a shared mode of action, no significant differences in overall glucose AUC0-360min (24,435 ± 2,940 versus 24,782 ± 2,354 mg min/dl) and insulin AUC0-360min (410 ± 192 versus 460 ± 159) in healthy control cats were observed. These findings may provide useful information when choosing a hypoglycemic drug suited for the treatment of diabetic cats depending on the degree of diabetes mellitus the cat is suffering from. More... »

PAGES

957

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11259-009-9314-4

DOI

http://dx.doi.org/10.1007/s11259-009-9314-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043934533

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19728131


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34 agents
35 alterations
36 cats
37 cell dysfunction
38 cell function
39 common oral hypoglycemic agents
40 concentration
41 control cats
42 degree
43 diabetes mellitus
44 diabetic cats
45 differences
46 drugs
47 duration type effect
48 dysfunction
49 early signs
50 effect
51 effect of glimepiride
52 excellent test
53 findings
54 function
55 glimepiride
56 glucose
57 glucose AUC0-360min
58 glucose concentration
59 glucose nadiring
60 glucose tolerance test
61 healthy cats
62 healthy control cats
63 higher preliminary insulin peak
64 humans
65 hypoglycemic agents
66 hypoglycemic drugs
67 information
68 insulin
69 insulin AUC0-360min
70 insulin peak
71 insulin response
72 insulin secretion
73 insulin secretion pattern
74 intravenous glucose tolerance test
75 long acting
76 medium
77 mellitus
78 minutes
79 mode
80 mode of action
81 nadiring
82 nateglinide
83 objective
84 oral hypoglycemic agents
85 order
86 overall glucose AUC0-360min
87 patterns
88 peak
89 period
90 potency
91 potential use
92 preliminary insulin peak
93 quick action/short duration type effect
94 response
95 secretion
96 secretion pattern
97 serum glucose nadiring
98 serum insulin
99 short duration type effect
100 short period
101 significant differences
102 signs
103 species
104 study
105 test
106 time
107 tolerance test
108 treatment
109 type 2 diabetes mellitus
110 type effects
111 use
112 useful information
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