Decreased gene expression of insulin signaling genes in insulin sensitive tissues of obese cats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-10-23

AUTHORS

A. Mori, P. Lee, H. Takemitsu, E. Iwasaki, N. Kimura, M. Yagishita, M. Hayasaka, T. Arai

ABSTRACT

Type 2 diabetes mellitus (DM) animal models have provided ample opportunity for investigating pathogenesis, as well as to evaluate novel treatment and prevention options for the disease. Because the domestic cat shares a similar environment with humans, it is also confronted with many similar risk factors for diabetes, such as physical inactivity and obesity. Obesity is a significant risk factor for diabetes in cats, and as such, the domestic cat may serve as an ideal model for investigating obesity induced insulin resistance. This study determined changes in insulin signaling genes within insulin sensitive tissues of obese felines. Quantitative RT-PCR was performed to determine mRNA levels of three important insulin signaling genes which have been implicated with insulin resistance: insulin receptor substrate (IRS)-1, IRS-2, and phosphatidylinositol 3’-kinase (PI3-K) p85α. Obese cats had significantly lower IRS-2 and PI3-K p85α mRNA levels in liver and skeletal muscle as compared to control cats. This down regulation of insulin signaling genes in obese cats mirrors that of obese humans and rodents suffering from insulin resistance. Interestingly, preprandial blood tests indicated that our obese cats were no different from control cats with regards to glucose tolerance and insulin resistance, thus indicating that the obese cats used in our study had a moderate level of obesity. Therefore, insulin signaling gene alterations were occurring in insulin sensitive tissues of moderately obese felines before glucose intolerance was clinically evident. As such, the monitoring of key insulin signaling genes may have some important diagnostic value to determine the risk level and degree of obesity induced insulin resistance. More... »

PAGES

315

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11259-008-9179-y

DOI

http://dx.doi.org/10.1007/s11259-008-9179-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047488332

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18946721


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/07", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Agricultural and Veterinary Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0707", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Veterinary Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Abdominal Fat", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cat Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin Receptor Substrate Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin Resistance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle, Skeletal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neutrophils", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Obesity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphatidylinositol 3-Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 171 Kyonancho, Musashino, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412202.7", 
          "name": [
            "Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 171 Kyonancho, Musashino, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mori", 
        "givenName": "A.", 
        "id": "sg:person.0645005167.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645005167.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 171 Kyonancho, Musashino, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412202.7", 
          "name": [
            "Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 171 Kyonancho, Musashino, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "P.", 
        "id": "sg:person.01074433063.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074433063.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 171 Kyonancho, Musashino, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412202.7", 
          "name": [
            "Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 171 Kyonancho, Musashino, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takemitsu", 
        "givenName": "H.", 
        "id": "sg:person.0645604577.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645604577.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Animal Science, Faculty of Applied Life Science, Nippon Veterinary and Life Science University, 171 Kyonancho, Musashino, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412202.7", 
          "name": [
            "Department of Animal Science, Faculty of Applied Life Science, Nippon Veterinary and Life Science University, 171 Kyonancho, Musashino, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iwasaki", 
        "givenName": "E.", 
        "id": "sg:person.0601724072.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601724072.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Animal Science, Faculty of Applied Life Science, Nippon Veterinary and Life Science University, 171 Kyonancho, Musashino, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412202.7", 
          "name": [
            "Department of Animal Science, Faculty of Applied Life Science, Nippon Veterinary and Life Science University, 171 Kyonancho, Musashino, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kimura", 
        "givenName": "N.", 
        "id": "sg:person.01005506450.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005506450.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Corporate R&D Center, Olympus Corporation, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.471236.5", 
          "name": [
            "Corporate R&D Center, Olympus Corporation, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yagishita", 
        "givenName": "M.", 
        "id": "sg:person.0716152472.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716152472.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Corporate R&D Center, Olympus Corporation, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.471236.5", 
          "name": [
            "Corporate R&D Center, Olympus Corporation, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hayasaka", 
        "givenName": "M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 171 Kyonancho, Musashino, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412202.7", 
          "name": [
            "Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 171 Kyonancho, Musashino, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arai", 
        "givenName": "T.", 
        "id": "sg:person.0750657730.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750657730.52"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00125-003-1089-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053397184", 
          "https://doi.org/10.1007/s00125-003-1089-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00403911", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035119187", 
          "https://doi.org/10.1007/bf00403911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11259-008-9168-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035174664", 
          "https://doi.org/10.1007/s11259-008-9168-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/372186a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049271444", 
          "https://doi.org/10.1038/372186a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1012787012433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050220914", 
          "https://doi.org/10.1023/a:1012787012433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/36116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019591506", 
          "https://doi.org/10.1038/36116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11259-005-1868-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033867082", 
          "https://doi.org/10.1007/s11259-005-1868-1"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-10-23", 
    "datePublishedReg": "2008-10-23", 
    "description": "Type 2 diabetes mellitus (DM) animal models have provided ample opportunity for investigating pathogenesis, as well as to evaluate novel treatment and prevention options for the disease. Because the domestic cat shares a similar environment with humans, it is also confronted with many similar risk factors for diabetes, such as physical inactivity and obesity. Obesity is a significant risk factor for diabetes in cats, and as such, the domestic cat may serve as an ideal model for investigating obesity induced insulin resistance. This study determined changes in insulin signaling genes within insulin sensitive tissues of obese felines. Quantitative RT-PCR was performed to determine mRNA levels of three important insulin signaling genes which have been implicated with insulin resistance: insulin receptor substrate (IRS)-1, IRS-2, and phosphatidylinositol 3\u2019-kinase (PI3-K) p85\u03b1. Obese cats had significantly lower IRS-2 and PI3-K p85\u03b1 mRNA levels in liver and skeletal muscle as compared to control cats. This down regulation of insulin signaling genes in obese cats mirrors that of obese humans and rodents suffering from insulin resistance. Interestingly, preprandial blood tests indicated that our obese cats were no different from control cats with regards to glucose tolerance and insulin resistance, thus indicating that the obese cats used in our study had a moderate level of obesity. Therefore, insulin signaling gene alterations were occurring in insulin sensitive tissues of moderately obese felines before glucose intolerance was clinically evident. As such, the monitoring of key insulin signaling genes may have some important diagnostic value to determine the risk level and degree of obesity induced insulin resistance.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s11259-008-9179-y", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1091998", 
        "issn": [
          "0165-7380", 
          "1573-7446"
        ], 
        "name": "Veterinary Research Communications", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "33"
      }
    ], 
    "keywords": [
      "insulin sensitive tissues", 
      "insulin receptor substrate", 
      "mRNA levels", 
      "gene expression", 
      "quantitative RT-PCR", 
      "insulin resistance", 
      "receptor substrate", 
      "genes", 
      "obese cats", 
      "RT-PCR", 
      "domestic cats", 
      "down regulation", 
      "type 2 diabetes mellitus animal model", 
      "key insulin", 
      "risk factors", 
      "sensitive tissues", 
      "skeletal muscle", 
      "IRS-2", 
      "gene alterations", 
      "degree of obesity", 
      "similar risk factors", 
      "significant risk factors", 
      "important insulin", 
      "ideal model", 
      "similar environments", 
      "glucose intolerance", 
      "blood tests", 
      "obese humans", 
      "physical inactivity", 
      "p85\u03b1", 
      "control cats", 
      "important diagnostic value", 
      "novel treatments", 
      "animal models", 
      "obesity", 
      "prevention options", 
      "tissue", 
      "diagnostic value", 
      "insulin", 
      "regulation", 
      "cats", 
      "humans", 
      "moderate levels", 
      "diabetes", 
      "feline", 
      "resistance", 
      "expression", 
      "ample opportunities", 
      "tolerance", 
      "levels", 
      "rodents", 
      "substrate", 
      "alterations", 
      "pathogenesis", 
      "intolerance", 
      "disease", 
      "factors", 
      "liver", 
      "muscle", 
      "inactivity", 
      "risk level", 
      "treatment", 
      "study", 
      "options", 
      "environment", 
      "changes", 
      "test", 
      "regard", 
      "monitoring", 
      "opportunities", 
      "model", 
      "degree", 
      "values", 
      "mirror", 
      "diabetes mellitus (DM) animal models", 
      "mellitus (DM) animal models", 
      "obese felines", 
      "phosphatidylinositol 3\u2019-kinase (PI3-K) p85\u03b1", 
      "lower IRS-2", 
      "PI3-K p85\u03b1 mRNA levels", 
      "p85\u03b1 mRNA levels", 
      "obese cats mirrors", 
      "cats mirrors", 
      "preprandial blood tests"
    ], 
    "name": "Decreased gene expression of insulin signaling genes in insulin sensitive tissues of obese cats", 
    "pagination": "315", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1047488332"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11259-008-9179-y"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18946721"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11259-008-9179-y", 
      "https://app.dimensions.ai/details/publication/pub.1047488332"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_464.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s11259-008-9179-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11259-008-9179-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11259-008-9179-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11259-008-9179-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11259-008-9179-y'


 

This table displays all metadata directly associated to this object as RDF triples.

295 TRIPLES      22 PREDICATES      134 URIs      119 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11259-008-9179-y schema:about N0c3d32db185b49b2a49c16f69d6b8f9f
2 N2279a8e0185545b1b1d012e3c05cb91b
3 N247c36dc87844ca1a4cc54c25bdb665f
4 N472a41df6b2440e49a08b3364e0346e9
5 N490d54b7bb4b4f258fa7d981dbd6199e
6 N4f1ab6eca98a4d1689e5b0183ac55aac
7 N61814153481b469b8b4f0db58e275b40
8 N681c00cbce524e73b5401edc6885a1d7
9 N70c9186e1097477ab2f2b7b0c5ef108d
10 N84d02ac505de42ac93d35c624ac551ed
11 N9a5601615b1e442ebb50f3173cd7f41e
12 N9bbb7796736341dbb2069cb9e8cf1218
13 Na14e2a17f0f540b58c88c92de2c2eaaf
14 Nb14b7fed36dc401ebdcfd3ed22090731
15 Nd502a6f68da740d48e033af67ef68a13
16 Ndd2f5e5c26d94ef2ae87f5fe98eae9de
17 Neda665fd6dfd4ade8a65112d2f48cc00
18 anzsrc-for:07
19 anzsrc-for:0707
20 schema:author N5ad3ae875c84431e9065202716798b68
21 schema:citation sg:pub.10.1007/bf00403911
22 sg:pub.10.1007/s00125-003-1089-5
23 sg:pub.10.1007/s11259-005-1868-1
24 sg:pub.10.1007/s11259-008-9168-1
25 sg:pub.10.1023/a:1012787012433
26 sg:pub.10.1038/36116
27 sg:pub.10.1038/372186a0
28 schema:datePublished 2008-10-23
29 schema:datePublishedReg 2008-10-23
30 schema:description Type 2 diabetes mellitus (DM) animal models have provided ample opportunity for investigating pathogenesis, as well as to evaluate novel treatment and prevention options for the disease. Because the domestic cat shares a similar environment with humans, it is also confronted with many similar risk factors for diabetes, such as physical inactivity and obesity. Obesity is a significant risk factor for diabetes in cats, and as such, the domestic cat may serve as an ideal model for investigating obesity induced insulin resistance. This study determined changes in insulin signaling genes within insulin sensitive tissues of obese felines. Quantitative RT-PCR was performed to determine mRNA levels of three important insulin signaling genes which have been implicated with insulin resistance: insulin receptor substrate (IRS)-1, IRS-2, and phosphatidylinositol 3’-kinase (PI3-K) p85α. Obese cats had significantly lower IRS-2 and PI3-K p85α mRNA levels in liver and skeletal muscle as compared to control cats. This down regulation of insulin signaling genes in obese cats mirrors that of obese humans and rodents suffering from insulin resistance. Interestingly, preprandial blood tests indicated that our obese cats were no different from control cats with regards to glucose tolerance and insulin resistance, thus indicating that the obese cats used in our study had a moderate level of obesity. Therefore, insulin signaling gene alterations were occurring in insulin sensitive tissues of moderately obese felines before glucose intolerance was clinically evident. As such, the monitoring of key insulin signaling genes may have some important diagnostic value to determine the risk level and degree of obesity induced insulin resistance.
31 schema:genre article
32 schema:inLanguage en
33 schema:isAccessibleForFree false
34 schema:isPartOf N1648fc1b972947ee91f143caf6c439e2
35 N715cc77bc85b4f8ca585c6002b0768f0
36 sg:journal.1091998
37 schema:keywords IRS-2
38 PI3-K p85α mRNA levels
39 RT-PCR
40 alterations
41 ample opportunities
42 animal models
43 blood tests
44 cats
45 cats mirrors
46 changes
47 control cats
48 degree
49 degree of obesity
50 diabetes
51 diabetes mellitus (DM) animal models
52 diagnostic value
53 disease
54 domestic cats
55 down regulation
56 environment
57 expression
58 factors
59 feline
60 gene alterations
61 gene expression
62 genes
63 glucose intolerance
64 humans
65 ideal model
66 important diagnostic value
67 important insulin
68 inactivity
69 insulin
70 insulin receptor substrate
71 insulin resistance
72 insulin sensitive tissues
73 intolerance
74 key insulin
75 levels
76 liver
77 lower IRS-2
78 mRNA levels
79 mellitus (DM) animal models
80 mirror
81 model
82 moderate levels
83 monitoring
84 muscle
85 novel treatments
86 obese cats
87 obese cats mirrors
88 obese felines
89 obese humans
90 obesity
91 opportunities
92 options
93 p85α
94 p85α mRNA levels
95 pathogenesis
96 phosphatidylinositol 3’-kinase (PI3-K) p85α
97 physical inactivity
98 preprandial blood tests
99 prevention options
100 quantitative RT-PCR
101 receptor substrate
102 regard
103 regulation
104 resistance
105 risk factors
106 risk level
107 rodents
108 sensitive tissues
109 significant risk factors
110 similar environments
111 similar risk factors
112 skeletal muscle
113 study
114 substrate
115 test
116 tissue
117 tolerance
118 treatment
119 type 2 diabetes mellitus animal model
120 values
121 schema:name Decreased gene expression of insulin signaling genes in insulin sensitive tissues of obese cats
122 schema:pagination 315
123 schema:productId N3675db0ac19c437ca444dd4d1b23cdc4
124 N69feff147ecd4e46bee42d213441d2c2
125 Nef52e0697710475e8993fb9e5540f01d
126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047488332
127 https://doi.org/10.1007/s11259-008-9179-y
128 schema:sdDatePublished 2021-12-01T19:20
129 schema:sdLicense https://scigraph.springernature.com/explorer/license/
130 schema:sdPublisher Nf0796adc8ccf417a96bfb694fadf05bf
131 schema:url https://doi.org/10.1007/s11259-008-9179-y
132 sgo:license sg:explorer/license/
133 sgo:sdDataset articles
134 rdf:type schema:ScholarlyArticle
135 N0123050840884f118fa33f823a3dffd8 rdf:first sg:person.01074433063.07
136 rdf:rest Nc2c50c4275f74ce48ea7caceaa748c3b
137 N0c3d32db185b49b2a49c16f69d6b8f9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Signal Transduction
139 rdf:type schema:DefinedTerm
140 N1648fc1b972947ee91f143caf6c439e2 schema:volumeNumber 33
141 rdf:type schema:PublicationVolume
142 N2279a8e0185545b1b1d012e3c05cb91b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Obesity
144 rdf:type schema:DefinedTerm
145 N247c36dc87844ca1a4cc54c25bdb665f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Cats
147 rdf:type schema:DefinedTerm
148 N3675db0ac19c437ca444dd4d1b23cdc4 schema:name doi
149 schema:value 10.1007/s11259-008-9179-y
150 rdf:type schema:PropertyValue
151 N47032e31980246889ec75a326e9754c0 rdf:first sg:person.0601724072.03
152 rdf:rest Nda0f041e13654972b0c8169e6f7ec3c3
153 N472a41df6b2440e49a08b3364e0346e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Insulin Resistance
155 rdf:type schema:DefinedTerm
156 N490d54b7bb4b4f258fa7d981dbd6199e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Abdominal Fat
158 rdf:type schema:DefinedTerm
159 N4f1ab6eca98a4d1689e5b0183ac55aac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Disease Models, Animal
161 rdf:type schema:DefinedTerm
162 N588ebb634a9e4d318d9e031cac0da8ea rdf:first sg:person.0716152472.64
163 rdf:rest Nd743afb9c058473ea748476acfb629fb
164 N5ad3ae875c84431e9065202716798b68 rdf:first sg:person.0645005167.00
165 rdf:rest N0123050840884f118fa33f823a3dffd8
166 N61814153481b469b8b4f0db58e275b40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Liver
168 rdf:type schema:DefinedTerm
169 N681c00cbce524e73b5401edc6885a1d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name RNA, Messenger
171 rdf:type schema:DefinedTerm
172 N69feff147ecd4e46bee42d213441d2c2 schema:name dimensions_id
173 schema:value pub.1047488332
174 rdf:type schema:PropertyValue
175 N70c9186e1097477ab2f2b7b0c5ef108d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Neutrophils
177 rdf:type schema:DefinedTerm
178 N715cc77bc85b4f8ca585c6002b0768f0 schema:issueNumber 4
179 rdf:type schema:PublicationIssue
180 N84d02ac505de42ac93d35c624ac551ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Gene Expression
182 rdf:type schema:DefinedTerm
183 N926c6ccccdda420ca5b84ecf91810133 rdf:first sg:person.0750657730.52
184 rdf:rest rdf:nil
185 N9a5601615b1e442ebb50f3173cd7f41e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Animals
187 rdf:type schema:DefinedTerm
188 N9bbb7796736341dbb2069cb9e8cf1218 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Phosphatidylinositol 3-Kinases
190 rdf:type schema:DefinedTerm
191 Na14e2a17f0f540b58c88c92de2c2eaaf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Reverse Transcriptase Polymerase Chain Reaction
193 rdf:type schema:DefinedTerm
194 Nb14b7fed36dc401ebdcfd3ed22090731 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Insulin Receptor Substrate Proteins
196 rdf:type schema:DefinedTerm
197 Nc2c50c4275f74ce48ea7caceaa748c3b rdf:first sg:person.0645604577.26
198 rdf:rest N47032e31980246889ec75a326e9754c0
199 Nd502a6f68da740d48e033af67ef68a13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Muscle, Skeletal
201 rdf:type schema:DefinedTerm
202 Nd743afb9c058473ea748476acfb629fb rdf:first Necab806074364555ab1420dd6978f9eb
203 rdf:rest N926c6ccccdda420ca5b84ecf91810133
204 Nda0f041e13654972b0c8169e6f7ec3c3 rdf:first sg:person.01005506450.88
205 rdf:rest N588ebb634a9e4d318d9e031cac0da8ea
206 Ndd2f5e5c26d94ef2ae87f5fe98eae9de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Male
208 rdf:type schema:DefinedTerm
209 Necab806074364555ab1420dd6978f9eb schema:affiliation grid-institutes:grid.471236.5
210 schema:familyName Hayasaka
211 schema:givenName M.
212 rdf:type schema:Person
213 Neda665fd6dfd4ade8a65112d2f48cc00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Cat Diseases
215 rdf:type schema:DefinedTerm
216 Nef52e0697710475e8993fb9e5540f01d schema:name pubmed_id
217 schema:value 18946721
218 rdf:type schema:PropertyValue
219 Nf0796adc8ccf417a96bfb694fadf05bf schema:name Springer Nature - SN SciGraph project
220 rdf:type schema:Organization
221 anzsrc-for:07 schema:inDefinedTermSet anzsrc-for:
222 schema:name Agricultural and Veterinary Sciences
223 rdf:type schema:DefinedTerm
224 anzsrc-for:0707 schema:inDefinedTermSet anzsrc-for:
225 schema:name Veterinary Sciences
226 rdf:type schema:DefinedTerm
227 sg:journal.1091998 schema:issn 0165-7380
228 1573-7446
229 schema:name Veterinary Research Communications
230 schema:publisher Springer Nature
231 rdf:type schema:Periodical
232 sg:person.01005506450.88 schema:affiliation grid-institutes:grid.412202.7
233 schema:familyName Kimura
234 schema:givenName N.
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005506450.88
236 rdf:type schema:Person
237 sg:person.01074433063.07 schema:affiliation grid-institutes:grid.412202.7
238 schema:familyName Lee
239 schema:givenName P.
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074433063.07
241 rdf:type schema:Person
242 sg:person.0601724072.03 schema:affiliation grid-institutes:grid.412202.7
243 schema:familyName Iwasaki
244 schema:givenName E.
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601724072.03
246 rdf:type schema:Person
247 sg:person.0645005167.00 schema:affiliation grid-institutes:grid.412202.7
248 schema:familyName Mori
249 schema:givenName A.
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645005167.00
251 rdf:type schema:Person
252 sg:person.0645604577.26 schema:affiliation grid-institutes:grid.412202.7
253 schema:familyName Takemitsu
254 schema:givenName H.
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645604577.26
256 rdf:type schema:Person
257 sg:person.0716152472.64 schema:affiliation grid-institutes:grid.471236.5
258 schema:familyName Yagishita
259 schema:givenName M.
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716152472.64
261 rdf:type schema:Person
262 sg:person.0750657730.52 schema:affiliation grid-institutes:grid.412202.7
263 schema:familyName Arai
264 schema:givenName T.
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750657730.52
266 rdf:type schema:Person
267 sg:pub.10.1007/bf00403911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035119187
268 https://doi.org/10.1007/bf00403911
269 rdf:type schema:CreativeWork
270 sg:pub.10.1007/s00125-003-1089-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053397184
271 https://doi.org/10.1007/s00125-003-1089-5
272 rdf:type schema:CreativeWork
273 sg:pub.10.1007/s11259-005-1868-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033867082
274 https://doi.org/10.1007/s11259-005-1868-1
275 rdf:type schema:CreativeWork
276 sg:pub.10.1007/s11259-008-9168-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035174664
277 https://doi.org/10.1007/s11259-008-9168-1
278 rdf:type schema:CreativeWork
279 sg:pub.10.1023/a:1012787012433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050220914
280 https://doi.org/10.1023/a:1012787012433
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/36116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019591506
283 https://doi.org/10.1038/36116
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/372186a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049271444
286 https://doi.org/10.1038/372186a0
287 rdf:type schema:CreativeWork
288 grid-institutes:grid.412202.7 schema:alternateName Department of Animal Science, Faculty of Applied Life Science, Nippon Veterinary and Life Science University, 171 Kyonancho, Musashino, Tokyo, Japan
289 Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 171 Kyonancho, Musashino, Tokyo, Japan
290 schema:name Department of Animal Science, Faculty of Applied Life Science, Nippon Veterinary and Life Science University, 171 Kyonancho, Musashino, Tokyo, Japan
291 Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 171 Kyonancho, Musashino, Tokyo, Japan
292 rdf:type schema:Organization
293 grid-institutes:grid.471236.5 schema:alternateName Corporate R&D Center, Olympus Corporation, Tokyo, Japan
294 schema:name Corporate R&D Center, Olympus Corporation, Tokyo, Japan
295 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...