Comparison of time-action profiles of insulin Glargine and NPH insulin in normal and diabetic dogs View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-06-25

AUTHORS

A. Mori, T. Sako, P. Lee, T. Motoike, K. Iwase, Y. Kanaya, H. Fukuta, H. Mizutani, T. Arai

ABSTRACT

Intermediate insulin injections are commonly used for glycemic control in insulin dependent diabetic dogs acting as a replacement for natural insulin. Neutral Protamin Hagedorn (NPH) insulin and insulin glargine are two types of injectable insulin preparations commonly used in humans. In our study, we investigated the time-action profiles of both aforementioned insulin preparations in normal dogs in order to determine whether co-administration of NPH and glargine would be of benefit to insulin dependent diabetic dogs as it is for humans suffering from insulin dependent diabetes. Time-action profiles of NPH insulin and insulin glargine in normal dogs demonstrated a clear difference between both insulin preparations confirming that NPH insulin is an intermediate-acting preparation whereas insulin glargine is a long-lasting preparation. In addition, co-administration of NPH insulin and insulin glargine resulted in tight glycemic control as compared to NPH insulin alone in insulin dependent diabetic dogs. However, co-administration result in hypoglycemia at the dosages tested. More... »

PAGES

563-573

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11259-008-9059-5

DOI

http://dx.doi.org/10.1007/s11259-008-9059-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053569324

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18575956


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