Uremia-caused changes of ghrelin system in hippocampus may be associated with impaired cognitive function of hippocampus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-05

AUTHORS

Zhian Lv, Jie Gao, Li Wang, Zhao Chen, Haozheng Yuan, Xiaoqin Ma, Jiamei Lu, Jianrui Lv, Xili Wu, Lei Zhang, Linting Wei, Rongliang Xue, Rongguo Fu, Liqun Ma

ABSTRACT

PURPOSE: Hippocampus plays an important role in spatial learning and memory. Ghrelin, a brain-gut peptide, participates in the mnestic functions of hippocampus through its receptor growth hormone secretagogue receptor (GHS-R) distributed in hippocampus. This study was to investigate whether there was a correlation between the changes of ghrelin system in hippocampus and the spatial cognitive impairment caused by chronic renal failure (CRF). METHODS: Sprague-Dawley rats (male, 180 ± 10 g, 7-8 weeks old) were randomly classified into CRF group and control group (n = 18 per group). The CRF model was constructed by 5/6 nephrectomy and the controls treated with sham operation. By the 8th week after the surgery, the spatial cognitive function of rats was assessed by Morris water-maze test (MWM), the protein expression of ghrelin and GHS-R in the hippocampus by immunohistochemistry, and the mRNA expression by real-time PCR. Statistical analysis was performed using ANOVA, Student-Newman-Keuls-q test and Pearson correlation analysis, and P < 0.05 was considered significant. RESULTS: Compared with the controls, the time spent in "platform" quadrant (TSPQ) of rats with CRF was decreased, but the escape latency (EL) was increased significantly in MWM, and meanwhile the protein and mRNA expression of ghrelin and GHS-R in hippocampus was also increased significantly (P < 0.05 or P < 0.01). Correlation analysis suggested that the TSPQ was negatively but the EL was positively correlated with the mRNA expression of ghrelin and GHS-R (P < 0.01). CONCLUSION: The CRF-caused changes of ghrelin system in hippocampus might be correlated with the CRF-caused cognitive function impairment. More... »

PAGES

807-815

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11255-016-1228-9

DOI

http://dx.doi.org/10.1007/s11255-016-1228-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012240668

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26861060


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