Outcome of kidney paired donation transplantation to increase donor pool and to prevent commercial transplantation: a single-center experience from a ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-08

AUTHORS

Vivek B. Kute, Manoj R. Gumber, Himanshu V. Patel, Pankaj R. Shah, Aruna V. Vanikar, Pranjal R. Modi, Veena R. Shah, Mohan P. Patel, Hargovind L. Trivedi

ABSTRACT

BACKGROUND: Economic constraints in operating an effective maintenance dialysis program leaves renal transplantation as the only viable option for end-stage renal disease patients in India. Kidney paired donation (KPD) is a rapidly growing modality for facilitating living donor (LD) transplantation for patients who are incompatible with their healthy, willing LD. MATERIALS AND METHODS: The aim of our study was to report a single-center feasibilities and outcomes of KPD transplantation between 2000 and 2012. We performed KPD transplants in 70 recipients to avoid blood group incompatibility (n = 56) or to avoid a positive crossmatch (n = 14). RESULTS: Over a mean follow-up of 2.72 ± 2.96 years, one-, five- and ten-year patient survival were 94.6, 81, 81 %, and death-censored graft survival was 96.4, 90.2, 90.2 %, respectively. Ten percent of patients were lost, mainly due to infections (n = 4). There was 14.2 % biopsy-proven acute rejection, and 5.7 % interstitial fibrosis with tubular atrophy eventually leading to graft loss. CONCLUSION: The incidences of acute rejection, patient/graft survival rates were acceptable in our KPD program and, therefore, we believe it should be encouraged. These findings are valuable for encouraging participation of KPD pairs and transplant centers in national KPD program. It should be promoted in centers with low-deceased donor transplantation. Our study findings are relevant in the context of Indian government amending the Transplantation of Human Organs Act to encourage national KPD program. To our knowledge, it is largest single-center report from India. More... »

PAGES

1171-1178

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11255-012-0323-9

DOI

http://dx.doi.org/10.1007/s11255-012-0323-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048414491

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23136032


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305 schema:name Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr. HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Civil Hospital Campus, Asarwa, 380016, Ahmedabad, Gujarat, India
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307 https://www.grid.ac/institutes/grid.418780.2 schema:alternateName Institute of Transplantation Sciences
308 schema:name Department of Anesthesia and Critical Care, IKDRC-ITS, Ahmedabad, India
309 Department of Urology and Transplantation, IKDRC-ITS, Ahmedabad, India
310 Laboratory Medicine, Department of Pathology, Transfusion Services and Immunohematology, IKDRC-ITS, Ahmedabad, India
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