Hypertriglyceridemia and delayed clearance of fat load in transgenic rabbits expressing human apolipoprotein CIII View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-12-01

AUTHORS

Yinyuan Ding, Yuhui Wang, Hong Zhu, Jianglin Fan, Liqing Yu, George Liu, Enqi Liu

ABSTRACT

Apolipoprotein CIII (apoCIII) has been implicated in hypertriglyceridemia and plasma apoCIII independently predicts risk for coronary heart disease. While hypertriglyceridemia in patients has been demonstrated to correlate with elevated plasma apoCIII levels and reduced lipoprotein lipase (LPL) activity, apoCIII transgenic mice show elevated LPL activity. In this study, we generated transgenic (Tg) rabbits expressing human apoCIII gene exclusively in liver and investigated the effect of apoCIII overexpression on lipid metabolism of rabbits. In comparison with non-Tg littermates, Tg rabbits had 3- and 3.2-fold increases in fed and fasted plasma triglycerides, respectively. In contrast, no significant differences were observed in plasma total cholesterol and high density lipoprotein cholesterol levels between Tg and non-Tg rabbits. Analysis of lipoprotein fractions revealed that elevated plasma triglyceride levels in Tg rabbits were mainly attributed to an increase in very low density lipoprotein/chylomicron-sized particles. Furthermore, Tg rabbits showed markedly delayed clearance of plasma triglycerides accompanied with significantly reduced LPL activity in post-heparin plasma compared to that in non-Tg controls. In conclusion, these results indicate apoCIII transgenic rabbits develop hypertriglyceridemia with similar mechanism in hypertriglyceridemic patients via delayed clearance of plasma triglycerides, and could be used as a valuable tool for the study of human hyperlipidemia in relation with atherosclerotic disorders. More... »

PAGES

867-875

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11248-010-9467-5

DOI

http://dx.doi.org/10.1007/s11248-010-9467-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005307647

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21120692


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/10", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Technology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals, Genetically Modified", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apolipoprotein C-III", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cholesterol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cholesterol, HDL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coronary Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypertriglyceridemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipid Metabolism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipoprotein Lipase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rabbits", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Triglycerides", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ding", 
        "givenName": "Yinyuan", 
        "id": "sg:person.01323537312.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323537312.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Yuhui", 
        "id": "sg:person.0672041256.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672041256.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory Animal Center, Xi\u2019an Jiaotong University, 710061, Xi\u2019an, China", 
          "id": "http://www.grid.ac/institutes/grid.43169.39", 
          "name": [
            "Laboratory Animal Center, Xi\u2019an Jiaotong University, 710061, Xi\u2019an, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhu", 
        "givenName": "Hong", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 409-3898, Yamanashi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.267500.6", 
          "name": [
            "Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 409-3898, Yamanashi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fan", 
        "givenName": "Jianglin", 
        "id": "sg:person.01136672602.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136672602.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology Section on Lipid Sciences, Wake Forest University School of Medicine, Medical Center Blvd, 27157-1040, Winston-Salem, NC, USA", 
          "id": "http://www.grid.ac/institutes/grid.412860.9", 
          "name": [
            "Department of Pathology Section on Lipid Sciences, Wake Forest University School of Medicine, Medical Center Blvd, 27157-1040, Winston-Salem, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "Liqing", 
        "id": "sg:person.01303346710.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303346710.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "George", 
        "id": "sg:person.01054403056.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054403056.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory Animal Center, Xi\u2019an Jiaotong University, 710061, Xi\u2019an, China", 
          "id": "http://www.grid.ac/institutes/grid.43169.39", 
          "name": [
            "Laboratory Animal Center, Xi\u2019an Jiaotong University, 710061, Xi\u2019an, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Enqi", 
        "id": "sg:person.016446245112.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016446245112.43"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.ijo.0803646", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007050950", 
          "https://doi.org/10.1038/sj.ijo.0803646"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-12-01", 
    "datePublishedReg": "2010-12-01", 
    "description": "Apolipoprotein CIII (apoCIII) has been implicated in hypertriglyceridemia and plasma apoCIII independently predicts risk for coronary heart disease. While hypertriglyceridemia in patients has been demonstrated to correlate with elevated plasma apoCIII levels and reduced lipoprotein lipase (LPL) activity, apoCIII transgenic mice show elevated LPL activity. In this study, we generated transgenic (Tg) rabbits expressing human apoCIII gene exclusively in liver and investigated the effect of apoCIII overexpression on lipid metabolism of rabbits. In comparison with non-Tg littermates, Tg rabbits had 3- and 3.2-fold increases in fed and fasted plasma triglycerides, respectively. In contrast, no significant differences were observed in plasma total cholesterol and high density lipoprotein cholesterol levels between Tg and non-Tg rabbits. Analysis of lipoprotein fractions revealed that elevated plasma triglyceride levels in Tg rabbits were mainly attributed to an increase in very low density lipoprotein/chylomicron-sized particles. Furthermore, Tg rabbits showed markedly delayed clearance of plasma triglycerides accompanied with significantly reduced LPL activity in post-heparin plasma compared to that in non-Tg controls. In conclusion, these results indicate apoCIII transgenic rabbits develop hypertriglyceridemia with similar mechanism in hypertriglyceridemic patients via delayed clearance of plasma triglycerides, and could be used as a valuable tool for the study of human hyperlipidemia in relation with atherosclerotic disorders.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s11248-010-9467-5", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.4993686", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6021222", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6046164", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1102526", 
        "issn": [
          "0962-8819", 
          "1573-9368"
        ], 
        "name": "Transgenic Research", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "20"
      }
    ], 
    "keywords": [
      "Tg rabbits", 
      "plasma triglycerides", 
      "apolipoprotein CIII", 
      "LPL activity", 
      "high-density lipoprotein cholesterol levels", 
      "density lipoprotein cholesterol levels", 
      "elevated plasma triglyceride levels", 
      "non-Tg rabbits", 
      "lipoprotein cholesterol levels", 
      "coronary heart disease", 
      "plasma total cholesterol", 
      "non-Tg littermates", 
      "transgenic rabbits", 
      "non-Tg controls", 
      "plasma triglyceride levels", 
      "lipoprotein lipase activity", 
      "transgenic mice show", 
      "chylomicron-sized particles", 
      "post-heparin plasma", 
      "apoCIII levels", 
      "ApoCIII overexpression", 
      "atherosclerotic disorders", 
      "total cholesterol", 
      "hypertriglyceridemic patients", 
      "triglyceride levels", 
      "heart disease", 
      "cholesterol levels", 
      "lipoprotein fractions", 
      "hypertriglyceridemia", 
      "mice show", 
      "human hyperlipidemia", 
      "fat load", 
      "lipid metabolism", 
      "triglycerides", 
      "human apoCIII gene", 
      "rabbits", 
      "clearance", 
      "significant differences", 
      "patients", 
      "human apolipoprotein CIII", 
      "lipase activity", 
      "apoCIII gene", 
      "similar mechanism", 
      "hyperlipidemia", 
      "littermates", 
      "CIII", 
      "apoCIII", 
      "levels", 
      "disease", 
      "liver", 
      "cholesterol", 
      "activity", 
      "disorders", 
      "valuable tool", 
      "risk", 
      "study", 
      "metabolism", 
      "overexpression", 
      "increase", 
      "conclusion", 
      "fed", 
      "differences", 
      "plasma", 
      "control", 
      "genes", 
      "contrast", 
      "effect", 
      "mechanism", 
      "fraction", 
      "Tg", 
      "comparison", 
      "analysis", 
      "results", 
      "tool", 
      "relation", 
      "load", 
      "show", 
      "particles"
    ], 
    "name": "Hypertriglyceridemia and delayed clearance of fat load in transgenic rabbits expressing human apolipoprotein CIII", 
    "pagination": "867-875", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1005307647"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11248-010-9467-5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21120692"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11248-010-9467-5", 
      "https://app.dimensions.ai/details/publication/pub.1005307647"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:53", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_506.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s11248-010-9467-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11248-010-9467-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11248-010-9467-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11248-010-9467-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11248-010-9467-5'


 

This table displays all metadata directly associated to this object as RDF triples.

263 TRIPLES      21 PREDICATES      120 URIs      111 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11248-010-9467-5 schema:about N0286fa44467748388acf82e6ffc553d4
2 N0dd13fc6afb04f34b3d487473fa81deb
3 N3b95968eedfa4a499e9151e708c6c0d9
4 N3db4bc3601444f019aa3aa29c490a169
5 N4cd9e0cd87334de985b72a70156b69e3
6 N6dded61aaf344238b2b38d4cf023eff3
7 N729bd8544c0d43608e2c1c968b8c58fb
8 N875251190dd74d958097e6a23fcc46a7
9 N9d0baa1d54534765a57b6cebc29c07f1
10 Na5aafa801cc34aafae6edd3567b1b62d
11 Na9907358564d460f82ce39a0aab1bd1b
12 Nac095c9c3d384b36890f9fc51152f2c7
13 Nd250be4fdd234a0282143427f8f783e8
14 Ne17e876d699c494da69a88923c84b36e
15 Ne55b5c8d9d1b4e96af5ef6ef004f4a3f
16 Ne64922b4ba27458c953554e85e2c9dca
17 anzsrc-for:06
18 anzsrc-for:10
19 schema:author N9a40a5c21afc44d78c5a1d1e782567ad
20 schema:citation sg:pub.10.1038/sj.ijo.0803646
21 schema:datePublished 2010-12-01
22 schema:datePublishedReg 2010-12-01
23 schema:description Apolipoprotein CIII (apoCIII) has been implicated in hypertriglyceridemia and plasma apoCIII independently predicts risk for coronary heart disease. While hypertriglyceridemia in patients has been demonstrated to correlate with elevated plasma apoCIII levels and reduced lipoprotein lipase (LPL) activity, apoCIII transgenic mice show elevated LPL activity. In this study, we generated transgenic (Tg) rabbits expressing human apoCIII gene exclusively in liver and investigated the effect of apoCIII overexpression on lipid metabolism of rabbits. In comparison with non-Tg littermates, Tg rabbits had 3- and 3.2-fold increases in fed and fasted plasma triglycerides, respectively. In contrast, no significant differences were observed in plasma total cholesterol and high density lipoprotein cholesterol levels between Tg and non-Tg rabbits. Analysis of lipoprotein fractions revealed that elevated plasma triglyceride levels in Tg rabbits were mainly attributed to an increase in very low density lipoprotein/chylomicron-sized particles. Furthermore, Tg rabbits showed markedly delayed clearance of plasma triglycerides accompanied with significantly reduced LPL activity in post-heparin plasma compared to that in non-Tg controls. In conclusion, these results indicate apoCIII transgenic rabbits develop hypertriglyceridemia with similar mechanism in hypertriglyceridemic patients via delayed clearance of plasma triglycerides, and could be used as a valuable tool for the study of human hyperlipidemia in relation with atherosclerotic disorders.
24 schema:genre article
25 schema:isAccessibleForFree false
26 schema:isPartOf Nbce796980306473e87842182f1531328
27 Nc9045c09cb7b4fd8a1024667ab8577fa
28 sg:journal.1102526
29 schema:keywords ApoCIII overexpression
30 CIII
31 LPL activity
32 Tg
33 Tg rabbits
34 activity
35 analysis
36 apoCIII
37 apoCIII gene
38 apoCIII levels
39 apolipoprotein CIII
40 atherosclerotic disorders
41 cholesterol
42 cholesterol levels
43 chylomicron-sized particles
44 clearance
45 comparison
46 conclusion
47 contrast
48 control
49 coronary heart disease
50 density lipoprotein cholesterol levels
51 differences
52 disease
53 disorders
54 effect
55 elevated plasma triglyceride levels
56 fat load
57 fed
58 fraction
59 genes
60 heart disease
61 high-density lipoprotein cholesterol levels
62 human apoCIII gene
63 human apolipoprotein CIII
64 human hyperlipidemia
65 hyperlipidemia
66 hypertriglyceridemia
67 hypertriglyceridemic patients
68 increase
69 levels
70 lipase activity
71 lipid metabolism
72 lipoprotein cholesterol levels
73 lipoprotein fractions
74 lipoprotein lipase activity
75 littermates
76 liver
77 load
78 mechanism
79 metabolism
80 mice show
81 non-Tg controls
82 non-Tg littermates
83 non-Tg rabbits
84 overexpression
85 particles
86 patients
87 plasma
88 plasma total cholesterol
89 plasma triglyceride levels
90 plasma triglycerides
91 post-heparin plasma
92 rabbits
93 relation
94 results
95 risk
96 show
97 significant differences
98 similar mechanism
99 study
100 tool
101 total cholesterol
102 transgenic mice show
103 transgenic rabbits
104 triglyceride levels
105 triglycerides
106 valuable tool
107 schema:name Hypertriglyceridemia and delayed clearance of fat load in transgenic rabbits expressing human apolipoprotein CIII
108 schema:pagination 867-875
109 schema:productId N3a7e75501af44508a81d1d3dd2ac0e3b
110 N51128abe25c648328df31abec2b8907d
111 N9be804d717894709af591b270488a4ae
112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005307647
113 https://doi.org/10.1007/s11248-010-9467-5
114 schema:sdDatePublished 2022-09-02T15:53
115 schema:sdLicense https://scigraph.springernature.com/explorer/license/
116 schema:sdPublisher Nc3dc4cdd1d794d3f9945beaeb44d9aa8
117 schema:url https://doi.org/10.1007/s11248-010-9467-5
118 sgo:license sg:explorer/license/
119 sgo:sdDataset articles
120 rdf:type schema:ScholarlyArticle
121 N0286fa44467748388acf82e6ffc553d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Triglycerides
123 rdf:type schema:DefinedTerm
124 N0dd13fc6afb04f34b3d487473fa81deb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Humans
126 rdf:type schema:DefinedTerm
127 N18a9bff5a57d494abbb4fc997e1e91e7 rdf:first sg:person.01136672602.49
128 rdf:rest N8b4e48e6735243ef9533896de62bda88
129 N3a7e75501af44508a81d1d3dd2ac0e3b schema:name dimensions_id
130 schema:value pub.1005307647
131 rdf:type schema:PropertyValue
132 N3b95968eedfa4a499e9151e708c6c0d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Lipid Metabolism
134 rdf:type schema:DefinedTerm
135 N3db4bc3601444f019aa3aa29c490a169 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Rabbits
137 rdf:type schema:DefinedTerm
138 N4cd9e0cd87334de985b72a70156b69e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Disease Models, Animal
140 rdf:type schema:DefinedTerm
141 N51128abe25c648328df31abec2b8907d schema:name doi
142 schema:value 10.1007/s11248-010-9467-5
143 rdf:type schema:PropertyValue
144 N6382ab30ee7c41b9a8b5897d312a02d0 rdf:first sg:person.0672041256.86
145 rdf:rest N8be03d0f6b3b49d0a7b598525891529e
146 N6dded61aaf344238b2b38d4cf023eff3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Coronary Disease
148 rdf:type schema:DefinedTerm
149 N729bd8544c0d43608e2c1c968b8c58fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Cholesterol
151 rdf:type schema:DefinedTerm
152 N875251190dd74d958097e6a23fcc46a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Animals
154 rdf:type schema:DefinedTerm
155 N8b4e48e6735243ef9533896de62bda88 rdf:first sg:person.01303346710.78
156 rdf:rest Ncabd8d9cee4541958276e6c3a4a49828
157 N8be03d0f6b3b49d0a7b598525891529e rdf:first Nf53c2efa2dd148f1963eff65db6b2d38
158 rdf:rest N18a9bff5a57d494abbb4fc997e1e91e7
159 N9a40a5c21afc44d78c5a1d1e782567ad rdf:first sg:person.01323537312.49
160 rdf:rest N6382ab30ee7c41b9a8b5897d312a02d0
161 N9be804d717894709af591b270488a4ae schema:name pubmed_id
162 schema:value 21120692
163 rdf:type schema:PropertyValue
164 N9d0baa1d54534765a57b6cebc29c07f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Lipoprotein Lipase
166 rdf:type schema:DefinedTerm
167 Na5aafa801cc34aafae6edd3567b1b62d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Fats
169 rdf:type schema:DefinedTerm
170 Na9907358564d460f82ce39a0aab1bd1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Liver
172 rdf:type schema:DefinedTerm
173 Nac095c9c3d384b36890f9fc51152f2c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Apolipoprotein C-III
175 rdf:type schema:DefinedTerm
176 Nb07c6a1090f541949668371f5975098c rdf:first sg:person.016446245112.43
177 rdf:rest rdf:nil
178 Nbce796980306473e87842182f1531328 schema:issueNumber 4
179 rdf:type schema:PublicationIssue
180 Nc3dc4cdd1d794d3f9945beaeb44d9aa8 schema:name Springer Nature - SN SciGraph project
181 rdf:type schema:Organization
182 Nc9045c09cb7b4fd8a1024667ab8577fa schema:volumeNumber 20
183 rdf:type schema:PublicationVolume
184 Ncabd8d9cee4541958276e6c3a4a49828 rdf:first sg:person.01054403056.31
185 rdf:rest Nb07c6a1090f541949668371f5975098c
186 Nd250be4fdd234a0282143427f8f783e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Animals, Genetically Modified
188 rdf:type schema:DefinedTerm
189 Ne17e876d699c494da69a88923c84b36e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Gene Expression
191 rdf:type schema:DefinedTerm
192 Ne55b5c8d9d1b4e96af5ef6ef004f4a3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Cholesterol, HDL
194 rdf:type schema:DefinedTerm
195 Ne64922b4ba27458c953554e85e2c9dca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Hypertriglyceridemia
197 rdf:type schema:DefinedTerm
198 Nf53c2efa2dd148f1963eff65db6b2d38 schema:affiliation grid-institutes:grid.43169.39
199 schema:familyName Zhu
200 schema:givenName Hong
201 rdf:type schema:Person
202 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
203 schema:name Biological Sciences
204 rdf:type schema:DefinedTerm
205 anzsrc-for:10 schema:inDefinedTermSet anzsrc-for:
206 schema:name Technology
207 rdf:type schema:DefinedTerm
208 sg:grant.4993686 http://pending.schema.org/fundedItem sg:pub.10.1007/s11248-010-9467-5
209 rdf:type schema:MonetaryGrant
210 sg:grant.6021222 http://pending.schema.org/fundedItem sg:pub.10.1007/s11248-010-9467-5
211 rdf:type schema:MonetaryGrant
212 sg:grant.6046164 http://pending.schema.org/fundedItem sg:pub.10.1007/s11248-010-9467-5
213 rdf:type schema:MonetaryGrant
214 sg:journal.1102526 schema:issn 0962-8819
215 1573-9368
216 schema:name Transgenic Research
217 schema:publisher Springer Nature
218 rdf:type schema:Periodical
219 sg:person.01054403056.31 schema:affiliation grid-institutes:None
220 schema:familyName Liu
221 schema:givenName George
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054403056.31
223 rdf:type schema:Person
224 sg:person.01136672602.49 schema:affiliation grid-institutes:grid.267500.6
225 schema:familyName Fan
226 schema:givenName Jianglin
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136672602.49
228 rdf:type schema:Person
229 sg:person.01303346710.78 schema:affiliation grid-institutes:grid.412860.9
230 schema:familyName Yu
231 schema:givenName Liqing
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303346710.78
233 rdf:type schema:Person
234 sg:person.01323537312.49 schema:affiliation grid-institutes:None
235 schema:familyName Ding
236 schema:givenName Yinyuan
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323537312.49
238 rdf:type schema:Person
239 sg:person.016446245112.43 schema:affiliation grid-institutes:grid.43169.39
240 schema:familyName Liu
241 schema:givenName Enqi
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016446245112.43
243 rdf:type schema:Person
244 sg:person.0672041256.86 schema:affiliation grid-institutes:None
245 schema:familyName Wang
246 schema:givenName Yuhui
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672041256.86
248 rdf:type schema:Person
249 sg:pub.10.1038/sj.ijo.0803646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007050950
250 https://doi.org/10.1038/sj.ijo.0803646
251 rdf:type schema:CreativeWork
252 grid-institutes:None schema:alternateName Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China
253 schema:name Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China
254 rdf:type schema:Organization
255 grid-institutes:grid.267500.6 schema:alternateName Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 409-3898, Yamanashi, Japan
256 schema:name Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 409-3898, Yamanashi, Japan
257 rdf:type schema:Organization
258 grid-institutes:grid.412860.9 schema:alternateName Department of Pathology Section on Lipid Sciences, Wake Forest University School of Medicine, Medical Center Blvd, 27157-1040, Winston-Salem, NC, USA
259 schema:name Department of Pathology Section on Lipid Sciences, Wake Forest University School of Medicine, Medical Center Blvd, 27157-1040, Winston-Salem, NC, USA
260 rdf:type schema:Organization
261 grid-institutes:grid.43169.39 schema:alternateName Laboratory Animal Center, Xi’an Jiaotong University, 710061, Xi’an, China
262 schema:name Laboratory Animal Center, Xi’an Jiaotong University, 710061, Xi’an, China
263 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...