Production of Two Vaccinating Recombinant Rotavirus Proteins in the Milk of Transgenic Rabbits View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-12

AUTHORS

Eric Soler, Agnès Le Saux, Frédéric Guinut, Bruno Passet, Ruxandra Cohen, Christine Merle, Annie Charpilienne, Cynthia Fourgeux, Véronique Sorel, Antoine Piriou, Isabelle Schwartz-Cornil, Jean Cohen, Louis-Marie Houdebine

ABSTRACT

Rotaviruses are the main cause of infantile viral gastroenteritis worldwide leading to approximately 500,000 deaths each year mostly in the developing world. For unknown reasons, live attenuated viruses used in classical vaccine strategies were shown to be responsible for intussusception (a bowel obstruction). New strategies allowing production of safe recombinant non-replicating rotavirus candidate vaccine are thus clearly needed. In this study we utilized transgenic rabbit milk as a source of rotavirus antigens. Individual transgenic rabbit lines were able to produce several hundreds of micrograms per ml of secreted recombinant VP2 and VP6 proteins in their milk. Viral proteins expressed in our model were immunogenic and were shown to induce a significant reduction in viral antigen shedding after challenge with virulent rotavirus in the adult mouse model. To our knowledge, this is the first report of transgenic mammal bioreactors allowing the rapid co-production of two recombinant viral proteins in milk to be used as a vaccine. More... »

PAGES

833-844

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11248-005-1771-0

DOI

http://dx.doi.org/10.1007/s11248-005-1771-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023920147

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16315090


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