Production of Two Vaccinating Recombinant Rotavirus Proteins in the Milk of Transgenic Rabbits View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-12

AUTHORS

Eric Soler, Agnès Le Saux, Frédéric Guinut, Bruno Passet, Ruxandra Cohen, Christine Merle, Annie Charpilienne, Cynthia Fourgeux, Véronique Sorel, Antoine Piriou, Isabelle Schwartz-Cornil, Jean Cohen, Louis-Marie Houdebine

ABSTRACT

Rotaviruses are the main cause of infantile viral gastroenteritis worldwide leading to approximately 500,000 deaths each year mostly in the developing world. For unknown reasons, live attenuated viruses used in classical vaccine strategies were shown to be responsible for intussusception (a bowel obstruction). New strategies allowing production of safe recombinant non-replicating rotavirus candidate vaccine are thus clearly needed. In this study we utilized transgenic rabbit milk as a source of rotavirus antigens. Individual transgenic rabbit lines were able to produce several hundreds of micrograms per ml of secreted recombinant VP2 and VP6 proteins in their milk. Viral proteins expressed in our model were immunogenic and were shown to induce a significant reduction in viral antigen shedding after challenge with virulent rotavirus in the adult mouse model. To our knowledge, this is the first report of transgenic mammal bioreactors allowing the rapid co-production of two recombinant viral proteins in milk to be used as a vaccine. More... »

PAGES

833-844

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11248-005-1771-0

DOI

http://dx.doi.org/10.1007/s11248-005-1771-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023920147

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16315090


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals, Genetically Modified", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Capsid Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme-Linked Immunosorbent Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Milk", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rabbits", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rotavirus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rotavirus Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rotavirus Vaccines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vaccination", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vaccines, Synthetic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Centre de Recherches de Jouy-en-Josas", 
          "id": "https://www.grid.ac/institutes/grid.417961.c", 
          "name": [
            "Biologie du D\u00e9veloppement et de la Reproduction, INRA, b\u00e2t.440, 78352, Jouy-en-Josas, France", 
            "Bioprotein Technologies, 63\u201365 bd Mass\u00e9na, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Soler", 
        "givenName": "Eric", 
        "id": "sg:person.0774025252.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774025252.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Bioprotein Technologies, 63\u201365 bd Mass\u00e9na, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saux", 
        "givenName": "Agn\u00e8s Le", 
        "id": "sg:person.0735526407.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735526407.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Bioprotein Technologies, 63\u201365 bd Mass\u00e9na, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guinut", 
        "givenName": "Fr\u00e9d\u00e9ric", 
        "id": "sg:person.0665031441.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665031441.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Bioprotein Technologies, 63\u201365 bd Mass\u00e9na, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Passet", 
        "givenName": "Bruno", 
        "id": "sg:person.0643676555.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643676555.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Bioprotein Technologies, 63\u201365 bd Mass\u00e9na, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cohen", 
        "givenName": "Ruxandra", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Bioprotein Technologies, 63\u201365 bd Mass\u00e9na, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Merle", 
        "givenName": "Christine", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Virologie Mol\u00e9culaire & Structurale, CNRS-INRA, Gif-sur-Yvette, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Charpilienne", 
        "givenName": "Annie", 
        "id": "sg:person.01267611625.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267611625.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre de Recherches de Jouy-en-Josas", 
          "id": "https://www.grid.ac/institutes/grid.417961.c", 
          "name": [
            "Virologie et Immunologie Mol\u00e9culaires, INRA, Jouy-en-Josas, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fourgeux", 
        "givenName": "Cynthia", 
        "id": "sg:person.01131156237.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131156237.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Bioprotein Technologies, 63\u201365 bd Mass\u00e9na, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sorel", 
        "givenName": "V\u00e9ronique", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Bioprotein Technologies, 63\u201365 bd Mass\u00e9na, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Piriou", 
        "givenName": "Antoine", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre de Recherches de Jouy-en-Josas", 
          "id": "https://www.grid.ac/institutes/grid.417961.c", 
          "name": [
            "Virologie et Immunologie Mol\u00e9culaires, INRA, Jouy-en-Josas, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schwartz-Cornil", 
        "givenName": "Isabelle", 
        "id": "sg:person.01113527666.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113527666.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Virologie Mol\u00e9culaire & Structurale, CNRS-INRA, Gif-sur-Yvette, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cohen", 
        "givenName": "Jean", 
        "id": "sg:person.0707304150.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707304150.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre de Recherches de Jouy-en-Josas", 
          "id": "https://www.grid.ac/institutes/grid.417961.c", 
          "name": [
            "Biologie du D\u00e9veloppement et de la Reproduction, INRA, b\u00e2t.440, 78352, Jouy-en-Josas, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Houdebine", 
        "givenName": "Louis-Marie", 
        "id": "sg:person.01221277576.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221277576.70"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0958-1669(02)00362-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002150699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0958-1669(02)00362-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002150699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1022912130286", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003046986", 
          "https://doi.org/10.1023/a:1022912130286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.74.19.8966-8971.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003921811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1008919925303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009308455", 
          "https://doi.org/10.1023/a:1008919925303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/b:trag.0000005242.72076.d1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009962551", 
          "https://doi.org/10.1023/b:trag.0000005242.72076.d1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00705-002-0808-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010315182", 
          "https://doi.org/10.1007/s00705-002-0808-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mrd.90007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015847382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0264-410x(00)00543-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020400063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.74.24.11574-11580.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021483955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.76.16.8110-8117.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022880800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/20.7.1498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023813438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vaccine.2004.01.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025196774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.102179399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025300903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(04)16155-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025613036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.012590199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025967197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00299-003-0697-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026931616", 
          "https://doi.org/10.1007/s00299-003-0697-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00299-003-0697-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026931616", 
          "https://doi.org/10.1007/s00299-003-0697-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/8.12.2145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027096024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m101935200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030801722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.76.15.7822-7831.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031157130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0042-6822(03)00280-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032374478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0042-6822(03)00280-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032374478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0042-6822(03)00280-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032374478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0264-410x(03)00308-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034345089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0264-410x(03)00308-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034345089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0163-7258(03)00069-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040880042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0163-7258(03)00069-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040880042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/20.7.1485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043552979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-1656(99)00221-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045281115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pep.2004.08.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045457259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vaccine.2004.06.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046607630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s101420000002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047317547", 
          "https://doi.org/10.1007/s101420000002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg1177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050745230", 
          "https://doi.org/10.1038/nrg1177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg1177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050745230", 
          "https://doi.org/10.1038/nrg1177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1008934912555", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050836022", 
          "https://doi.org/10.1023/a:1008934912555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.75.22.11010-11016.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051005995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/glycob/cwh127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052502761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/dna.1.1982.1.239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059250542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/protein/3.5.433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059980516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/vir.0.19659-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060400119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.272.5258.104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062552618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.305.5692.1890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062586122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074556061", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00299-003-0599-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075296755", 
          "https://doi.org/10.1007/s00299-003-0599-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00299-003-0599-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075296755", 
          "https://doi.org/10.1007/s00299-003-0599-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075594008", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077655525", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082586011", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083163762", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083326899", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2005-12", 
    "datePublishedReg": "2005-12-01", 
    "description": "Rotaviruses are the main cause of infantile viral gastroenteritis worldwide leading to approximately 500,000 deaths each year mostly in the developing world. For unknown reasons, live attenuated viruses used in classical vaccine strategies were shown to be responsible for intussusception (a bowel obstruction). New strategies allowing production of safe recombinant non-replicating rotavirus candidate vaccine are thus clearly needed. In this study we utilized transgenic rabbit milk as a source of rotavirus antigens. Individual transgenic rabbit lines were able to produce several hundreds of micrograms per ml of secreted recombinant VP2 and VP6 proteins in their milk. Viral proteins expressed in our model were immunogenic and were shown to induce a significant reduction in viral antigen shedding after challenge with virulent rotavirus in the adult mouse model. To our knowledge, this is the first report of transgenic mammal bioreactors allowing the rapid co-production of two recombinant viral proteins in milk to be used as a vaccine.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11248-005-1771-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1102526", 
        "issn": [
          "0962-8819", 
          "1573-9368"
        ], 
        "name": "Transgenic Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "Production of Two Vaccinating Recombinant Rotavirus Proteins in the Milk of Transgenic Rabbits", 
    "pagination": "833-844", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "71f54b0d3cec51464309b33b41f638a5f15ae3795423919cd7860d6345c24b0f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16315090"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9209120"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11248-005-1771-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1023920147"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11248-005-1771-0", 
      "https://app.dimensions.ai/details/publication/pub.1023920147"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87083_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11248-005-1771-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11248-005-1771-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11248-005-1771-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11248-005-1771-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11248-005-1771-0'


 

This table displays all metadata directly associated to this object as RDF triples.

373 TRIPLES      21 PREDICATES      90 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11248-005-1771-0 schema:about N1dde4809291142a299d8c00b0a9d9a3c
2 N2a0639f522364c24a290cefa6dbeeef1
3 N2e3900fb52684364a1bef9955028e4e2
4 N30ab0467b9d14712a4ce6ca94fbd76f0
5 N4f89660500ee428dbe4d57e747139a0d
6 N79895ffe7c2742c09cef2e7d92284cf0
7 N7cb92d08ea8c4655922c075fbec56b52
8 N7fab554463f54161b117554ff741c2a0
9 N80c6a8bb42b34e4d9be82ee972073eff
10 N820b4cef86934f42a4b51a839ec37bab
11 Na8ec55b910684fda9c8eace2c523faae
12 Nab23f070faef4253af271919f3e4a349
13 Nad4796bf46b64cc8997be15543caa12c
14 Nc714fedf612f4de388ac264498657841
15 Ndc5a8b1eee0542c8a0d811406e69b278
16 Nedb6d38e58834aa4b220935cc7301ebb
17 Nf5645bf523ce408395e4f46b66782f7e
18 Nfb84f845eef64c1d9495fd65673861cc
19 anzsrc-for:11
20 anzsrc-for:1108
21 schema:author N680c1e550bf145cf9b306e02e19ba564
22 schema:citation sg:pub.10.1007/s00299-003-0599-4
23 sg:pub.10.1007/s00299-003-0697-3
24 sg:pub.10.1007/s00705-002-0808-4
25 sg:pub.10.1007/s101420000002
26 sg:pub.10.1023/a:1008919925303
27 sg:pub.10.1023/a:1008934912555
28 sg:pub.10.1023/a:1022912130286
29 sg:pub.10.1023/b:trag.0000005242.72076.d1
30 sg:pub.10.1038/nrg1177
31 https://app.dimensions.ai/details/publication/pub.1074556061
32 https://app.dimensions.ai/details/publication/pub.1075594008
33 https://app.dimensions.ai/details/publication/pub.1077655525
34 https://app.dimensions.ai/details/publication/pub.1082586011
35 https://app.dimensions.ai/details/publication/pub.1083163762
36 https://app.dimensions.ai/details/publication/pub.1083326899
37 https://doi.org/10.1002/mrd.90007
38 https://doi.org/10.1016/j.pep.2004.08.009
39 https://doi.org/10.1016/j.vaccine.2004.01.044
40 https://doi.org/10.1016/j.vaccine.2004.06.018
41 https://doi.org/10.1016/s0042-6822(03)00280-0
42 https://doi.org/10.1016/s0140-6736(04)16155-2
43 https://doi.org/10.1016/s0163-7258(03)00069-x
44 https://doi.org/10.1016/s0168-1656(99)00221-7
45 https://doi.org/10.1016/s0264-410x(00)00543-0
46 https://doi.org/10.1016/s0264-410x(03)00308-6
47 https://doi.org/10.1016/s0958-1669(02)00362-2
48 https://doi.org/10.1073/pnas.012590199
49 https://doi.org/10.1073/pnas.102179399
50 https://doi.org/10.1074/jbc.m101935200
51 https://doi.org/10.1089/dna.1.1982.1.239
52 https://doi.org/10.1093/emboj/20.7.1485
53 https://doi.org/10.1093/emboj/20.7.1498
54 https://doi.org/10.1093/glycob/cwh127
55 https://doi.org/10.1093/hmg/8.12.2145
56 https://doi.org/10.1093/protein/3.5.433
57 https://doi.org/10.1099/vir.0.19659-0
58 https://doi.org/10.1126/science.272.5258.104
59 https://doi.org/10.1126/science.305.5692.1890
60 https://doi.org/10.1128/jvi.74.19.8966-8971.2000
61 https://doi.org/10.1128/jvi.74.24.11574-11580.2000
62 https://doi.org/10.1128/jvi.75.22.11010-11016.2001
63 https://doi.org/10.1128/jvi.76.15.7822-7831.2002
64 https://doi.org/10.1128/jvi.76.16.8110-8117.2002
65 schema:datePublished 2005-12
66 schema:datePublishedReg 2005-12-01
67 schema:description Rotaviruses are the main cause of infantile viral gastroenteritis worldwide leading to approximately 500,000 deaths each year mostly in the developing world. For unknown reasons, live attenuated viruses used in classical vaccine strategies were shown to be responsible for intussusception (a bowel obstruction). New strategies allowing production of safe recombinant non-replicating rotavirus candidate vaccine are thus clearly needed. In this study we utilized transgenic rabbit milk as a source of rotavirus antigens. Individual transgenic rabbit lines were able to produce several hundreds of micrograms per ml of secreted recombinant VP2 and VP6 proteins in their milk. Viral proteins expressed in our model were immunogenic and were shown to induce a significant reduction in viral antigen shedding after challenge with virulent rotavirus in the adult mouse model. To our knowledge, this is the first report of transgenic mammal bioreactors allowing the rapid co-production of two recombinant viral proteins in milk to be used as a vaccine.
68 schema:genre research_article
69 schema:inLanguage en
70 schema:isAccessibleForFree false
71 schema:isPartOf N6165fd6af7b94d20ad25d87f3434d694
72 N83870878325249c9830c1f7960485ba5
73 sg:journal.1102526
74 schema:name Production of Two Vaccinating Recombinant Rotavirus Proteins in the Milk of Transgenic Rabbits
75 schema:pagination 833-844
76 schema:productId N099d6604f9be40618662d5bf70549d4e
77 N40d1acfed9ea4cbb8def0a1a1ee636f6
78 N86b99242f085404ea86ede69bf359c2e
79 Ne1cb6d62f6d64f4f96dc6936e7463d96
80 Nf17ac045bd2b492a9252cd5643517b29
81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023920147
82 https://doi.org/10.1007/s11248-005-1771-0
83 schema:sdDatePublished 2019-04-11T12:22
84 schema:sdLicense https://scigraph.springernature.com/explorer/license/
85 schema:sdPublisher N54b1c73afe4f45cb9af3eb91f34fdee5
86 schema:url http://link.springer.com/10.1007%2Fs11248-005-1771-0
87 sgo:license sg:explorer/license/
88 sgo:sdDataset articles
89 rdf:type schema:ScholarlyArticle
90 N01142f377233480c9dac779fd3d522f2 rdf:first sg:person.0707304150.20
91 rdf:rest Nfa62fb8e77634dabae63656a650e2385
92 N01792de5c0e84acfa6f4351b070bc238 rdf:first sg:person.01131156237.11
93 rdf:rest Nf611dd416d8d44f0a866703bb06d57d9
94 N099d6604f9be40618662d5bf70549d4e schema:name doi
95 schema:value 10.1007/s11248-005-1771-0
96 rdf:type schema:PropertyValue
97 N1dde4809291142a299d8c00b0a9d9a3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Rotavirus Vaccines
99 rdf:type schema:DefinedTerm
100 N21f142ada17f4f1b99463944827ff522 rdf:first sg:person.0735526407.52
101 rdf:rest N5813b039576840e39a439daffd960dbd
102 N28770b6f203e485bb23fce7a24bccb56 schema:name Bioprotein Technologies, 63–65 bd Masséna, Paris, France
103 rdf:type schema:Organization
104 N2a0639f522364c24a290cefa6dbeeef1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Mice
106 rdf:type schema:DefinedTerm
107 N2ca812c9c83e4ca5ab2cdffa20197796 schema:name Bioprotein Technologies, 63–65 bd Masséna, Paris, France
108 rdf:type schema:Organization
109 N2e3900fb52684364a1bef9955028e4e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Molecular Sequence Data
111 rdf:type schema:DefinedTerm
112 N30ab0467b9d14712a4ce6ca94fbd76f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Enzyme-Linked Immunosorbent Assay
114 rdf:type schema:DefinedTerm
115 N40d1acfed9ea4cbb8def0a1a1ee636f6 schema:name readcube_id
116 schema:value 71f54b0d3cec51464309b33b41f638a5f15ae3795423919cd7860d6345c24b0f
117 rdf:type schema:PropertyValue
118 N47a75ee907f04711b6ded2866df7cc0b rdf:first sg:person.01267611625.15
119 rdf:rest N01792de5c0e84acfa6f4351b070bc238
120 N47f05d74fb2f468ba65a2bd3830dabbe rdf:first Nf3b28a06cf8542e6a42355987e5cc069
121 rdf:rest N90b3ddfbeac4494ab5d8903cfe001e2c
122 N4abcff12df9b43cda3980ace0469073a schema:affiliation N2ca812c9c83e4ca5ab2cdffa20197796
123 schema:familyName Cohen
124 schema:givenName Ruxandra
125 rdf:type schema:Person
126 N4c637177b3ab43bfaa6b764e6dd38b5b schema:name Bioprotein Technologies, 63–65 bd Masséna, Paris, France
127 rdf:type schema:Organization
128 N4f89660500ee428dbe4d57e747139a0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Rabbits
130 rdf:type schema:DefinedTerm
131 N54b1c73afe4f45cb9af3eb91f34fdee5 schema:name Springer Nature - SN SciGraph project
132 rdf:type schema:Organization
133 N5813b039576840e39a439daffd960dbd rdf:first sg:person.0665031441.40
134 rdf:rest Nb08b815d2ff94ed6a192ae8c80a8493f
135 N6165fd6af7b94d20ad25d87f3434d694 schema:issueNumber 6
136 rdf:type schema:PublicationIssue
137 N680c1e550bf145cf9b306e02e19ba564 rdf:first sg:person.0774025252.72
138 rdf:rest N21f142ada17f4f1b99463944827ff522
139 N79895ffe7c2742c09cef2e7d92284cf0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Animals
141 rdf:type schema:DefinedTerm
142 N7cb92d08ea8c4655922c075fbec56b52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Female
144 rdf:type schema:DefinedTerm
145 N7fab554463f54161b117554ff741c2a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Milk
147 rdf:type schema:DefinedTerm
148 N80c6a8bb42b34e4d9be82ee972073eff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Vaccines, Synthetic
150 rdf:type schema:DefinedTerm
151 N820b4cef86934f42a4b51a839ec37bab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Recombinant Proteins
153 rdf:type schema:DefinedTerm
154 N83870878325249c9830c1f7960485ba5 schema:volumeNumber 14
155 rdf:type schema:PublicationVolume
156 N86b99242f085404ea86ede69bf359c2e schema:name pubmed_id
157 schema:value 16315090
158 rdf:type schema:PropertyValue
159 N8b8a6a2f64584545a67698b5dedd27b7 schema:name Bioprotein Technologies, 63–65 bd Masséna, Paris, France
160 rdf:type schema:Organization
161 N90b3ddfbeac4494ab5d8903cfe001e2c rdf:first sg:person.01113527666.34
162 rdf:rest N01142f377233480c9dac779fd3d522f2
163 Na1172ecb08e54643ba69869f9d7d6e2d schema:name Virologie Moléculaire & Structurale, CNRS-INRA, Gif-sur-Yvette, France
164 rdf:type schema:Organization
165 Na7cd39c23aa74012b8a40db97e5f2d9c schema:affiliation Nfcbdf2805db04cb4b07c8da4d4702245
166 schema:familyName Merle
167 schema:givenName Christine
168 rdf:type schema:Person
169 Na8ec55b910684fda9c8eace2c523faae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Animals, Genetically Modified
171 rdf:type schema:DefinedTerm
172 Nab23f070faef4253af271919f3e4a349 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Rotavirus
174 rdf:type schema:DefinedTerm
175 Nad4796bf46b64cc8997be15543caa12c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Amino Acid Sequence
177 rdf:type schema:DefinedTerm
178 Nb08b815d2ff94ed6a192ae8c80a8493f rdf:first sg:person.0643676555.17
179 rdf:rest Nb652e55e40ca434eafb84fd10fdba298
180 Nb652e55e40ca434eafb84fd10fdba298 rdf:first N4abcff12df9b43cda3980ace0469073a
181 rdf:rest Ne6bb652be48e468cb65998c97325b0dc
182 Nc714fedf612f4de388ac264498657841 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Vaccination
184 rdf:type schema:DefinedTerm
185 Nd3cca649b60f411a9d13e8028c42a34b schema:name Bioprotein Technologies, 63–65 bd Masséna, Paris, France
186 rdf:type schema:Organization
187 Ndb33e2aa7ac74130b3f20a1a12c25ff8 schema:name Bioprotein Technologies, 63–65 bd Masséna, Paris, France
188 rdf:type schema:Organization
189 Ndc5a8b1eee0542c8a0d811406e69b278 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Antigens, Viral
191 rdf:type schema:DefinedTerm
192 Ne1cb6d62f6d64f4f96dc6936e7463d96 schema:name nlm_unique_id
193 schema:value 9209120
194 rdf:type schema:PropertyValue
195 Ne6bb652be48e468cb65998c97325b0dc rdf:first Na7cd39c23aa74012b8a40db97e5f2d9c
196 rdf:rest N47a75ee907f04711b6ded2866df7cc0b
197 Nec142f50b04a4f5eae58bbe60c22145e schema:name Virologie Moléculaire & Structurale, CNRS-INRA, Gif-sur-Yvette, France
198 rdf:type schema:Organization
199 Nedb6d38e58834aa4b220935cc7301ebb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Rotavirus Infections
201 rdf:type schema:DefinedTerm
202 Nf17ac045bd2b492a9252cd5643517b29 schema:name dimensions_id
203 schema:value pub.1023920147
204 rdf:type schema:PropertyValue
205 Nf3b28a06cf8542e6a42355987e5cc069 schema:affiliation N8b8a6a2f64584545a67698b5dedd27b7
206 schema:familyName Piriou
207 schema:givenName Antoine
208 rdf:type schema:Person
209 Nf5645bf523ce408395e4f46b66782f7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Mice, Inbred BALB C
211 rdf:type schema:DefinedTerm
212 Nf611dd416d8d44f0a866703bb06d57d9 rdf:first Nfdf527f6672f416499cbc1d9058591f7
213 rdf:rest N47f05d74fb2f468ba65a2bd3830dabbe
214 Nfa62fb8e77634dabae63656a650e2385 rdf:first sg:person.01221277576.70
215 rdf:rest rdf:nil
216 Nfb84f845eef64c1d9495fd65673861cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name Capsid Proteins
218 rdf:type schema:DefinedTerm
219 Nfcbdf2805db04cb4b07c8da4d4702245 schema:name Bioprotein Technologies, 63–65 bd Masséna, Paris, France
220 rdf:type schema:Organization
221 Nfdf527f6672f416499cbc1d9058591f7 schema:affiliation Ndb33e2aa7ac74130b3f20a1a12c25ff8
222 schema:familyName Sorel
223 schema:givenName Véronique
224 rdf:type schema:Person
225 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
226 schema:name Medical and Health Sciences
227 rdf:type schema:DefinedTerm
228 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
229 schema:name Medical Microbiology
230 rdf:type schema:DefinedTerm
231 sg:journal.1102526 schema:issn 0962-8819
232 1573-9368
233 schema:name Transgenic Research
234 rdf:type schema:Periodical
235 sg:person.01113527666.34 schema:affiliation https://www.grid.ac/institutes/grid.417961.c
236 schema:familyName Schwartz-Cornil
237 schema:givenName Isabelle
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113527666.34
239 rdf:type schema:Person
240 sg:person.01131156237.11 schema:affiliation https://www.grid.ac/institutes/grid.417961.c
241 schema:familyName Fourgeux
242 schema:givenName Cynthia
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131156237.11
244 rdf:type schema:Person
245 sg:person.01221277576.70 schema:affiliation https://www.grid.ac/institutes/grid.417961.c
246 schema:familyName Houdebine
247 schema:givenName Louis-Marie
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221277576.70
249 rdf:type schema:Person
250 sg:person.01267611625.15 schema:affiliation Nec142f50b04a4f5eae58bbe60c22145e
251 schema:familyName Charpilienne
252 schema:givenName Annie
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267611625.15
254 rdf:type schema:Person
255 sg:person.0643676555.17 schema:affiliation N28770b6f203e485bb23fce7a24bccb56
256 schema:familyName Passet
257 schema:givenName Bruno
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643676555.17
259 rdf:type schema:Person
260 sg:person.0665031441.40 schema:affiliation Nd3cca649b60f411a9d13e8028c42a34b
261 schema:familyName Guinut
262 schema:givenName Frédéric
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665031441.40
264 rdf:type schema:Person
265 sg:person.0707304150.20 schema:affiliation Na1172ecb08e54643ba69869f9d7d6e2d
266 schema:familyName Cohen
267 schema:givenName Jean
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707304150.20
269 rdf:type schema:Person
270 sg:person.0735526407.52 schema:affiliation N4c637177b3ab43bfaa6b764e6dd38b5b
271 schema:familyName Saux
272 schema:givenName Agnès Le
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735526407.52
274 rdf:type schema:Person
275 sg:person.0774025252.72 schema:affiliation https://www.grid.ac/institutes/grid.417961.c
276 schema:familyName Soler
277 schema:givenName Eric
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774025252.72
279 rdf:type schema:Person
280 sg:pub.10.1007/s00299-003-0599-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075296755
281 https://doi.org/10.1007/s00299-003-0599-4
282 rdf:type schema:CreativeWork
283 sg:pub.10.1007/s00299-003-0697-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026931616
284 https://doi.org/10.1007/s00299-003-0697-3
285 rdf:type schema:CreativeWork
286 sg:pub.10.1007/s00705-002-0808-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010315182
287 https://doi.org/10.1007/s00705-002-0808-4
288 rdf:type schema:CreativeWork
289 sg:pub.10.1007/s101420000002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047317547
290 https://doi.org/10.1007/s101420000002
291 rdf:type schema:CreativeWork
292 sg:pub.10.1023/a:1008919925303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009308455
293 https://doi.org/10.1023/a:1008919925303
294 rdf:type schema:CreativeWork
295 sg:pub.10.1023/a:1008934912555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050836022
296 https://doi.org/10.1023/a:1008934912555
297 rdf:type schema:CreativeWork
298 sg:pub.10.1023/a:1022912130286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003046986
299 https://doi.org/10.1023/a:1022912130286
300 rdf:type schema:CreativeWork
301 sg:pub.10.1023/b:trag.0000005242.72076.d1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009962551
302 https://doi.org/10.1023/b:trag.0000005242.72076.d1
303 rdf:type schema:CreativeWork
304 sg:pub.10.1038/nrg1177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050745230
305 https://doi.org/10.1038/nrg1177
306 rdf:type schema:CreativeWork
307 https://app.dimensions.ai/details/publication/pub.1074556061 schema:CreativeWork
308 https://app.dimensions.ai/details/publication/pub.1075594008 schema:CreativeWork
309 https://app.dimensions.ai/details/publication/pub.1077655525 schema:CreativeWork
310 https://app.dimensions.ai/details/publication/pub.1082586011 schema:CreativeWork
311 https://app.dimensions.ai/details/publication/pub.1083163762 schema:CreativeWork
312 https://app.dimensions.ai/details/publication/pub.1083326899 schema:CreativeWork
313 https://doi.org/10.1002/mrd.90007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015847382
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.pep.2004.08.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045457259
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/j.vaccine.2004.01.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025196774
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/j.vaccine.2004.06.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046607630
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/s0042-6822(03)00280-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032374478
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/s0140-6736(04)16155-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025613036
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/s0163-7258(03)00069-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040880042
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/s0168-1656(99)00221-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045281115
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/s0264-410x(00)00543-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020400063
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/s0264-410x(03)00308-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034345089
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1016/s0958-1669(02)00362-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002150699
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1073/pnas.012590199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025967197
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1073/pnas.102179399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025300903
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1074/jbc.m101935200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030801722
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1089/dna.1.1982.1.239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059250542
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1093/emboj/20.7.1485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043552979
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1093/emboj/20.7.1498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023813438
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1093/glycob/cwh127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052502761
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1093/hmg/8.12.2145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027096024
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1093/protein/3.5.433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059980516
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1099/vir.0.19659-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060400119
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1126/science.272.5258.104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062552618
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1126/science.305.5692.1890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062586122
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1128/jvi.74.19.8966-8971.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003921811
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1128/jvi.74.24.11574-11580.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021483955
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1128/jvi.75.22.11010-11016.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051005995
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1128/jvi.76.15.7822-7831.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031157130
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1128/jvi.76.16.8110-8117.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022880800
368 rdf:type schema:CreativeWork
369 https://www.grid.ac/institutes/grid.417961.c schema:alternateName Centre de Recherches de Jouy-en-Josas
370 schema:name Biologie du Développement et de la Reproduction, INRA, bât.440, 78352, Jouy-en-Josas, France
371 Bioprotein Technologies, 63–65 bd Masséna, Paris, France
372 Virologie et Immunologie Moléculaires, INRA, Jouy-en-Josas, France
373 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...