Enantioselective Biotransformations of Nitriles in Organic Synthesis View Full Text


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Article Info

DATE

2005-06

AUTHORS

Mei-Xiang Wang

ABSTRACT

Recent advances in enantioselective biotransformations of nitriles utilizing nitrile-hydrolyzing microorganisms and enzymes are summarized in this article. Various examples of biocatalytic synthesis of highly enantiopure carboxylic acids including amino acids, hydroxyl acids, cyclopropanecarboxylic acids and amide derivatives and oxiranecarboxamides are presented. The enantioselectivity of the nitrile hydratases, nitrilases and amideses is discussed. More... »

PAGES

117-130

References to SciGraph publications

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  • 2001-03. Purification and characterization of the enantioselective nitrile hydratase from Rhodococcus equi A4 in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
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  • 1991-04. Stereoselective microbial hydrolysis of 2-aryloxypropionitriles in BIOTECHNOLOGY LETTERS
  • 1986-03. Hydrolysis of the nitrile group in α-aminophenylacetonitrile by nitrilase; Development of a new biotechnology for stereospecific production ofS-α-phenylglycine in ARCHIVES OF PHARMACAL RESEARCH
  • 1992-11. Enantioselective hydrolysis of O-acetylmandelonitrile to O-acetylmandelic acid by bacterial nitrilases in ARCHIVES OF MICROBIOLOGY
  • 1996-09. Enantioselectivitiy of the nitrile hydratase from Rhodococcus equi A4 towards substituted (R,S)-2-arylpropionitriles in BIOTECHNOLOGY LETTERS
  • 1990-12. ε-caprolactam, a new powerful inducer for the formation of Rhodococcus rhodochrous J1 nitrilase in ARCHIVES OF MICROBIOLOGY
  • 1993-10. Substrate specificity and stereoselectivity of hydrolytic enzymes from Brevibacterium imperiale B222 in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 1994-01. Asymmetric hydrolysis of chiral nitriles byRhodococcusrhodochrous NCIMB 11216 nitrilase in BIOTECHNOLOGY LETTERS
  • 1992-05. Asymmetric hydrolysis of α-aminonitriles to optically active amino acids by a nitrilase of Rhodococcus rhodochrous PA-34 in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 1998-05. Novel non-heme iron center of nitrile hydratase with a claw setting of oxygen atoms in NATURE STRUCTURAL & MOLECULAR BIOLOGY
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    http://scigraph.springernature.com/pub.10.1007/s11244-005-3817-1

    DOI

    http://dx.doi.org/10.1007/s11244-005-3817-1

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