Determinants of ST-segment elevation myocardial infarction as clinical presentation of acute coronary syndrome View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-09-21

AUTHORS

Osamu Kurihara, Masamichi Takano, Tsunekazu Kakuta, Tsunenari Soeda, Filippo Crea, Tom Adriaenssens, Holger M. Nef, Niklas F. Boeder, Erika Yamamoto, Hyung Oh Kim, Michele Russo, Iris McNulty, Makoto Araki, Akihiro Nakajima, Hang Lee, Kyoichi Mizuno, Ik -Kyung Jang

ABSTRACT

Antiplatelet agents and statin therapies are widely used in patients with known cardiovascular disease. Plaque rupture (PR) and plaque erosion (PE) are the most frequent underlying mechanisms of acute coronary syndromes (ACS). The conditions and medications that are associated with ST-segment elevation myocardial infarction (STEMI) following PR or PE have not been systematically studied. A total of 838 ACS patients (494 with STEMI, 344 with NSTE-ACS) who were diagnosed with PR or PE by optical coherence tomography were included. The patients were categorized into two groups based on underlying pathology, and the baseline characteristics and culprit plaque morphology associated with STEMI were investigated within each group. Among 838 patients, 467 (55.7%) had PR, and 371 (44.3%) were diagnosed with PE. Among patients with PR, older age, hyperlipidemia, no antiplatelet therapy, higher level of low-density lipoprotein cholesterol, and greater lipid burden and macrophage infiltration were associated with increased probability of STEMI. Among patients with PE, no dual antiplatelet therapy and no statin therapy were associated with increased probability of STEMI. The incidence of STEMI caused by PR was significantly lower on antiplatelet therapy (P < 0.001), and the incidence of STEMI caused by PE was significantly lower on antiplatelet therapy (P < 0.001) or on statin therapy (P < 0.001). Antiplatelet therapy is associated with lower probability of STEMI, regardless of underlying pathology, and statin therapy is associated with lower probability of STEMI in PE as clinical presentation of ACS.Graphic AbstractStatin therapy prior to the onset of acute coronary syndromes (ACS) may reduce the probability of plaque rupture. Antiplatelet therapy prior to the onset of ACS is associated with reduced probability of ST-segment elevation myocardial infarction (STEMI) following both plaque rupture and plaque erosion, and dual antiplatelet therapy offers additional protection compared to a single antiplatelet agent in plaque erosion. The combination of statin and antiplatelet therapy may have an additive effect on reducing the probability of STEMI caused by plaque erosion.Yellow: lipid pool(necrotic core); red: fibrin-rich thrombus; gray; platelet-rich thrombus More... »

PAGES

1026-1035

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11239-020-02281-7

DOI

http://dx.doi.org/10.1007/s11239-020-02281-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1131006161

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32955695


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acute Coronary Syndrome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coronary Angiography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydroxymethylglutaryl-CoA Reductase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plaque, Atherosclerotic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Platelet Aggregation Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ST Elevation Myocardial Infarction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thrombosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tomography, Optical Coherence", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRB 800, 02114, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRB 800, 02114, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kurihara", 
        "givenName": "Osamu", 
        "id": "sg:person.0707102743.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707102743.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiovascular Center, Nippon Medical School Chiba Hokusoh Hospital, 1715 Kamakari, 270-1694, Inzai, Chiba, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416273.5", 
          "name": [
            "Cardiovascular Center, Nippon Medical School Chiba Hokusoh Hospital, 1715 Kamakari, 270-1694, Inzai, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takano", 
        "givenName": "Masamichi", 
        "id": "sg:person.0611573717.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611573717.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Ibaraki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410824.b", 
          "name": [
            "Division of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kakuta", 
        "givenName": "Tsunekazu", 
        "id": "sg:person.01055154135.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055154135.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular Medicine, Nara Medical University, Nara, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410814.8", 
          "name": [
            "Department of Cardiovascular Medicine, Nara Medical University, Nara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Soeda", 
        "givenName": "Tsunenari", 
        "id": "sg:person.0746001440.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746001440.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy", 
          "id": "http://www.grid.ac/institutes/grid.414603.4", 
          "name": [
            "Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Crea", 
        "givenName": "Filippo", 
        "id": "sg:person.0745627704.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745627704.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular Medicine, University Hospitals Leuven, Leuven, Belgium", 
          "id": "http://www.grid.ac/institutes/grid.410569.f", 
          "name": [
            "Department of Cardiovascular Medicine, University Hospitals Leuven, Leuven, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Adriaenssens", 
        "givenName": "Tom", 
        "id": "sg:person.0750415650.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750415650.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, University of Giessen, Giessen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.8664.c", 
          "name": [
            "Department of Cardiology, University of Giessen, Giessen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nef", 
        "givenName": "Holger M.", 
        "id": "sg:person.0623557131.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623557131.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, University of Giessen, Giessen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.8664.c", 
          "name": [
            "Department of Cardiology, University of Giessen, Giessen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boeder", 
        "givenName": "Niklas F.", 
        "id": "sg:person.01167111775.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167111775.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRB 800, 02114, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRB 800, 02114, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamamoto", 
        "givenName": "Erika", 
        "id": "sg:person.07634657005.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07634657005.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRB 800, 02114, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRB 800, 02114, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Hyung Oh", 
        "id": "sg:person.011554350225.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011554350225.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRB 800, 02114, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRB 800, 02114, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Russo", 
        "givenName": "Michele", 
        "id": "sg:person.016665066472.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016665066472.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRB 800, 02114, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRB 800, 02114, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McNulty", 
        "givenName": "Iris", 
        "id": "sg:person.0600222531.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600222531.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRB 800, 02114, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRB 800, 02114, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Araki", 
        "givenName": "Makoto", 
        "id": "sg:person.01255540637.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255540637.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRB 800, 02114, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRB 800, 02114, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakajima", 
        "givenName": "Akihiro", 
        "id": "sg:person.014770623231.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014770623231.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biostatistics Center, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Biostatistics Center, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Hang", 
        "id": "sg:person.016505303214.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016505303214.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mitsukoshi Health and Welfare Foundation, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.490945.5", 
          "name": [
            "Mitsukoshi Health and Welfare Foundation, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mizuno", 
        "givenName": "Kyoichi", 
        "id": "sg:person.01224612517.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224612517.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Kyung Hee University Hospital, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.411231.4", 
          "name": [
            "Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRB 800, 02114, Boston, MA, USA", 
            "Department of Cardiology, Kyung Hee University Hospital, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jang", 
        "givenName": "Ik -Kyung", 
        "id": "sg:person.0766106100.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766106100.00"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2020-09-21", 
    "datePublishedReg": "2020-09-21", 
    "description": "Antiplatelet agents and statin therapies are widely used in patients with known cardiovascular disease. Plaque rupture (PR) and plaque erosion (PE) are the most frequent underlying mechanisms of acute coronary syndromes (ACS). The conditions and medications that are associated with ST-segment elevation myocardial infarction (STEMI) following PR or PE have not been systematically studied. A total of 838 ACS patients (494 with STEMI, 344 with NSTE-ACS) who were diagnosed with PR or PE by optical coherence tomography were included. The patients were categorized into two groups based on underlying pathology, and the baseline characteristics and culprit plaque morphology associated with STEMI were investigated within each group. Among 838 patients, 467 (55.7%) had PR, and 371 (44.3%) were diagnosed with PE. Among patients with PR, older age, hyperlipidemia, no antiplatelet therapy, higher level of low-density lipoprotein cholesterol, and greater lipid burden and macrophage infiltration were associated with increased probability of STEMI. Among patients with PE, no dual antiplatelet therapy and no statin therapy were associated with increased probability of STEMI. The incidence of STEMI caused by PR was significantly lower on antiplatelet therapy (P\u2009<\u20090.001), and the incidence of STEMI caused by PE was significantly lower on antiplatelet therapy (P\u2009<\u20090.001) or on statin therapy (P\u2009<\u20090.001). Antiplatelet therapy is associated with lower probability of STEMI, regardless of underlying pathology, and statin therapy is associated with lower probability of STEMI in PE as clinical presentation of ACS.Graphic AbstractStatin therapy prior to the onset of acute coronary syndromes (ACS) may reduce the probability of plaque rupture. Antiplatelet therapy prior to the onset of ACS is associated with reduced probability of ST-segment elevation myocardial infarction (STEMI) following both plaque rupture and plaque erosion, and dual antiplatelet therapy offers additional protection compared to a single antiplatelet agent in plaque erosion. The combination of statin and antiplatelet therapy may have an additive effect on reducing the probability of STEMI caused by plaque erosion.Yellow: lipid pool(necrotic core); red: fibrin-rich thrombus; gray; platelet-rich thrombus", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s11239-020-02281-7", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1113719", 
        "issn": [
          "0929-5305", 
          "1573-742X"
        ], 
        "name": "Journal of Thrombosis and Thrombolysis", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "51"
      }
    ], 
    "keywords": [
      "ST-segment elevation myocardial infarction", 
      "acute coronary syndrome", 
      "elevation myocardial infarction", 
      "incidence of STEMI", 
      "antiplatelet therapy", 
      "dual antiplatelet therapy", 
      "plaque erosion", 
      "statin therapy", 
      "plaque rupture", 
      "coronary syndrome", 
      "myocardial infarction", 
      "antiplatelet agents", 
      "clinical presentation", 
      "onset of ACS", 
      "low-density lipoprotein cholesterol", 
      "frequent underlying mechanism", 
      "single antiplatelet agent", 
      "combination of statins", 
      "culprit plaque morphology", 
      "fibrin-rich thrombi", 
      "optical coherence tomography", 
      "ACS patients", 
      "baseline characteristics", 
      "lipoprotein cholesterol", 
      "macrophage infiltration", 
      "cardiovascular disease", 
      "lipid burden", 
      "patients", 
      "therapy", 
      "plaque morphology", 
      "coherence tomography", 
      "older age", 
      "infarction", 
      "syndrome", 
      "underlying mechanism", 
      "incidence", 
      "additive effect", 
      "pathology", 
      "low probability", 
      "rupture", 
      "additional protection", 
      "onset", 
      "presentation", 
      "reduced probability", 
      "high levels", 
      "medications", 
      "hyperlipidemia", 
      "statins", 
      "thrombus", 
      "group", 
      "agents", 
      "disease", 
      "cholesterol", 
      "infiltration", 
      "tomography", 
      "age", 
      "total", 
      "burden", 
      "determinants", 
      "levels", 
      "effect", 
      "protection", 
      "mechanism", 
      "combination", 
      "probability", 
      "erosion", 
      "characteristics", 
      "conditions", 
      "morphology"
    ], 
    "name": "Determinants of ST-segment elevation myocardial infarction as clinical presentation of acute coronary syndrome", 
    "pagination": "1026-1035", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1131006161"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11239-020-02281-7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "32955695"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11239-020-02281-7", 
      "https://app.dimensions.ai/details/publication/pub.1131006161"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T16:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_848.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s11239-020-02281-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11239-020-02281-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11239-020-02281-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11239-020-02281-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11239-020-02281-7'


 

This table displays all metadata directly associated to this object as RDF triples.

313 TRIPLES      20 PREDICATES      105 URIs      96 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11239-020-02281-7 schema:about N2bc7a70e8529446187e06b568f22d524
2 N30a55ce922bb4d5b9cbc0fffd8ee0773
3 N43114ca067684dfb9ad57035a8ad567a
4 N433bc31c043a424d85d8ecaab79b595b
5 N64c2af2252334429848c582a52ed1e17
6 N84f0695e887a4746abe600d8f30de7b0
7 N8e30bdefd0d24292aefe3c7949559705
8 Nbab976a030de4a4b9d02a0546508f0ca
9 Ncc31b9fbb47e4214a7875fa732ed7300
10 Nf2b3160cf24d497a8cc128900ad19a0a
11 anzsrc-for:11
12 anzsrc-for:1102
13 anzsrc-for:1103
14 schema:author Nd567b309ebfe44649c7742551879eb3e
15 schema:datePublished 2020-09-21
16 schema:datePublishedReg 2020-09-21
17 schema:description Antiplatelet agents and statin therapies are widely used in patients with known cardiovascular disease. Plaque rupture (PR) and plaque erosion (PE) are the most frequent underlying mechanisms of acute coronary syndromes (ACS). The conditions and medications that are associated with ST-segment elevation myocardial infarction (STEMI) following PR or PE have not been systematically studied. A total of 838 ACS patients (494 with STEMI, 344 with NSTE-ACS) who were diagnosed with PR or PE by optical coherence tomography were included. The patients were categorized into two groups based on underlying pathology, and the baseline characteristics and culprit plaque morphology associated with STEMI were investigated within each group. Among 838 patients, 467 (55.7%) had PR, and 371 (44.3%) were diagnosed with PE. Among patients with PR, older age, hyperlipidemia, no antiplatelet therapy, higher level of low-density lipoprotein cholesterol, and greater lipid burden and macrophage infiltration were associated with increased probability of STEMI. Among patients with PE, no dual antiplatelet therapy and no statin therapy were associated with increased probability of STEMI. The incidence of STEMI caused by PR was significantly lower on antiplatelet therapy (P < 0.001), and the incidence of STEMI caused by PE was significantly lower on antiplatelet therapy (P < 0.001) or on statin therapy (P < 0.001). Antiplatelet therapy is associated with lower probability of STEMI, regardless of underlying pathology, and statin therapy is associated with lower probability of STEMI in PE as clinical presentation of ACS.Graphic AbstractStatin therapy prior to the onset of acute coronary syndromes (ACS) may reduce the probability of plaque rupture. Antiplatelet therapy prior to the onset of ACS is associated with reduced probability of ST-segment elevation myocardial infarction (STEMI) following both plaque rupture and plaque erosion, and dual antiplatelet therapy offers additional protection compared to a single antiplatelet agent in plaque erosion. The combination of statin and antiplatelet therapy may have an additive effect on reducing the probability of STEMI caused by plaque erosion.Yellow: lipid pool(necrotic core); red: fibrin-rich thrombus; gray; platelet-rich thrombus
18 schema:genre article
19 schema:isAccessibleForFree false
20 schema:isPartOf N842b005b11ec40a48a87c1ef715db714
21 Nf33c7c53cf69466face4942cf330d84c
22 sg:journal.1113719
23 schema:keywords ACS patients
24 ST-segment elevation myocardial infarction
25 acute coronary syndrome
26 additional protection
27 additive effect
28 age
29 agents
30 antiplatelet agents
31 antiplatelet therapy
32 baseline characteristics
33 burden
34 cardiovascular disease
35 characteristics
36 cholesterol
37 clinical presentation
38 coherence tomography
39 combination
40 combination of statins
41 conditions
42 coronary syndrome
43 culprit plaque morphology
44 determinants
45 disease
46 dual antiplatelet therapy
47 effect
48 elevation myocardial infarction
49 erosion
50 fibrin-rich thrombi
51 frequent underlying mechanism
52 group
53 high levels
54 hyperlipidemia
55 incidence
56 incidence of STEMI
57 infarction
58 infiltration
59 levels
60 lipid burden
61 lipoprotein cholesterol
62 low probability
63 low-density lipoprotein cholesterol
64 macrophage infiltration
65 mechanism
66 medications
67 morphology
68 myocardial infarction
69 older age
70 onset
71 onset of ACS
72 optical coherence tomography
73 pathology
74 patients
75 plaque erosion
76 plaque morphology
77 plaque rupture
78 presentation
79 probability
80 protection
81 reduced probability
82 rupture
83 single antiplatelet agent
84 statin therapy
85 statins
86 syndrome
87 therapy
88 thrombus
89 tomography
90 total
91 underlying mechanism
92 schema:name Determinants of ST-segment elevation myocardial infarction as clinical presentation of acute coronary syndrome
93 schema:pagination 1026-1035
94 schema:productId N24d1b76ca9434ec195ceacde013b43d7
95 Nc51132b9db2843599fea29b5a853764f
96 Ned0c9d0f338441458c912bb268c5b8be
97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1131006161
98 https://doi.org/10.1007/s11239-020-02281-7
99 schema:sdDatePublished 2022-09-02T16:04
100 schema:sdLicense https://scigraph.springernature.com/explorer/license/
101 schema:sdPublisher N0b492ecc54ae4013bb9844990af2971a
102 schema:url https://doi.org/10.1007/s11239-020-02281-7
103 sgo:license sg:explorer/license/
104 sgo:sdDataset articles
105 rdf:type schema:ScholarlyArticle
106 N0b492ecc54ae4013bb9844990af2971a schema:name Springer Nature - SN SciGraph project
107 rdf:type schema:Organization
108 N1ce73699ecd74c8a94810e996c03f8ca rdf:first sg:person.01055154135.16
109 rdf:rest N2291de5a659d4daa8359382bd7a252ec
110 N2291de5a659d4daa8359382bd7a252ec rdf:first sg:person.0746001440.76
111 rdf:rest N8982e9903ac140e7a5857bdc0ed05c90
112 N24d1b76ca9434ec195ceacde013b43d7 schema:name pubmed_id
113 schema:value 32955695
114 rdf:type schema:PropertyValue
115 N2bc7a70e8529446187e06b568f22d524 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Tomography, Optical Coherence
117 rdf:type schema:DefinedTerm
118 N30a55ce922bb4d5b9cbc0fffd8ee0773 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Hydroxymethylglutaryl-CoA Reductase Inhibitors
120 rdf:type schema:DefinedTerm
121 N43114ca067684dfb9ad57035a8ad567a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Plaque, Atherosclerotic
123 rdf:type schema:DefinedTerm
124 N433bc31c043a424d85d8ecaab79b595b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Thrombosis
126 rdf:type schema:DefinedTerm
127 N507d865d203e420da2c720882d33d9f6 rdf:first sg:person.0766106100.00
128 rdf:rest rdf:nil
129 N5efaf468b08e402d8dc2ffd3b15426c6 rdf:first sg:person.014770623231.12
130 rdf:rest N63cde289d3a449449e24ff4bb8529f25
131 N63cde289d3a449449e24ff4bb8529f25 rdf:first sg:person.016505303214.05
132 rdf:rest Nacdc0ec85beb4e239807ef0e42dfcac4
133 N64c2af2252334429848c582a52ed1e17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Aged
135 rdf:type schema:DefinedTerm
136 N73ef127690194c19a2521d1276506e41 rdf:first sg:person.07634657005.91
137 rdf:rest N7403e771f9364ef8b1e22ee98c0aa592
138 N7403e771f9364ef8b1e22ee98c0aa592 rdf:first sg:person.011554350225.83
139 rdf:rest Ne5332dd52cd74d8ab088ac0490a0fe74
140 N842b005b11ec40a48a87c1ef715db714 schema:issueNumber 4
141 rdf:type schema:PublicationIssue
142 N84f0695e887a4746abe600d8f30de7b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Platelet Aggregation Inhibitors
144 rdf:type schema:DefinedTerm
145 N8982e9903ac140e7a5857bdc0ed05c90 rdf:first sg:person.0745627704.68
146 rdf:rest Nca32dabe12d64c608dccb9887214d049
147 N8b2c246d31884e40a088b8b7e4ddd2eb rdf:first sg:person.0600222531.54
148 rdf:rest Na70385b21ce4495484ebf0c5775a3ba5
149 N8e30bdefd0d24292aefe3c7949559705 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Humans
151 rdf:type schema:DefinedTerm
152 Na70385b21ce4495484ebf0c5775a3ba5 rdf:first sg:person.01255540637.29
153 rdf:rest N5efaf468b08e402d8dc2ffd3b15426c6
154 Nacdc0ec85beb4e239807ef0e42dfcac4 rdf:first sg:person.01224612517.39
155 rdf:rest N507d865d203e420da2c720882d33d9f6
156 Naf977a9018ca4dd99e5a88f9d4360dd7 rdf:first sg:person.01167111775.98
157 rdf:rest N73ef127690194c19a2521d1276506e41
158 Nbab976a030de4a4b9d02a0546508f0ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Acute Coronary Syndrome
160 rdf:type schema:DefinedTerm
161 Nc1515423edb640a48fc7538f0ad7a2be rdf:first sg:person.0611573717.76
162 rdf:rest N1ce73699ecd74c8a94810e996c03f8ca
163 Nc51132b9db2843599fea29b5a853764f schema:name dimensions_id
164 schema:value pub.1131006161
165 rdf:type schema:PropertyValue
166 Nc6b53cd696b347ada9f08969f260d979 rdf:first sg:person.0623557131.14
167 rdf:rest Naf977a9018ca4dd99e5a88f9d4360dd7
168 Nca32dabe12d64c608dccb9887214d049 rdf:first sg:person.0750415650.28
169 rdf:rest Nc6b53cd696b347ada9f08969f260d979
170 Ncc31b9fbb47e4214a7875fa732ed7300 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Coronary Angiography
172 rdf:type schema:DefinedTerm
173 Nd567b309ebfe44649c7742551879eb3e rdf:first sg:person.0707102743.08
174 rdf:rest Nc1515423edb640a48fc7538f0ad7a2be
175 Ne5332dd52cd74d8ab088ac0490a0fe74 rdf:first sg:person.016665066472.30
176 rdf:rest N8b2c246d31884e40a088b8b7e4ddd2eb
177 Ned0c9d0f338441458c912bb268c5b8be schema:name doi
178 schema:value 10.1007/s11239-020-02281-7
179 rdf:type schema:PropertyValue
180 Nf2b3160cf24d497a8cc128900ad19a0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name ST Elevation Myocardial Infarction
182 rdf:type schema:DefinedTerm
183 Nf33c7c53cf69466face4942cf330d84c schema:volumeNumber 51
184 rdf:type schema:PublicationVolume
185 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
186 schema:name Medical and Health Sciences
187 rdf:type schema:DefinedTerm
188 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
189 schema:name Cardiorespiratory Medicine and Haematology
190 rdf:type schema:DefinedTerm
191 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
192 schema:name Clinical Sciences
193 rdf:type schema:DefinedTerm
194 sg:journal.1113719 schema:issn 0929-5305
195 1573-742X
196 schema:name Journal of Thrombosis and Thrombolysis
197 schema:publisher Springer Nature
198 rdf:type schema:Periodical
199 sg:person.01055154135.16 schema:affiliation grid-institutes:grid.410824.b
200 schema:familyName Kakuta
201 schema:givenName Tsunekazu
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055154135.16
203 rdf:type schema:Person
204 sg:person.011554350225.83 schema:affiliation grid-institutes:grid.38142.3c
205 schema:familyName Kim
206 schema:givenName Hyung Oh
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011554350225.83
208 rdf:type schema:Person
209 sg:person.01167111775.98 schema:affiliation grid-institutes:grid.8664.c
210 schema:familyName Boeder
211 schema:givenName Niklas F.
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167111775.98
213 rdf:type schema:Person
214 sg:person.01224612517.39 schema:affiliation grid-institutes:grid.490945.5
215 schema:familyName Mizuno
216 schema:givenName Kyoichi
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224612517.39
218 rdf:type schema:Person
219 sg:person.01255540637.29 schema:affiliation grid-institutes:grid.38142.3c
220 schema:familyName Araki
221 schema:givenName Makoto
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255540637.29
223 rdf:type schema:Person
224 sg:person.014770623231.12 schema:affiliation grid-institutes:grid.38142.3c
225 schema:familyName Nakajima
226 schema:givenName Akihiro
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014770623231.12
228 rdf:type schema:Person
229 sg:person.016505303214.05 schema:affiliation grid-institutes:grid.38142.3c
230 schema:familyName Lee
231 schema:givenName Hang
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016505303214.05
233 rdf:type schema:Person
234 sg:person.016665066472.30 schema:affiliation grid-institutes:grid.38142.3c
235 schema:familyName Russo
236 schema:givenName Michele
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016665066472.30
238 rdf:type schema:Person
239 sg:person.0600222531.54 schema:affiliation grid-institutes:grid.38142.3c
240 schema:familyName McNulty
241 schema:givenName Iris
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600222531.54
243 rdf:type schema:Person
244 sg:person.0611573717.76 schema:affiliation grid-institutes:grid.416273.5
245 schema:familyName Takano
246 schema:givenName Masamichi
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611573717.76
248 rdf:type schema:Person
249 sg:person.0623557131.14 schema:affiliation grid-institutes:grid.8664.c
250 schema:familyName Nef
251 schema:givenName Holger M.
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623557131.14
253 rdf:type schema:Person
254 sg:person.0707102743.08 schema:affiliation grid-institutes:grid.38142.3c
255 schema:familyName Kurihara
256 schema:givenName Osamu
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707102743.08
258 rdf:type schema:Person
259 sg:person.0745627704.68 schema:affiliation grid-institutes:grid.414603.4
260 schema:familyName Crea
261 schema:givenName Filippo
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745627704.68
263 rdf:type schema:Person
264 sg:person.0746001440.76 schema:affiliation grid-institutes:grid.410814.8
265 schema:familyName Soeda
266 schema:givenName Tsunenari
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746001440.76
268 rdf:type schema:Person
269 sg:person.0750415650.28 schema:affiliation grid-institutes:grid.410569.f
270 schema:familyName Adriaenssens
271 schema:givenName Tom
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750415650.28
273 rdf:type schema:Person
274 sg:person.07634657005.91 schema:affiliation grid-institutes:grid.38142.3c
275 schema:familyName Yamamoto
276 schema:givenName Erika
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07634657005.91
278 rdf:type schema:Person
279 sg:person.0766106100.00 schema:affiliation grid-institutes:grid.411231.4
280 schema:familyName Jang
281 schema:givenName Ik -Kyung
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766106100.00
283 rdf:type schema:Person
284 grid-institutes:grid.38142.3c schema:alternateName Biostatistics Center, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA
285 Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRB 800, 02114, Boston, MA, USA
286 schema:name Biostatistics Center, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA
287 Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRB 800, 02114, Boston, MA, USA
288 rdf:type schema:Organization
289 grid-institutes:grid.410569.f schema:alternateName Department of Cardiovascular Medicine, University Hospitals Leuven, Leuven, Belgium
290 schema:name Department of Cardiovascular Medicine, University Hospitals Leuven, Leuven, Belgium
291 rdf:type schema:Organization
292 grid-institutes:grid.410814.8 schema:alternateName Department of Cardiovascular Medicine, Nara Medical University, Nara, Japan
293 schema:name Department of Cardiovascular Medicine, Nara Medical University, Nara, Japan
294 rdf:type schema:Organization
295 grid-institutes:grid.410824.b schema:alternateName Division of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Ibaraki, Japan
296 schema:name Division of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Ibaraki, Japan
297 rdf:type schema:Organization
298 grid-institutes:grid.411231.4 schema:alternateName Department of Cardiology, Kyung Hee University Hospital, Seoul, Korea
299 schema:name Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRB 800, 02114, Boston, MA, USA
300 Department of Cardiology, Kyung Hee University Hospital, Seoul, Korea
301 rdf:type schema:Organization
302 grid-institutes:grid.414603.4 schema:alternateName Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy
303 schema:name Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy
304 rdf:type schema:Organization
305 grid-institutes:grid.416273.5 schema:alternateName Cardiovascular Center, Nippon Medical School Chiba Hokusoh Hospital, 1715 Kamakari, 270-1694, Inzai, Chiba, Japan
306 schema:name Cardiovascular Center, Nippon Medical School Chiba Hokusoh Hospital, 1715 Kamakari, 270-1694, Inzai, Chiba, Japan
307 rdf:type schema:Organization
308 grid-institutes:grid.490945.5 schema:alternateName Mitsukoshi Health and Welfare Foundation, Tokyo, Japan
309 schema:name Mitsukoshi Health and Welfare Foundation, Tokyo, Japan
310 rdf:type schema:Organization
311 grid-institutes:grid.8664.c schema:alternateName Department of Cardiology, University of Giessen, Giessen, Germany
312 schema:name Department of Cardiology, University of Giessen, Giessen, Germany
313 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...