Relative risk of plaque erosion among different age and sex groups in patients with acute coronary syndrome View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-10-09

AUTHORS

Hyung Oh Kim, Chong Jin Kim, Weon Kim, Jin-Man Cho, Tsunenari Soeda, Masamichi Takano, Bryan P. Yan, Filippo Crea, Giampaolo Niccoli, Rocco Vergallo, Yoshiyasu Minami, Takumi Higuma, Shigeki Kimura, Niklas Frederik Boeder, Holger Nef, Tom Adriaenssens, Osamu Kurihara, Vikas Thondapu, Michele Russo, Erika Yamamoto, Tomoyo Sugiyama, Hang Lee, Tsunekazu Kakuta, Taishi Yonetsu, Ik-Kyung Jang

ABSTRACT

Postmortem studies reported plaque erosion is frequent in young women. Recent in vivo studies failed to show age and sex differences in the plaque erosion prevalence. The aim of this study was to investigate the prevalence of plaque erosion by age and sex among acute coronary syndromes (ACS) patients. From 1699 ACS patients, 1083 with plaque erosion or rupture were analyzed. Patients were categorized as 5 age groups (≤ 50, 51–60, 61–70, 71–80, ≥ 81 years). Overall prevalence of plaque erosion was similar between males and females (p = 0.831). Males age ≤ 50 had higher (p = 0.018) and age 71–80 had lower (p = 0.006) prevalence of plaque erosion. Females age 61–70 had higher (p = 0.021) and age 71–80 had lower (p = 0.045) prevalence of plaque erosion. In advanced age groups (≥ 71 years), rupture was the dominant etiology in both sexes. In multivariate analysis of males, age ≤ 50 demonstrated a trend to increase (OR 1.418, 95% CI 0.961–2.093, p = 0.078) the erosion risk. Females age ≤ 70 independently increased (OR 2.138, 95% CI 1.249–3.661, p = 0.006) the risk for erosion. The prevalence of plaque erosion was similar between males and females. Plaque erosion risk was increased in the males age ≤ 50 and in the females age ≤ 70 among ACS patients. More... »

PAGES

352-359

Journal

TITLE

Journal of Thrombosis and Thrombolysis

ISSUE

3

VOLUME

49

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11239-019-01969-9

DOI

http://dx.doi.org/10.1007/s11239-019-01969-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1121612138

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31598930


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341 grid-institutes:grid.410824.b schema:alternateName Department of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Tsuchiura, Ibaraki, Japan
342 schema:name Department of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Tsuchiura, Ibaraki, Japan
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344 grid-institutes:grid.412764.2 schema:alternateName Division of Cardiology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan
345 schema:name Division of Cardiology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan
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347 grid-institutes:grid.414927.d schema:alternateName Division of Cardiology, Kameda Medical Center, Kamogawa, Chiba, Japan
348 schema:name Division of Cardiology, Kameda Medical Center, Kamogawa, Chiba, Japan
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350 grid-institutes:grid.416273.5 schema:alternateName Cardiovascular Center, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Chiba, Japan
351 schema:name Cardiovascular Center, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Chiba, Japan
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353 grid-institutes:grid.8142.f schema:alternateName Department of Cardiovascular and Thoracic Science, Catholic University of the Sacred Heart, Rome, Italy
354 schema:name Department of Cardiovascular and Thoracic Science, Catholic University of the Sacred Heart, Rome, Italy
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356 grid-institutes:grid.8664.c schema:alternateName Department of Cardiology, University of Giessen, Giessen, Germany
357 schema:name Department of Cardiology, University of Giessen, Giessen, Germany
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