Thrombolysis with tissue plasminogen activator in patients with acute pulmonary embolisms in the real world: from the COMMAND VTE registry View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-07-05

AUTHORS

Yuji Nishimoto, Yugo Yamashita, Takeshi Morimoto, Syunsuke Saga, Hidewo Amano, Toru Takase, Seiichi Hiramori, Kitae Kim, Maki Oi, Masaharu Akao, Yohei Kobayashi, Mamoru Toyofuku, Toshiaki Izumi, Tomohisa Tada, Po-Min Chen, Koichiro Murata, Yoshiaki Tsuyuki, Tomoki Sasa, Jiro Sakamoto, Minako Kinoshita, Kiyonori Togi, Hiroshi Mabuchi, Kensuke Takabayashi, Yusuke Yoshikawa, Hiroki Shiomi, Takao Kato, Takeru Makiyama, Koh Ono, Yukihito Sato, Takeshi Kimura

ABSTRACT

There is still uncertainty about the optimal usage of thrombolysis for acute pulmonary embolisms (PEs), leading to a widely varying usage in the real world. The COMMAND VTE Registry is a multicenter retrospective registry enrolling consecutive patients with acute symptomatic venous thromboembolisms (VTEs) in Japan. The present study population consisted of 1549 patients with PEs treated with tissue plasminogen activator (t-PA) thrombolysis (N = 180, 12%) or without thrombolysis (N = 1369). Thrombolysis with t-PA was implemented in 33% of patients with severe PEs, and 9.2% of patients with mild PEs with a wide variation across the participating centers. Patients with t-PA thrombolysis were younger, and less frequently had active cancer, history of major bleeding, and anemia. At 30 days, t-PA thrombolysis as compared to no thrombolysis was associated with similar mortality rates (5.0% vs. 6.9%, P = 0.33), but a lower adjusted mortality risk (OR 0.41; 95% CI 0.18–0.90, P = 0.03), while it was associated with a trend for higher rates of major bleeding (5.6% vs. 2.9%, P = 0.06) and a significantly higher adjusted risk for major bleeding (OR 2.39; 95% CI 1.06–5.36, P = 0.03). In patients with severe PEs, the mortality rates at 30 days were significantly lower in the t-PA thrombolysis group than no thrombolysis group (15% vs. 37%, P = 0.006). In the present real-world VTE registry in Japan, t-PA thrombolysis was not infrequently implemented, not only in patients with severe PEs, but also in patients with mild PEs. A substantial mortality risk reduction might be suggested with t-PA thrombolysis in patients with severe PEs. More... »

PAGES

587-595

Journal

TITLE

Journal of Thrombosis and Thrombolysis

ISSUE

4

VOLUME

48

Author Affiliations

  • Department of Cardiology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan
  • Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan
  • Department of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, Japan
  • Department of Cardiovascular Medicine, Kurashiki Central Hospital, Kurashiki, Japan
  • Department of Cardiology, Kinki University Hospital, Osaka, Japan
  • Department of Cardiology, Kokura Memorial Hospital, Kokura, Japan
  • Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan
  • Department of Cardiology, Japanese Red Cross Otsu Hospital, Otsu, Japan
  • Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
  • Department of Cardiovascular Center, Osaka Red Cross Hospital, Osaka, Japan
  • Department of Cardiology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan
  • Cardiovascular Center, The Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan
  • Department of Cardiology, Shizuoka General Hospital, Shizuoka, Japan
  • Department of Cardiology, Osaka Saiseikai Noe Hospital, Osaka, Japan
  • Department of Cardiology, Shizuoka City Shizuoka Hospital, Shizuoka, Japan
  • Division of Cardiology, Shimada Municipal Hospital, Shimada, Japan
  • Department of Cardiology, Kishiwada City Hospital, Kishiwada, Japan
  • Department of Cardiology, Tenri Hospital, Tenri, Japan
  • Department of Cardiology, Nishikobe Medical Center, Kobe, Japan
  • Division of Cardiology, Nara Hospital, Kinki University Faculty of Medicine, Ikoma, Japan
  • Department of Cardiology, Koto Memorial Hospital, Higashiomi, Japan
  • Department of Cardiology, Hirakata Kohsai Hospital, Hirakata, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11239-019-01913-x

    DOI

    http://dx.doi.org/10.1007/s11239-019-01913-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1117789273

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31278648


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Acute Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hemorrhage", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Japan", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pulmonary Embolism", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Registries", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retrospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Thrombolytic Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tissue Plasminogen Activator", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan", 
              "id": "http://www.grid.ac/institutes/grid.413697.e", 
              "name": [
                "Department of Cardiology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nishimoto", 
            "givenName": "Yuji", 
            "id": "sg:person.0652165442.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652165442.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan", 
              "id": "http://www.grid.ac/institutes/grid.258799.8", 
              "name": [
                "Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamashita", 
            "givenName": "Yugo", 
            "id": "sg:person.01012471043.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012471043.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.272264.7", 
              "name": [
                "Department of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Morimoto", 
            "givenName": "Takeshi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan", 
              "id": "http://www.grid.ac/institutes/grid.413697.e", 
              "name": [
                "Department of Cardiology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Saga", 
            "givenName": "Syunsuke", 
            "id": "sg:person.015660632000.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015660632000.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiovascular Medicine, Kurashiki Central Hospital, Kurashiki, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415565.6", 
              "name": [
                "Department of Cardiovascular Medicine, Kurashiki Central Hospital, Kurashiki, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Amano", 
            "givenName": "Hidewo", 
            "id": "sg:person.01235650005.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235650005.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, Kinki University Hospital, Osaka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.413111.7", 
              "name": [
                "Department of Cardiology, Kinki University Hospital, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takase", 
            "givenName": "Toru", 
            "id": "sg:person.01212613515.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212613515.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, Kokura Memorial Hospital, Kokura, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415432.5", 
              "name": [
                "Department of Cardiology, Kokura Memorial Hospital, Kokura, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hiramori", 
            "givenName": "Seiichi", 
            "id": "sg:person.01013656366.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013656366.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410843.a", 
              "name": [
                "Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim", 
            "givenName": "Kitae", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, Japanese Red Cross Otsu Hospital, Otsu, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Cardiology, Japanese Red Cross Otsu Hospital, Otsu, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Oi", 
            "givenName": "Maki", 
            "id": "sg:person.0744703632.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744703632.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410835.b", 
              "name": [
                "Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Akao", 
            "givenName": "Masaharu", 
            "id": "sg:person.0773246571.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773246571.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiovascular Center, Osaka Red Cross Hospital, Osaka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.417000.2", 
              "name": [
                "Department of Cardiovascular Center, Osaka Red Cross Hospital, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kobayashi", 
            "givenName": "Yohei", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.414936.d", 
              "name": [
                "Department of Cardiology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Toyofuku", 
            "givenName": "Mamoru", 
            "id": "sg:person.0626560217.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626560217.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cardiovascular Center, The Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415392.8", 
              "name": [
                "Cardiovascular Center, The Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Izumi", 
            "givenName": "Toshiaki", 
            "id": "sg:person.01201560555.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201560555.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, Shizuoka General Hospital, Shizuoka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415804.c", 
              "name": [
                "Department of Cardiology, Shizuoka General Hospital, Shizuoka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tada", 
            "givenName": "Tomohisa", 
            "id": "sg:person.0731157334.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731157334.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, Osaka Saiseikai Noe Hospital, Osaka, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Cardiology, Osaka Saiseikai Noe Hospital, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Po-Min", 
            "id": "sg:person.013470310400.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013470310400.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, Shizuoka City Shizuoka Hospital, Shizuoka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415800.8", 
              "name": [
                "Department of Cardiology, Shizuoka City Shizuoka Hospital, Shizuoka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Murata", 
            "givenName": "Koichiro", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Cardiology, Shimada Municipal Hospital, Shimada, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415744.7", 
              "name": [
                "Division of Cardiology, Shimada Municipal Hospital, Shimada, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tsuyuki", 
            "givenName": "Yoshiaki", 
            "id": "sg:person.012170724640.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012170724640.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, Kishiwada City Hospital, Kishiwada, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415381.a", 
              "name": [
                "Department of Cardiology, Kishiwada City Hospital, Kishiwada, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sasa", 
            "givenName": "Tomoki", 
            "id": "sg:person.014426770710.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014426770710.61"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, Tenri Hospital, Tenri, Japan", 
              "id": "http://www.grid.ac/institutes/grid.416952.d", 
              "name": [
                "Department of Cardiology, Tenri Hospital, Tenri, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sakamoto", 
            "givenName": "Jiro", 
            "id": "sg:person.01235357120.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235357120.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, Nishikobe Medical Center, Kobe, Japan", 
              "id": "http://www.grid.ac/institutes/grid.416289.0", 
              "name": [
                "Department of Cardiology, Nishikobe Medical Center, Kobe, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kinoshita", 
            "givenName": "Minako", 
            "id": "sg:person.015156626640.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015156626640.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Cardiology, Nara Hospital, Kinki University Faculty of Medicine, Ikoma, Japan", 
              "id": "http://www.grid.ac/institutes/grid.258622.9", 
              "name": [
                "Division of Cardiology, Nara Hospital, Kinki University Faculty of Medicine, Ikoma, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Togi", 
            "givenName": "Kiyonori", 
            "id": "sg:person.0641356173.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641356173.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, Koto Memorial Hospital, Higashiomi, Japan", 
              "id": "http://www.grid.ac/institutes/grid.513109.f", 
              "name": [
                "Department of Cardiology, Koto Memorial Hospital, Higashiomi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mabuchi", 
            "givenName": "Hiroshi", 
            "id": "sg:person.010661377710.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010661377710.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, Hirakata Kohsai Hospital, Hirakata, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Cardiology, Hirakata Kohsai Hospital, Hirakata, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takabayashi", 
            "givenName": "Kensuke", 
            "id": "sg:person.015740746271.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015740746271.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan", 
              "id": "http://www.grid.ac/institutes/grid.258799.8", 
              "name": [
                "Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yoshikawa", 
            "givenName": "Yusuke", 
            "id": "sg:person.015717666203.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015717666203.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan", 
              "id": "http://www.grid.ac/institutes/grid.258799.8", 
              "name": [
                "Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shiomi", 
            "givenName": "Hiroki", 
            "id": "sg:person.01272152120.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272152120.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan", 
              "id": "http://www.grid.ac/institutes/grid.258799.8", 
              "name": [
                "Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kato", 
            "givenName": "Takao", 
            "id": "sg:person.01372163341.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372163341.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan", 
              "id": "http://www.grid.ac/institutes/grid.258799.8", 
              "name": [
                "Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Makiyama", 
            "givenName": "Takeru", 
            "id": "sg:person.0665450123.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665450123.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan", 
              "id": "http://www.grid.ac/institutes/grid.258799.8", 
              "name": [
                "Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ono", 
            "givenName": "Koh", 
            "id": "sg:person.01070333054.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070333054.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan", 
              "id": "http://www.grid.ac/institutes/grid.413697.e", 
              "name": [
                "Department of Cardiology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sato", 
            "givenName": "Yukihito", 
            "id": "sg:person.011711422662.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011711422662.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan", 
              "id": "http://www.grid.ac/institutes/grid.258799.8", 
              "name": [
                "Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kimura", 
            "givenName": "Takeshi", 
            "id": "sg:person.012173163322.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012173163322.36"
            ], 
            "type": "Person"
          }
        ], 
        "datePublished": "2019-07-05", 
        "datePublishedReg": "2019-07-05", 
        "description": "There is still uncertainty about the optimal usage of thrombolysis for acute pulmonary embolisms (PEs), leading to a widely varying usage in the real world. The COMMAND VTE Registry is a multicenter retrospective registry enrolling consecutive patients with acute symptomatic venous thromboembolisms (VTEs) in Japan. The present study population consisted of 1549 patients with PEs treated with tissue plasminogen activator (t-PA) thrombolysis (N\u2009=\u2009180, 12%) or without thrombolysis (N\u2009=\u20091369). Thrombolysis with t-PA was implemented in 33% of patients with severe PEs, and 9.2% of patients with mild PEs with a wide variation across the participating centers. Patients with t-PA thrombolysis were younger, and less frequently had active cancer, history of major bleeding, and anemia. At 30\u00a0days, t-PA thrombolysis as compared to no thrombolysis was associated with similar mortality rates (5.0% vs. 6.9%, P\u2009=\u20090.33), but a lower adjusted mortality risk (OR 0.41; 95% CI 0.18\u20130.90, P\u2009=\u20090.03), while it was associated with a trend for higher rates of major bleeding (5.6% vs. 2.9%, P\u2009=\u20090.06) and a significantly higher adjusted risk for major bleeding (OR 2.39; 95% CI 1.06\u20135.36, P\u2009=\u20090.03). In patients with severe PEs, the mortality rates at 30\u00a0days were significantly lower in the t-PA thrombolysis group than no thrombolysis group (15% vs. 37%, P\u2009=\u20090.006). In the present real-world VTE registry in Japan, t-PA thrombolysis was not infrequently implemented, not only in patients with severe PEs, but also in patients with mild PEs. A substantial mortality risk reduction might be suggested with t-PA thrombolysis in patients with severe PEs.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s11239-019-01913-x", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1113719", 
            "issn": [
              "0929-5305", 
              "1573-742X"
            ], 
            "name": "Journal of Thrombosis and Thrombolysis", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "48"
          }
        ], 
        "keywords": [
          "t-PA thrombolysis", 
          "severe pulmonary embolism", 
          "COMMAND VTE Registry", 
          "mild pulmonary embolism", 
          "acute pulmonary embolism", 
          "pulmonary embolism", 
          "VTE Registry", 
          "major bleeding", 
          "thrombolysis group", 
          "venous thromboembolism", 
          "mortality rate", 
          "acute symptomatic venous thromboembolism", 
          "tissue plasminogen activator thrombolysis", 
          "multicenter retrospective registry", 
          "symptomatic venous thromboembolism", 
          "adjusted mortality risk", 
          "present study population", 
          "similar mortality rates", 
          "tissue plasminogen activator", 
          "retrospective registry", 
          "active cancer", 
          "adjusted risk", 
          "consecutive patients", 
          "thrombolysis", 
          "study population", 
          "mortality risk", 
          "patients", 
          "registry", 
          "mortality risk reduction", 
          "bleeding", 
          "t-PA", 
          "plasminogen activator", 
          "embolism", 
          "risk reduction", 
          "high rate", 
          "risk", 
          "days", 
          "wide variation", 
          "thromboembolism", 
          "anemia", 
          "group", 
          "cancer", 
          "rate", 
          "population", 
          "activator", 
          "history", 
          "center", 
          "Japan", 
          "reduction", 
          "usage", 
          "trends", 
          "optimal usage", 
          "world", 
          "real world", 
          "variation", 
          "uncertainty"
        ], 
        "name": "Thrombolysis with tissue plasminogen activator in patients with acute pulmonary embolisms in the real world: from the COMMAND VTE registry", 
        "pagination": "587-595", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1117789273"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s11239-019-01913-x"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "31278648"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s11239-019-01913-x", 
          "https://app.dimensions.ai/details/publication/pub.1117789273"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-09-02T16:05", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_834.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s11239-019-01913-x"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11239-019-01913-x'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11239-019-01913-x'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11239-019-01913-x'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11239-019-01913-x'


     

    This table displays all metadata directly associated to this object as RDF triples.

    425 TRIPLES      20 PREDICATES      93 URIs      85 LITERALS      19 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s11239-019-01913-x schema:about N1282c494df504a4b8c0c8ad370cd23cb
    2 N15441ff7021f41878e7e8e355018d68c
    3 N3bf161e43639425089c9608c78252913
    4 N47c7fc5dc656409fb637b34712501b9d
    5 N4f22dd80023e43928b714e0afbf79445
    6 N623789ec669840ff9db9cd081dcf344c
    7 N878bb7af0fae405d975924095b164db6
    8 N997c8a506f624c389b4c417e0c84408e
    9 N9e53b249b9c345b4b17745755625a0b2
    10 Nb0f1fab3af714e0eac2282d671926ff8
    11 Nb0fca535e7834317b1416de9d91ddb68
    12 Nf0b302a69a0747188b379309b63b8b67
    13 anzsrc-for:11
    14 anzsrc-for:1103
    15 schema:author Nb09adfa4f0004ab783a1a3011df2001c
    16 schema:datePublished 2019-07-05
    17 schema:datePublishedReg 2019-07-05
    18 schema:description There is still uncertainty about the optimal usage of thrombolysis for acute pulmonary embolisms (PEs), leading to a widely varying usage in the real world. The COMMAND VTE Registry is a multicenter retrospective registry enrolling consecutive patients with acute symptomatic venous thromboembolisms (VTEs) in Japan. The present study population consisted of 1549 patients with PEs treated with tissue plasminogen activator (t-PA) thrombolysis (N = 180, 12%) or without thrombolysis (N = 1369). Thrombolysis with t-PA was implemented in 33% of patients with severe PEs, and 9.2% of patients with mild PEs with a wide variation across the participating centers. Patients with t-PA thrombolysis were younger, and less frequently had active cancer, history of major bleeding, and anemia. At 30 days, t-PA thrombolysis as compared to no thrombolysis was associated with similar mortality rates (5.0% vs. 6.9%, P = 0.33), but a lower adjusted mortality risk (OR 0.41; 95% CI 0.18–0.90, P = 0.03), while it was associated with a trend for higher rates of major bleeding (5.6% vs. 2.9%, P = 0.06) and a significantly higher adjusted risk for major bleeding (OR 2.39; 95% CI 1.06–5.36, P = 0.03). In patients with severe PEs, the mortality rates at 30 days were significantly lower in the t-PA thrombolysis group than no thrombolysis group (15% vs. 37%, P = 0.006). In the present real-world VTE registry in Japan, t-PA thrombolysis was not infrequently implemented, not only in patients with severe PEs, but also in patients with mild PEs. A substantial mortality risk reduction might be suggested with t-PA thrombolysis in patients with severe PEs.
    19 schema:genre article
    20 schema:isAccessibleForFree false
    21 schema:isPartOf N4298d70ffce54853b5b1564e1c4ce31e
    22 N9877ff1d74e94bbf853026a7d186b81c
    23 sg:journal.1113719
    24 schema:keywords COMMAND VTE Registry
    25 Japan
    26 VTE Registry
    27 activator
    28 active cancer
    29 acute pulmonary embolism
    30 acute symptomatic venous thromboembolism
    31 adjusted mortality risk
    32 adjusted risk
    33 anemia
    34 bleeding
    35 cancer
    36 center
    37 consecutive patients
    38 days
    39 embolism
    40 group
    41 high rate
    42 history
    43 major bleeding
    44 mild pulmonary embolism
    45 mortality rate
    46 mortality risk
    47 mortality risk reduction
    48 multicenter retrospective registry
    49 optimal usage
    50 patients
    51 plasminogen activator
    52 population
    53 present study population
    54 pulmonary embolism
    55 rate
    56 real world
    57 reduction
    58 registry
    59 retrospective registry
    60 risk
    61 risk reduction
    62 severe pulmonary embolism
    63 similar mortality rates
    64 study population
    65 symptomatic venous thromboembolism
    66 t-PA
    67 t-PA thrombolysis
    68 thromboembolism
    69 thrombolysis
    70 thrombolysis group
    71 tissue plasminogen activator
    72 tissue plasminogen activator thrombolysis
    73 trends
    74 uncertainty
    75 usage
    76 variation
    77 venous thromboembolism
    78 wide variation
    79 world
    80 schema:name Thrombolysis with tissue plasminogen activator in patients with acute pulmonary embolisms in the real world: from the COMMAND VTE registry
    81 schema:pagination 587-595
    82 schema:productId N2c30123f775a4b32949bbed6eaeaee02
    83 N7a0f1d695e1c46f1aab7c9208dd65962
    84 N92072d5a1b1146eaba51e5fefdebc64b
    85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1117789273
    86 https://doi.org/10.1007/s11239-019-01913-x
    87 schema:sdDatePublished 2022-09-02T16:05
    88 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    89 schema:sdPublisher N49f1b10fa2984c11b01d83c8dd27fe3b
    90 schema:url https://doi.org/10.1007/s11239-019-01913-x
    91 sgo:license sg:explorer/license/
    92 sgo:sdDataset articles
    93 rdf:type schema:ScholarlyArticle
    94 N0627bce1a24d4d7e8ec4bc8cfcd8be12 rdf:first sg:person.01070333054.04
    95 rdf:rest N166c8b287046444992dd4fb2cb8371bc
    96 N068d537954c14d5e962bb18f24cb9c8c schema:affiliation grid-institutes:grid.410843.a
    97 schema:familyName Kim
    98 schema:givenName Kitae
    99 rdf:type schema:Person
    100 N090061f321634217b63311c860feec86 rdf:first sg:person.01272152120.47
    101 rdf:rest Nc6370459b63c4a3b87f6e1144ed9b8a5
    102 N09e2030b43a341b3b084f6aa79b01e04 rdf:first sg:person.015156626640.00
    103 rdf:rest N8bb700be695748f0a369aed4315b078a
    104 N09fdb3c626534483a0e2612404287e36 schema:affiliation grid-institutes:grid.272264.7
    105 schema:familyName Morimoto
    106 schema:givenName Takeshi
    107 rdf:type schema:Person
    108 N0dac3597d0874e318dd317d173dca816 schema:affiliation grid-institutes:grid.417000.2
    109 schema:familyName Kobayashi
    110 schema:givenName Yohei
    111 rdf:type schema:Person
    112 N1282c494df504a4b8c0c8ad370cd23cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Acute Disease
    114 rdf:type schema:DefinedTerm
    115 N15441ff7021f41878e7e8e355018d68c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Humans
    117 rdf:type schema:DefinedTerm
    118 N166c8b287046444992dd4fb2cb8371bc rdf:first sg:person.011711422662.66
    119 rdf:rest N173d8f917ff94354b083eb92c113231b
    120 N173d8f917ff94354b083eb92c113231b rdf:first sg:person.012173163322.36
    121 rdf:rest rdf:nil
    122 N24fd1cd91c5d4ece81333d375c55c89c rdf:first sg:person.01012471043.12
    123 rdf:rest Nd73099adfa4c430696808c91ed588a97
    124 N2c30123f775a4b32949bbed6eaeaee02 schema:name dimensions_id
    125 schema:value pub.1117789273
    126 rdf:type schema:PropertyValue
    127 N2e3f7ff39be046f4ae7e4cece8d131c8 rdf:first sg:person.012170724640.46
    128 rdf:rest N3b17947744034d99b4e23da810530a44
    129 N3861d713093b444e82263330a9c9cef0 rdf:first sg:person.01013656366.66
    130 rdf:rest N8c26a38b87f84fdd84b44029772c2d0d
    131 N3b17947744034d99b4e23da810530a44 rdf:first sg:person.014426770710.61
    132 rdf:rest N93a63b1f8f174ce4a79b448a78965642
    133 N3bf161e43639425089c9608c78252913 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Hemorrhage
    135 rdf:type schema:DefinedTerm
    136 N3c732cec34ce4393ac3db0159fde7ffb rdf:first Na57242ace6ca4beaade20512cb8a77ea
    137 rdf:rest N2e3f7ff39be046f4ae7e4cece8d131c8
    138 N4190624ba8744a2e88d63fb77beaf498 rdf:first N0dac3597d0874e318dd317d173dca816
    139 rdf:rest N65c426bad3844f8a93b2cc1efee54a21
    140 N4298d70ffce54853b5b1564e1c4ce31e schema:issueNumber 4
    141 rdf:type schema:PublicationIssue
    142 N47c7fc5dc656409fb637b34712501b9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Thrombolytic Therapy
    144 rdf:type schema:DefinedTerm
    145 N49f1b10fa2984c11b01d83c8dd27fe3b schema:name Springer Nature - SN SciGraph project
    146 rdf:type schema:Organization
    147 N4b494590ccdc49cd90c9250f5c13a908 rdf:first sg:person.015717666203.08
    148 rdf:rest N090061f321634217b63311c860feec86
    149 N4baadce913fb40f0b7f56ddb5b1204f9 rdf:first sg:person.01201560555.19
    150 rdf:rest N81ff3e87d7ae4827949162685ff54215
    151 N4f22dd80023e43928b714e0afbf79445 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Tissue Plasminogen Activator
    153 rdf:type schema:DefinedTerm
    154 N5d7ee48cc97944e4854a01e7bfec6f13 rdf:first sg:person.0773246571.15
    155 rdf:rest N4190624ba8744a2e88d63fb77beaf498
    156 N623789ec669840ff9db9cd081dcf344c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Retrospective Studies
    158 rdf:type schema:DefinedTerm
    159 N65c426bad3844f8a93b2cc1efee54a21 rdf:first sg:person.0626560217.70
    160 rdf:rest N4baadce913fb40f0b7f56ddb5b1204f9
    161 N6ae150d0d709439c9a37092692dedd31 rdf:first sg:person.013470310400.38
    162 rdf:rest N3c732cec34ce4393ac3db0159fde7ffb
    163 N74b90c445c124d7db72bd68c88668dca rdf:first sg:person.015660632000.31
    164 rdf:rest Nbdffc62a7a0e456d9b88ded879ef5b2d
    165 N7a0f1d695e1c46f1aab7c9208dd65962 schema:name doi
    166 schema:value 10.1007/s11239-019-01913-x
    167 rdf:type schema:PropertyValue
    168 N81ff3e87d7ae4827949162685ff54215 rdf:first sg:person.0731157334.23
    169 rdf:rest N6ae150d0d709439c9a37092692dedd31
    170 N82356e6152a7472ca405cf48659ec873 rdf:first sg:person.015740746271.36
    171 rdf:rest N4b494590ccdc49cd90c9250f5c13a908
    172 N878bb7af0fae405d975924095b164db6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Aged
    174 rdf:type schema:DefinedTerm
    175 N8bb700be695748f0a369aed4315b078a rdf:first sg:person.0641356173.33
    176 rdf:rest Nf467517b307d45a8be271b6c1e938c82
    177 N8c26a38b87f84fdd84b44029772c2d0d rdf:first N068d537954c14d5e962bb18f24cb9c8c
    178 rdf:rest Na7b225b5c8754bafae1dd0f325348af4
    179 N92072d5a1b1146eaba51e5fefdebc64b schema:name pubmed_id
    180 schema:value 31278648
    181 rdf:type schema:PropertyValue
    182 N93a63b1f8f174ce4a79b448a78965642 rdf:first sg:person.01235357120.23
    183 rdf:rest N09e2030b43a341b3b084f6aa79b01e04
    184 N9877ff1d74e94bbf853026a7d186b81c schema:volumeNumber 48
    185 rdf:type schema:PublicationVolume
    186 N997c8a506f624c389b4c417e0c84408e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Japan
    188 rdf:type schema:DefinedTerm
    189 N9e53b249b9c345b4b17745755625a0b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Middle Aged
    191 rdf:type schema:DefinedTerm
    192 Na3a4360849ea44ceb97983e9abc78a11 rdf:first sg:person.0665450123.33
    193 rdf:rest N0627bce1a24d4d7e8ec4bc8cfcd8be12
    194 Na57242ace6ca4beaade20512cb8a77ea schema:affiliation grid-institutes:grid.415800.8
    195 schema:familyName Murata
    196 schema:givenName Koichiro
    197 rdf:type schema:Person
    198 Na7b225b5c8754bafae1dd0f325348af4 rdf:first sg:person.0744703632.41
    199 rdf:rest N5d7ee48cc97944e4854a01e7bfec6f13
    200 Nb09adfa4f0004ab783a1a3011df2001c rdf:first sg:person.0652165442.55
    201 rdf:rest N24fd1cd91c5d4ece81333d375c55c89c
    202 Nb0f1fab3af714e0eac2282d671926ff8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name Pulmonary Embolism
    204 rdf:type schema:DefinedTerm
    205 Nb0fca535e7834317b1416de9d91ddb68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Registries
    207 rdf:type schema:DefinedTerm
    208 Nbdffc62a7a0e456d9b88ded879ef5b2d rdf:first sg:person.01235650005.52
    209 rdf:rest Ne43d1c3a440240b7b8f60d1412df129c
    210 Nc6370459b63c4a3b87f6e1144ed9b8a5 rdf:first sg:person.01372163341.41
    211 rdf:rest Na3a4360849ea44ceb97983e9abc78a11
    212 Nd73099adfa4c430696808c91ed588a97 rdf:first N09fdb3c626534483a0e2612404287e36
    213 rdf:rest N74b90c445c124d7db72bd68c88668dca
    214 Ne43d1c3a440240b7b8f60d1412df129c rdf:first sg:person.01212613515.21
    215 rdf:rest N3861d713093b444e82263330a9c9cef0
    216 Nf0b302a69a0747188b379309b63b8b67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    217 schema:name Adult
    218 rdf:type schema:DefinedTerm
    219 Nf467517b307d45a8be271b6c1e938c82 rdf:first sg:person.010661377710.98
    220 rdf:rest N82356e6152a7472ca405cf48659ec873
    221 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    222 schema:name Medical and Health Sciences
    223 rdf:type schema:DefinedTerm
    224 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    225 schema:name Clinical Sciences
    226 rdf:type schema:DefinedTerm
    227 sg:journal.1113719 schema:issn 0929-5305
    228 1573-742X
    229 schema:name Journal of Thrombosis and Thrombolysis
    230 schema:publisher Springer Nature
    231 rdf:type schema:Periodical
    232 sg:person.01012471043.12 schema:affiliation grid-institutes:grid.258799.8
    233 schema:familyName Yamashita
    234 schema:givenName Yugo
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012471043.12
    236 rdf:type schema:Person
    237 sg:person.01013656366.66 schema:affiliation grid-institutes:grid.415432.5
    238 schema:familyName Hiramori
    239 schema:givenName Seiichi
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013656366.66
    241 rdf:type schema:Person
    242 sg:person.010661377710.98 schema:affiliation grid-institutes:grid.513109.f
    243 schema:familyName Mabuchi
    244 schema:givenName Hiroshi
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010661377710.98
    246 rdf:type schema:Person
    247 sg:person.01070333054.04 schema:affiliation grid-institutes:grid.258799.8
    248 schema:familyName Ono
    249 schema:givenName Koh
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070333054.04
    251 rdf:type schema:Person
    252 sg:person.011711422662.66 schema:affiliation grid-institutes:grid.413697.e
    253 schema:familyName Sato
    254 schema:givenName Yukihito
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011711422662.66
    256 rdf:type schema:Person
    257 sg:person.01201560555.19 schema:affiliation grid-institutes:grid.415392.8
    258 schema:familyName Izumi
    259 schema:givenName Toshiaki
    260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201560555.19
    261 rdf:type schema:Person
    262 sg:person.01212613515.21 schema:affiliation grid-institutes:grid.413111.7
    263 schema:familyName Takase
    264 schema:givenName Toru
    265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212613515.21
    266 rdf:type schema:Person
    267 sg:person.012170724640.46 schema:affiliation grid-institutes:grid.415744.7
    268 schema:familyName Tsuyuki
    269 schema:givenName Yoshiaki
    270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012170724640.46
    271 rdf:type schema:Person
    272 sg:person.012173163322.36 schema:affiliation grid-institutes:grid.258799.8
    273 schema:familyName Kimura
    274 schema:givenName Takeshi
    275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012173163322.36
    276 rdf:type schema:Person
    277 sg:person.01235357120.23 schema:affiliation grid-institutes:grid.416952.d
    278 schema:familyName Sakamoto
    279 schema:givenName Jiro
    280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235357120.23
    281 rdf:type schema:Person
    282 sg:person.01235650005.52 schema:affiliation grid-institutes:grid.415565.6
    283 schema:familyName Amano
    284 schema:givenName Hidewo
    285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235650005.52
    286 rdf:type schema:Person
    287 sg:person.01272152120.47 schema:affiliation grid-institutes:grid.258799.8
    288 schema:familyName Shiomi
    289 schema:givenName Hiroki
    290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272152120.47
    291 rdf:type schema:Person
    292 sg:person.013470310400.38 schema:affiliation grid-institutes:None
    293 schema:familyName Chen
    294 schema:givenName Po-Min
    295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013470310400.38
    296 rdf:type schema:Person
    297 sg:person.01372163341.41 schema:affiliation grid-institutes:grid.258799.8
    298 schema:familyName Kato
    299 schema:givenName Takao
    300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372163341.41
    301 rdf:type schema:Person
    302 sg:person.014426770710.61 schema:affiliation grid-institutes:grid.415381.a
    303 schema:familyName Sasa
    304 schema:givenName Tomoki
    305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014426770710.61
    306 rdf:type schema:Person
    307 sg:person.015156626640.00 schema:affiliation grid-institutes:grid.416289.0
    308 schema:familyName Kinoshita
    309 schema:givenName Minako
    310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015156626640.00
    311 rdf:type schema:Person
    312 sg:person.015660632000.31 schema:affiliation grid-institutes:grid.413697.e
    313 schema:familyName Saga
    314 schema:givenName Syunsuke
    315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015660632000.31
    316 rdf:type schema:Person
    317 sg:person.015717666203.08 schema:affiliation grid-institutes:grid.258799.8
    318 schema:familyName Yoshikawa
    319 schema:givenName Yusuke
    320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015717666203.08
    321 rdf:type schema:Person
    322 sg:person.015740746271.36 schema:affiliation grid-institutes:None
    323 schema:familyName Takabayashi
    324 schema:givenName Kensuke
    325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015740746271.36
    326 rdf:type schema:Person
    327 sg:person.0626560217.70 schema:affiliation grid-institutes:grid.414936.d
    328 schema:familyName Toyofuku
    329 schema:givenName Mamoru
    330 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626560217.70
    331 rdf:type schema:Person
    332 sg:person.0641356173.33 schema:affiliation grid-institutes:grid.258622.9
    333 schema:familyName Togi
    334 schema:givenName Kiyonori
    335 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641356173.33
    336 rdf:type schema:Person
    337 sg:person.0652165442.55 schema:affiliation grid-institutes:grid.413697.e
    338 schema:familyName Nishimoto
    339 schema:givenName Yuji
    340 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652165442.55
    341 rdf:type schema:Person
    342 sg:person.0665450123.33 schema:affiliation grid-institutes:grid.258799.8
    343 schema:familyName Makiyama
    344 schema:givenName Takeru
    345 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665450123.33
    346 rdf:type schema:Person
    347 sg:person.0731157334.23 schema:affiliation grid-institutes:grid.415804.c
    348 schema:familyName Tada
    349 schema:givenName Tomohisa
    350 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731157334.23
    351 rdf:type schema:Person
    352 sg:person.0744703632.41 schema:affiliation grid-institutes:None
    353 schema:familyName Oi
    354 schema:givenName Maki
    355 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744703632.41
    356 rdf:type schema:Person
    357 sg:person.0773246571.15 schema:affiliation grid-institutes:grid.410835.b
    358 schema:familyName Akao
    359 schema:givenName Masaharu
    360 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773246571.15
    361 rdf:type schema:Person
    362 grid-institutes:None schema:alternateName Department of Cardiology, Hirakata Kohsai Hospital, Hirakata, Japan
    363 Department of Cardiology, Japanese Red Cross Otsu Hospital, Otsu, Japan
    364 Department of Cardiology, Osaka Saiseikai Noe Hospital, Osaka, Japan
    365 schema:name Department of Cardiology, Hirakata Kohsai Hospital, Hirakata, Japan
    366 Department of Cardiology, Japanese Red Cross Otsu Hospital, Otsu, Japan
    367 Department of Cardiology, Osaka Saiseikai Noe Hospital, Osaka, Japan
    368 rdf:type schema:Organization
    369 grid-institutes:grid.258622.9 schema:alternateName Division of Cardiology, Nara Hospital, Kinki University Faculty of Medicine, Ikoma, Japan
    370 schema:name Division of Cardiology, Nara Hospital, Kinki University Faculty of Medicine, Ikoma, Japan
    371 rdf:type schema:Organization
    372 grid-institutes:grid.258799.8 schema:alternateName Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan
    373 schema:name Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, 606-8507, Kyoto, Japan
    374 rdf:type schema:Organization
    375 grid-institutes:grid.272264.7 schema:alternateName Department of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, Japan
    376 schema:name Department of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, Japan
    377 rdf:type schema:Organization
    378 grid-institutes:grid.410835.b schema:alternateName Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    379 schema:name Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    380 rdf:type schema:Organization
    381 grid-institutes:grid.410843.a schema:alternateName Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan
    382 schema:name Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan
    383 rdf:type schema:Organization
    384 grid-institutes:grid.413111.7 schema:alternateName Department of Cardiology, Kinki University Hospital, Osaka, Japan
    385 schema:name Department of Cardiology, Kinki University Hospital, Osaka, Japan
    386 rdf:type schema:Organization
    387 grid-institutes:grid.413697.e schema:alternateName Department of Cardiology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan
    388 schema:name Department of Cardiology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan
    389 rdf:type schema:Organization
    390 grid-institutes:grid.414936.d schema:alternateName Department of Cardiology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan
    391 schema:name Department of Cardiology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan
    392 rdf:type schema:Organization
    393 grid-institutes:grid.415381.a schema:alternateName Department of Cardiology, Kishiwada City Hospital, Kishiwada, Japan
    394 schema:name Department of Cardiology, Kishiwada City Hospital, Kishiwada, Japan
    395 rdf:type schema:Organization
    396 grid-institutes:grid.415392.8 schema:alternateName Cardiovascular Center, The Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan
    397 schema:name Cardiovascular Center, The Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan
    398 rdf:type schema:Organization
    399 grid-institutes:grid.415432.5 schema:alternateName Department of Cardiology, Kokura Memorial Hospital, Kokura, Japan
    400 schema:name Department of Cardiology, Kokura Memorial Hospital, Kokura, Japan
    401 rdf:type schema:Organization
    402 grid-institutes:grid.415565.6 schema:alternateName Department of Cardiovascular Medicine, Kurashiki Central Hospital, Kurashiki, Japan
    403 schema:name Department of Cardiovascular Medicine, Kurashiki Central Hospital, Kurashiki, Japan
    404 rdf:type schema:Organization
    405 grid-institutes:grid.415744.7 schema:alternateName Division of Cardiology, Shimada Municipal Hospital, Shimada, Japan
    406 schema:name Division of Cardiology, Shimada Municipal Hospital, Shimada, Japan
    407 rdf:type schema:Organization
    408 grid-institutes:grid.415800.8 schema:alternateName Department of Cardiology, Shizuoka City Shizuoka Hospital, Shizuoka, Japan
    409 schema:name Department of Cardiology, Shizuoka City Shizuoka Hospital, Shizuoka, Japan
    410 rdf:type schema:Organization
    411 grid-institutes:grid.415804.c schema:alternateName Department of Cardiology, Shizuoka General Hospital, Shizuoka, Japan
    412 schema:name Department of Cardiology, Shizuoka General Hospital, Shizuoka, Japan
    413 rdf:type schema:Organization
    414 grid-institutes:grid.416289.0 schema:alternateName Department of Cardiology, Nishikobe Medical Center, Kobe, Japan
    415 schema:name Department of Cardiology, Nishikobe Medical Center, Kobe, Japan
    416 rdf:type schema:Organization
    417 grid-institutes:grid.416952.d schema:alternateName Department of Cardiology, Tenri Hospital, Tenri, Japan
    418 schema:name Department of Cardiology, Tenri Hospital, Tenri, Japan
    419 rdf:type schema:Organization
    420 grid-institutes:grid.417000.2 schema:alternateName Department of Cardiovascular Center, Osaka Red Cross Hospital, Osaka, Japan
    421 schema:name Department of Cardiovascular Center, Osaka Red Cross Hospital, Osaka, Japan
    422 rdf:type schema:Organization
    423 grid-institutes:grid.513109.f schema:alternateName Department of Cardiology, Koto Memorial Hospital, Higashiomi, Japan
    424 schema:name Department of Cardiology, Koto Memorial Hospital, Higashiomi, Japan
    425 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...