Thrombin generation profile in non-thrombotic factor V Leiden carriers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Paul Billoir, Thomas Duflot, Marielle Fresel, Marie Hélène Chrétien, Virginie Barbay, Véronique Le Cam Duchez

ABSTRACT

Factor V Leiden (FVL) mutation is the most common genetic risk factor for venous thromboembolism. In families with a history of thrombosis, FVL can be present in 18%. Thrombin generation test is commonly used as an evaluation tool of thrombotic risk. The objective of this study was to evaluate the thrombogenic potential of FVL in asymptomatic carriers and in patients with personal or familial history of thrombosis. This was a retrospective single center study including 160 patients. Among them, 43 had personal history of thrombosis and 117 had familial history of thrombosis. Thrombin generation (TG) was realized in frozen platelet poor plasma with 1 pM of tissue factor and 4 µM of phospholipid. FVL mutation was associated with a global increase of TG. No difference was observed between patients with provoked thrombosis and patients with first-degree familial history of thrombosis (endogenous thrombin potential (ETP): 1501.0 ± 316.4 nM min and thrombin peak: 253.4 ± 71.5 nM vs. 1520.4 ± 283.8 nM min and 268.6 ± 68.0 nM). An increase of TG was observed in patients with unprovoked thrombosis (n = 23) and in patients with provoked thrombosis (n = 20) (ETP: 1819.5 ± 319.8 nM min and peak: 332.3 ± 55.8 nM). In the unprovoked thrombosis group, patients with a pulmonary embolism had a higher ETP than patients with deep vein thrombosis (DVT) (2036 ± 343 nM min vs. 1707 ± 261 nM min). With a predictive score formula (s = 0.1315 × Age + 0.0105 × ETP) with a threshold of 22.1 as risk to develop an unprovoked thrombosis among patients with second-degree familial history. The results of our analysis suggest that measurement of thrombin generation in patients with FVL mutation may identify subjects with an increased risk of unprovoked thrombosis. Further studies are needed to examine the usefulness of predicting thrombotic presentation in asymptomatic carriers. More... »

PAGES

473-477

References to SciGraph publications

  • 2011-12. pROC: an open-source package for R and S+ to analyze and compare ROC curves in BMC BIOINFORMATICS
  • 2015-08. Epidemiology of venous thromboembolism in NATURE REVIEWS CARDIOLOGY
  • 2016. ggplot2 in NONE
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    http://scigraph.springernature.com/pub.10.1007/s11239-019-01821-0

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    http://dx.doi.org/10.1007/s11239-019-01821-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111774823

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30701464


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