3-Factor Versus 4-Factor Prothrombin Complex Concentrate for Warfarin Reversal in Severe Bleeding: A Multicenter, Retrospective, Propensity-Matched Pilot Study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-07

AUTHORS

G. Morgan Jones, Michael J. Erdman, Keaton S. Smetana, Kerry M. Mohrien, Joseph E. Vandigo, Lucas Elijovich

ABSTRACT

Current guidelines recommend 4-factor prothrombin complex concentrate (4PCC) for emergent reversal of bleeding secondary to warfarin. While current research has demonstrated superiority of 4PCC over plasma, direct comparisons with 3-factor PCC (3PCC) are lacking. The purpose of this study is to compare the efficacy and safety of 3PCC and 4PCC. We conducted a retrospective analysis of patients who received PCC at one of four medical centers. All patients in the 3PCC group were treated at one center that utilizes a fixed, weight-based dosing protocol. After evaluation of all patients meeting inclusion criteria, propensity-score matching was used to adjust for differences in treatment characteristics. There was no difference in the primary outcome of INR ≤ 1.4 between 3PCC and 4PCC in both the unmatched (85.7 vs. 90.6 %; p = 0.37) and matched (84.2 vs. 92.1 %; p = 0.48) analyses. There was a significant difference in goal INR achieved favoring 4PCC (56.3 vs 90.0 %; p < 0.02) when baseline INR > 4.0. A total of three thrombotic events were documented, all in the 4PCC group. We found no difference in the rate of INR reversal in those treated with 3PCC and 4PCC. However, those with a baseline INR > 4.0 may experience more successful INR reversal with 4PCC. More... »

PAGES

19-26

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11239-015-1330-3

DOI

http://dx.doi.org/10.1007/s11239-015-1330-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048929484

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26721625


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anticoagulants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Coagulation Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Interactions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hemorrhage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "International Normalized Ratio", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pilot Projects", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Propensity Score", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Warfarin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Tennessee Health Science Center", 
          "id": "https://www.grid.ac/institutes/grid.267301.1", 
          "name": [
            "Department of Pharmacy, Methodist University Hospital, 1265 Union Avenue, 38104, Memphis, TN, USA", 
            "Department of Clinical Pharmacy, University of Tennessee Health Sciences Center (UTHSC), 920 Court Ave, 38163, Memphis, TN, USA", 
            "Department of Neurology and Neurosurgery, UTHSC, 920 Court Ave, 38163, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jones", 
        "givenName": "G. Morgan", 
        "id": "sg:person.01042563235.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042563235.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Florida Health Science Center", 
          "id": "https://www.grid.ac/institutes/grid.413116.0", 
          "name": [
            "Department of Pharmacy, University of Florida Health, 655 West 8th Street, 32209, Jacksonville, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Erdman", 
        "givenName": "Michael J.", 
        "id": "sg:person.0735310360.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735310360.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kentucky HealthCare", 
          "id": "https://www.grid.ac/institutes/grid.413001.7", 
          "name": [
            "Department of Pharmacy, University of Kentucky HealthCare, 800 Rose St, 40536, Lexington, KY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smetana", 
        "givenName": "Keaton S.", 
        "id": "sg:person.016635170627.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016635170627.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Temple University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412374.7", 
          "name": [
            "Department of Pharmacy, Temple University Hospital, 3509\u00a0N Broad St, 19140, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mohrien", 
        "givenName": "Kerry M.", 
        "id": "sg:person.01202160032.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202160032.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Maryland, Baltimore", 
          "id": "https://www.grid.ac/institutes/grid.411024.2", 
          "name": [
            "Department of Pharmaceutical Health Services Research, University of Maryland School of Pharmacy, 620\u00a0W Lexington St, 21201, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vandigo", 
        "givenName": "Joseph E.", 
        "id": "sg:person.0704111256.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704111256.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tennessee Health Science Center", 
          "id": "https://www.grid.ac/institutes/grid.267301.1", 
          "name": [
            "Department of Neurology and Neurosurgery, UTHSC, 920 Court Ave, 38163, Memphis, TN, USA", 
            "Semmes-Murphey Neurologic and Spine Institute, 6325 Humphreys Blvd, 38120, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Elijovich", 
        "givenName": "Lucas", 
        "id": "sg:person.01201040307.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201040307.50"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/phar.1384", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001556577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc13843", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002198417", 
          "https://doi.org/10.1186/cc13843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000457934.27628.4d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005164630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000457934.27628.4d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005164630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archinternmed.2010.407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008533529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.thromres.2006.07.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012421426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12028-014-9984-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016463030", 
          "https://doi.org/10.1007/s12028-014-9984-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.thromres.2005.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016527501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.thromres.2005.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016527501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000221786.81354.d6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016625234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000221786.81354.d6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016625234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.112.100628", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018236870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.112.100628", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018236870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3148.2010.01050.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023317722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jemermed.2015.07.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023337442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1445-5994.2010.02237.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028572523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2015.0846", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028598057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000457938.50499.d6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030191490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000457938.50499.d6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030191490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.11-2295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030538705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2516.2004.00944.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035483664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.08-0674", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038782284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2011.08753.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039118133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.113.002283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039649864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.113.002283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039649864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.thromres.2012.10.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042803577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1537-2995.2008.02080.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045683454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.112.661454", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046688812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.112.661454", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046688812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000195047.21562.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046714873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000195047.21562.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046714873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pst.433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052069221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000094831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053615205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1160/th11-01-0052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063292645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000138428.40673.83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000138428.40673.83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000138428.40673.83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076959406", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5694/j.1326-5377.2004.tb06407.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076959406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078169269", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0310057x1003800310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078169269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0310057x1003800310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078169269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0310057x1003800310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078169269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2450/2011.0065-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078332753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2450/2011.0111-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078332754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1043/2009-0474-oa.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078377533"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-07", 
    "datePublishedReg": "2016-07-01", 
    "description": "Current guidelines recommend 4-factor prothrombin complex concentrate (4PCC) for emergent reversal of bleeding secondary to warfarin. While current research has demonstrated superiority of 4PCC over plasma, direct comparisons with 3-factor PCC (3PCC) are lacking. The purpose of this study is to compare the efficacy and safety of 3PCC and 4PCC. We conducted a retrospective analysis of patients who received PCC at one of four medical centers. All patients in the 3PCC group were treated at one center that utilizes a fixed, weight-based dosing protocol. After evaluation of all patients meeting inclusion criteria, propensity-score matching was used to adjust for differences in treatment characteristics. There was no difference in the primary outcome of INR\u00a0\u2264\u00a01.4 between 3PCC and 4PCC in both the unmatched (85.7 vs. 90.6\u00a0%; p\u00a0=\u00a00.37) and matched (84.2 vs. 92.1\u00a0%; p\u00a0=\u00a00.48) analyses. There was a significant difference in goal INR achieved favoring 4PCC (56.3 vs 90.0\u00a0%; p\u00a0<\u00a00.02) when baseline INR\u00a0>\u00a04.0. A total of three thrombotic events were documented, all in the 4PCC group. We found no difference in the rate of INR reversal in those treated with 3PCC and 4PCC. However, those with a baseline INR\u00a0>\u00a04.0 may experience more successful INR reversal with 4PCC. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11239-015-1330-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1113719", 
        "issn": [
          "0929-5305", 
          "1573-742X"
        ], 
        "name": "Journal of Thrombosis and Thrombolysis", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "42"
      }
    ], 
    "name": "3-Factor Versus 4-Factor Prothrombin Complex Concentrate for Warfarin Reversal in Severe Bleeding: A Multicenter, Retrospective, Propensity-Matched Pilot Study", 
    "pagination": "19-26", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e917469a421f3b5823fce2af4069b9b58b2f6e0498848f6e197d590a8ecfd463"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26721625"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9502018"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11239-015-1330-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1048929484"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11239-015-1330-3", 
      "https://app.dimensions.ai/details/publication/pub.1048929484"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000524.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11239-015-1330-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11239-015-1330-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11239-015-1330-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11239-015-1330-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11239-015-1330-3'


 

This table displays all metadata directly associated to this object as RDF triples.

265 TRIPLES      21 PREDICATES      74 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11239-015-1330-3 schema:about N00ce41461956462cbad0d011c088f95d
2 N176eac9035e1487f871d50abc905454d
3 N1e4cd789862a4f61bd0e79c8c7979757
4 N1e820f81a89941b680535a1cf41a1f09
5 N1f8d8616b2d7454db8112dd11ccf9154
6 N3e2121b9198a4f91a2029cd1a22b595b
7 N98cad2633ad649829ddc0687a727a86f
8 Nbc73a3fa4d7b4ea7a4fa5b19825b10ee
9 Nd4f00809822f405a9f0b3fa66e770e6d
10 Nddc490cd94904aefbd38a9d0bc29321d
11 Nea69664871ee4f96ba8fa0e7f1989206
12 anzsrc-for:11
13 anzsrc-for:1103
14 schema:author Nc9066778d3764f0094dcacaa0164ded2
15 schema:citation sg:pub.10.1007/s12028-014-9984-9
16 sg:pub.10.1186/cc13843
17 https://app.dimensions.ai/details/publication/pub.1076959406
18 https://app.dimensions.ai/details/publication/pub.1078169269
19 https://doi.org/10.1001/archinternmed.2010.407
20 https://doi.org/10.1001/jama.2015.0846
21 https://doi.org/10.1002/phar.1384
22 https://doi.org/10.1002/pst.433
23 https://doi.org/10.1016/j.jemermed.2015.07.024
24 https://doi.org/10.1016/j.thromres.2005.08.005
25 https://doi.org/10.1016/j.thromres.2006.07.002
26 https://doi.org/10.1016/j.thromres.2012.10.001
27 https://doi.org/10.1043/2009-0474-oa.1
28 https://doi.org/10.1097/01.ccm.0000457934.27628.4d
29 https://doi.org/10.1097/01.ccm.0000457938.50499.d6
30 https://doi.org/10.1111/j.1365-2141.2011.08753.x
31 https://doi.org/10.1111/j.1365-2516.2004.00944.x
32 https://doi.org/10.1111/j.1365-3148.2010.01050.x
33 https://doi.org/10.1111/j.1445-5994.2010.02237.x
34 https://doi.org/10.1111/j.1537-2995.2008.02080.x
35 https://doi.org/10.1159/000094831
36 https://doi.org/10.1160/th11-01-0052
37 https://doi.org/10.1161/01.str.0000195047.21562.23
38 https://doi.org/10.1161/01.str.0000221786.81354.d6
39 https://doi.org/10.1161/circulationaha.112.100628
40 https://doi.org/10.1161/circulationaha.113.002283
41 https://doi.org/10.1161/strokeaha.112.661454
42 https://doi.org/10.1177/0310057x1003800310
43 https://doi.org/10.1212/01.wnl.0000138428.40673.83
44 https://doi.org/10.1378/chest.08-0674
45 https://doi.org/10.1378/chest.11-2295
46 https://doi.org/10.2450/2011.0065-10
47 https://doi.org/10.2450/2011.0111-10
48 https://doi.org/10.5694/j.1326-5377.2004.tb06407.x
49 schema:datePublished 2016-07
50 schema:datePublishedReg 2016-07-01
51 schema:description Current guidelines recommend 4-factor prothrombin complex concentrate (4PCC) for emergent reversal of bleeding secondary to warfarin. While current research has demonstrated superiority of 4PCC over plasma, direct comparisons with 3-factor PCC (3PCC) are lacking. The purpose of this study is to compare the efficacy and safety of 3PCC and 4PCC. We conducted a retrospective analysis of patients who received PCC at one of four medical centers. All patients in the 3PCC group were treated at one center that utilizes a fixed, weight-based dosing protocol. After evaluation of all patients meeting inclusion criteria, propensity-score matching was used to adjust for differences in treatment characteristics. There was no difference in the primary outcome of INR ≤ 1.4 between 3PCC and 4PCC in both the unmatched (85.7 vs. 90.6 %; p = 0.37) and matched (84.2 vs. 92.1 %; p = 0.48) analyses. There was a significant difference in goal INR achieved favoring 4PCC (56.3 vs 90.0 %; p < 0.02) when baseline INR > 4.0. A total of three thrombotic events were documented, all in the 4PCC group. We found no difference in the rate of INR reversal in those treated with 3PCC and 4PCC. However, those with a baseline INR > 4.0 may experience more successful INR reversal with 4PCC.
52 schema:genre research_article
53 schema:inLanguage en
54 schema:isAccessibleForFree false
55 schema:isPartOf N6cf97d7f39614deab53ba140065a17eb
56 N8b1f5ee9efcc4e4ba65fb4d29db552e4
57 sg:journal.1113719
58 schema:name 3-Factor Versus 4-Factor Prothrombin Complex Concentrate for Warfarin Reversal in Severe Bleeding: A Multicenter, Retrospective, Propensity-Matched Pilot Study
59 schema:pagination 19-26
60 schema:productId N5081a21ffd92485ba2604bc280a46c4c
61 N9b63d8d3e0e4413cad648bc2f05aba0c
62 Nbab97b7f7c9b47818afeef0bb9fc2116
63 Ndb677ae2f7874eeb802679aa87b289f6
64 Nf59b2395bf32419187bbda91fa6a7da5
65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048929484
66 https://doi.org/10.1007/s11239-015-1330-3
67 schema:sdDatePublished 2019-04-10T15:04
68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
69 schema:sdPublisher N6d97c58de259419bb4d86d2861eb8423
70 schema:url http://link.springer.com/10.1007%2Fs11239-015-1330-3
71 sgo:license sg:explorer/license/
72 sgo:sdDataset articles
73 rdf:type schema:ScholarlyArticle
74 N00ce41461956462cbad0d011c088f95d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Warfarin
76 rdf:type schema:DefinedTerm
77 N176eac9035e1487f871d50abc905454d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Humans
79 rdf:type schema:DefinedTerm
80 N1e4cd789862a4f61bd0e79c8c7979757 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Anticoagulants
82 rdf:type schema:DefinedTerm
83 N1e820f81a89941b680535a1cf41a1f09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Retrospective Studies
85 rdf:type schema:DefinedTerm
86 N1f8d8616b2d7454db8112dd11ccf9154 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Hemorrhage
88 rdf:type schema:DefinedTerm
89 N2167ba67847845638ccb8fdf028f00f3 rdf:first sg:person.01201040307.50
90 rdf:rest rdf:nil
91 N2fdb4ad4703d4e48b9ed349db7878f3b rdf:first sg:person.01202160032.24
92 rdf:rest Nd627dce9a1bf4224a2fc1cba5ea50e2f
93 N3e2121b9198a4f91a2029cd1a22b595b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Pilot Projects
95 rdf:type schema:DefinedTerm
96 N5081a21ffd92485ba2604bc280a46c4c schema:name readcube_id
97 schema:value e917469a421f3b5823fce2af4069b9b58b2f6e0498848f6e197d590a8ecfd463
98 rdf:type schema:PropertyValue
99 N6cf97d7f39614deab53ba140065a17eb schema:volumeNumber 42
100 rdf:type schema:PublicationVolume
101 N6d97c58de259419bb4d86d2861eb8423 schema:name Springer Nature - SN SciGraph project
102 rdf:type schema:Organization
103 N8b1f5ee9efcc4e4ba65fb4d29db552e4 schema:issueNumber 1
104 rdf:type schema:PublicationIssue
105 N98cad2633ad649829ddc0687a727a86f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Blood Coagulation Factors
107 rdf:type schema:DefinedTerm
108 N9b63d8d3e0e4413cad648bc2f05aba0c schema:name pubmed_id
109 schema:value 26721625
110 rdf:type schema:PropertyValue
111 Nbab97b7f7c9b47818afeef0bb9fc2116 schema:name nlm_unique_id
112 schema:value 9502018
113 rdf:type schema:PropertyValue
114 Nbc73a3fa4d7b4ea7a4fa5b19825b10ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name International Normalized Ratio
116 rdf:type schema:DefinedTerm
117 Nc9066778d3764f0094dcacaa0164ded2 rdf:first sg:person.01042563235.91
118 rdf:rest Nee9e4f5a87ec4cc8a3f2f4a3b1a4d616
119 Nd4f00809822f405a9f0b3fa66e770e6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Propensity Score
121 rdf:type schema:DefinedTerm
122 Nd50cde24c0c84f7a88bc3733af64512b rdf:first sg:person.016635170627.93
123 rdf:rest N2fdb4ad4703d4e48b9ed349db7878f3b
124 Nd627dce9a1bf4224a2fc1cba5ea50e2f rdf:first sg:person.0704111256.46
125 rdf:rest N2167ba67847845638ccb8fdf028f00f3
126 Ndb677ae2f7874eeb802679aa87b289f6 schema:name dimensions_id
127 schema:value pub.1048929484
128 rdf:type schema:PropertyValue
129 Nddc490cd94904aefbd38a9d0bc29321d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Treatment Outcome
131 rdf:type schema:DefinedTerm
132 Nea69664871ee4f96ba8fa0e7f1989206 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Drug Interactions
134 rdf:type schema:DefinedTerm
135 Nee9e4f5a87ec4cc8a3f2f4a3b1a4d616 rdf:first sg:person.0735310360.13
136 rdf:rest Nd50cde24c0c84f7a88bc3733af64512b
137 Nf59b2395bf32419187bbda91fa6a7da5 schema:name doi
138 schema:value 10.1007/s11239-015-1330-3
139 rdf:type schema:PropertyValue
140 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
141 schema:name Medical and Health Sciences
142 rdf:type schema:DefinedTerm
143 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
144 schema:name Clinical Sciences
145 rdf:type schema:DefinedTerm
146 sg:journal.1113719 schema:issn 0929-5305
147 1573-742X
148 schema:name Journal of Thrombosis and Thrombolysis
149 rdf:type schema:Periodical
150 sg:person.01042563235.91 schema:affiliation https://www.grid.ac/institutes/grid.267301.1
151 schema:familyName Jones
152 schema:givenName G. Morgan
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042563235.91
154 rdf:type schema:Person
155 sg:person.01201040307.50 schema:affiliation https://www.grid.ac/institutes/grid.267301.1
156 schema:familyName Elijovich
157 schema:givenName Lucas
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201040307.50
159 rdf:type schema:Person
160 sg:person.01202160032.24 schema:affiliation https://www.grid.ac/institutes/grid.412374.7
161 schema:familyName Mohrien
162 schema:givenName Kerry M.
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202160032.24
164 rdf:type schema:Person
165 sg:person.016635170627.93 schema:affiliation https://www.grid.ac/institutes/grid.413001.7
166 schema:familyName Smetana
167 schema:givenName Keaton S.
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016635170627.93
169 rdf:type schema:Person
170 sg:person.0704111256.46 schema:affiliation https://www.grid.ac/institutes/grid.411024.2
171 schema:familyName Vandigo
172 schema:givenName Joseph E.
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704111256.46
174 rdf:type schema:Person
175 sg:person.0735310360.13 schema:affiliation https://www.grid.ac/institutes/grid.413116.0
176 schema:familyName Erdman
177 schema:givenName Michael J.
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735310360.13
179 rdf:type schema:Person
180 sg:pub.10.1007/s12028-014-9984-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016463030
181 https://doi.org/10.1007/s12028-014-9984-9
182 rdf:type schema:CreativeWork
183 sg:pub.10.1186/cc13843 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002198417
184 https://doi.org/10.1186/cc13843
185 rdf:type schema:CreativeWork
186 https://app.dimensions.ai/details/publication/pub.1076959406 schema:CreativeWork
187 https://app.dimensions.ai/details/publication/pub.1078169269 schema:CreativeWork
188 https://doi.org/10.1001/archinternmed.2010.407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008533529
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1001/jama.2015.0846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028598057
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1002/phar.1384 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001556577
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1002/pst.433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052069221
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/j.jemermed.2015.07.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023337442
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/j.thromres.2005.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016527501
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/j.thromres.2006.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012421426
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/j.thromres.2012.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042803577
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1043/2009-0474-oa.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078377533
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1097/01.ccm.0000457934.27628.4d schema:sameAs https://app.dimensions.ai/details/publication/pub.1005164630
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1097/01.ccm.0000457938.50499.d6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030191490
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1111/j.1365-2141.2011.08753.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039118133
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1111/j.1365-2516.2004.00944.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035483664
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1111/j.1365-3148.2010.01050.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023317722
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1111/j.1445-5994.2010.02237.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028572523
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1111/j.1537-2995.2008.02080.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045683454
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1159/000094831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053615205
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1160/th11-01-0052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063292645
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1161/01.str.0000195047.21562.23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046714873
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1161/01.str.0000221786.81354.d6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016625234
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1161/circulationaha.112.100628 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018236870
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1161/circulationaha.113.002283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039649864
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1161/strokeaha.112.661454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046688812
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1177/0310057x1003800310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078169269
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1212/01.wnl.0000138428.40673.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064346325
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1378/chest.08-0674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038782284
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1378/chest.11-2295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030538705
241 rdf:type schema:CreativeWork
242 https://doi.org/10.2450/2011.0065-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078332753
243 rdf:type schema:CreativeWork
244 https://doi.org/10.2450/2011.0111-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078332754
245 rdf:type schema:CreativeWork
246 https://doi.org/10.5694/j.1326-5377.2004.tb06407.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1076959406
247 rdf:type schema:CreativeWork
248 https://www.grid.ac/institutes/grid.267301.1 schema:alternateName University of Tennessee Health Science Center
249 schema:name Department of Clinical Pharmacy, University of Tennessee Health Sciences Center (UTHSC), 920 Court Ave, 38163, Memphis, TN, USA
250 Department of Neurology and Neurosurgery, UTHSC, 920 Court Ave, 38163, Memphis, TN, USA
251 Department of Pharmacy, Methodist University Hospital, 1265 Union Avenue, 38104, Memphis, TN, USA
252 Semmes-Murphey Neurologic and Spine Institute, 6325 Humphreys Blvd, 38120, Memphis, TN, USA
253 rdf:type schema:Organization
254 https://www.grid.ac/institutes/grid.411024.2 schema:alternateName University of Maryland, Baltimore
255 schema:name Department of Pharmaceutical Health Services Research, University of Maryland School of Pharmacy, 620 W Lexington St, 21201, Baltimore, MD, USA
256 rdf:type schema:Organization
257 https://www.grid.ac/institutes/grid.412374.7 schema:alternateName Temple University Hospital
258 schema:name Department of Pharmacy, Temple University Hospital, 3509 N Broad St, 19140, Philadelphia, PA, USA
259 rdf:type schema:Organization
260 https://www.grid.ac/institutes/grid.413001.7 schema:alternateName University of Kentucky HealthCare
261 schema:name Department of Pharmacy, University of Kentucky HealthCare, 800 Rose St, 40536, Lexington, KY, USA
262 rdf:type schema:Organization
263 https://www.grid.ac/institutes/grid.413116.0 schema:alternateName University of Florida Health Science Center
264 schema:name Department of Pharmacy, University of Florida Health, 655 West 8th Street, 32209, Jacksonville, FL, USA
265 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...