3-Factor Versus 4-Factor Prothrombin Complex Concentrate for Warfarin Reversal in Severe Bleeding: A Multicenter, Retrospective, Propensity-Matched Pilot Study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-07

AUTHORS

G. Morgan Jones, Michael J. Erdman, Keaton S. Smetana, Kerry M. Mohrien, Joseph E. Vandigo, Lucas Elijovich

ABSTRACT

Current guidelines recommend 4-factor prothrombin complex concentrate (4PCC) for emergent reversal of bleeding secondary to warfarin. While current research has demonstrated superiority of 4PCC over plasma, direct comparisons with 3-factor PCC (3PCC) are lacking. The purpose of this study is to compare the efficacy and safety of 3PCC and 4PCC. We conducted a retrospective analysis of patients who received PCC at one of four medical centers. All patients in the 3PCC group were treated at one center that utilizes a fixed, weight-based dosing protocol. After evaluation of all patients meeting inclusion criteria, propensity-score matching was used to adjust for differences in treatment characteristics. There was no difference in the primary outcome of INR ≤ 1.4 between 3PCC and 4PCC in both the unmatched (85.7 vs. 90.6 %; p = 0.37) and matched (84.2 vs. 92.1 %; p = 0.48) analyses. There was a significant difference in goal INR achieved favoring 4PCC (56.3 vs 90.0 %; p < 0.02) when baseline INR > 4.0. A total of three thrombotic events were documented, all in the 4PCC group. We found no difference in the rate of INR reversal in those treated with 3PCC and 4PCC. However, those with a baseline INR > 4.0 may experience more successful INR reversal with 4PCC. More... »

PAGES

19-26

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11239-015-1330-3

DOI

http://dx.doi.org/10.1007/s11239-015-1330-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048929484

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26721625


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anticoagulants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Coagulation Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Interactions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hemorrhage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "International Normalized Ratio", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pilot Projects", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Propensity Score", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Warfarin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Tennessee Health Science Center", 
          "id": "https://www.grid.ac/institutes/grid.267301.1", 
          "name": [
            "Department of Pharmacy, Methodist University Hospital, 1265 Union Avenue, 38104, Memphis, TN, USA", 
            "Department of Clinical Pharmacy, University of Tennessee Health Sciences Center (UTHSC), 920 Court Ave, 38163, Memphis, TN, USA", 
            "Department of Neurology and Neurosurgery, UTHSC, 920 Court Ave, 38163, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jones", 
        "givenName": "G. Morgan", 
        "id": "sg:person.01042563235.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042563235.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Florida Health Science Center", 
          "id": "https://www.grid.ac/institutes/grid.413116.0", 
          "name": [
            "Department of Pharmacy, University of Florida Health, 655 West 8th Street, 32209, Jacksonville, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Erdman", 
        "givenName": "Michael J.", 
        "id": "sg:person.0735310360.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735310360.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kentucky HealthCare", 
          "id": "https://www.grid.ac/institutes/grid.413001.7", 
          "name": [
            "Department of Pharmacy, University of Kentucky HealthCare, 800 Rose St, 40536, Lexington, KY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smetana", 
        "givenName": "Keaton S.", 
        "id": "sg:person.016635170627.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016635170627.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Temple University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412374.7", 
          "name": [
            "Department of Pharmacy, Temple University Hospital, 3509\u00a0N Broad St, 19140, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mohrien", 
        "givenName": "Kerry M.", 
        "id": "sg:person.01202160032.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202160032.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Maryland, Baltimore", 
          "id": "https://www.grid.ac/institutes/grid.411024.2", 
          "name": [
            "Department of Pharmaceutical Health Services Research, University of Maryland School of Pharmacy, 620\u00a0W Lexington St, 21201, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vandigo", 
        "givenName": "Joseph E.", 
        "id": "sg:person.0704111256.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704111256.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tennessee Health Science Center", 
          "id": "https://www.grid.ac/institutes/grid.267301.1", 
          "name": [
            "Department of Neurology and Neurosurgery, UTHSC, 920 Court Ave, 38163, Memphis, TN, USA", 
            "Semmes-Murphey Neurologic and Spine Institute, 6325 Humphreys Blvd, 38120, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Elijovich", 
        "givenName": "Lucas", 
        "id": "sg:person.01201040307.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201040307.50"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/phar.1384", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001556577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc13843", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002198417", 
          "https://doi.org/10.1186/cc13843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000457934.27628.4d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005164630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000457934.27628.4d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005164630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archinternmed.2010.407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008533529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.thromres.2006.07.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012421426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12028-014-9984-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016463030", 
          "https://doi.org/10.1007/s12028-014-9984-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.thromres.2005.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016527501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.thromres.2005.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016527501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000221786.81354.d6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016625234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000221786.81354.d6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016625234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.112.100628", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018236870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.112.100628", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018236870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3148.2010.01050.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023317722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jemermed.2015.07.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023337442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1445-5994.2010.02237.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028572523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2015.0846", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028598057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000457938.50499.d6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030191490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000457938.50499.d6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030191490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.11-2295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030538705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2516.2004.00944.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035483664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.08-0674", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038782284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2011.08753.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039118133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.113.002283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039649864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.113.002283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039649864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.thromres.2012.10.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042803577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1537-2995.2008.02080.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045683454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.112.661454", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046688812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.112.661454", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046688812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000195047.21562.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046714873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000195047.21562.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046714873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pst.433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052069221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000094831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053615205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1160/th11-01-0052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063292645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000138428.40673.83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000138428.40673.83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000138428.40673.83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064346325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076959406", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5694/j.1326-5377.2004.tb06407.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076959406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078169269", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0310057x1003800310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078169269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0310057x1003800310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078169269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0310057x1003800310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078169269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2450/2011.0065-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078332753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2450/2011.0111-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078332754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1043/2009-0474-oa.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078377533"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-07", 
    "datePublishedReg": "2016-07-01", 
    "description": "Current guidelines recommend 4-factor prothrombin complex concentrate (4PCC) for emergent reversal of bleeding secondary to warfarin. While current research has demonstrated superiority of 4PCC over plasma, direct comparisons with 3-factor PCC (3PCC) are lacking. The purpose of this study is to compare the efficacy and safety of 3PCC and 4PCC. We conducted a retrospective analysis of patients who received PCC at one of four medical centers. All patients in the 3PCC group were treated at one center that utilizes a fixed, weight-based dosing protocol. After evaluation of all patients meeting inclusion criteria, propensity-score matching was used to adjust for differences in treatment characteristics. There was no difference in the primary outcome of INR\u00a0\u2264\u00a01.4 between 3PCC and 4PCC in both the unmatched (85.7 vs. 90.6\u00a0%; p\u00a0=\u00a00.37) and matched (84.2 vs. 92.1\u00a0%; p\u00a0=\u00a00.48) analyses. There was a significant difference in goal INR achieved favoring 4PCC (56.3 vs 90.0\u00a0%; p\u00a0<\u00a00.02) when baseline INR\u00a0>\u00a04.0. A total of three thrombotic events were documented, all in the 4PCC group. We found no difference in the rate of INR reversal in those treated with 3PCC and 4PCC. However, those with a baseline INR\u00a0>\u00a04.0 may experience more successful INR reversal with 4PCC. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11239-015-1330-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1113719", 
        "issn": [
          "0929-5305", 
          "1573-742X"
        ], 
        "name": "Journal of Thrombosis and Thrombolysis", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "42"
      }
    ], 
    "name": "3-Factor Versus 4-Factor Prothrombin Complex Concentrate for Warfarin Reversal in Severe Bleeding: A Multicenter, Retrospective, Propensity-Matched Pilot Study", 
    "pagination": "19-26", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e917469a421f3b5823fce2af4069b9b58b2f6e0498848f6e197d590a8ecfd463"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26721625"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9502018"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11239-015-1330-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1048929484"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11239-015-1330-3", 
      "https://app.dimensions.ai/details/publication/pub.1048929484"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000524.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11239-015-1330-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11239-015-1330-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11239-015-1330-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11239-015-1330-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11239-015-1330-3'


 

This table displays all metadata directly associated to this object as RDF triples.

265 TRIPLES      21 PREDICATES      74 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11239-015-1330-3 schema:about N197eb29eb6624765ae7eb0d56ab51f61
2 N23e939cb44b64666b347ac3be454516d
3 N29e1cd2d94a64d84aa37d64892d497fc
4 N4c746cac8e7943e4a0e41bdd18406e47
5 N768e4a3f34044620844dba6ea8d88fb1
6 N8e03ff0df55e4451855b4de800d165b1
7 N9f9ace0a8910482fa3ba30f2f79ca2da
8 Naf12199b6de94ed79dbc92fe167f3062
9 Nb0bf7816a94d4322a0bfef7ec011724f
10 Nc9a355db439947ae8354b947fd14ea11
11 Nf3d652c26d2f41a28523a1a8af7b5d1a
12 anzsrc-for:11
13 anzsrc-for:1103
14 schema:author N67fa6c4f6cb3453a80b6c26c4dba344f
15 schema:citation sg:pub.10.1007/s12028-014-9984-9
16 sg:pub.10.1186/cc13843
17 https://app.dimensions.ai/details/publication/pub.1076959406
18 https://app.dimensions.ai/details/publication/pub.1078169269
19 https://doi.org/10.1001/archinternmed.2010.407
20 https://doi.org/10.1001/jama.2015.0846
21 https://doi.org/10.1002/phar.1384
22 https://doi.org/10.1002/pst.433
23 https://doi.org/10.1016/j.jemermed.2015.07.024
24 https://doi.org/10.1016/j.thromres.2005.08.005
25 https://doi.org/10.1016/j.thromres.2006.07.002
26 https://doi.org/10.1016/j.thromres.2012.10.001
27 https://doi.org/10.1043/2009-0474-oa.1
28 https://doi.org/10.1097/01.ccm.0000457934.27628.4d
29 https://doi.org/10.1097/01.ccm.0000457938.50499.d6
30 https://doi.org/10.1111/j.1365-2141.2011.08753.x
31 https://doi.org/10.1111/j.1365-2516.2004.00944.x
32 https://doi.org/10.1111/j.1365-3148.2010.01050.x
33 https://doi.org/10.1111/j.1445-5994.2010.02237.x
34 https://doi.org/10.1111/j.1537-2995.2008.02080.x
35 https://doi.org/10.1159/000094831
36 https://doi.org/10.1160/th11-01-0052
37 https://doi.org/10.1161/01.str.0000195047.21562.23
38 https://doi.org/10.1161/01.str.0000221786.81354.d6
39 https://doi.org/10.1161/circulationaha.112.100628
40 https://doi.org/10.1161/circulationaha.113.002283
41 https://doi.org/10.1161/strokeaha.112.661454
42 https://doi.org/10.1177/0310057x1003800310
43 https://doi.org/10.1212/01.wnl.0000138428.40673.83
44 https://doi.org/10.1378/chest.08-0674
45 https://doi.org/10.1378/chest.11-2295
46 https://doi.org/10.2450/2011.0065-10
47 https://doi.org/10.2450/2011.0111-10
48 https://doi.org/10.5694/j.1326-5377.2004.tb06407.x
49 schema:datePublished 2016-07
50 schema:datePublishedReg 2016-07-01
51 schema:description Current guidelines recommend 4-factor prothrombin complex concentrate (4PCC) for emergent reversal of bleeding secondary to warfarin. While current research has demonstrated superiority of 4PCC over plasma, direct comparisons with 3-factor PCC (3PCC) are lacking. The purpose of this study is to compare the efficacy and safety of 3PCC and 4PCC. We conducted a retrospective analysis of patients who received PCC at one of four medical centers. All patients in the 3PCC group were treated at one center that utilizes a fixed, weight-based dosing protocol. After evaluation of all patients meeting inclusion criteria, propensity-score matching was used to adjust for differences in treatment characteristics. There was no difference in the primary outcome of INR ≤ 1.4 between 3PCC and 4PCC in both the unmatched (85.7 vs. 90.6 %; p = 0.37) and matched (84.2 vs. 92.1 %; p = 0.48) analyses. There was a significant difference in goal INR achieved favoring 4PCC (56.3 vs 90.0 %; p < 0.02) when baseline INR > 4.0. A total of three thrombotic events were documented, all in the 4PCC group. We found no difference in the rate of INR reversal in those treated with 3PCC and 4PCC. However, those with a baseline INR > 4.0 may experience more successful INR reversal with 4PCC.
52 schema:genre research_article
53 schema:inLanguage en
54 schema:isAccessibleForFree false
55 schema:isPartOf N081a27778d1640af8917ce849b593faa
56 N5ab1c8818c294fc59546037ebfbc9e9e
57 sg:journal.1113719
58 schema:name 3-Factor Versus 4-Factor Prothrombin Complex Concentrate for Warfarin Reversal in Severe Bleeding: A Multicenter, Retrospective, Propensity-Matched Pilot Study
59 schema:pagination 19-26
60 schema:productId N0491c44ed4b44166a8b8b880a1025e75
61 N17050ab081514254abb9036918bd4c80
62 N84a6bf3e0aa74a718c1744066bb2f652
63 Nb206108eae00437689e729d9850069f5
64 Nc33269f89bbe4a49816f6ed7d00c1096
65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048929484
66 https://doi.org/10.1007/s11239-015-1330-3
67 schema:sdDatePublished 2019-04-10T15:04
68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
69 schema:sdPublisher Nf7c1fc3769f147c68d7f78f953a9fc57
70 schema:url http://link.springer.com/10.1007%2Fs11239-015-1330-3
71 sgo:license sg:explorer/license/
72 sgo:sdDataset articles
73 rdf:type schema:ScholarlyArticle
74 N0491c44ed4b44166a8b8b880a1025e75 schema:name pubmed_id
75 schema:value 26721625
76 rdf:type schema:PropertyValue
77 N081a27778d1640af8917ce849b593faa schema:issueNumber 1
78 rdf:type schema:PublicationIssue
79 N17050ab081514254abb9036918bd4c80 schema:name dimensions_id
80 schema:value pub.1048929484
81 rdf:type schema:PropertyValue
82 N197eb29eb6624765ae7eb0d56ab51f61 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Drug Interactions
84 rdf:type schema:DefinedTerm
85 N23e939cb44b64666b347ac3be454516d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Humans
87 rdf:type schema:DefinedTerm
88 N29e1cd2d94a64d84aa37d64892d497fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Pilot Projects
90 rdf:type schema:DefinedTerm
91 N3ee841887f6f444e92f94556bff2c511 rdf:first sg:person.01202160032.24
92 rdf:rest N6b3a358a60ee43f3abe0f2d7fd6976d3
93 N3f20d629ea4c4a1eaf4f6fd9ffa94101 rdf:first sg:person.0735310360.13
94 rdf:rest N695c1a97ecb046dfa8b4e1c63e68c74f
95 N4c746cac8e7943e4a0e41bdd18406e47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name International Normalized Ratio
97 rdf:type schema:DefinedTerm
98 N5ab1c8818c294fc59546037ebfbc9e9e schema:volumeNumber 42
99 rdf:type schema:PublicationVolume
100 N60342c2e07a04876aa56488808a7f8e8 rdf:first sg:person.01201040307.50
101 rdf:rest rdf:nil
102 N67fa6c4f6cb3453a80b6c26c4dba344f rdf:first sg:person.01042563235.91
103 rdf:rest N3f20d629ea4c4a1eaf4f6fd9ffa94101
104 N695c1a97ecb046dfa8b4e1c63e68c74f rdf:first sg:person.016635170627.93
105 rdf:rest N3ee841887f6f444e92f94556bff2c511
106 N6b3a358a60ee43f3abe0f2d7fd6976d3 rdf:first sg:person.0704111256.46
107 rdf:rest N60342c2e07a04876aa56488808a7f8e8
108 N768e4a3f34044620844dba6ea8d88fb1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Anticoagulants
110 rdf:type schema:DefinedTerm
111 N84a6bf3e0aa74a718c1744066bb2f652 schema:name nlm_unique_id
112 schema:value 9502018
113 rdf:type schema:PropertyValue
114 N8e03ff0df55e4451855b4de800d165b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Propensity Score
116 rdf:type schema:DefinedTerm
117 N9f9ace0a8910482fa3ba30f2f79ca2da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Blood Coagulation Factors
119 rdf:type schema:DefinedTerm
120 Naf12199b6de94ed79dbc92fe167f3062 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Hemorrhage
122 rdf:type schema:DefinedTerm
123 Nb0bf7816a94d4322a0bfef7ec011724f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Retrospective Studies
125 rdf:type schema:DefinedTerm
126 Nb206108eae00437689e729d9850069f5 schema:name doi
127 schema:value 10.1007/s11239-015-1330-3
128 rdf:type schema:PropertyValue
129 Nc33269f89bbe4a49816f6ed7d00c1096 schema:name readcube_id
130 schema:value e917469a421f3b5823fce2af4069b9b58b2f6e0498848f6e197d590a8ecfd463
131 rdf:type schema:PropertyValue
132 Nc9a355db439947ae8354b947fd14ea11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Treatment Outcome
134 rdf:type schema:DefinedTerm
135 Nf3d652c26d2f41a28523a1a8af7b5d1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Warfarin
137 rdf:type schema:DefinedTerm
138 Nf7c1fc3769f147c68d7f78f953a9fc57 schema:name Springer Nature - SN SciGraph project
139 rdf:type schema:Organization
140 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
141 schema:name Medical and Health Sciences
142 rdf:type schema:DefinedTerm
143 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
144 schema:name Clinical Sciences
145 rdf:type schema:DefinedTerm
146 sg:journal.1113719 schema:issn 0929-5305
147 1573-742X
148 schema:name Journal of Thrombosis and Thrombolysis
149 rdf:type schema:Periodical
150 sg:person.01042563235.91 schema:affiliation https://www.grid.ac/institutes/grid.267301.1
151 schema:familyName Jones
152 schema:givenName G. Morgan
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042563235.91
154 rdf:type schema:Person
155 sg:person.01201040307.50 schema:affiliation https://www.grid.ac/institutes/grid.267301.1
156 schema:familyName Elijovich
157 schema:givenName Lucas
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201040307.50
159 rdf:type schema:Person
160 sg:person.01202160032.24 schema:affiliation https://www.grid.ac/institutes/grid.412374.7
161 schema:familyName Mohrien
162 schema:givenName Kerry M.
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202160032.24
164 rdf:type schema:Person
165 sg:person.016635170627.93 schema:affiliation https://www.grid.ac/institutes/grid.413001.7
166 schema:familyName Smetana
167 schema:givenName Keaton S.
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016635170627.93
169 rdf:type schema:Person
170 sg:person.0704111256.46 schema:affiliation https://www.grid.ac/institutes/grid.411024.2
171 schema:familyName Vandigo
172 schema:givenName Joseph E.
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704111256.46
174 rdf:type schema:Person
175 sg:person.0735310360.13 schema:affiliation https://www.grid.ac/institutes/grid.413116.0
176 schema:familyName Erdman
177 schema:givenName Michael J.
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735310360.13
179 rdf:type schema:Person
180 sg:pub.10.1007/s12028-014-9984-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016463030
181 https://doi.org/10.1007/s12028-014-9984-9
182 rdf:type schema:CreativeWork
183 sg:pub.10.1186/cc13843 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002198417
184 https://doi.org/10.1186/cc13843
185 rdf:type schema:CreativeWork
186 https://app.dimensions.ai/details/publication/pub.1076959406 schema:CreativeWork
187 https://app.dimensions.ai/details/publication/pub.1078169269 schema:CreativeWork
188 https://doi.org/10.1001/archinternmed.2010.407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008533529
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1001/jama.2015.0846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028598057
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1002/phar.1384 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001556577
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1002/pst.433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052069221
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/j.jemermed.2015.07.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023337442
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/j.thromres.2005.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016527501
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/j.thromres.2006.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012421426
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/j.thromres.2012.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042803577
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1043/2009-0474-oa.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078377533
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1097/01.ccm.0000457934.27628.4d schema:sameAs https://app.dimensions.ai/details/publication/pub.1005164630
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1097/01.ccm.0000457938.50499.d6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030191490
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1111/j.1365-2141.2011.08753.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039118133
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1111/j.1365-2516.2004.00944.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035483664
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1111/j.1365-3148.2010.01050.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023317722
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1111/j.1445-5994.2010.02237.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028572523
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1111/j.1537-2995.2008.02080.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045683454
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1159/000094831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053615205
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1160/th11-01-0052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063292645
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1161/01.str.0000195047.21562.23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046714873
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1161/01.str.0000221786.81354.d6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016625234
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1161/circulationaha.112.100628 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018236870
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1161/circulationaha.113.002283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039649864
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1161/strokeaha.112.661454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046688812
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1177/0310057x1003800310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078169269
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1212/01.wnl.0000138428.40673.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064346325
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1378/chest.08-0674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038782284
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1378/chest.11-2295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030538705
241 rdf:type schema:CreativeWork
242 https://doi.org/10.2450/2011.0065-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078332753
243 rdf:type schema:CreativeWork
244 https://doi.org/10.2450/2011.0111-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078332754
245 rdf:type schema:CreativeWork
246 https://doi.org/10.5694/j.1326-5377.2004.tb06407.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1076959406
247 rdf:type schema:CreativeWork
248 https://www.grid.ac/institutes/grid.267301.1 schema:alternateName University of Tennessee Health Science Center
249 schema:name Department of Clinical Pharmacy, University of Tennessee Health Sciences Center (UTHSC), 920 Court Ave, 38163, Memphis, TN, USA
250 Department of Neurology and Neurosurgery, UTHSC, 920 Court Ave, 38163, Memphis, TN, USA
251 Department of Pharmacy, Methodist University Hospital, 1265 Union Avenue, 38104, Memphis, TN, USA
252 Semmes-Murphey Neurologic and Spine Institute, 6325 Humphreys Blvd, 38120, Memphis, TN, USA
253 rdf:type schema:Organization
254 https://www.grid.ac/institutes/grid.411024.2 schema:alternateName University of Maryland, Baltimore
255 schema:name Department of Pharmaceutical Health Services Research, University of Maryland School of Pharmacy, 620 W Lexington St, 21201, Baltimore, MD, USA
256 rdf:type schema:Organization
257 https://www.grid.ac/institutes/grid.412374.7 schema:alternateName Temple University Hospital
258 schema:name Department of Pharmacy, Temple University Hospital, 3509 N Broad St, 19140, Philadelphia, PA, USA
259 rdf:type schema:Organization
260 https://www.grid.ac/institutes/grid.413001.7 schema:alternateName University of Kentucky HealthCare
261 schema:name Department of Pharmacy, University of Kentucky HealthCare, 800 Rose St, 40536, Lexington, KY, USA
262 rdf:type schema:Organization
263 https://www.grid.ac/institutes/grid.413116.0 schema:alternateName University of Florida Health Science Center
264 schema:name Department of Pharmacy, University of Florida Health, 655 West 8th Street, 32209, Jacksonville, FL, USA
265 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...