Hyperfibrinogenemia predicts long-term risk of death after ischemic stroke View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-11

AUTHORS

Marta Swarowska, Agnieszka Polczak, Joanna Pera, Aleksandra Klimkowicz-Mrowiec, Agnieszka Slowik, Tomasz Dziedzic

ABSTRACT

In stroke patients higher levels of plasma fibrinogen are associated with increased risk of unfavourable functional outcome and short-term mortality. The aim of our study was to determine the relationship between plasma fibrinogen level and long-term risk of death in ischemic stroke patients. Seven hundred thirty six patients (median age 71; 47.1% men) admitted to the stroke unit within 24 h after stroke were included. Plasma fibrinogen level was measured on day 1 of hospitalisation. Hyperfibrinogenemia was defined as plasma fibrinogen concentration >3.5 g/L. The maximal follow-up period was 84 months. Hyperfibrinogenemia was found in 25.0% of patients. On multivariate logistic regression analysis, after adjustment for age, stroke severity, atrial fibrillation, smoking, white blood cell count, fever, in-hospital pneumonia and hyperglycemia, hyperfibrinogenemia was associated with increased case fatality (HR 1.71, 95% CI 1.29-2.26, P < 0.01). Hyperfibrinogenemia predicts the long-term risk of death in ischemic stroke patients. More... »

PAGES

517-521

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11239-014-1122-1

DOI

http://dx.doi.org/10.1007/s11239-014-1122-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024798840

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25106735


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