Urinary albumin concentration and long-term cardiovascular risk in acute coronary syndrome patients: a PROVE IT-TIMI 22 substudy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-10

AUTHORS

Babak Nazer, Kausik K. Ray, Sabina A. Murphy, C. Michael Gibson, Christopher P. Cannon

ABSTRACT

Albuminuria has been shown to be associated with mortality and cardiovascular events, independent of traditional cardiovascular risk factors. This suggests that albuminuria may not just represent glomerular damage, but may be a marker of more diffuse endothelial dysfunction. We investigated the relationship between urinary albumin levels after an acute coronary syndrome and cardiovascular outcomes in statin treated subjects after acute coronary syndromes (ACS). Furthermore we assessed the effect of intensive statin treatment on albuminuria among patients in the PROVE IT-TIMI 22 trial, in which patients who had been hospitalized with ACS were randomized to pravastatin 40 mg (standard therapy) or atorvastatin 80 mg daily (intensive therapy). In univariate analyses, increasing urine albumin concentration was associated with increased risk of myocardial infarction, stroke, heart failure, and composite of death, myocardial infarction and stroke at 2 years. However, in a multivariable model containing traditional cardiovascular risk factors, albuminuria was not an independent predictor of the primary PROVE IT endpoint of death, myocardial infarction, unstable angina, revascularization and stroke, and was only an independent predictor of all-cause mortality at urinary albumin concentration >300 mcg/ml. There was no significant change in urinary albumin concentration from enrolment to end of study in either the standard or intensive statin therapy groups, and no significant difference between treatment groups. Our results suggest that after an acute coronary syndrome in statin treated patients, microalbuminuria may reflect traditional cardiovascular risk factor burden and offer little prognostic information independent of those factors. More... »

PAGES

233-239

References to SciGraph publications

  • 1980-09. Isolated proteinuria in asymptomatic patients in KIDNEY INTERNATIONAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11239-012-0853-0

    DOI

    http://dx.doi.org/10.1007/s11239-012-0853-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1007063105

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23212806


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Acute Coronary Syndrome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Albuminuria", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anticholesteremic Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Atorvastatin Calcium", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Heart Failure", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Heptanoic Acids", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Models, Biological", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Myocardial Infarction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pravastatin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pyrroles", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Risk Factors", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of California, San Francisco", 
              "id": "https://www.grid.ac/institutes/grid.266102.1", 
              "name": [
                "Division of Cardiology, University of California, San Francisco, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nazer", 
            "givenName": "Babak", 
            "id": "sg:person.01235024064.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235024064.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "St George's, University of London", 
              "id": "https://www.grid.ac/institutes/grid.264200.2", 
              "name": [
                "Division of Cardiac and Vascular Sciences, St. George\u2019s University of London, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ray", 
            "givenName": "Kausik K.", 
            "id": "sg:person.0651160077.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651160077.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Thrombolysis in Myocardial Infarction (TIMI) Study Group, Cardiovascular Division, Brigham & Women\u2019s Hospital and Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Murphy", 
            "givenName": "Sabina A.", 
            "id": "sg:person.0714034144.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714034144.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Cardiovascular Division, Beth Israel/Deaconess Hospital, Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gibson", 
            "givenName": "C. Michael", 
            "id": "sg:person.0750215673.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750215673.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Thrombolysis in Myocardial Infarction (TIMI) Study Group, Cardiovascular Division, Brigham & Women\u2019s Hospital and Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cannon", 
            "givenName": "Christopher P.", 
            "id": "sg:person.01172544713.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172544713.06"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.2337/diacare.27.2007.s79", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001807621"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ndt/gfm114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004102000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2796.2001.00833.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004588524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/clc.20792", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007695222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/clc.20792", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007695222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004872-199816040-00014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010740516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004872-199816040-00014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010740516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004872-199816040-00014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010740516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pmed.0050207", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010976845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.105.538132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020401476"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2004070539", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024184824"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1681/asn.2004070539", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024184824"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa040583", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024700175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(10)60674-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033235001"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.0000031732.78052.81", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033319537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0272-6386(03)00742-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038537849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0272-6386(03)00742-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038537849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ki.1980.151", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038924465", 
              "https://doi.org/10.1038/ki.1980.151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.286.4.421", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042440144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/ajkd.2002.31388", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049165920"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/diabetes.51.4.1157", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050688008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/euhj.2000.2582", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1057074837"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.96.10.3338", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063338108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078383773", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078408652", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-10", 
        "datePublishedReg": "2013-10-01", 
        "description": "Albuminuria has been shown to be associated with mortality and cardiovascular events, independent of traditional cardiovascular risk factors. This suggests that albuminuria may not just represent glomerular damage, but may be a marker of more diffuse endothelial dysfunction. We investigated the relationship between urinary albumin levels after an acute coronary syndrome and cardiovascular outcomes in statin treated subjects after acute coronary syndromes (ACS). Furthermore we assessed the effect of intensive statin treatment on albuminuria among patients in the PROVE IT-TIMI 22 trial, in which patients who had been hospitalized with ACS were randomized to pravastatin 40\u00a0mg (standard therapy) or atorvastatin 80\u00a0mg daily (intensive therapy). In univariate analyses, increasing urine albumin concentration was associated with increased risk of myocardial infarction, stroke, heart failure, and composite of death, myocardial infarction and stroke at 2 years. However, in a multivariable model containing traditional cardiovascular risk factors, albuminuria was not an independent predictor of the primary PROVE IT endpoint of death, myocardial infarction, unstable angina, revascularization and stroke, and was only an independent predictor of all-cause mortality at urinary albumin concentration >300\u00a0mcg/ml. There was no significant change in urinary albumin concentration from enrolment to end of study in either the standard or intensive statin therapy groups, and no significant difference between treatment groups. Our results suggest that after an acute coronary syndrome in statin treated patients, microalbuminuria may reflect traditional cardiovascular risk factor burden and offer little prognostic information independent of those factors. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s11239-012-0853-0", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1113719", 
            "issn": [
              "0929-5305", 
              "1573-742X"
            ], 
            "name": "Journal of Thrombosis and Thrombolysis", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "36"
          }
        ], 
        "name": "Urinary albumin concentration and long-term cardiovascular risk in acute coronary syndrome patients: a PROVE IT-TIMI 22 substudy", 
        "pagination": "233-239", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "21a525c3d047cd6301528854852547d904840190b6667a999bf320e4ea52e87f"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23212806"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9502018"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s11239-012-0853-0"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1007063105"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s11239-012-0853-0", 
          "https://app.dimensions.ai/details/publication/pub.1007063105"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T02:07", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000520.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs11239-012-0853-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11239-012-0853-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11239-012-0853-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11239-012-0853-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11239-012-0853-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    228 TRIPLES      21 PREDICATES      65 URIs      37 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s11239-012-0853-0 schema:about N01c18c79185d4f779d2a28a16f2b2ae8
    2 N17f99be62c2a446fa07b4ee1cf2edb39
    3 N196b737189d84184b28502417e53dd40
    4 N28aa6cc296bc4c24aafbdbd454b93272
    5 N79cb05da5fb54098bbd7ad911001fbee
    6 N90546b1536f24557a38876f74d1af1c5
    7 N94fd292129054d67b22cc6d359209352
    8 Na2f529dddc6140ea93b5fefc5ad7514d
    9 Na96e1de38d6e41039bffdf4b4af99134
    10 Nab03e8f7743f4b01803473cde22de157
    11 Nbea6b85e457242d593d5adc8f2a441ab
    12 Ncaaed6a3d4db488dbfecfdff1d3932d1
    13 Ncd9e07f940e94710b7e8be4ed9b60a8b
    14 Nde0fb9c9a433467f8b2450713c5e90d1
    15 Ndf0917ddd57243199f23c874d9314553
    16 Nf3a29bf59b664e8bb6b8d8aa0266c110
    17 anzsrc-for:11
    18 anzsrc-for:1102
    19 schema:author N63692291b834485b8dda9f7497d16d8c
    20 schema:citation sg:pub.10.1038/ki.1980.151
    21 https://app.dimensions.ai/details/publication/pub.1078383773
    22 https://app.dimensions.ai/details/publication/pub.1078408652
    23 https://doi.org/10.1001/jama.286.4.421
    24 https://doi.org/10.1002/clc.20792
    25 https://doi.org/10.1016/s0140-6736(10)60674-5
    26 https://doi.org/10.1016/s0272-6386(03)00742-x
    27 https://doi.org/10.1046/j.1365-2796.2001.00833.x
    28 https://doi.org/10.1053/ajkd.2002.31388
    29 https://doi.org/10.1053/euhj.2000.2582
    30 https://doi.org/10.1056/nejmoa040583
    31 https://doi.org/10.1093/ndt/gfm114
    32 https://doi.org/10.1097/00004872-199816040-00014
    33 https://doi.org/10.1161/01.cir.0000031732.78052.81
    34 https://doi.org/10.1161/01.cir.96.10.3338
    35 https://doi.org/10.1161/circulationaha.105.538132
    36 https://doi.org/10.1371/journal.pmed.0050207
    37 https://doi.org/10.1681/asn.2004070539
    38 https://doi.org/10.2337/diabetes.51.4.1157
    39 https://doi.org/10.2337/diacare.27.2007.s79
    40 schema:datePublished 2013-10
    41 schema:datePublishedReg 2013-10-01
    42 schema:description Albuminuria has been shown to be associated with mortality and cardiovascular events, independent of traditional cardiovascular risk factors. This suggests that albuminuria may not just represent glomerular damage, but may be a marker of more diffuse endothelial dysfunction. We investigated the relationship between urinary albumin levels after an acute coronary syndrome and cardiovascular outcomes in statin treated subjects after acute coronary syndromes (ACS). Furthermore we assessed the effect of intensive statin treatment on albuminuria among patients in the PROVE IT-TIMI 22 trial, in which patients who had been hospitalized with ACS were randomized to pravastatin 40 mg (standard therapy) or atorvastatin 80 mg daily (intensive therapy). In univariate analyses, increasing urine albumin concentration was associated with increased risk of myocardial infarction, stroke, heart failure, and composite of death, myocardial infarction and stroke at 2 years. However, in a multivariable model containing traditional cardiovascular risk factors, albuminuria was not an independent predictor of the primary PROVE IT endpoint of death, myocardial infarction, unstable angina, revascularization and stroke, and was only an independent predictor of all-cause mortality at urinary albumin concentration >300 mcg/ml. There was no significant change in urinary albumin concentration from enrolment to end of study in either the standard or intensive statin therapy groups, and no significant difference between treatment groups. Our results suggest that after an acute coronary syndrome in statin treated patients, microalbuminuria may reflect traditional cardiovascular risk factor burden and offer little prognostic information independent of those factors.
    43 schema:genre research_article
    44 schema:inLanguage en
    45 schema:isAccessibleForFree false
    46 schema:isPartOf Nd55f75331121416d86f562d2a86922fd
    47 Ne8696b89522e41238e183b1f24d7c1fb
    48 sg:journal.1113719
    49 schema:name Urinary albumin concentration and long-term cardiovascular risk in acute coronary syndrome patients: a PROVE IT-TIMI 22 substudy
    50 schema:pagination 233-239
    51 schema:productId N00971dc943144900b1bd6e028627d8c0
    52 N183c1e43e7464610ab7bf5ba4c964e21
    53 N27830018563c43c4a2ec9bf997f0d60d
    54 N4ec4a18b8cc640dba6351434e38ce83f
    55 N655f6a50022047948c91a7b107008afa
    56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007063105
    57 https://doi.org/10.1007/s11239-012-0853-0
    58 schema:sdDatePublished 2019-04-11T02:07
    59 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    60 schema:sdPublisher Naf8f02a0b86b4431a8ae2c64316940a8
    61 schema:url http://link.springer.com/10.1007%2Fs11239-012-0853-0
    62 sgo:license sg:explorer/license/
    63 sgo:sdDataset articles
    64 rdf:type schema:ScholarlyArticle
    65 N00971dc943144900b1bd6e028627d8c0 schema:name pubmed_id
    66 schema:value 23212806
    67 rdf:type schema:PropertyValue
    68 N01c18c79185d4f779d2a28a16f2b2ae8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    69 schema:name Pyrroles
    70 rdf:type schema:DefinedTerm
    71 N17f99be62c2a446fa07b4ee1cf2edb39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    72 schema:name Atorvastatin Calcium
    73 rdf:type schema:DefinedTerm
    74 N183c1e43e7464610ab7bf5ba4c964e21 schema:name dimensions_id
    75 schema:value pub.1007063105
    76 rdf:type schema:PropertyValue
    77 N196b737189d84184b28502417e53dd40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    78 schema:name Female
    79 rdf:type schema:DefinedTerm
    80 N1c5e9ae6a20643a0a276ce37bd23dc1b rdf:first sg:person.01172544713.06
    81 rdf:rest rdf:nil
    82 N27830018563c43c4a2ec9bf997f0d60d schema:name doi
    83 schema:value 10.1007/s11239-012-0853-0
    84 rdf:type schema:PropertyValue
    85 N28aa6cc296bc4c24aafbdbd454b93272 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    86 schema:name Heptanoic Acids
    87 rdf:type schema:DefinedTerm
    88 N4ec4a18b8cc640dba6351434e38ce83f schema:name nlm_unique_id
    89 schema:value 9502018
    90 rdf:type schema:PropertyValue
    91 N63692291b834485b8dda9f7497d16d8c rdf:first sg:person.01235024064.89
    92 rdf:rest Nbc276cabbbd149b0b5d47993a3b59ade
    93 N655f6a50022047948c91a7b107008afa schema:name readcube_id
    94 schema:value 21a525c3d047cd6301528854852547d904840190b6667a999bf320e4ea52e87f
    95 rdf:type schema:PropertyValue
    96 N79cb05da5fb54098bbd7ad911001fbee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    97 schema:name Pravastatin
    98 rdf:type schema:DefinedTerm
    99 N8fd814a6a0014f75b9a1d5949bfb4937 rdf:first sg:person.0750215673.07
    100 rdf:rest N1c5e9ae6a20643a0a276ce37bd23dc1b
    101 N90546b1536f24557a38876f74d1af1c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Heart Failure
    103 rdf:type schema:DefinedTerm
    104 N94fd292129054d67b22cc6d359209352 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    105 schema:name Middle Aged
    106 rdf:type schema:DefinedTerm
    107 Na2f529dddc6140ea93b5fefc5ad7514d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name Humans
    109 rdf:type schema:DefinedTerm
    110 Na96e1de38d6e41039bffdf4b4af99134 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Myocardial Infarction
    112 rdf:type schema:DefinedTerm
    113 Nab03e8f7743f4b01803473cde22de157 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Acute Coronary Syndrome
    115 rdf:type schema:DefinedTerm
    116 Naf8f02a0b86b4431a8ae2c64316940a8 schema:name Springer Nature - SN SciGraph project
    117 rdf:type schema:Organization
    118 Nb2affe6b721c4b4b92e984575debf68f rdf:first sg:person.0714034144.03
    119 rdf:rest N8fd814a6a0014f75b9a1d5949bfb4937
    120 Nbc276cabbbd149b0b5d47993a3b59ade rdf:first sg:person.0651160077.02
    121 rdf:rest Nb2affe6b721c4b4b92e984575debf68f
    122 Nbea6b85e457242d593d5adc8f2a441ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Aged
    124 rdf:type schema:DefinedTerm
    125 Nc0e146dec2b54ab792fb2c8843b45fb0 schema:name Cardiovascular Division, Beth Israel/Deaconess Hospital, Harvard Medical School, Boston, MA, USA
    126 rdf:type schema:Organization
    127 Ncaaed6a3d4db488dbfecfdff1d3932d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Risk Factors
    129 rdf:type schema:DefinedTerm
    130 Ncd9e07f940e94710b7e8be4ed9b60a8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Male
    132 rdf:type schema:DefinedTerm
    133 Nd55f75331121416d86f562d2a86922fd schema:issueNumber 3
    134 rdf:type schema:PublicationIssue
    135 Nde0fb9c9a433467f8b2450713c5e90d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Albuminuria
    137 rdf:type schema:DefinedTerm
    138 Ndf0917ddd57243199f23c874d9314553 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Anticholesteremic Agents
    140 rdf:type schema:DefinedTerm
    141 Ne8696b89522e41238e183b1f24d7c1fb schema:volumeNumber 36
    142 rdf:type schema:PublicationVolume
    143 Nf3a29bf59b664e8bb6b8d8aa0266c110 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Models, Biological
    145 rdf:type schema:DefinedTerm
    146 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    147 schema:name Medical and Health Sciences
    148 rdf:type schema:DefinedTerm
    149 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    150 schema:name Cardiorespiratory Medicine and Haematology
    151 rdf:type schema:DefinedTerm
    152 sg:journal.1113719 schema:issn 0929-5305
    153 1573-742X
    154 schema:name Journal of Thrombosis and Thrombolysis
    155 rdf:type schema:Periodical
    156 sg:person.01172544713.06 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    157 schema:familyName Cannon
    158 schema:givenName Christopher P.
    159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172544713.06
    160 rdf:type schema:Person
    161 sg:person.01235024064.89 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
    162 schema:familyName Nazer
    163 schema:givenName Babak
    164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235024064.89
    165 rdf:type schema:Person
    166 sg:person.0651160077.02 schema:affiliation https://www.grid.ac/institutes/grid.264200.2
    167 schema:familyName Ray
    168 schema:givenName Kausik K.
    169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651160077.02
    170 rdf:type schema:Person
    171 sg:person.0714034144.03 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    172 schema:familyName Murphy
    173 schema:givenName Sabina A.
    174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714034144.03
    175 rdf:type schema:Person
    176 sg:person.0750215673.07 schema:affiliation Nc0e146dec2b54ab792fb2c8843b45fb0
    177 schema:familyName Gibson
    178 schema:givenName C. Michael
    179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750215673.07
    180 rdf:type schema:Person
    181 sg:pub.10.1038/ki.1980.151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038924465
    182 https://doi.org/10.1038/ki.1980.151
    183 rdf:type schema:CreativeWork
    184 https://app.dimensions.ai/details/publication/pub.1078383773 schema:CreativeWork
    185 https://app.dimensions.ai/details/publication/pub.1078408652 schema:CreativeWork
    186 https://doi.org/10.1001/jama.286.4.421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042440144
    187 rdf:type schema:CreativeWork
    188 https://doi.org/10.1002/clc.20792 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007695222
    189 rdf:type schema:CreativeWork
    190 https://doi.org/10.1016/s0140-6736(10)60674-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033235001
    191 rdf:type schema:CreativeWork
    192 https://doi.org/10.1016/s0272-6386(03)00742-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038537849
    193 rdf:type schema:CreativeWork
    194 https://doi.org/10.1046/j.1365-2796.2001.00833.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004588524
    195 rdf:type schema:CreativeWork
    196 https://doi.org/10.1053/ajkd.2002.31388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049165920
    197 rdf:type schema:CreativeWork
    198 https://doi.org/10.1053/euhj.2000.2582 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057074837
    199 rdf:type schema:CreativeWork
    200 https://doi.org/10.1056/nejmoa040583 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024700175
    201 rdf:type schema:CreativeWork
    202 https://doi.org/10.1093/ndt/gfm114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004102000
    203 rdf:type schema:CreativeWork
    204 https://doi.org/10.1097/00004872-199816040-00014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010740516
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.1161/01.cir.0000031732.78052.81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033319537
    207 rdf:type schema:CreativeWork
    208 https://doi.org/10.1161/01.cir.96.10.3338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063338108
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.1161/circulationaha.105.538132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020401476
    211 rdf:type schema:CreativeWork
    212 https://doi.org/10.1371/journal.pmed.0050207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010976845
    213 rdf:type schema:CreativeWork
    214 https://doi.org/10.1681/asn.2004070539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024184824
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.2337/diabetes.51.4.1157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050688008
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.2337/diacare.27.2007.s79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001807621
    219 rdf:type schema:CreativeWork
    220 https://www.grid.ac/institutes/grid.264200.2 schema:alternateName St George's, University of London
    221 schema:name Division of Cardiac and Vascular Sciences, St. George’s University of London, London, UK
    222 rdf:type schema:Organization
    223 https://www.grid.ac/institutes/grid.266102.1 schema:alternateName University of California, San Francisco
    224 schema:name Division of Cardiology, University of California, San Francisco, CA, USA
    225 rdf:type schema:Organization
    226 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
    227 schema:name Thrombolysis in Myocardial Infarction (TIMI) Study Group, Cardiovascular Division, Brigham & Women’s Hospital and Harvard Medical School, Boston, MA, USA
    228 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...