Expression of ADAMTS-2, -3, -13, and -14 in culprit coronary lesions in patients with acute myocardial infarction or stable angina View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-05

AUTHORS

Cheol Whan Lee, Ilseon Hwang, Chan-Sik Park, Hyangsin Lee, Duk-Woo Park, Su-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Seong-Wook Park, Seung-Jung Park

ABSTRACT

ADAMTS (a disintegrin and metalloproteinase with thrombospondin type 1 motifs) proteases are emerging as key participants in the pathogenesis of vascular diseases. We studied the expression of ADAMTS-2, -3, -4 and -14 in the culprit plaques from patients presenting with acute myocardial infarction (AMI) versus stable angina. Tissue samples were gathered from 52 patients with AMI (n = 35) or stable angina (n = 17) who underwent directional coronary atherectomy. The specimens were stained with hematoxylin-eosin and analyzed immunohistochemically using antibodies specific to ADAMTS-2, -3, -13 and -14, and markers for endothelial cells, macrophages, and smooth muscle cells. Baseline characteristics of the groups were mostly similar. The proportion of smooth muscle α-actin-immunopositive area was smaller in the AMI group than in the stable angina group, but the areas immunopositive for CD31 or CD68 were higher in the AMI group. The relative areas immunopositive for ADAMTS-2, -3, and -13 in AMI were significantly larger than those in stable angina. However, the proportion of areas immunopositive for ADAMTS-14 did not differ between the two groups. Areas that stained for ADAMTS-2, -3, -13, and -14 largely overlapped with those positive for CD31 or CD68. The areas immunopositive for ADAMTS proteases were significantly correlated with CD31- or CD68-immunostained areas. In conclusions, ADAMTS-2, -3, and -13 expression, but not that of ADAMTS-14, are increased in plaques causing AMI compared those associated with stable angina. These results support a role for these enzymes in the pathogenesis of AMI. More... »

PAGES

362-370

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11239-011-0673-7

DOI

http://dx.doi.org/10.1007/s11239-011-0673-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034564015

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22205175


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ADAM Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ADAMTS Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ADAMTS13 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ADAMTS4 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Actins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Angina, Stable", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, CD", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, Differentiation, Myelomonocytic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Enzymologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardial Infarction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Platelet Endothelial Cell Adhesion Molecule-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Procollagen N-Endopeptidase", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Ulsan", 
          "id": "https://www.grid.ac/institutes/grid.267370.7", 
          "name": [
            "Department of Medicine, University of Ulsan, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Cheol Whan", 
        "id": "sg:person.0634207106.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634207106.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keimyung University", 
          "id": "https://www.grid.ac/institutes/grid.412091.f", 
          "name": [
            "Department of Pathology, School of Medicine, Keimyung University, 194 Dongsan-Dong, Choong-Ku, Daegu, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hwang", 
        "givenName": "Ilseon", 
        "id": "sg:person.01102733074.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102733074.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Asan Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413967.e", 
          "name": [
            "Department of Pathology, Asan Medical Center, University of Ulsan, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Chan-Sik", 
        "id": "sg:person.01035410362.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035410362.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Asan Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413967.e", 
          "name": [
            "Asan Institute of Life Science, University of Ulsan, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Hyangsin", 
        "id": "sg:person.0577341002.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577341002.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ulsan", 
          "id": "https://www.grid.ac/institutes/grid.267370.7", 
          "name": [
            "Department of Medicine, University of Ulsan, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Duk-Woo", 
        "id": "sg:person.01234270432.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234270432.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ulsan", 
          "id": "https://www.grid.ac/institutes/grid.267370.7", 
          "name": [
            "Department of Medicine, University of Ulsan, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kang", 
        "givenName": "Su-Jin", 
        "id": "sg:person.01147272530.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147272530.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ulsan", 
          "id": "https://www.grid.ac/institutes/grid.267370.7", 
          "name": [
            "Department of Medicine, University of Ulsan, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Seung-Whan", 
        "id": "sg:person.0637607145.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637607145.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ulsan", 
          "id": "https://www.grid.ac/institutes/grid.267370.7", 
          "name": [
            "Department of Medicine, University of Ulsan, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Young-Hak", 
        "id": "sg:person.014413113604.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014413113604.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ulsan", 
          "id": "https://www.grid.ac/institutes/grid.267370.7", 
          "name": [
            "Department of Medicine, University of Ulsan, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Seong-Wook", 
        "id": "sg:person.016111752604.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016111752604.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Asan Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413967.e", 
          "name": [
            "Department of Medicine, University of Ulsan, Seoul, Korea", 
            "Division of Cardiology, Asan Medical Center, University of Ulsan, 388-1 Pungnap-dong, 138-736, Songpa-gu, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Seung-Jung", 
        "id": "sg:person.01330410175.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330410175.52"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1074/jbc.m105601200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001333722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.atherosclerosis.2006.02.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005137242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.6.2374", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009427379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.atherosclerosis.2008.07.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010018189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.270.28.16724", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011598608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci4853", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013937686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20040424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015150832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20040424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015150832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2004-10-4097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024140079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m300767200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030865913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0735-1097(90)90299-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031427492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m103466200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032747415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000025609.13806.31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033232121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.biochem.67.1.395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033750623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v98.6.1662", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033764641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000157141.00778.ac", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035063467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-010-0654-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038863577", 
          "https://doi.org/10.1007/s00109-010-0654-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2010-01-262709", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042695692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-007-0284-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044402581", 
          "https://doi.org/10.1007/s00109-007-0284-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-007-0284-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044402581", 
          "https://doi.org/10.1007/s00109-007-0284-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.103.7.934", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045006251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2009.09.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048843045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-8703(97)70066-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048977681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0008-6363(98)00321-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054580284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.jbchem.a003009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059959686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1538-7836.2006.01959.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061943650"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.91.11.2844", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063335933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074830383", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-05", 
    "datePublishedReg": "2012-05-01", 
    "description": "ADAMTS (a disintegrin and metalloproteinase with thrombospondin type 1 motifs) proteases are emerging as key participants in the pathogenesis of vascular diseases. We studied the expression of ADAMTS-2, -3, -4 and -14 in the culprit plaques from patients presenting with acute myocardial infarction (AMI) versus stable angina. Tissue samples were gathered from 52 patients with AMI (n\u00a0=\u00a035) or stable angina (n\u00a0=\u00a017) who underwent directional coronary atherectomy. The specimens were stained with hematoxylin-eosin and analyzed immunohistochemically using antibodies specific to ADAMTS-2, -3, -13 and -14, and markers for endothelial cells, macrophages, and smooth muscle cells. Baseline characteristics of the groups were mostly similar. The proportion of smooth muscle \u03b1-actin-immunopositive area was smaller in the AMI group than in the stable angina group, but the areas immunopositive for CD31 or CD68 were higher in the AMI group. The relative areas immunopositive for ADAMTS-2, -3, and -13 in AMI were significantly larger than those in stable angina. However, the proportion of areas immunopositive for ADAMTS-14 did not differ between the two groups. Areas that stained for ADAMTS-2, -3, -13, and -14 largely overlapped with those positive for CD31 or CD68. The areas immunopositive for ADAMTS proteases were significantly correlated with CD31- or CD68-immunostained areas. In conclusions, ADAMTS-2, -3, and -13 expression, but not that of ADAMTS-14, are increased in plaques causing AMI compared those associated with stable angina. These results support a role for these enzymes in the pathogenesis of AMI.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11239-011-0673-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1113719", 
        "issn": [
          "0929-5305", 
          "1573-742X"
        ], 
        "name": "Journal of Thrombosis and Thrombolysis", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "33"
      }
    ], 
    "name": "Expression of ADAMTS-2, -3, -13, and -14 in culprit coronary lesions in patients with acute myocardial infarction or stable angina", 
    "pagination": "362-370", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a4a68588205bc0ff14fa7ffde47254c57871f5cf16dfbf87a6ff571726f8e581"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22205175"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9502018"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11239-011-0673-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1034564015"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11239-011-0673-7", 
      "https://app.dimensions.ai/details/publication/pub.1034564015"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000523.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11239-011-0673-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11239-011-0673-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11239-011-0673-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11239-011-0673-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11239-011-0673-7'


 

This table displays all metadata directly associated to this object as RDF triples.

292 TRIPLES      21 PREDICATES      73 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11239-011-0673-7 schema:about N03cd630b0e2142efa4eaaa03f14396bb
2 N30c2c139d8994ab588b341e4a4cb643f
3 N366622b5e2af483196892941bf1b677a
4 N56d37c334d2941cfb0d65b5ac31c7dd9
5 N81a5a71fb9c34e4581e952bc8a9e59f5
6 N92ac75c77001483ca3fe0a80a2442412
7 N944a9f7042444439bef448e6a065dc9e
8 Na1b564658cf84bcb80340ac54cf297f3
9 Na3ed5fc4a1214c1b8a1e06239982ac46
10 Nb9285879da9a4a84b663f772de27159f
11 Ncdbc4498fe524a2984c6c7cd4a2ec0dd
12 Nd6b203fb3e0849e0850a26ee332d6877
13 Nd94a39d7d0714e33b484d3b226e3b5ef
14 Ne7a4fc0fce00432080a19d697aca10a3
15 Nec25fe92d08542f59902a73fdccffb65
16 Nf432a2d657d647b7b91aa9e0723955ff
17 Nf5f54c8acf104ea5ac31474b4f752e49
18 Nf6037ed8e06142e89b51d7001dd61b06
19 anzsrc-for:11
20 anzsrc-for:1102
21 schema:author N069fd8d7c0c547ff9c433a2d91c17e04
22 schema:citation sg:pub.10.1007/s00109-007-0284-0
23 sg:pub.10.1007/s00109-010-0654-x
24 https://app.dimensions.ai/details/publication/pub.1074830383
25 https://doi.org/10.1016/0735-1097(90)90299-5
26 https://doi.org/10.1016/j.atherosclerosis.2006.02.040
27 https://doi.org/10.1016/j.atherosclerosis.2008.07.043
28 https://doi.org/10.1016/j.jacc.2009.09.007
29 https://doi.org/10.1016/s0002-8703(97)70066-8
30 https://doi.org/10.1016/s0008-6363(98)00321-6
31 https://doi.org/10.1042/bj20040424
32 https://doi.org/10.1073/pnas.94.6.2374
33 https://doi.org/10.1074/jbc.270.28.16724
34 https://doi.org/10.1074/jbc.m103466200
35 https://doi.org/10.1074/jbc.m105601200
36 https://doi.org/10.1074/jbc.m300767200
37 https://doi.org/10.1093/oxfordjournals.jbchem.a003009
38 https://doi.org/10.1111/j.1538-7836.2006.01959.x
39 https://doi.org/10.1146/annurev.biochem.67.1.395
40 https://doi.org/10.1161/01.cir.0000025609.13806.31
41 https://doi.org/10.1161/01.cir.0000157141.00778.ac
42 https://doi.org/10.1161/01.cir.103.7.934
43 https://doi.org/10.1161/01.cir.91.11.2844
44 https://doi.org/10.1172/jci4853
45 https://doi.org/10.1182/blood-2004-10-4097
46 https://doi.org/10.1182/blood-2010-01-262709
47 https://doi.org/10.1182/blood.v98.6.1662
48 schema:datePublished 2012-05
49 schema:datePublishedReg 2012-05-01
50 schema:description ADAMTS (a disintegrin and metalloproteinase with thrombospondin type 1 motifs) proteases are emerging as key participants in the pathogenesis of vascular diseases. We studied the expression of ADAMTS-2, -3, -4 and -14 in the culprit plaques from patients presenting with acute myocardial infarction (AMI) versus stable angina. Tissue samples were gathered from 52 patients with AMI (n = 35) or stable angina (n = 17) who underwent directional coronary atherectomy. The specimens were stained with hematoxylin-eosin and analyzed immunohistochemically using antibodies specific to ADAMTS-2, -3, -13 and -14, and markers for endothelial cells, macrophages, and smooth muscle cells. Baseline characteristics of the groups were mostly similar. The proportion of smooth muscle α-actin-immunopositive area was smaller in the AMI group than in the stable angina group, but the areas immunopositive for CD31 or CD68 were higher in the AMI group. The relative areas immunopositive for ADAMTS-2, -3, and -13 in AMI were significantly larger than those in stable angina. However, the proportion of areas immunopositive for ADAMTS-14 did not differ between the two groups. Areas that stained for ADAMTS-2, -3, -13, and -14 largely overlapped with those positive for CD31 or CD68. The areas immunopositive for ADAMTS proteases were significantly correlated with CD31- or CD68-immunostained areas. In conclusions, ADAMTS-2, -3, and -13 expression, but not that of ADAMTS-14, are increased in plaques causing AMI compared those associated with stable angina. These results support a role for these enzymes in the pathogenesis of AMI.
51 schema:genre research_article
52 schema:inLanguage en
53 schema:isAccessibleForFree false
54 schema:isPartOf N2fe8f47f18334228abd0d59ed22fb5a2
55 N6a080fc75fe74c3e8161c3d8d0754ec3
56 sg:journal.1113719
57 schema:name Expression of ADAMTS-2, -3, -13, and -14 in culprit coronary lesions in patients with acute myocardial infarction or stable angina
58 schema:pagination 362-370
59 schema:productId N1377ec73222a49b098f5105d9cad569f
60 N1a540f91d3794c67a6c7da5b792cc45d
61 Na5c0a726c4264fc2a985e6283d9e11fa
62 Nac9f1f7b8cea41fdadda1b64674069cc
63 Ne89f11c0959f4c16a5a6958daed46b7a
64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034564015
65 https://doi.org/10.1007/s11239-011-0673-7
66 schema:sdDatePublished 2019-04-10T18:23
67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
68 schema:sdPublisher N76bd3f2722e34f83abbe80190478dcda
69 schema:url http://link.springer.com/10.1007%2Fs11239-011-0673-7
70 sgo:license sg:explorer/license/
71 sgo:sdDataset articles
72 rdf:type schema:ScholarlyArticle
73 N03cd630b0e2142efa4eaaa03f14396bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Platelet Endothelial Cell Adhesion Molecule-1
75 rdf:type schema:DefinedTerm
76 N069fd8d7c0c547ff9c433a2d91c17e04 rdf:first sg:person.0634207106.19
77 rdf:rest Nd71a5941a6f5479c95171aff6d07dd73
78 N1377ec73222a49b098f5105d9cad569f schema:name nlm_unique_id
79 schema:value 9502018
80 rdf:type schema:PropertyValue
81 N1a540f91d3794c67a6c7da5b792cc45d schema:name dimensions_id
82 schema:value pub.1034564015
83 rdf:type schema:PropertyValue
84 N2fe8f47f18334228abd0d59ed22fb5a2 schema:volumeNumber 33
85 rdf:type schema:PublicationVolume
86 N30c2c139d8994ab588b341e4a4cb643f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Middle Aged
88 rdf:type schema:DefinedTerm
89 N321fe0de610e45169411a49b79deb558 rdf:first sg:person.01035410362.18
90 rdf:rest Nd8d556c3b935409ca812573d69eb87e8
91 N3570cf8912aa4ee49cec4f808ff33d84 rdf:first sg:person.01147272530.60
92 rdf:rest Nc218121054e846babff29b123c93a80f
93 N366622b5e2af483196892941bf1b677a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Male
95 rdf:type schema:DefinedTerm
96 N56d37c334d2941cfb0d65b5ac31c7dd9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Muscle Proteins
98 rdf:type schema:DefinedTerm
99 N64d4118a9daa4333a8d1d5acd6ab1d93 rdf:first sg:person.01330410175.52
100 rdf:rest rdf:nil
101 N6a080fc75fe74c3e8161c3d8d0754ec3 schema:issueNumber 4
102 rdf:type schema:PublicationIssue
103 N76bd3f2722e34f83abbe80190478dcda schema:name Springer Nature - SN SciGraph project
104 rdf:type schema:Organization
105 N81a5a71fb9c34e4581e952bc8a9e59f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Actins
107 rdf:type schema:DefinedTerm
108 N8838b2c9592d45479ec1593690c735ee rdf:first sg:person.01234270432.41
109 rdf:rest N3570cf8912aa4ee49cec4f808ff33d84
110 N92ac75c77001483ca3fe0a80a2442412 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Antigens, CD
112 rdf:type schema:DefinedTerm
113 N944a9f7042444439bef448e6a065dc9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name ADAMTS Proteins
115 rdf:type schema:DefinedTerm
116 Na1b564658cf84bcb80340ac54cf297f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name ADAMTS4 Protein
118 rdf:type schema:DefinedTerm
119 Na3ed5fc4a1214c1b8a1e06239982ac46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Female
121 rdf:type schema:DefinedTerm
122 Na5c0a726c4264fc2a985e6283d9e11fa schema:name doi
123 schema:value 10.1007/s11239-011-0673-7
124 rdf:type schema:PropertyValue
125 Na5f916164ab74ae494cce249047d170b rdf:first sg:person.016111752604.87
126 rdf:rest N64d4118a9daa4333a8d1d5acd6ab1d93
127 Nac9f1f7b8cea41fdadda1b64674069cc schema:name pubmed_id
128 schema:value 22205175
129 rdf:type schema:PropertyValue
130 Nb9285879da9a4a84b663f772de27159f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Aged
132 rdf:type schema:DefinedTerm
133 Nc218121054e846babff29b123c93a80f rdf:first sg:person.0637607145.75
134 rdf:rest Nc3392d3ce8354b1f8b84e68a4184a160
135 Nc3392d3ce8354b1f8b84e68a4184a160 rdf:first sg:person.014413113604.18
136 rdf:rest Na5f916164ab74ae494cce249047d170b
137 Ncdbc4498fe524a2984c6c7cd4a2ec0dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Gene Expression Regulation, Enzymologic
139 rdf:type schema:DefinedTerm
140 Nd6b203fb3e0849e0850a26ee332d6877 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Angina, Stable
142 rdf:type schema:DefinedTerm
143 Nd71a5941a6f5479c95171aff6d07dd73 rdf:first sg:person.01102733074.59
144 rdf:rest N321fe0de610e45169411a49b79deb558
145 Nd8d556c3b935409ca812573d69eb87e8 rdf:first sg:person.0577341002.44
146 rdf:rest N8838b2c9592d45479ec1593690c735ee
147 Nd94a39d7d0714e33b484d3b226e3b5ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Humans
149 rdf:type schema:DefinedTerm
150 Ne7a4fc0fce00432080a19d697aca10a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Myocardial Infarction
152 rdf:type schema:DefinedTerm
153 Ne89f11c0959f4c16a5a6958daed46b7a schema:name readcube_id
154 schema:value a4a68588205bc0ff14fa7ffde47254c57871f5cf16dfbf87a6ff571726f8e581
155 rdf:type schema:PropertyValue
156 Nec25fe92d08542f59902a73fdccffb65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name ADAMTS13 Protein
158 rdf:type schema:DefinedTerm
159 Nf432a2d657d647b7b91aa9e0723955ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Procollagen N-Endopeptidase
161 rdf:type schema:DefinedTerm
162 Nf5f54c8acf104ea5ac31474b4f752e49 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Antigens, Differentiation, Myelomonocytic
164 rdf:type schema:DefinedTerm
165 Nf6037ed8e06142e89b51d7001dd61b06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name ADAM Proteins
167 rdf:type schema:DefinedTerm
168 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
169 schema:name Medical and Health Sciences
170 rdf:type schema:DefinedTerm
171 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
172 schema:name Cardiorespiratory Medicine and Haematology
173 rdf:type schema:DefinedTerm
174 sg:journal.1113719 schema:issn 0929-5305
175 1573-742X
176 schema:name Journal of Thrombosis and Thrombolysis
177 rdf:type schema:Periodical
178 sg:person.01035410362.18 schema:affiliation https://www.grid.ac/institutes/grid.413967.e
179 schema:familyName Park
180 schema:givenName Chan-Sik
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035410362.18
182 rdf:type schema:Person
183 sg:person.01102733074.59 schema:affiliation https://www.grid.ac/institutes/grid.412091.f
184 schema:familyName Hwang
185 schema:givenName Ilseon
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102733074.59
187 rdf:type schema:Person
188 sg:person.01147272530.60 schema:affiliation https://www.grid.ac/institutes/grid.267370.7
189 schema:familyName Kang
190 schema:givenName Su-Jin
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147272530.60
192 rdf:type schema:Person
193 sg:person.01234270432.41 schema:affiliation https://www.grid.ac/institutes/grid.267370.7
194 schema:familyName Park
195 schema:givenName Duk-Woo
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234270432.41
197 rdf:type schema:Person
198 sg:person.01330410175.52 schema:affiliation https://www.grid.ac/institutes/grid.413967.e
199 schema:familyName Park
200 schema:givenName Seung-Jung
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330410175.52
202 rdf:type schema:Person
203 sg:person.014413113604.18 schema:affiliation https://www.grid.ac/institutes/grid.267370.7
204 schema:familyName Kim
205 schema:givenName Young-Hak
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014413113604.18
207 rdf:type schema:Person
208 sg:person.016111752604.87 schema:affiliation https://www.grid.ac/institutes/grid.267370.7
209 schema:familyName Park
210 schema:givenName Seong-Wook
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016111752604.87
212 rdf:type schema:Person
213 sg:person.0577341002.44 schema:affiliation https://www.grid.ac/institutes/grid.413967.e
214 schema:familyName Lee
215 schema:givenName Hyangsin
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577341002.44
217 rdf:type schema:Person
218 sg:person.0634207106.19 schema:affiliation https://www.grid.ac/institutes/grid.267370.7
219 schema:familyName Lee
220 schema:givenName Cheol Whan
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634207106.19
222 rdf:type schema:Person
223 sg:person.0637607145.75 schema:affiliation https://www.grid.ac/institutes/grid.267370.7
224 schema:familyName Lee
225 schema:givenName Seung-Whan
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637607145.75
227 rdf:type schema:Person
228 sg:pub.10.1007/s00109-007-0284-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044402581
229 https://doi.org/10.1007/s00109-007-0284-0
230 rdf:type schema:CreativeWork
231 sg:pub.10.1007/s00109-010-0654-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038863577
232 https://doi.org/10.1007/s00109-010-0654-x
233 rdf:type schema:CreativeWork
234 https://app.dimensions.ai/details/publication/pub.1074830383 schema:CreativeWork
235 https://doi.org/10.1016/0735-1097(90)90299-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031427492
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/j.atherosclerosis.2006.02.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005137242
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/j.atherosclerosis.2008.07.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010018189
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/j.jacc.2009.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048843045
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/s0002-8703(97)70066-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048977681
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/s0008-6363(98)00321-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054580284
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1042/bj20040424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015150832
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1073/pnas.94.6.2374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009427379
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1074/jbc.270.28.16724 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011598608
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1074/jbc.m103466200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032747415
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1074/jbc.m105601200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001333722
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1074/jbc.m300767200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030865913
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1093/oxfordjournals.jbchem.a003009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059959686
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1111/j.1538-7836.2006.01959.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1061943650
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1146/annurev.biochem.67.1.395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033750623
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1161/01.cir.0000025609.13806.31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033232121
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1161/01.cir.0000157141.00778.ac schema:sameAs https://app.dimensions.ai/details/publication/pub.1035063467
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1161/01.cir.103.7.934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045006251
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1161/01.cir.91.11.2844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063335933
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1172/jci4853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013937686
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1182/blood-2004-10-4097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024140079
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1182/blood-2010-01-262709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042695692
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1182/blood.v98.6.1662 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033764641
280 rdf:type schema:CreativeWork
281 https://www.grid.ac/institutes/grid.267370.7 schema:alternateName University of Ulsan
282 schema:name Department of Medicine, University of Ulsan, Seoul, Korea
283 rdf:type schema:Organization
284 https://www.grid.ac/institutes/grid.412091.f schema:alternateName Keimyung University
285 schema:name Department of Pathology, School of Medicine, Keimyung University, 194 Dongsan-Dong, Choong-Ku, Daegu, Korea
286 rdf:type schema:Organization
287 https://www.grid.ac/institutes/grid.413967.e schema:alternateName Asan Medical Center
288 schema:name Asan Institute of Life Science, University of Ulsan, Seoul, Korea
289 Department of Medicine, University of Ulsan, Seoul, Korea
290 Department of Pathology, Asan Medical Center, University of Ulsan, Seoul, Korea
291 Division of Cardiology, Asan Medical Center, University of Ulsan, 388-1 Pungnap-dong, 138-736, Songpa-gu, Seoul, Korea
292 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...