Update on phase II studies of erythropoietin in acute myocardial infarction. Rationale and design of Exogenous erythroPoietin in Acute Myocardial ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-06-17

AUTHORS

Felicita Andreotti, Luciano Agati, Elena Conti, Eleonora Santucci, Teresa Rio, Federica Tarantino, Luigi Natale, Daniele Berardi, Antonella Mattatelli, Beatrice Musumeci, Lorenzo Bonomo, Massimo Volpe, Filippo Crea, Camillo Autore

ABSTRACT

Erythropoietin (Epo) is a hematopoietic hormone produced mainly by the kidneys in response to hypoxia. Recent acquisitions in the fields of hematology, neurology, cardiology, and experimental medicine show cytoprotective, angiogenetic and antinflammatory effects of Epo. Exogenous erythroPoietin in Acute Myocardial Infarction: New Outlook aNd Dose Association Study (EPAMINONDAS, EudraCTno. 200500485386) is one of four ongoing randomized controlled trials, each testing the effects of Epo in ≥100 patients with STEMI. EPAMINONDAS is a multicenter, prospective, double-blind, placebo-controlled, dose-finding study assessing intravenous moderate doses of human recombinant Epo (epoietin-α, 100 or 200 IU/kg/die) versus placebo, given on the first 3 days, in 102 patients with first ST-segment elevation myocardial infarction. Initial dosing is within 12 h of primary percutaneous coronary revascularization. The primary endpoint is infarct size, quantified by CK-MB time–concentration curve, left ventricular wall motion score index, and pattern of contrast-enhanced magnetic resonance imaging. Secondary endpoints are ischemic recurrences, ventricular remodelling, and safety events, assessed in-hospital and at 12 months’ follow-up. The results of current phase II studies will help define the safety/efficacy profile of Epo for patients with STEMI. More... »

PAGES

489-495

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11239-009-0363-x

DOI

http://dx.doi.org/10.1007/s11239-009-0363-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023554791

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19533304


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22 schema:description Erythropoietin (Epo) is a hematopoietic hormone produced mainly by the kidneys in response to hypoxia. Recent acquisitions in the fields of hematology, neurology, cardiology, and experimental medicine show cytoprotective, angiogenetic and antinflammatory effects of Epo. Exogenous erythroPoietin in Acute Myocardial Infarction: New Outlook aNd Dose Association Study (EPAMINONDAS, EudraCTno. 200500485386) is one of four ongoing randomized controlled trials, each testing the effects of Epo in ≥100 patients with STEMI. EPAMINONDAS is a multicenter, prospective, double-blind, placebo-controlled, dose-finding study assessing intravenous moderate doses of human recombinant Epo (epoietin-α, 100 or 200 IU/kg/die) versus placebo, given on the first 3 days, in 102 patients with first ST-segment elevation myocardial infarction. Initial dosing is within 12 h of primary percutaneous coronary revascularization. The primary endpoint is infarct size, quantified by CK-MB time–concentration curve, left ventricular wall motion score index, and pattern of contrast-enhanced magnetic resonance imaging. Secondary endpoints are ischemic recurrences, ventricular remodelling, and safety events, assessed in-hospital and at 12 months’ follow-up. The results of current phase II studies will help define the safety/efficacy profile of Epo for patients with STEMI.
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29 schema:keywords CK-MB time–concentration curve
30 Dose Association Study
31 EPAMINONDAS
32 EPO
33 II study
34 ST-segment elevation myocardial infarction
35 STEMI
36 Secondary endpoints
37 acquisition
38 acute myocardial infarction
39 antinflammatory effects
40 association studies
41 cardiology
42 contrast-enhanced magnetic resonance imaging
43 coronary revascularization
44 current phase II study
45 curves
46 days
47 design
48 dose-finding study
49 doses
50 dosing
51 effect
52 effects of Epo
53 efficacy profile
54 elevation myocardial infarction
55 endpoint
56 erythropoietin
57 events
58 exogenous erythropoietin
59 experimental medicine show
60 field
61 field of hematology
62 first ST-segment elevation myocardial infarction
63 hematology
64 hematopoietic hormone
65 hormone
66 hospital
67 human recombinant Epo
68 hypoxia
69 imaging
70 index
71 infarct size
72 infarction
73 initial dosing
74 intravenous moderate doses
75 ischemic recurrence
76 kidney
77 magnetic resonance imaging
78 medicine show
79 moderate doses
80 months
81 motion score index
82 multicenter
83 myocardial infarction
84 neurology
85 new outlook
86 outlook
87 patients
88 patterns
89 percutaneous coronary revascularization
90 phase II study
91 placebo
92 primary endpoint
93 primary percutaneous coronary revascularization
94 profile
95 rationale
96 recent acquisition
97 recombinant Epo
98 recurrence
99 remodelling
100 resonance imaging
101 response
102 results
103 revascularization
104 safety events
105 safety/efficacy profile
106 score index
107 show
108 size
109 study
110 time-concentration curve
111 trials
112 ventricular remodelling
113 ventricular wall motion score index
114 wall motion score index
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