Novel structural type of bridged urea derivatives bearing azatricyclo[4.3.1.03,8]decane moiety View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Alexander A. Alexeev, Evgeniya V. Nurieva, Konstantin A. Lyssenko, Yuri K. Grishin, Olga N. Zefirova

ABSTRACT

In an attempt to synthesize 4-thia-6-azatricyclo[5.3.1.13,9]dodecan-5-imine as putative antihypotensive agent with prolonged effect, a reaction of 1-[(1RS,3SR,5SR)-bicyclo[3.3.1]non-6-en-3-yl]-3-tert-butylthiourea in the presence of bromine was undertaken. The intramolecular cyclization however was accompanied by precursive oxidation of thiourea to urea fragment and proceeded via nitrogen atom yielding the bridged tricyclic urea derivative as determined by X-ray analysis and liquid chromatography–mass spectrometry technique. The compounds obtained in the present study belong to a novel and unusual structural type of bridged tricyclic ureas. More... »

PAGES

473-479

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11224-018-1252-8

DOI

http://dx.doi.org/10.1007/s11224-018-1252-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110786225


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