Synthesis of 3,4-diaryl- and 4-acyl-3-arylpyrroles and study of their antimitotic activity View Full Text


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Article Info

DATE

2018-05

AUTHORS

A. V. Samet, E. A. Sil’yanova, V. I. Ushkarov, M. N. Semenova, V. V. Semenov

ABSTRACT

The Barton–Zard reaction of nitro substituted stilbenes and chalcones with ethyl isocyanoacetate afforded 3,4-diaryl- and 4-acyl-3-arylpyrroles, respectively. 3-Arylpyrrole-2,4- dicarboxylates and 4-arylisoxazoline N-oxides were side reaction products. Antimitotic activity of target 3,4-disubstituted pyrroles was studied on a sea urchin embryo model. Pyrroles unsubstituted at positions 2 and 5 were the most active. The activity increased with the number of methoxy groups in the Ar substituent. More... »

PAGES

858-865

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11172-018-2150-3

DOI

http://dx.doi.org/10.1007/s11172-018-2150-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106255455


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