Synthesis of oxalic acid derivatives and their antitumor activity in experiments in vivo View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-04

AUTHORS

B. S. Fedorov, S. A. Goncharova, T. A. Rajevskaya, A. B. Eremeev, A. N. Utenyshev, M. A. Fadeev, G. N. Bogdanov, N. P. Konovalova, S. M. Aldoshin

ABSTRACT

A series of amino acid derivatives of oxalic acid were obtained. In combination therapy with conventional cytostatics used in lower doses, the new compounds substantially increase the efficacy of the drugs in the treatment of experimental P388 murine leukemia and some its drug-resistant strains.

PAGES

694-699

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11172-018-2124-5

DOI

http://dx.doi.org/10.1007/s11172-018-2124-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105571438


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation, Russia", 
          "id": "http://www.grid.ac/institutes/grid.418949.9", 
          "name": [
            "Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fedorov", 
        "givenName": "B. S.", 
        "id": "sg:person.011404055357.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011404055357.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation, Russia", 
          "id": "http://www.grid.ac/institutes/grid.418949.9", 
          "name": [
            "Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goncharova", 
        "givenName": "S. A.", 
        "id": "sg:person.01101103133.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101103133.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation, Russia", 
          "id": "http://www.grid.ac/institutes/grid.418949.9", 
          "name": [
            "Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rajevskaya", 
        "givenName": "T. A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation, Russia", 
          "id": "http://www.grid.ac/institutes/grid.418949.9", 
          "name": [
            "Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eremeev", 
        "givenName": "A. B.", 
        "id": "sg:person.015377343516.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015377343516.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation, Russia", 
          "id": "http://www.grid.ac/institutes/grid.418949.9", 
          "name": [
            "Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Utenyshev", 
        "givenName": "A. N.", 
        "id": "sg:person.015236213545.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015236213545.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation, Russia", 
          "id": "http://www.grid.ac/institutes/grid.418949.9", 
          "name": [
            "Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fadeev", 
        "givenName": "M. A.", 
        "id": "sg:person.012116005275.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012116005275.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation, Russia", 
          "id": "http://www.grid.ac/institutes/grid.418949.9", 
          "name": [
            "Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bogdanov", 
        "givenName": "G. N.", 
        "id": "sg:person.066670546.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.066670546.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation, Russia", 
          "id": "http://www.grid.ac/institutes/grid.418949.9", 
          "name": [
            "Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Konovalova", 
        "givenName": "N. P.", 
        "id": "sg:person.0756570422.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756570422.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation, Russia", 
          "id": "http://www.grid.ac/institutes/grid.418949.9", 
          "name": [
            "Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aldoshin", 
        "givenName": "S. M.", 
        "id": "sg:person.014353217357.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014353217357.41"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s11172-016-1377-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048267519", 
          "https://doi.org/10.1007/s11172-016-1377-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.clpt.6100296", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016073470", 
          "https://doi.org/10.1038/sj.clpt.6100296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01233623", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039606916", 
          "https://doi.org/10.1007/bf01233623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-60761-416-6_4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035140702", 
          "https://doi.org/10.1007/978-1-60761-416-6_4"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-04", 
    "datePublishedReg": "2018-04-01", 
    "description": "A series of amino acid derivatives of oxalic acid were obtained. In combination therapy with conventional cytostatics used in lower doses, the new compounds substantially increase the efficacy of the drugs in the treatment of experimental P388 murine leukemia and some its drug-resistant strains.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s11172-018-2124-5", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1022309", 
        "issn": [
          "1066-5285", 
          "1573-9171"
        ], 
        "name": "Russian Chemical Bulletin", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "67"
      }
    ], 
    "keywords": [
      "drug-resistant strains", 
      "conventional cytostatics", 
      "combination therapy", 
      "P388 murine leukemia", 
      "low doses", 
      "antitumor activity", 
      "murine leukemia", 
      "acid derivatives", 
      "therapy", 
      "leukemia", 
      "doses", 
      "cytostatics", 
      "drugs", 
      "efficacy", 
      "treatment", 
      "oxalic acid derivatives", 
      "vivo", 
      "amino acid derivatives", 
      "new compounds", 
      "oxalic acid", 
      "activity", 
      "strains", 
      "acid", 
      "derivatives", 
      "series", 
      "compounds", 
      "synthesis", 
      "experiments"
    ], 
    "name": "Synthesis of oxalic acid derivatives and their antitumor activity in experiments in vivo", 
    "pagination": "694-699", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1105571438"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11172-018-2124-5"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11172-018-2124-5", 
      "https://app.dimensions.ai/details/publication/pub.1105571438"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:45", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_786.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s11172-018-2124-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11172-018-2124-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11172-018-2124-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11172-018-2124-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11172-018-2124-5'


 

This table displays all metadata directly associated to this object as RDF triples.

152 TRIPLES      21 PREDICATES      56 URIs      45 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11172-018-2124-5 schema:about anzsrc-for:03
2 schema:author Ndc3fd9038d2a40baa80bc5db117e48a8
3 schema:citation sg:pub.10.1007/978-1-60761-416-6_4
4 sg:pub.10.1007/bf01233623
5 sg:pub.10.1007/s11172-016-1377-0
6 sg:pub.10.1038/sj.clpt.6100296
7 schema:datePublished 2018-04
8 schema:datePublishedReg 2018-04-01
9 schema:description A series of amino acid derivatives of oxalic acid were obtained. In combination therapy with conventional cytostatics used in lower doses, the new compounds substantially increase the efficacy of the drugs in the treatment of experimental P388 murine leukemia and some its drug-resistant strains.
10 schema:genre article
11 schema:isAccessibleForFree false
12 schema:isPartOf N21b98372b9364322be994fa3b2433757
13 N5323612d53ad43019bc96102b27aec7e
14 sg:journal.1022309
15 schema:keywords P388 murine leukemia
16 acid
17 acid derivatives
18 activity
19 amino acid derivatives
20 antitumor activity
21 combination therapy
22 compounds
23 conventional cytostatics
24 cytostatics
25 derivatives
26 doses
27 drug-resistant strains
28 drugs
29 efficacy
30 experiments
31 leukemia
32 low doses
33 murine leukemia
34 new compounds
35 oxalic acid
36 oxalic acid derivatives
37 series
38 strains
39 synthesis
40 therapy
41 treatment
42 vivo
43 schema:name Synthesis of oxalic acid derivatives and their antitumor activity in experiments in vivo
44 schema:pagination 694-699
45 schema:productId N062b0b1cec5446c3866a8ec03299c826
46 N0bce953940a143bcaaaf73cd971d0067
47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105571438
48 https://doi.org/10.1007/s11172-018-2124-5
49 schema:sdDatePublished 2022-10-01T06:45
50 schema:sdLicense https://scigraph.springernature.com/explorer/license/
51 schema:sdPublisher Ndcc83e645f2b49f0bf3892f38cdf6848
52 schema:url https://doi.org/10.1007/s11172-018-2124-5
53 sgo:license sg:explorer/license/
54 sgo:sdDataset articles
55 rdf:type schema:ScholarlyArticle
56 N062b0b1cec5446c3866a8ec03299c826 schema:name dimensions_id
57 schema:value pub.1105571438
58 rdf:type schema:PropertyValue
59 N0bce953940a143bcaaaf73cd971d0067 schema:name doi
60 schema:value 10.1007/s11172-018-2124-5
61 rdf:type schema:PropertyValue
62 N1da265d520e7488bb7209d0e8801950e rdf:first sg:person.0756570422.94
63 rdf:rest N4388c4090edd4cd3a3f207e7b5a4720c
64 N21b98372b9364322be994fa3b2433757 schema:volumeNumber 67
65 rdf:type schema:PublicationVolume
66 N3be36e0110814804ae3000c9a7d1ad61 rdf:first N442d02f01fb048609674e5cfbb059d0c
67 rdf:rest Ndec328d99d05486f9da71d6794d8cc8f
68 N4388c4090edd4cd3a3f207e7b5a4720c rdf:first sg:person.014353217357.41
69 rdf:rest rdf:nil
70 N442d02f01fb048609674e5cfbb059d0c schema:affiliation grid-institutes:grid.418949.9
71 schema:familyName Rajevskaya
72 schema:givenName T. A.
73 rdf:type schema:Person
74 N5323612d53ad43019bc96102b27aec7e schema:issueNumber 4
75 rdf:type schema:PublicationIssue
76 N658ffd6127a24b2a8d701f6e7c925478 rdf:first sg:person.015236213545.72
77 rdf:rest Ndae5d80d59bf4d50b3707483a1e57167
78 N7aa5e854b8f64df68c4994fe0d82e670 rdf:first sg:person.01101103133.17
79 rdf:rest N3be36e0110814804ae3000c9a7d1ad61
80 Nd38aca4298ca4b05a26693b886e50275 rdf:first sg:person.066670546.58
81 rdf:rest N1da265d520e7488bb7209d0e8801950e
82 Ndae5d80d59bf4d50b3707483a1e57167 rdf:first sg:person.012116005275.97
83 rdf:rest Nd38aca4298ca4b05a26693b886e50275
84 Ndc3fd9038d2a40baa80bc5db117e48a8 rdf:first sg:person.011404055357.29
85 rdf:rest N7aa5e854b8f64df68c4994fe0d82e670
86 Ndcc83e645f2b49f0bf3892f38cdf6848 schema:name Springer Nature - SN SciGraph project
87 rdf:type schema:Organization
88 Ndec328d99d05486f9da71d6794d8cc8f rdf:first sg:person.015377343516.91
89 rdf:rest N658ffd6127a24b2a8d701f6e7c925478
90 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
91 schema:name Chemical Sciences
92 rdf:type schema:DefinedTerm
93 sg:journal.1022309 schema:issn 1066-5285
94 1573-9171
95 schema:name Russian Chemical Bulletin
96 schema:publisher Springer Nature
97 rdf:type schema:Periodical
98 sg:person.01101103133.17 schema:affiliation grid-institutes:grid.418949.9
99 schema:familyName Goncharova
100 schema:givenName S. A.
101 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101103133.17
102 rdf:type schema:Person
103 sg:person.011404055357.29 schema:affiliation grid-institutes:grid.418949.9
104 schema:familyName Fedorov
105 schema:givenName B. S.
106 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011404055357.29
107 rdf:type schema:Person
108 sg:person.012116005275.97 schema:affiliation grid-institutes:grid.418949.9
109 schema:familyName Fadeev
110 schema:givenName M. A.
111 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012116005275.97
112 rdf:type schema:Person
113 sg:person.014353217357.41 schema:affiliation grid-institutes:grid.418949.9
114 schema:familyName Aldoshin
115 schema:givenName S. M.
116 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014353217357.41
117 rdf:type schema:Person
118 sg:person.015236213545.72 schema:affiliation grid-institutes:grid.418949.9
119 schema:familyName Utenyshev
120 schema:givenName A. N.
121 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015236213545.72
122 rdf:type schema:Person
123 sg:person.015377343516.91 schema:affiliation grid-institutes:grid.418949.9
124 schema:familyName Eremeev
125 schema:givenName A. B.
126 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015377343516.91
127 rdf:type schema:Person
128 sg:person.066670546.58 schema:affiliation grid-institutes:grid.418949.9
129 schema:familyName Bogdanov
130 schema:givenName G. N.
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.066670546.58
132 rdf:type schema:Person
133 sg:person.0756570422.94 schema:affiliation grid-institutes:grid.418949.9
134 schema:familyName Konovalova
135 schema:givenName N. P.
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756570422.94
137 rdf:type schema:Person
138 sg:pub.10.1007/978-1-60761-416-6_4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035140702
139 https://doi.org/10.1007/978-1-60761-416-6_4
140 rdf:type schema:CreativeWork
141 sg:pub.10.1007/bf01233623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039606916
142 https://doi.org/10.1007/bf01233623
143 rdf:type schema:CreativeWork
144 sg:pub.10.1007/s11172-016-1377-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048267519
145 https://doi.org/10.1007/s11172-016-1377-0
146 rdf:type schema:CreativeWork
147 sg:pub.10.1038/sj.clpt.6100296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016073470
148 https://doi.org/10.1038/sj.clpt.6100296
149 rdf:type schema:CreativeWork
150 grid-institutes:grid.418949.9 schema:alternateName Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation, Russia
151 schema:name Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation, Russia
152 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...