Experimental study of the antitumor effect of aurumacryl View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-12

AUTHORS

L. A. Ostrovskaya, D. B. Korman, A. K. Grehova, A. N. Osipov, N. V. Bluhterova, M. M. Fomina, V. A. Rikova, K. A. Abzaeva

ABSTRACT

Gold polyacrylate (aurumacryl) belonging to a new class of compounds for oncology — metal polyacrylates — was shown to exhibit strong antitumor activity. Aurumacryl causes 80—90% growth inhibition in vivo of murine solid tumors (Lewis lung carcinoma, Ca-755 adenocarcinoma, and Acatol adenocarcinoma) compared to the control and induces cell death in vitro in 60% of MCF-7 human breast carcinoma cells. Substantial changes in proliferation kinetics of the surviving fraction of tumor cells following treatment with aurumacryl were observed, which are related to the predominant accumulation (93%) of cells in the proliferative resting phase G0 and a substantial decrease in the percentage of proliferating cells (7%). These data provide evidence that the cells that survive lose reproductive ability under treatment with aurumacryl. More... »

PAGES

2333-2338

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11172-017-2025-z

DOI

http://dx.doi.org/10.1007/s11172-017-2025-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101541894


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