Synthesis and antineoplastic properties of (1H-1,2,3-triazol-1-yl)furazans View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-03

AUTHORS

A. S. Kulikov, M. A. Epishina, L. V. Batog, V. Yu. Rozhkov, N. N. Makhova, L. D. Konyushkin, M. N. Semenova, V. V. Semenov

ABSTRACT

A method of 3-amino-4-[5-aryl(heteroaryl)-1H-1,2,3-triazol-1-yl)]furazan synthesis was optimized. Condensation of these compounds with 2,5-dimethoxytetrahydrofuran resulted in a series of previously unknown 4-[5-aryl(heteroaryl)-1H-1,2,3-triazol-1-yl)]-3-(pyrrol-1-yl)furazans. All target compounds were evaluated for both antimitotic microtubule destabilizing effect in a phenotypic sea urchin embryo assay and cytotoxicity in a panel of 60 human cancer cell lines. Pyrrolyl derivatives of triazolylfurazans were determined as antiproliferative compounds. The most potent microtubule targeting compounds 7a and 7e are of interest for further trials as antineoplastic agents. More... »

PAGES

836-843

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11172-013-0113-2

DOI

http://dx.doi.org/10.1007/s11172-013-0113-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029984302

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32214776


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