Copper complexes with nitronylnitroxyl radicals as lipoxygenase inhibitors with antioxidant activity View Full Text


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Article Info

DATE

2011-12

AUTHORS

E. R. Milaeva, S. I. Orlova, D. I. Osolodkin, V. A. Palyulin, E. Yu. Fursova, V. I. Ovcharenko, N. S. Zefirov

ABSTRACT

The effects of the complexes Cu(LRH)2(NO3)2 (R = H, Me) with the nitronylnitroxyl radicals LRH on the lipoxygenase (LOX-1) activity upon peroxidation of linoleic acid were studied. The complexes under study are reversible enzyme inhibitors, competitive and non-competitive inhibition type being observed for the complex with the methyl-substituted and unsubstituted ligands, respectively. The results of molecular docking showed that the complexes under study are incorporated into the hydrophobic pocket of the LOX-1 active site and the change in the type of inhibition can be explained by introduction of additional methyl group into the imidazole fragment of the ligand, which provides a slightly more favorable interaction of the inhibitor with the enzyme and results in the non-competitive mechanism of inhibition. The starting diamagnetic compounds (LRH2), nitronylnitroxyl radicals (LRH), and CuII complexes exhibit high activity in the nonenzymatic peroxidation of linoleic acid, as well as in generation of the superoxide radical anion O2·− in the xanthine-xanthine oxidase system. More... »

PAGES

2564-2571

References to SciGraph publications

  • 2008-10-13. Redox mechanisms in hepatic chronic wound healing and fibrogenesis in FIBROGENESIS & TISSUE REPAIR
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    http://scigraph.springernature.com/pub.10.1007/s11172-011-0394-2

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    http://dx.doi.org/10.1007/s11172-011-0394-2

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