Synthesis of N-(phosphonomethyl)glycine derivatives and studies of their immunotropic activity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-04

AUTHORS

M. V. Shevchuk, L. A. Metelitsa, L. L. Charochkina, S. E. Mogilevich, E. B. Rusanov, A. E. Sorochinsky, V. P. Khilya, V. D. Romanenko, V. P. Kukhar

ABSTRACT

The Petasis reaction between glyoxylic acid, α-amino phosphonates, and organylboronic acid afforded N-phosphonomethyl-α-amino acids. This method has an advantage of preparative simplicity and high diastereoselectivity of the reactions. Immunotropic activity of the synthesized compounds was studied using the models in vivo.

PAGES

712

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11172-011-0111-1

DOI

http://dx.doi.org/10.1007/s11172-011-0111-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017773235


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