Polyalkoxybenzenes from plant raw materials 4. Parsley and dill seed extracts in the synthesis of polyalkoxy-3,5-diaryl-1,2,4-oxadiazoles with antiproliferative activity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-12

AUTHORS

L. D. Konyushkin, T. I. Godovikova, S. K. Vorontsova, D. V. Tsyganov, I. B. Karmanova, M. M. Raihstat, S. I. Firgang, M. A. Pokrovskii, A. G. Pokrovskii, M. N. Semenova, V. V. Semenov

ABSTRACT

Polyalkoxy-5-(4-hydroxyphenyl)-3-phenyl-1,2,4-oxadiazoles were prepared from allylpolyalkoxybenzenes, the main metabolites of parsley and dill seeds. Due to the spatial arrangement of the aryl substituents provided by 1,2,4-oxadiozole fragment, these compounds can be considered as structural analogs of natural antimitotic combretastatins. The antimitotic activity of the synthesized compounds was evaluated in vivo using sea urchin embryo test. More... »

PAGES

2268-2275

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11172-010-0387-6

DOI

http://dx.doi.org/10.1007/s11172-010-0387-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048105359


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