Synthesis of bi- and tervalent ligands of galectins, derivatives of β-lactosylamine, with the amino group in the terminal position of ... View Full Text


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Article Info

DATE

2008-03

AUTHORS

L. M. Likhosherstov, O. S. Novikova, G. V. Mokrov

ABSTRACT

A method for the synthesis of glycoclusters by N-alkylation of N-glycyl-β-lactosylamine with N-chloroacetyl derivatives of β-lactosylamine and N,N’-iminodiacetyldilactosylamine has been developed. The glycoclusters obtained with two and three lactosylamine residues with the amino group in the spacer were found to be suitable for further conjugation with carboxy-containing physiologically active compounds.

PAGES

660-664

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11172-008-0104-x

DOI

http://dx.doi.org/10.1007/s11172-008-0104-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046371373


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