Quinoline-3-carboxylates as potential antibacterial agents View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-10

AUTHORS

V. Krishnakumar, Fazlur-Rahman Nawaz Khan, Badal Kumar Mandal, Sukanya Mitta, Ramu Dhasamandha, Vindhya Nanu Govindan

ABSTRACT

The ethyl-2-chloroquinoline-3-carboxylates, 4, were achieved from o-aminobenzophenones in two steps. i.e. initially, the ethyl-2-oxoquinoline-3-carboxylates, 3, were obtained by base-catalyzed Friedlander condensations of o-aminobenzophenones, 1, and diethylmalonate, 2. The 2-chloroquinoline-3-carboxylates, 4, were then obtained by the reaction with POCl3 in good yields. The chemical structures were confirmed by FTIR, mass and 1H-NMR spectroscopic techniques. All the synthesized compounds were tested for their in vitro antibacterial activity against Bacillus subtilis and Vibrio cholera and found to possess moderate activity. More... »

PAGES

1819-1826

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URI

http://scigraph.springernature.com/pub.10.1007/s11164-012-0505-1

DOI

http://dx.doi.org/10.1007/s11164-012-0505-1

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https://app.dimensions.ai/details/publication/pub.1012424478


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