Flushing in (neuro)endocrinology View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-09

AUTHORS

Fady Hannah-Shmouni, Constantine A. Stratakis, Christian A. Koch

ABSTRACT

Cutaneous flushing is a common presenting complaint in endocrine disorders. The pathophysiology of flushing involves changes in cutaneous blood flow triggered by multiple intrinsic factors that are either related to physiology or disease. Flushing can be divided into episodic or persistent causes. Episodic flushing is mediated by the release of endogenous vasoactive mediators or medications, while persistent flushing results in a fixed facial erythema with telangiectasia and cyanosis due to slow-flowing deoxygenated blood in large cutaneous blood vessels. The differential diagnosis of cutaneous flushing in neuroendocrine disorders is limited, yet encompasses a broad spectrum of benign and malignant entities, including carcinoid syndrome, pheochromocytoma, Cushing syndrome, medullary thyroid cancer, and pancreatic neuroendocrine tumors. In this review, we provide a concise and up-to-date discussion on the differential diagnosis and approach of flushing in neuroendocrinology. More... »

PAGES

373-380

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11154-016-9394-8

DOI

http://dx.doi.org/10.1007/s11154-016-9394-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031605530

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27873108


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