Exercise resistance across the prediabetes phenotypes: Impact on insulin sensitivity and substrate metabolism View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-03

AUTHORS

Steven K. Malin, Zhenqi Liu, Eugene J. Barrett, Arthur Weltman

ABSTRACT

Prediabetes is a heterogeneous term that encompasses different origins of insulin resistance and insulin secretion that contribute to distinct patterns of hyperglycemia. In fact, prediabetes is an umbrella term that characterizes individuals at high risk for developing type 2 diabetes (T2D) and/or cardiovascular disease (CVD). Based on current definitions there are at least 3 distinct phenotypes of prediabetes: impaired fasting glucose (IFG), impaired glucose tolerant (IGT), or the combination of both (IFG + IGT). Each phenotype is clinically relevant as they are uniquely recognized as having different levels of risk for progressing to T2D and CVD. Herein, we discuss the underlying pathophysiology that characterizes IFG, IGT and the combination, as well as examine how some of these phenotypes appear resistant to traditional exercise interventions. We propose that substrate metabolism differences between the prediabetes phenotypes may be a unifying mechanism that explains the inter-subject variation in response to exercise seen across obese, metabolic syndrome, pre-diabetic and T2D patients in the current literature. Ultimately, a better understanding of the pathophysiologic mechanisms that govern disturbances responsible for fasting vs. postprandial hyperglycemia and the combination of both is important for designing optimal and personalized exercise treatment strategies that treat and prevent hyperglycemia and CVD risk. More... »

PAGES

81-90

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11154-016-9352-5

    DOI

    http://dx.doi.org/10.1007/s11154-016-9352-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1050539868

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27106830


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