Methionine, homocysteine, one carbon metabolism and fetal growth View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-03-15

AUTHORS

Satish C. Kalhan, Susan E. Marczewski

ABSTRACT

Methionine and folate are the key components of one carbon metabolism, providing the methyl groups for numerous methyl transferase reactions via the ubiquitous methyl donor, s-adenosyl methionine. Methionine metabolism is responsive to nutrient intake, is regulated by several hormones and requires a number of vitamins (B12, pyridoxine, riboflavin) as co-factors. The critical relationship between perturbations in the mother’s methionine metabolism and its impact on fetal growth and development is now becoming evident. The relation of folate intake to fetal teratogenesis has been known for some time. Studies in human pregnancy show a continuous decrease in plasma homocysteine, and an increase in plasma choline concentrations with advancing gestation. A higher rate of transsulfuration of methionine in early gestation and of transmethylation in the 3rd trimester was seen in healthy pregnant women. How these processes are impacted by nutritional, hormonal and other influences in human pregnancy and their effect on fetal growth has not been examined. Isocaloric protein restriction in pregnant rats, resulted in fetal growth restriction and metabolic reprogramming. Isocaloric protein restriction in the non-pregnant rat, resulted in differential expression of a number of genes in the liver, a 50% increase in whole body serine biosynthesis and high rate of transmethylation, suggesting high methylation demands. These responses were associated with a significant decrease in intracellular taurine levels in the liver suggesting a role of cellular osmolarity in the observed metabolic responses. These unique changes in methionine and one carbon metabolism in response to physiological, nutritional and hormonal influences make these processes critical for cellular and organ function and growth. More... »

PAGES

109-119

References to SciGraph publications

  • 2010-01. Gestational Protein Restriction in Mice Has Pronounced Effects on Gene Expression in Newborn Offspring's Liver and Skeletal Muscle; Protective Effect of Taurine in PEDIATRIC RESEARCH
  • 2008-10. Metabolism of Methionine in the Newborn Infant: Response to the Parenteral and Enteral Administration of Nutrients in PEDIATRIC RESEARCH
  • 2004-07-07. Metabolic Responses to Protein Restriction During Pregnancy in Rat and Translation Initiation Factors in the Mother and Fetus in PEDIATRIC RESEARCH
  • 2007-07-11. Relationship between dietary folate intakes, maternal plasma total homocysteine and B-vitamins during pregnancy and fetal growth in Japan in EUROPEAN JOURNAL OF NUTRITION
  • 1968-03. The Plasma Aminogram. I. Influence of the Level of Protein Intake and a Comparison of Whole Protein and Amino Acid Diets in PEDIATRIC RESEARCH
  • 2001-04. Impact of maternal undernutrition on hypothalamo-pituitary-adrenal axis and adipocyte functions in male rat offspring in ENDOCRINE
  • 2007-09-13. Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study in DIABETOLOGIA
  • 2002-05-08. Taurine supplementation to a low protein diet during foetal and early postnatal life restores a normal proliferation and apoptosis of rat pancreatic islets in DIABETOLOGIA
  • 2009-05-30. Gene and protein expression profiles in the foetal liver of the pregnant rat fed a low protein diet in GENES & NUTRITION
  • 2008-08-16. Dietary folate intake during pregnancy and birth weight in Japan in EUROPEAN JOURNAL OF NUTRITION
  • 2007-02-07. Mechanisms of homocysteine toxicity in humans in AMINO ACIDS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11154-012-9215-7

    DOI

    http://dx.doi.org/10.1007/s11154-012-9215-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1002705413

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22418620


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Paediatrics and Reproductive Medicine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carbon", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dietary Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Energy Intake", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fetal Development", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Folic Acid", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Homocysteine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Methionine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pregnancy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rats", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vitamin B 12", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vitamins", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Pathobiology, NE-40, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, 44195, Cleveland, OH, USA", 
              "id": "http://www.grid.ac/institutes/grid.239578.2", 
              "name": [
                "Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, 9500 Euclid Avenue, 44195, Cleveland, OH, USA", 
                "Department of Pathobiology, NE-40, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, 44195, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kalhan", 
            "givenName": "Satish C.", 
            "id": "sg:person.0603127205.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603127205.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathobiology, NE-40, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, 44195, Cleveland, OH, USA", 
              "id": "http://www.grid.ac/institutes/grid.239578.2", 
              "name": [
                "Department of Pathobiology, NE-40, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, 44195, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Marczewski", 
            "givenName": "Susan E.", 
            "id": "sg:person.0644645204.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644645204.42"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1203/00006450-196803000-00009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011391391", 
              "https://doi.org/10.1203/00006450-196803000-00009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00394-007-0667-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033955652", 
              "https://doi.org/10.1007/s00394-007-0667-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1203/01.pdr.0000136277.10365.84", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012609148", 
              "https://doi.org/10.1203/01.pdr.0000136277.10365.84"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1203/pdr.0b013e3181c4735c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036090571", 
              "https://doi.org/10.1203/pdr.0b013e3181c4735c"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12263-009-0125-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037970411", 
              "https://doi.org/10.1007/s12263-009-0125-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00394-008-0733-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038533842", 
              "https://doi.org/10.1007/s00394-008-0733-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1203/pdr.0b013e318180e499", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035590587", 
              "https://doi.org/10.1203/pdr.0b013e318180e499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-002-0833-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018149509", 
              "https://doi.org/10.1007/s00125-002-0833-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1385/endo:14:3:375", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036590577", 
              "https://doi.org/10.1385/endo:14:3:375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00726-006-0432-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034613356", 
              "https://doi.org/10.1007/s00726-006-0432-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-007-0793-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047473115", 
              "https://doi.org/10.1007/s00125-007-0793-y"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2012-03-15", 
        "datePublishedReg": "2012-03-15", 
        "description": "Methionine and folate are the key components of one carbon metabolism, providing the methyl groups for numerous methyl transferase reactions via the ubiquitous methyl donor, s-adenosyl methionine. Methionine metabolism is responsive to nutrient intake, is regulated by several hormones and requires a number of vitamins (B12, pyridoxine, riboflavin) as co-factors. The critical relationship between perturbations in the mother\u2019s methionine metabolism and its impact on fetal growth and development is now becoming evident. The relation of folate intake to fetal teratogenesis has been known for some time. Studies in human pregnancy show a continuous decrease in plasma homocysteine, and an increase in plasma choline concentrations with advancing gestation. A higher rate of transsulfuration of methionine in early gestation and of transmethylation in the 3rd trimester was seen in healthy pregnant women. How these processes are impacted by nutritional, hormonal and other influences in human pregnancy and their effect on fetal growth has not been examined. Isocaloric protein restriction in pregnant rats, resulted in fetal growth restriction and metabolic reprogramming. Isocaloric protein restriction in the non-pregnant rat, resulted in differential expression of a number of genes in the liver, a 50% increase in whole body serine biosynthesis and high rate of transmethylation, suggesting high methylation demands. These responses were associated with a significant decrease in intracellular taurine levels in the liver suggesting a role of cellular osmolarity in the observed metabolic responses. These unique changes in methionine and one carbon metabolism in response to physiological, nutritional and hormonal influences make these processes critical for cellular and organ function and growth.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s11154-012-9215-7", 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2440555", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2405602", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2526607", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2499438", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2436473", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1022713", 
            "issn": [
              "1389-9155", 
              "1573-2606"
            ], 
            "name": "Reviews in Endocrine and Metabolic Disorders", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "13"
          }
        ], 
        "keywords": [
          "isocaloric protein restriction", 
          "fetal growth", 
          "human pregnancy", 
          "protein restriction", 
          "methionine metabolism", 
          "healthy pregnant women", 
          "fetal growth restriction", 
          "plasma choline concentrations", 
          "non-pregnant rats", 
          "intracellular taurine levels", 
          "high rate", 
          "ubiquitous methyl donor", 
          "number of vitamins", 
          "pregnant women", 
          "pregnant rats", 
          "plasma homocysteine", 
          "folate intake", 
          "growth restriction", 
          "early gestation", 
          "fetal teratogenesis", 
          "taurine levels", 
          "hormonal influences", 
          "organ function", 
          "nutrient intake", 
          "choline concentrations", 
          "significant decrease", 
          "methylation demand", 
          "metabolic response", 
          "metabolic reprogramming", 
          "pregnancy", 
          "gestation", 
          "rats", 
          "metabolism", 
          "liver", 
          "homocysteine", 
          "intake", 
          "S-adenosyl methionine", 
          "differential expression", 
          "methyl donor", 
          "unique changes", 
          "trimester", 
          "response", 
          "methionine", 
          "hormone", 
          "folate", 
          "women", 
          "number of genes", 
          "teratogenesis", 
          "transmethylation", 
          "vitamin", 
          "decrease", 
          "cellular osmolarity", 
          "transsulfuration", 
          "rate", 
          "serine biosynthesis", 
          "restriction", 
          "increase", 
          "group", 
          "expression", 
          "donors", 
          "osmolarity", 
          "observed metabolic responses", 
          "levels", 
          "key component", 
          "continuous decrease", 
          "reprogramming", 
          "study", 
          "genes", 
          "number", 
          "role", 
          "growth", 
          "effect", 
          "changes", 
          "concentration", 
          "critical relationship", 
          "function", 
          "development", 
          "relationship", 
          "time", 
          "impact", 
          "influence", 
          "biosynthesis", 
          "components", 
          "reaction", 
          "relation", 
          "carbon metabolism", 
          "process", 
          "transferase reaction", 
          "methyl group", 
          "perturbations", 
          "demand"
        ], 
        "name": "Methionine, homocysteine, one carbon metabolism and fetal growth", 
        "pagination": "109-119", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1002705413"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s11154-012-9215-7"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "22418620"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s11154-012-9215-7", 
          "https://app.dimensions.ai/details/publication/pub.1002705413"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-08-04T16:59", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_561.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s11154-012-9215-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11154-012-9215-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11154-012-9215-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11154-012-9215-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11154-012-9215-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    274 TRIPLES      21 PREDICATES      142 URIs      123 LITERALS      22 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s11154-012-9215-7 schema:about N046f68c32ad44ca5bb6e88fa875431f4
    2 N0662bbc2f7d74150959e4cd5311df27f
    3 N2e409ac9c11f4c649bf00fe0bb95df4c
    4 N4b48bb7285da470483d454be54f0330a
    5 N4d56f06c794c4d6aa1e4d563b397ae19
    6 N55ac05877bf547808bd50b7110d03192
    7 N731d6d8619cd49e595d9ea62749649da
    8 N8757691fe741460bba4da70f09d0ab5b
    9 Na500880d37b34b2695f9f7bbe3b13608
    10 Nafc28f132aa1491a8779f3faba9d8d54
    11 Nb3b022e210024f1eb8acadf6338fe050
    12 Nc4cc4513aa8f4904b5c32d2f64120be5
    13 Ncde8caa7e81b48e4ac5de3c327ced352
    14 Nd88fda4d9e334d32b2fc533ca567881d
    15 Nfe2a6f544da74ff295f7a69fa7b6528c
    16 anzsrc-for:11
    17 anzsrc-for:1114
    18 schema:author Nc66a8e53dd444015a1dfdc3556c82094
    19 schema:citation sg:pub.10.1007/s00125-002-0833-6
    20 sg:pub.10.1007/s00125-007-0793-y
    21 sg:pub.10.1007/s00394-007-0667-6
    22 sg:pub.10.1007/s00394-008-0733-8
    23 sg:pub.10.1007/s00726-006-0432-9
    24 sg:pub.10.1007/s12263-009-0125-6
    25 sg:pub.10.1203/00006450-196803000-00009
    26 sg:pub.10.1203/01.pdr.0000136277.10365.84
    27 sg:pub.10.1203/pdr.0b013e318180e499
    28 sg:pub.10.1203/pdr.0b013e3181c4735c
    29 sg:pub.10.1385/endo:14:3:375
    30 schema:datePublished 2012-03-15
    31 schema:datePublishedReg 2012-03-15
    32 schema:description Methionine and folate are the key components of one carbon metabolism, providing the methyl groups for numerous methyl transferase reactions via the ubiquitous methyl donor, s-adenosyl methionine. Methionine metabolism is responsive to nutrient intake, is regulated by several hormones and requires a number of vitamins (B12, pyridoxine, riboflavin) as co-factors. The critical relationship between perturbations in the mother’s methionine metabolism and its impact on fetal growth and development is now becoming evident. The relation of folate intake to fetal teratogenesis has been known for some time. Studies in human pregnancy show a continuous decrease in plasma homocysteine, and an increase in plasma choline concentrations with advancing gestation. A higher rate of transsulfuration of methionine in early gestation and of transmethylation in the 3rd trimester was seen in healthy pregnant women. How these processes are impacted by nutritional, hormonal and other influences in human pregnancy and their effect on fetal growth has not been examined. Isocaloric protein restriction in pregnant rats, resulted in fetal growth restriction and metabolic reprogramming. Isocaloric protein restriction in the non-pregnant rat, resulted in differential expression of a number of genes in the liver, a 50% increase in whole body serine biosynthesis and high rate of transmethylation, suggesting high methylation demands. These responses were associated with a significant decrease in intracellular taurine levels in the liver suggesting a role of cellular osmolarity in the observed metabolic responses. These unique changes in methionine and one carbon metabolism in response to physiological, nutritional and hormonal influences make these processes critical for cellular and organ function and growth.
    33 schema:genre article
    34 schema:isAccessibleForFree false
    35 schema:isPartOf N52869dc2948548b88235d93e5ae0e9ea
    36 Nd0ab0f0354524ec08f8c8ce8dbb3e7e7
    37 sg:journal.1022713
    38 schema:keywords S-adenosyl methionine
    39 biosynthesis
    40 carbon metabolism
    41 cellular osmolarity
    42 changes
    43 choline concentrations
    44 components
    45 concentration
    46 continuous decrease
    47 critical relationship
    48 decrease
    49 demand
    50 development
    51 differential expression
    52 donors
    53 early gestation
    54 effect
    55 expression
    56 fetal growth
    57 fetal growth restriction
    58 fetal teratogenesis
    59 folate
    60 folate intake
    61 function
    62 genes
    63 gestation
    64 group
    65 growth
    66 growth restriction
    67 healthy pregnant women
    68 high rate
    69 homocysteine
    70 hormonal influences
    71 hormone
    72 human pregnancy
    73 impact
    74 increase
    75 influence
    76 intake
    77 intracellular taurine levels
    78 isocaloric protein restriction
    79 key component
    80 levels
    81 liver
    82 metabolic reprogramming
    83 metabolic response
    84 metabolism
    85 methionine
    86 methionine metabolism
    87 methyl donor
    88 methyl group
    89 methylation demand
    90 non-pregnant rats
    91 number
    92 number of genes
    93 number of vitamins
    94 nutrient intake
    95 observed metabolic responses
    96 organ function
    97 osmolarity
    98 perturbations
    99 plasma choline concentrations
    100 plasma homocysteine
    101 pregnancy
    102 pregnant rats
    103 pregnant women
    104 process
    105 protein restriction
    106 rate
    107 rats
    108 reaction
    109 relation
    110 relationship
    111 reprogramming
    112 response
    113 restriction
    114 role
    115 serine biosynthesis
    116 significant decrease
    117 study
    118 taurine levels
    119 teratogenesis
    120 time
    121 transferase reaction
    122 transmethylation
    123 transsulfuration
    124 trimester
    125 ubiquitous methyl donor
    126 unique changes
    127 vitamin
    128 women
    129 schema:name Methionine, homocysteine, one carbon metabolism and fetal growth
    130 schema:pagination 109-119
    131 schema:productId N1665eae3c85e4a54a371383a43327328
    132 Na3aafd3d4eab40ac85c6d01b32ddecfc
    133 Nc36f7a251855412f98c3eaffefd9b99a
    134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002705413
    135 https://doi.org/10.1007/s11154-012-9215-7
    136 schema:sdDatePublished 2022-08-04T16:59
    137 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    138 schema:sdPublisher N2d7a8c5ed43045fe8c5edbe523f8c93a
    139 schema:url https://doi.org/10.1007/s11154-012-9215-7
    140 sgo:license sg:explorer/license/
    141 sgo:sdDataset articles
    142 rdf:type schema:ScholarlyArticle
    143 N046f68c32ad44ca5bb6e88fa875431f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Folic Acid
    145 rdf:type schema:DefinedTerm
    146 N0662bbc2f7d74150959e4cd5311df27f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Female
    148 rdf:type schema:DefinedTerm
    149 N1665eae3c85e4a54a371383a43327328 schema:name pubmed_id
    150 schema:value 22418620
    151 rdf:type schema:PropertyValue
    152 N2d7a8c5ed43045fe8c5edbe523f8c93a schema:name Springer Nature - SN SciGraph project
    153 rdf:type schema:Organization
    154 N2e409ac9c11f4c649bf00fe0bb95df4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Pregnancy
    156 rdf:type schema:DefinedTerm
    157 N4b48bb7285da470483d454be54f0330a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Dietary Proteins
    159 rdf:type schema:DefinedTerm
    160 N4d56f06c794c4d6aa1e4d563b397ae19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Fetal Development
    162 rdf:type schema:DefinedTerm
    163 N52869dc2948548b88235d93e5ae0e9ea schema:volumeNumber 13
    164 rdf:type schema:PublicationVolume
    165 N55ac05877bf547808bd50b7110d03192 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Vitamin B 12
    167 rdf:type schema:DefinedTerm
    168 N5e1984e7fca14b28a087cecf26821496 rdf:first sg:person.0644645204.42
    169 rdf:rest rdf:nil
    170 N731d6d8619cd49e595d9ea62749649da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Animals
    172 rdf:type schema:DefinedTerm
    173 N8757691fe741460bba4da70f09d0ab5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Adult
    175 rdf:type schema:DefinedTerm
    176 Na3aafd3d4eab40ac85c6d01b32ddecfc schema:name dimensions_id
    177 schema:value pub.1002705413
    178 rdf:type schema:PropertyValue
    179 Na500880d37b34b2695f9f7bbe3b13608 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Energy Intake
    181 rdf:type schema:DefinedTerm
    182 Nafc28f132aa1491a8779f3faba9d8d54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Carbon
    184 rdf:type schema:DefinedTerm
    185 Nb3b022e210024f1eb8acadf6338fe050 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Rats
    187 rdf:type schema:DefinedTerm
    188 Nc36f7a251855412f98c3eaffefd9b99a schema:name doi
    189 schema:value 10.1007/s11154-012-9215-7
    190 rdf:type schema:PropertyValue
    191 Nc4cc4513aa8f4904b5c32d2f64120be5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Homocysteine
    193 rdf:type schema:DefinedTerm
    194 Nc66a8e53dd444015a1dfdc3556c82094 rdf:first sg:person.0603127205.83
    195 rdf:rest N5e1984e7fca14b28a087cecf26821496
    196 Ncde8caa7e81b48e4ac5de3c327ced352 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Vitamins
    198 rdf:type schema:DefinedTerm
    199 Nd0ab0f0354524ec08f8c8ce8dbb3e7e7 schema:issueNumber 2
    200 rdf:type schema:PublicationIssue
    201 Nd88fda4d9e334d32b2fc533ca567881d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    202 schema:name Methionine
    203 rdf:type schema:DefinedTerm
    204 Nfe2a6f544da74ff295f7a69fa7b6528c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    205 schema:name Humans
    206 rdf:type schema:DefinedTerm
    207 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    208 schema:name Medical and Health Sciences
    209 rdf:type schema:DefinedTerm
    210 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
    211 schema:name Paediatrics and Reproductive Medicine
    212 rdf:type schema:DefinedTerm
    213 sg:grant.2405602 http://pending.schema.org/fundedItem sg:pub.10.1007/s11154-012-9215-7
    214 rdf:type schema:MonetaryGrant
    215 sg:grant.2436473 http://pending.schema.org/fundedItem sg:pub.10.1007/s11154-012-9215-7
    216 rdf:type schema:MonetaryGrant
    217 sg:grant.2440555 http://pending.schema.org/fundedItem sg:pub.10.1007/s11154-012-9215-7
    218 rdf:type schema:MonetaryGrant
    219 sg:grant.2499438 http://pending.schema.org/fundedItem sg:pub.10.1007/s11154-012-9215-7
    220 rdf:type schema:MonetaryGrant
    221 sg:grant.2526607 http://pending.schema.org/fundedItem sg:pub.10.1007/s11154-012-9215-7
    222 rdf:type schema:MonetaryGrant
    223 sg:journal.1022713 schema:issn 1389-9155
    224 1573-2606
    225 schema:name Reviews in Endocrine and Metabolic Disorders
    226 schema:publisher Springer Nature
    227 rdf:type schema:Periodical
    228 sg:person.0603127205.83 schema:affiliation grid-institutes:grid.239578.2
    229 schema:familyName Kalhan
    230 schema:givenName Satish C.
    231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603127205.83
    232 rdf:type schema:Person
    233 sg:person.0644645204.42 schema:affiliation grid-institutes:grid.239578.2
    234 schema:familyName Marczewski
    235 schema:givenName Susan E.
    236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644645204.42
    237 rdf:type schema:Person
    238 sg:pub.10.1007/s00125-002-0833-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018149509
    239 https://doi.org/10.1007/s00125-002-0833-6
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1007/s00125-007-0793-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1047473115
    242 https://doi.org/10.1007/s00125-007-0793-y
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1007/s00394-007-0667-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033955652
    245 https://doi.org/10.1007/s00394-007-0667-6
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1007/s00394-008-0733-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038533842
    248 https://doi.org/10.1007/s00394-008-0733-8
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1007/s00726-006-0432-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034613356
    251 https://doi.org/10.1007/s00726-006-0432-9
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1007/s12263-009-0125-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037970411
    254 https://doi.org/10.1007/s12263-009-0125-6
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1203/00006450-196803000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011391391
    257 https://doi.org/10.1203/00006450-196803000-00009
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1203/01.pdr.0000136277.10365.84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012609148
    260 https://doi.org/10.1203/01.pdr.0000136277.10365.84
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1203/pdr.0b013e318180e499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035590587
    263 https://doi.org/10.1203/pdr.0b013e318180e499
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1203/pdr.0b013e3181c4735c schema:sameAs https://app.dimensions.ai/details/publication/pub.1036090571
    266 https://doi.org/10.1203/pdr.0b013e3181c4735c
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1385/endo:14:3:375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036590577
    269 https://doi.org/10.1385/endo:14:3:375
    270 rdf:type schema:CreativeWork
    271 grid-institutes:grid.239578.2 schema:alternateName Department of Pathobiology, NE-40, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, 44195, Cleveland, OH, USA
    272 schema:name Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, 9500 Euclid Avenue, 44195, Cleveland, OH, USA
    273 Department of Pathobiology, NE-40, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, 44195, Cleveland, OH, USA
    274 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...