Methionine, homocysteine, one carbon metabolism and fetal growth View Full Text


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Article Info

DATE

2012-03-15

AUTHORS

Satish C. Kalhan, Susan E. Marczewski

ABSTRACT

Methionine and folate are the key components of one carbon metabolism, providing the methyl groups for numerous methyl transferase reactions via the ubiquitous methyl donor, s-adenosyl methionine. Methionine metabolism is responsive to nutrient intake, is regulated by several hormones and requires a number of vitamins (B12, pyridoxine, riboflavin) as co-factors. The critical relationship between perturbations in the mother’s methionine metabolism and its impact on fetal growth and development is now becoming evident. The relation of folate intake to fetal teratogenesis has been known for some time. Studies in human pregnancy show a continuous decrease in plasma homocysteine, and an increase in plasma choline concentrations with advancing gestation. A higher rate of transsulfuration of methionine in early gestation and of transmethylation in the 3rd trimester was seen in healthy pregnant women. How these processes are impacted by nutritional, hormonal and other influences in human pregnancy and their effect on fetal growth has not been examined. Isocaloric protein restriction in pregnant rats, resulted in fetal growth restriction and metabolic reprogramming. Isocaloric protein restriction in the non-pregnant rat, resulted in differential expression of a number of genes in the liver, a 50% increase in whole body serine biosynthesis and high rate of transmethylation, suggesting high methylation demands. These responses were associated with a significant decrease in intracellular taurine levels in the liver suggesting a role of cellular osmolarity in the observed metabolic responses. These unique changes in methionine and one carbon metabolism in response to physiological, nutritional and hormonal influences make these processes critical for cellular and organ function and growth. More... »

PAGES

109-119

References to SciGraph publications

  • 2010-01. Gestational Protein Restriction in Mice Has Pronounced Effects on Gene Expression in Newborn Offspring's Liver and Skeletal Muscle; Protective Effect of Taurine in PEDIATRIC RESEARCH
  • 2008-10. Metabolism of Methionine in the Newborn Infant: Response to the Parenteral and Enteral Administration of Nutrients in PEDIATRIC RESEARCH
  • 2004-07-07. Metabolic Responses to Protein Restriction During Pregnancy in Rat and Translation Initiation Factors in the Mother and Fetus in PEDIATRIC RESEARCH
  • 2007-07-11. Relationship between dietary folate intakes, maternal plasma total homocysteine and B-vitamins during pregnancy and fetal growth in Japan in EUROPEAN JOURNAL OF NUTRITION
  • 1968-03. The Plasma Aminogram. I. Influence of the Level of Protein Intake and a Comparison of Whole Protein and Amino Acid Diets in PEDIATRIC RESEARCH
  • 2001-04. Impact of maternal undernutrition on hypothalamo-pituitary-adrenal axis and adipocyte functions in male rat offspring in ENDOCRINE
  • 2007-09-13. Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study in DIABETOLOGIA
  • 2002-05-08. Taurine supplementation to a low protein diet during foetal and early postnatal life restores a normal proliferation and apoptosis of rat pancreatic islets in DIABETOLOGIA
  • 2009-05-30. Gene and protein expression profiles in the foetal liver of the pregnant rat fed a low protein diet in GENES & NUTRITION
  • 2008-08-16. Dietary folate intake during pregnancy and birth weight in Japan in EUROPEAN JOURNAL OF NUTRITION
  • 2007-02-07. Mechanisms of homocysteine toxicity in humans in AMINO ACIDS
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    URI

    http://scigraph.springernature.com/pub.10.1007/s11154-012-9215-7

    DOI

    http://dx.doi.org/10.1007/s11154-012-9215-7

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    https://app.dimensions.ai/details/publication/pub.1002705413

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22418620


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