Ontology type: schema:ScholarlyArticle
2012-03-15
AUTHORSSatish C. Kalhan, Susan E. Marczewski
ABSTRACTMethionine and folate are the key components of one carbon metabolism, providing the methyl groups for numerous methyl transferase reactions via the ubiquitous methyl donor, s-adenosyl methionine. Methionine metabolism is responsive to nutrient intake, is regulated by several hormones and requires a number of vitamins (B12, pyridoxine, riboflavin) as co-factors. The critical relationship between perturbations in the mother’s methionine metabolism and its impact on fetal growth and development is now becoming evident. The relation of folate intake to fetal teratogenesis has been known for some time. Studies in human pregnancy show a continuous decrease in plasma homocysteine, and an increase in plasma choline concentrations with advancing gestation. A higher rate of transsulfuration of methionine in early gestation and of transmethylation in the 3rd trimester was seen in healthy pregnant women. How these processes are impacted by nutritional, hormonal and other influences in human pregnancy and their effect on fetal growth has not been examined. Isocaloric protein restriction in pregnant rats, resulted in fetal growth restriction and metabolic reprogramming. Isocaloric protein restriction in the non-pregnant rat, resulted in differential expression of a number of genes in the liver, a 50% increase in whole body serine biosynthesis and high rate of transmethylation, suggesting high methylation demands. These responses were associated with a significant decrease in intracellular taurine levels in the liver suggesting a role of cellular osmolarity in the observed metabolic responses. These unique changes in methionine and one carbon metabolism in response to physiological, nutritional and hormonal influences make these processes critical for cellular and organ function and growth. More... »
PAGES109-119
http://scigraph.springernature.com/pub.10.1007/s11154-012-9215-7
DOIhttp://dx.doi.org/10.1007/s11154-012-9215-7
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1002705413
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/22418620
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Paediatrics and Reproductive Medicine",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Carbon",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Dietary Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Energy Intake",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Fetal Development",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Folic Acid",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Homocysteine",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Methionine",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Pregnancy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rats",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Vitamin B 12",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Vitamins",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Pathobiology, NE-40, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, 44195, Cleveland, OH, USA",
"id": "http://www.grid.ac/institutes/grid.239578.2",
"name": [
"Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, 9500 Euclid Avenue, 44195, Cleveland, OH, USA",
"Department of Pathobiology, NE-40, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, 44195, Cleveland, OH, USA"
],
"type": "Organization"
},
"familyName": "Kalhan",
"givenName": "Satish C.",
"id": "sg:person.0603127205.83",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603127205.83"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathobiology, NE-40, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, 44195, Cleveland, OH, USA",
"id": "http://www.grid.ac/institutes/grid.239578.2",
"name": [
"Department of Pathobiology, NE-40, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, 44195, Cleveland, OH, USA"
],
"type": "Organization"
},
"familyName": "Marczewski",
"givenName": "Susan E.",
"id": "sg:person.0644645204.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644645204.42"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1203/00006450-196803000-00009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011391391",
"https://doi.org/10.1203/00006450-196803000-00009"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00394-007-0667-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033955652",
"https://doi.org/10.1007/s00394-007-0667-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1203/01.pdr.0000136277.10365.84",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012609148",
"https://doi.org/10.1203/01.pdr.0000136277.10365.84"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1203/pdr.0b013e3181c4735c",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036090571",
"https://doi.org/10.1203/pdr.0b013e3181c4735c"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12263-009-0125-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037970411",
"https://doi.org/10.1007/s12263-009-0125-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00394-008-0733-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038533842",
"https://doi.org/10.1007/s00394-008-0733-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1203/pdr.0b013e318180e499",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035590587",
"https://doi.org/10.1203/pdr.0b013e318180e499"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00125-002-0833-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018149509",
"https://doi.org/10.1007/s00125-002-0833-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1385/endo:14:3:375",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036590577",
"https://doi.org/10.1385/endo:14:3:375"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00726-006-0432-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034613356",
"https://doi.org/10.1007/s00726-006-0432-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00125-007-0793-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047473115",
"https://doi.org/10.1007/s00125-007-0793-y"
],
"type": "CreativeWork"
}
],
"datePublished": "2012-03-15",
"datePublishedReg": "2012-03-15",
"description": "Methionine and folate are the key components of one carbon metabolism, providing the methyl groups for numerous methyl transferase reactions via the ubiquitous methyl donor, s-adenosyl methionine. Methionine metabolism is responsive to nutrient intake, is regulated by several hormones and requires a number of vitamins (B12, pyridoxine, riboflavin) as co-factors. The critical relationship between perturbations in the mother\u2019s methionine metabolism and its impact on fetal growth and development is now becoming evident. The relation of folate intake to fetal teratogenesis has been known for some time. Studies in human pregnancy show a continuous decrease in plasma homocysteine, and an increase in plasma choline concentrations with advancing gestation. A higher rate of transsulfuration of methionine in early gestation and of transmethylation in the 3rd trimester was seen in healthy pregnant women. How these processes are impacted by nutritional, hormonal and other influences in human pregnancy and their effect on fetal growth has not been examined. Isocaloric protein restriction in pregnant rats, resulted in fetal growth restriction and metabolic reprogramming. Isocaloric protein restriction in the non-pregnant rat, resulted in differential expression of a number of genes in the liver, a 50% increase in whole body serine biosynthesis and high rate of transmethylation, suggesting high methylation demands. These responses were associated with a significant decrease in intracellular taurine levels in the liver suggesting a role of cellular osmolarity in the observed metabolic responses. These unique changes in methionine and one carbon metabolism in response to physiological, nutritional and hormonal influences make these processes critical for cellular and organ function and growth.",
"genre": "article",
"id": "sg:pub.10.1007/s11154-012-9215-7",
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.2440555",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2405602",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2526607",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2499438",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2436473",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1022713",
"issn": [
"1389-9155",
"1573-2606"
],
"name": "Reviews in Endocrine and Metabolic Disorders",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "13"
}
],
"keywords": [
"isocaloric protein restriction",
"fetal growth",
"human pregnancy",
"protein restriction",
"methionine metabolism",
"healthy pregnant women",
"fetal growth restriction",
"plasma choline concentrations",
"non-pregnant rats",
"intracellular taurine levels",
"high rate",
"ubiquitous methyl donor",
"number of vitamins",
"pregnant women",
"pregnant rats",
"plasma homocysteine",
"folate intake",
"growth restriction",
"early gestation",
"fetal teratogenesis",
"taurine levels",
"hormonal influences",
"organ function",
"nutrient intake",
"choline concentrations",
"significant decrease",
"methylation demand",
"metabolic response",
"metabolic reprogramming",
"pregnancy",
"gestation",
"rats",
"metabolism",
"liver",
"homocysteine",
"intake",
"S-adenosyl methionine",
"differential expression",
"methyl donor",
"unique changes",
"trimester",
"response",
"methionine",
"hormone",
"folate",
"women",
"number of genes",
"teratogenesis",
"transmethylation",
"vitamin",
"decrease",
"cellular osmolarity",
"transsulfuration",
"rate",
"serine biosynthesis",
"restriction",
"increase",
"group",
"expression",
"donors",
"osmolarity",
"observed metabolic responses",
"levels",
"key component",
"continuous decrease",
"reprogramming",
"study",
"genes",
"number",
"role",
"growth",
"effect",
"changes",
"concentration",
"critical relationship",
"function",
"development",
"relationship",
"time",
"impact",
"influence",
"biosynthesis",
"components",
"reaction",
"relation",
"carbon metabolism",
"process",
"transferase reaction",
"methyl group",
"perturbations",
"demand"
],
"name": "Methionine, homocysteine, one carbon metabolism and fetal growth",
"pagination": "109-119",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1002705413"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s11154-012-9215-7"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"22418620"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s11154-012-9215-7",
"https://app.dimensions.ai/details/publication/pub.1002705413"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T16:59",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_561.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s11154-012-9215-7"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11154-012-9215-7'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11154-012-9215-7'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11154-012-9215-7'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11154-012-9215-7'
This table displays all metadata directly associated to this object as RDF triples.
274 TRIPLES
21 PREDICATES
142 URIs
123 LITERALS
22 BLANK NODES