Association of generic health-related quality of life (EQ-5D dimensions) and inactivity with lung function in lung-healthy German adults: results from ... View Full Text


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Article Info

DATE

2018-02-06

AUTHORS

Agnes Luzak, Stefan Karrasch, Margarethe Wacker, Barbara Thorand, Dennis Nowak, Annette Peters, Holger Schulz

ABSTRACT

PurposeAmong patients with lung disease, decreased lung function is associated with lower health-related quality of life. However, whether this association is detectable within the physiological variability of respiratory function in lung-healthy populations is unknown. We analyzed the association of each EQ-5D-3L dimension (mobility, self-care, usual activities, pain/discomfort, anxiety/depression) and self-reported physical inactivity with spirometric indices in lung-healthy adults. Modulating effects between inactivity and EQ-5D dimensions were considered.Methods1132 non-smoking, apparently lung-healthy participants (48% male, aged 64 ± 12 years) from the population-based KORA F4L and Age surveys in Southern Germany were analyzed. Associations of each EQ-5D dimension and inactivity with spirometric indices serving as outcomes (forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, and mid-expiratory flow) were examined by linear regression, considering possible confounders. Interactions between EQ-5D dimensions (no problems/any problems) and inactivity (four categories of time spent engaging in exercise: inactive to most active) were assessed.ResultsAmong all participants 42% reported no problems in any EQ-5D dimension, 24% were inactive and 32% exercised > 2 h/week. After adjustment, FEV1 was − 99 ml (95% CI − 166; − 32) and FVC was − 109 ml (95% CI − 195; − 24) lower among subjects with mobility problems. Comparable estimates were observed for usual activities. Inactivity was negatively associated with FVC (β-coefficient: − 83 ml, 95% CI − 166; 0), but showed no interactions with EQ-5D.ConclusionsProblems with mobility or usual activities, and inactivity were associated with slightly lower spirometric parameters in lung-healthy adults, suggesting a relationship between perceived physical functioning and volumetric lung function. More... »

PAGES

735-745

References to SciGraph publications

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    28 schema:description PurposeAmong patients with lung disease, decreased lung function is associated with lower health-related quality of life. However, whether this association is detectable within the physiological variability of respiratory function in lung-healthy populations is unknown. We analyzed the association of each EQ-5D-3L dimension (mobility, self-care, usual activities, pain/discomfort, anxiety/depression) and self-reported physical inactivity with spirometric indices in lung-healthy adults. Modulating effects between inactivity and EQ-5D dimensions were considered.Methods1132 non-smoking, apparently lung-healthy participants (48% male, aged 64 ± 12 years) from the population-based KORA F4L and Age surveys in Southern Germany were analyzed. Associations of each EQ-5D dimension and inactivity with spirometric indices serving as outcomes (forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, and mid-expiratory flow) were examined by linear regression, considering possible confounders. Interactions between EQ-5D dimensions (no problems/any problems) and inactivity (four categories of time spent engaging in exercise: inactive to most active) were assessed.ResultsAmong all participants 42% reported no problems in any EQ-5D dimension, 24% were inactive and 32% exercised > 2 h/week. After adjustment, FEV1 was − 99 ml (95% CI − 166; − 32) and FVC was − 109 ml (95% CI − 195; − 24) lower among subjects with mobility problems. Comparable estimates were observed for usual activities. Inactivity was negatively associated with FVC (β-coefficient: − 83 ml, 95% CI − 166; 0), but showed no interactions with EQ-5D.ConclusionsProblems with mobility or usual activities, and inactivity were associated with slightly lower spirometric parameters in lung-healthy adults, suggesting a relationship between perceived physical functioning and volumetric lung function.
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    34 schema:keywords EQ-5D
    35 EQ-5D dimensions
    36 FEV1
    37 FVC
    38 German adults
    39 Germany
    40 PurposeAmong patients
    41 ResultsAmong
    42 activity
    43 adjustment
    44 adults
    45 age
    46 age survey
    47 association
    48 comparable estimates
    49 confounders
    50 dimensions
    51 disease
    52 effect
    53 estimates
    54 function
    55 functioning
    56 generic health-related quality
    57 health-related quality
    58 inactivity
    59 index
    60 interaction
    61 life
    62 linear regression
    63 lower health-related quality
    64 lower spirometric parameters
    65 lung disease
    66 lung function
    67 lung-healthy adults
    68 mobility
    69 mobility problems
    70 outcomes
    71 parameters
    72 participants
    73 participants 42
    74 patients
    75 physical functioning
    76 physical inactivity
    77 physiological variability
    78 population
    79 possible confounders
    80 problem
    81 quality
    82 regression
    83 relationship
    84 respiratory function
    85 results
    86 self-reported physical inactivity
    87 southern Germany
    88 spirometric indices
    89 spirometric parameters
    90 subjects
    91 survey
    92 usual activities
    93 variability
    94 weeks
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