Quality of life of patients with chronic lymphocytic leukaemia in the Netherlands: results of a longitudinal multicentre study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-07-24

AUTHORS

K. M. Holtzer-Goor, M. R. Schaafsma, P. Joosten, E. F. M. Posthuma, S. Wittebol, P. C. Huijgens, E. J. M. Mattijssen, G. Vreugdenhil, H. Visser, W. G. Peters, Z. Erjavec, P. W. Wijermans, S. M. G. J. Daenen, K. G. van der Hem, M. H. J. van Oers, C. A. Uyl-de Groot

ABSTRACT

PurposeTo describe the health-related quality of life (HRQoL) of an unselected population of patients with chronic lymphocytic leukaemia (CLL) including untreated patients.MethodsHRQoL was measured by the EORTC QLQ-C30 including the CLL16 module, EQ-5D, and VAS in an observational study over multiple years. All HRQoL measurements per patient were connected and analysed using area under the curve analysis over the entire study duration. The total patient group was compared with the general population, and three groups of CLL patients were described separately, i.e. patients without any active treatment (“watch and wait”), chlorambucil treatment only, and patients with other treatment(s).ResultsHRQoL in the total group of CLL patients was compromised when compared with age- and gender-matched norm scores of the general population. CLL patients scored statistically worse on the VAS and utility score of the EQ-5D, all functioning scales of the EORTC QLQ-C30, and the symptoms of fatigue, dyspnoea, sleeping disturbance, appetite loss, and financial difficulties. In untreated patients, the HRQoL was slightly reduced. In all treatment stages, HRQoL was compromised considerably. Patients treated with chlorambucil only scored worse on the EORTC QLQ-C30 than patients who were treated with other treatments with regard to emotional functioning, cognitive functioning, bruises, uncomfortable stomach, and apathy.ConclusionsCLL patients differ most from the general population on role functioning, fatigue, concerns about future health, and having not enough energy. Once treatment is indicated, HRQoL becomes considerably compromised. This applies to all treatments, including chlorambucil, which is considered to be a mild treatment. More... »

PAGES

2895-2906

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11136-015-1039-y

DOI

http://dx.doi.org/10.1007/s11136-015-1039-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038210116

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26205768


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25 schema:description PurposeTo describe the health-related quality of life (HRQoL) of an unselected population of patients with chronic lymphocytic leukaemia (CLL) including untreated patients.MethodsHRQoL was measured by the EORTC QLQ-C30 including the CLL16 module, EQ-5D, and VAS in an observational study over multiple years. All HRQoL measurements per patient were connected and analysed using area under the curve analysis over the entire study duration. The total patient group was compared with the general population, and three groups of CLL patients were described separately, i.e. patients without any active treatment (“watch and wait”), chlorambucil treatment only, and patients with other treatment(s).ResultsHRQoL in the total group of CLL patients was compromised when compared with age- and gender-matched norm scores of the general population. CLL patients scored statistically worse on the VAS and utility score of the EQ-5D, all functioning scales of the EORTC QLQ-C30, and the symptoms of fatigue, dyspnoea, sleeping disturbance, appetite loss, and financial difficulties. In untreated patients, the HRQoL was slightly reduced. In all treatment stages, HRQoL was compromised considerably. Patients treated with chlorambucil only scored worse on the EORTC QLQ-C30 than patients who were treated with other treatments with regard to emotional functioning, cognitive functioning, bruises, uncomfortable stomach, and apathy.ConclusionsCLL patients differ most from the general population on role functioning, fatigue, concerns about future health, and having not enough energy. Once treatment is indicated, HRQoL becomes considerably compromised. This applies to all treatments, including chlorambucil, which is considered to be a mild treatment.
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31 schema:keywords CLL patients
32 EORTC QLQ-C30
33 EQ-5D
34 HRQOL measurement
35 HRQoL
36 MethodsHRQoL
37 Netherlands
38 PurposeTo
39 QLQ-C30
40 ResultsHRQOL
41 VA
42 VAS
43 active treatment
44 age
45 analysis
46 apathy
47 appetite loss
48 area
49 bruises
50 chlorambucil
51 chlorambucil treatment
52 chronic lymphocytic leukemia
53 cognitive functioning
54 concern
55 curve analysis
56 difficulties
57 disturbances
58 duration
59 dyspnoea
60 emotional functioning
61 energy
62 enough energy
63 entire study duration
64 fatigue
65 financial difficulties
66 functioning
67 future health
68 general population
69 group
70 health
71 health-related quality
72 leukemia
73 life
74 longitudinal multicentre study
75 loss
76 lymphocytic leukemia
77 measurements
78 mild treatment
79 module
80 multicentre study
81 multiple years
82 norm scores
83 observational study
84 patient group
85 patients
86 population
87 quality
88 quality of life
89 regard
90 results
91 role functioning
92 scale
93 scores
94 stage
95 stomach
96 study
97 study duration
98 symptoms
99 symptoms of fatigue
100 total group
101 total patient group
102 treatment
103 treatment stage
104 unselected population
105 untreated patients
106 utility scores
107 years
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