A meta-analysis of health state valuations for people with diabetes: explaining the variation across methods and implications for economic evaluation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-04-07

AUTHORS

Tom W. C. Lung, Alison J. Hayes, Andrew Hayen, Andrew Farmer, Philip M. Clarke

ABSTRACT

PurposeTo review published studies on the effect of diabetes and its complications on utility scores to establish whether there is systematic variation across studies and to examine the implications for the estimation of quality-adjusted life years (QALYs).MethodsA systematic review was performed using studies reporting QALY measures elicited from people with diabetes including those with a history of complications. Meta-analysis was used to obtain the average utility, and meta-regression was employed to examine the impact of study characteristics and elicitation methods on these values. The effect of different utility scores on QALYs was examined using diabetes simulation models.ResultsIn the meta-analysis based on 45 studies reporting 66 values, the average utility score was 0.76 (95% CI 0.75–0.77). A meta-regression showed significant variation due to age, method of elicitation and the proportion of males. The average utility score for individual complications ranged from 0.48 (95% CI 0.25, 0.71) for chronic renal disease to 0.75 (95% CI 0.73, 0.78) for myocardial infarction, and these differences produced meaningful changes in simulated QALYs. There was significant heterogeneity between studies.ConclusionsWe provide summary utility scores for diabetes and its major complications that could help inform economic evaluation and policy analysis. More... »

PAGES

1669-1678

References to SciGraph publications

  • 2003-04-11. What is the relationship between the minimally important difference and health state utility values? The case of the SF-6D in HEALTH AND QUALITY OF LIFE OUTCOMES
  • 2008-03. Preferences of Patients with Diabetes Mellitus for Inhaled versus Injectable Insulin Regimens in PHARMACOECONOMICS
  • 2009-11. Quality of Life in Glaucoma and Three Other Chronic Diseases in DRUGS & AGING
  • 2004-03. Construct validity of the RAND-12 and Health Utilities Index Mark 2 and 3 in type 2 diabetes in QUALITY OF LIFE RESEARCH
  • 2005-09. The economic and quality of life impact of hypoglycemia in THE EUROPEAN JOURNAL OF HEALTH ECONOMICS
  • 2006-04-29. Correlates of health-related quality of life in type 2 diabetes in DIABETOLOGIA
  • 2006-10-11. Patient-reported outcomes in a trial of exenatide and insulin glargine for the treatment of type 2 diabetes in HEALTH AND QUALITY OF LIFE OUTCOMES
  • 2006-03-16. Misinterpretation with norm-based scoring of health status in adults with type 1 diabetes in HEALTH AND QUALITY OF LIFE OUTCOMES
  • 2008-09-29. Utility values for symptomatic non-severe hypoglycaemia elicited from persons with and without diabetes in Canada and the United Kingdom in HEALTH AND QUALITY OF LIFE OUTCOMES
  • 2005-06-01. Health-related quality of life deficits associated with diabetes and comorbidities in a Canadian National Population Health Survey in QUALITY OF LIFE RESEARCH
  • 2008-09-23. A comparison of EQ-5D index scores using the UK, US, and Japan preference weights in a Thai sample with type 2 diabetes in HEALTH AND QUALITY OF LIFE OUTCOMES
  • 2004-12. Comparison of a single global item and an index of a multi-item health status measure among persons with and without diabetes in the US in QUALITY OF LIFE RESEARCH
  • 2003-12. Quality of life of patients with type I diabetes mellitus in QUALITY OF LIFE RESEARCH
  • 2002-12. Health State Preference Assessment in Diabetic Peripheral Neuropathy in PHARMACOECONOMICS
  • 2007-04-27. Which health-related quality of life score? A comparison of alternative utility measures in patients with Type 2 diabetes in the ADVANCE trial in HEALTH AND QUALITY OF LIFE OUTCOMES
  • 2007-07-19. Utilities and disutilities for type 2 diabetes treatment-related attributes in QUALITY OF LIFE RESEARCH
  • 2004-10-27. A model to estimate the lifetime health outcomes of patients with Type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS) Outcomes Model (UKPDS no. 68) in DIABETOLOGIA
  • 2008-09-08. The impact of obesity on diabetes, hyperlipidemia and hypertension in the United States in QUALITY OF LIFE RESEARCH
  • 2005-01-12. The impact of diabetes mellitus and other chronic medical conditions on health-related Quality of Life: Is the whole greater than the sum of its parts? in HEALTH AND QUALITY OF LIFE OUTCOMES
  • 2003-02. A Meta-Analysis of Quality-of-Life Estimates for Stroke in PHARMACOECONOMICS
  • 2003-10-16. The Health Utilities Index (HUI®): concepts, measurement properties and applications in HEALTH AND QUALITY OF LIFE OUTCOMES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11136-011-9902-y

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    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21472392


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    37 schema:description PurposeTo review published studies on the effect of diabetes and its complications on utility scores to establish whether there is systematic variation across studies and to examine the implications for the estimation of quality-adjusted life years (QALYs).MethodsA systematic review was performed using studies reporting QALY measures elicited from people with diabetes including those with a history of complications. Meta-analysis was used to obtain the average utility, and meta-regression was employed to examine the impact of study characteristics and elicitation methods on these values. The effect of different utility scores on QALYs was examined using diabetes simulation models.ResultsIn the meta-analysis based on 45 studies reporting 66 values, the average utility score was 0.76 (95% CI 0.75–0.77). A meta-regression showed significant variation due to age, method of elicitation and the proportion of males. The average utility score for individual complications ranged from 0.48 (95% CI 0.25, 0.71) for chronic renal disease to 0.75 (95% CI 0.73, 0.78) for myocardial infarction, and these differences produced meaningful changes in simulated QALYs. There was significant heterogeneity between studies.ConclusionsWe provide summary utility scores for diabetes and its major complications that could help inform economic evaluation and policy analysis.
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    45 Meta-Analysis
    46 MethodsA systematic review
    47 PurposeTo review
    48 QALY measures
    49 ResultsIn
    50 age
    51 analysis
    52 average utility
    53 average utility score
    54 changes
    55 characteristics
    56 chronic renal disease
    57 complications
    58 diabetes
    59 diabetes simulation model
    60 differences
    61 different utility scores
    62 disease
    63 economic evaluation
    64 effect
    65 effect of diabetes
    66 elicitation
    67 elicitation methods
    68 estimation
    69 evaluation
    70 health state valuations
    71 heterogeneity
    72 history
    73 history of complications
    74 impact
    75 implications
    76 individual complications
    77 infarction
    78 life years
    79 major complications
    80 males
    81 meaningful change
    82 measures
    83 method
    84 method of elicitation
    85 model
    86 myocardial infarction
    87 people
    88 policy analysis
    89 proportion
    90 proportion of males
    91 quality-adjusted life years
    92 renal disease
    93 review
    94 scores
    95 significant heterogeneity
    96 significant variation
    97 simulated QALYs
    98 simulation model
    99 state valuations
    100 study
    101 study characteristics
    102 summary utility scores
    103 systematic review
    104 systematic variation
    105 utility
    106 utility scores
    107 valuation
    108 values
    109 variation
    110 years
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