Health-related quality of life in HIV-1-infected patients on HAART: a five-years longitudinal analysis accounting for dropout in the APROCO-COPILOTE cohort ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-02-01

AUTHORS

Camelia Protopopescu, Fabienne Marcellin, Bruno Spire, Marie Préau, Renaud Verdon, Dominique Peyramond, François Raffi, Geneviève Chêne, Catherine Leport, Maria-Patrizia Carrieri

ABSTRACT

BackgroundThe long-term efficacy of Highly Active Antiretroviral Therapies (HAART) has enlightened the crucial role of health-related quality of life (HRQL) among HIV-infected patients. However, any analysis of such extensive longitudinal data necessitates a suitable handling of dropout which may correlate with patients–health status.MethodsWe analysed the HRQL evolution over 5 years for 1,000 patients initiating a protease inhibitor (PI)-containing therapy, using MOS SF-36 physical (PCS) and mental (MCS) scores. In parallel with a classical separate random effects model, we used a joint parameter-dependent selection model to account for non-ignorable dropout.ResultsHRQL evolved according to a two-phase pattern, characterized by an initial improvement during the year following HAART initiation and a relative stabilization thereafter. Immunodepression and self-reported side effects were found to be negative predictors of both PCS and MCS scores. Hepatitis C virus coinfection and AIDS clinical stage were found to affect physical HRQL. Results were not significantly altered when accounting for dropout.ConclusionSuch results, obtained on a large sample of HIV-infected patients with extensive follow-up, underline the need for a regular monitoring of patients–immunological status and for a better management of their experience with hepatitis C and HAART. More... »

PAGES

577

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11136-006-9151-7

DOI

http://dx.doi.org/10.1007/s11136-006-9151-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002282154

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17268929


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55 antiretroviral therapy
56 better management
57 clinical stage
58 cohort
59 coinfection
60 crucial role
61 data
62 dropout
63 effect
64 effects model
65 efficacy
66 evolution
67 experience
68 extensive longitudinal data
69 five-year longitudinal analysis
70 handling
71 health-related quality
72 hepatitis C
73 hepatitis C virus coinfection
74 immunodepression
75 improvement
76 inhibitors
77 initial improvement
78 initiation
79 large sample
80 life
81 long-term efficacy
82 longitudinal analysis
83 longitudinal data
84 management
85 mental scores
86 model
87 monitoring
88 need
89 negative predictor
90 non-ignorable dropout
91 parallel
92 patient's immunological status
93 patients
94 patients' health status
95 patterns
96 physical HRQL
97 predictors
98 protease inhibitors
99 quality
100 random-effects model
101 regular monitoring
102 relative stabilization
103 results
104 role
105 samples
106 scores
107 selection model
108 self-reported side effects
109 side effects
110 stabilization
111 stage
112 status
113 suitable handling
114 therapy
115 two-phase pattern
116 virus coinfection
117 years
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