The Edible Plant Crithmum maritimum Shows Nutraceutical Properties by Targeting Energy Metabolism in Hepatic Cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-07-14

AUTHORS

Davide Gnocchi, Carlo Sabbà, Antonio Mazzocca

ABSTRACT

In the past few years, evidence has supported the role of plants as a valuable tool for the development of promising therapeutic support options for many diseases, including cancer. We recently discovered that the edible wild plant Crithmum maritimum L. effectively inhibits the growth of hepatocellular carcinoma (HCC) cells and we provide insights into the biological mechanisms involved. Here, we aimed to characterize the effect of ethyl acetate extract of Crithmum maritimum on the bioenergetic phenotype of HCC cells and if this is associated with the anti-tumour effect we previously described. Results show that Crithmum maritimum significantly increases cellular respiration and reduces lactic fermentation in HCC cells, and that this reduction of the fermentative glycolytic phenotype is linked to inhibition of HCC growth. These data provide new preclinical evidence supporting the role of Crithmum maritimum L. as a nutraceutical option to expand the therapeutic opportunities in the management of HCC. More... »

PAGES

481-483

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11130-022-00986-z

DOI

http://dx.doi.org/10.1007/s11130-022-00986-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1149442589

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35831770


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