The Immunomodulating Effect of Phlorotannins from a Brown Alga, Eisenia nipponica, on Mice Stimulated with Ovalbumin through T Cell Regulation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-05-28

AUTHORS

Yoshimasa Sugiura, Yuta Matsuura, Hirotaka Katsuzaki, Makoto Kakinuma, Hideomi Amano, Masakatsu Usui, Ryusuke Tanaka, Teruo Matsushita, Masaaki Miyata

ABSTRACT

The immunomodulating effect of phlorotannin was investigated in mice stimulated by ovalbumin. When analyzing the main components of phlorotannin concentrate (PTC) from Eisenia nipponica, seven phlorotannins [eckol, 6,6′-bieckol, 6,8′-bieckol, 8,8′-bieckol, dieckol, phlorofucofuroeckol (PFF)-A, and PFF-B] were detected. These phlorotannins accounted for approximately 80% of PTC. Oral administration of PTC to mice daily for 21 days reduced serum immunoglobulin E (IgE) and total IgG1 levels attributable to Th2 cells. The production of splenic cytokines [interleukin (IL)-10 and transforming growth factor-β1] and Treg cell-mediated expression of forkhead box protein P3 mRNA were significantly increased whereas the production of inflammatory cytokines (interferon-γ, IL-4, IL-5, and IL-17) by Th1, Th2, and Th17 cells was markedly suppressed. IL-21 production and basic leucine zipper ATF-like transcription factor mRNA expression attributable to follicular helper T (Tfh) cells were also suppressed. Flow cytometric analyses demonstrated increased number of Treg cells despite a decrease in the total T cell population. An increase in total B cells was also observed by the flow cytometric analyses in addition to increases in IL-10 production, which activates B cells. In contrast, the significantly suppressed production of inflammatory cytokines and moderate increase in Treg cell subpopulation indicated a direct impact of PTC on inflammatory lymphocytes (Th1, Th2, Th17, and Tfh). Thus, PTC may exert antiallergic effects by immunomodulation of T cells and inactivation of inflammatory lymphocyte.Graphical abstract More... »

PAGES

307-316

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11130-022-00974-3

DOI

http://dx.doi.org/10.1007/s11130-022-00974-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1148241111

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35633415


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