Anti-Diabetic Potential of Chlorella Pyrenoidosa-Based Mixture and its Regulation of Gut Microbiota View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-06-03

AUTHORS

Wenyu Xiong, Jie Chen, Junqiang He, Meifang Xiao, Xiaoyu He, Bin Liu, Feng Zeng

ABSTRACT

The aim of the present study was to investigate the anti-diabetic effect of CGSGCG and its beneficial effects on gut microbiota in type 2 diabetes (T2D) mice induced by streptozotocin and high sucrose and high fat diet. The results showed that treatment with CGSGCG reduced fasting blood glucose, improved oral glucose tolerance test, protected the liver from injury, and reduced inflammation in T2D mice. The contents of acetic acid, propionic acid, butyric acid, isobutyric acid, valeric acid and isovaleric acid in CGSGCG group were 2.49-, 1.74-, 3.31-, 1.93-, 1.36- and 1.30-fold than that of the model group. Moreover, administration of CGSGCG up-regulated the expression of INSR/IRS-1/PI3K/AKT/GLUT4 and mTOR but down-regulated the P38MAPK expression. Furthermore, the abundance of beneficial bacteria such as Verrucomicrobia, Proteobacteria, Osillibacter, Dubosiella and Lactococcus in intestinal tract increased, indicating that CGSCGG regulated and improved the bacterial community structure of T2D mice, which were closely related to glycometabolism.Graphical abstract More... »

PAGES

292-298

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11130-022-00968-1

DOI

http://dx.doi.org/10.1007/s11130-022-00968-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1148409210

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35657501


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