Measurement Methods of BDNF Levels in Major Depression: A Qualitative Systematic Review of Clinical Trials View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-12

AUTHORS

Stefania Pigatto Teche, Gabriela Lotin Nuernberg, Anne Orgler Sordi, Lívia Hartmann de Souza, Lysa Remy, Keila Maria Mendes Ceresér, Neusa Sica Rocha

ABSTRACT

There is evidence that the brain-derived neurotrophic factor (BDNF) has implications for the pathophysiology of major depressive disorders (MDD). Measures of BDNF levels are highly dependent on the methodologies used and these vary among different studies. Therefore, the aim of this study was to carry out a descriptive analysis of the methodologies used to measure BDNF in clinical trials (CT) in patients with the diagnosis of major depression. We conducted a qualitative systematic review of CT that included samples of subjects diagnosed with major depression and evaluated the BDNF levels as an outcome. The search was performed on Pubmed, Scielo, Psychinfo and Lilacs. The selected articles were analyzed according to the CONSORT Statement and their methods of BDNF collection and analysis were described. Twenty-eight studies were included in the final analysis. Of those, 6 trials (21.4%) involved non-pharmacological interventions and only half had the MDD diagnosis based on structured interview. Trials used different methods to evaluate BDNF levels: most of them verified serum BDNF levels, 17 (60.7%) trials mentioned that measured BDNF levels in duplicate and 9 (32.1%) collected blood in fasting. A variety of methods for BDNF collection and analysis was used in the different studies, making it difficult to compare results. However, despite of the methodology, BDNF seems to increase after treatment for major depression. More... »

PAGES

485-497

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11126-013-9261-7

DOI

http://dx.doi.org/10.1007/s11126-013-9261-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046000034

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23564563


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antidepressive Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain-Derived Neurotrophic Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clinical Trials as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Depressive Disorder, Major", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Qualitative Research", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reagent Kits, Diagnostic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Specimen Handling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Federal University of Rio Grande do Sul", 
          "id": "https://www.grid.ac/institutes/grid.8532.c", 
          "name": [
            "UFRGS, Porto Alegre, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Teche", 
        "givenName": "Stefania Pigatto", 
        "id": "sg:person.0776502172.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776502172.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Rio Grande do Sul", 
          "id": "https://www.grid.ac/institutes/grid.8532.c", 
          "name": [
            "UFRGS, Porto Alegre, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nuernberg", 
        "givenName": "Gabriela Lotin", 
        "id": "sg:person.01002062265.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002062265.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Rio Grande do Sul", 
          "id": "https://www.grid.ac/institutes/grid.8532.c", 
          "name": [
            "UFRGS, Porto Alegre, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sordi", 
        "givenName": "Anne Orgler", 
        "id": "sg:person.01364021655.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364021655.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Rio Grande do Sul", 
          "id": "https://www.grid.ac/institutes/grid.8532.c", 
          "name": [
            "UFRGS, Porto Alegre, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Souza", 
        "givenName": "L\u00edvia Hartmann", 
        "id": "sg:person.0603141600.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603141600.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Rio Grande do Sul", 
          "id": "https://www.grid.ac/institutes/grid.8532.c", 
          "name": [
            "UFRGS, Porto Alegre, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Remy", 
        "givenName": "Lysa", 
        "id": "sg:person.0706530755.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706530755.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Rio Grande do Sul", 
          "id": "https://www.grid.ac/institutes/grid.8532.c", 
          "name": [
            "UFRGS, Porto Alegre, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ceres\u00e9r", 
        "givenName": "Keila Maria Mendes", 
        "id": "sg:person.01265523077.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265523077.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Federal University of Rio Grande do Sul", 
          "id": "https://www.grid.ac/institutes/grid.8532.c", 
          "name": [
            "UFRGS, Porto Alegre, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rocha", 
        "givenName": "Neusa Sica", 
        "id": "sg:person.01106551554.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106551554.80"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00213-011-2180-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000431853", 
          "https://doi.org/10.1007/s00213-011-2180-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pnpbp.2006.03.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006521859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(95)01321-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007387183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/prep.1995.1062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008075499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1100135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008540305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jad.2007.05.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009335079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00406-005-0578-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010626924", 
          "https://doi.org/10.1007/s00406-005-0578-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00406-005-0578-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010626924", 
          "https://doi.org/10.1007/s00406-005-0578-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/s0103-507x2008000400015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011380533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jad.2005.12.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011819726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000321804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012930584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pnpbp.2007.03.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016218051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.286.19.2391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017140615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.psychres.2011.04.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018990522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.psychres.2008.06.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019338528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0269881109105457", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019454331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0269881109105457", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019454331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpsychires.2008.03.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020507411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2008.05.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020534397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1819.2010.02074.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021591403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1819.2010.02074.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021591403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpsychires.2007.05.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022833342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainresbull.2007.03.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024274155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.5123-04.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026615020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029321786", 
          "https://doi.org/10.1038/nn1510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029321786", 
          "https://doi.org/10.1038/nn1510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029321786", 
          "https://doi.org/10.1038/nn1510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1681.2008.05077.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030044081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000149817", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030863385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainresbull.2009.06.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032583731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.euroneuro.2006.04.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032689248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pnpbp.2009.03.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033012668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hup.979", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033035585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archpsyc.1994.03950010008002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033696748"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0269881109106899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034600740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0269881109106899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034600740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3566-09.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034655080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/npp.2008.208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036759990", 
          "https://doi.org/10.1038/npp.2008.208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pnpbp.2008.11.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041454046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archpsyc.1993.01820140007001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043130775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pnpbp.2004.11.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044187693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/yct.0b013e3181c18bbf", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046681838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/yct.0b013e3181c18bbf", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046681838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/yct.0b013e3181c18bbf", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046681838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/15622971003611319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049860392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pnpbp.2010.08.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050678733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00213-006-0399-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051019920", 
          "https://doi.org/10.1007/s00213-006-0399-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00213-006-0399-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051019920", 
          "https://doi.org/10.1007/s00213-006-0399-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s1461145708009309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054933309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2006-931542", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057457290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2007-1004594", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057479084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.274.5288.740", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062554657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4088/jcp.08m04659", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072204387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.10-11-03469.1990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078512881"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-12", 
    "datePublishedReg": "2013-12-01", 
    "description": "There is evidence that the brain-derived neurotrophic factor (BDNF) has implications for the pathophysiology of major depressive disorders (MDD). Measures of BDNF levels are highly dependent on the methodologies used and these vary among different studies. Therefore, the aim of this study was to carry out a descriptive analysis of the methodologies used to measure BDNF in clinical trials (CT) in patients with the diagnosis of major depression. We conducted a qualitative systematic review of CT that included samples of subjects diagnosed with major depression and evaluated the BDNF levels as an outcome. The search was performed on Pubmed, Scielo, Psychinfo and Lilacs. The selected articles were analyzed according to the CONSORT Statement and their methods of BDNF collection and analysis were described. Twenty-eight studies were included in the final analysis. Of those, 6 trials (21.4%) involved non-pharmacological interventions and only half had the MDD diagnosis based on structured interview. Trials used different methods to evaluate BDNF levels: most of them verified serum BDNF levels, 17 (60.7%) trials mentioned that measured BDNF levels in duplicate and 9 (32.1%) collected blood in fasting. A variety of methods for BDNF collection and analysis was used in the different studies, making it difficult to compare results. However, despite of the methodology, BDNF seems to increase after treatment for major depression.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11126-013-9261-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1017895", 
        "issn": [
          "0033-2720", 
          "1573-6709"
        ], 
        "name": "Psychiatric Quarterly", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "84"
      }
    ], 
    "name": "Measurement Methods of BDNF Levels in Major Depression: A Qualitative Systematic Review of Clinical Trials", 
    "pagination": "485-497", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "db1e34a84c64d68547bc0d04861cacd2db9c92357c432185aef246be59ac84d6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23564563"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0376465"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11126-013-9261-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1046000034"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11126-013-9261-7", 
      "https://app.dimensions.ai/details/publication/pub.1046000034"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:10", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000524.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11126-013-9261-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11126-013-9261-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11126-013-9261-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11126-013-9261-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11126-013-9261-7'


 

This table displays all metadata directly associated to this object as RDF triples.

291 TRIPLES      21 PREDICATES      84 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11126-013-9261-7 schema:about N466db0800fd54b09a9413ebe1d3075a8
2 N5c197efab2e642489ad2e8ce44a284b6
3 N6997ec8cb0774d55afbaffcefb14e447
4 N73a4f6397d014bcd83652968b9371c60
5 Na2227afcaa20425a9bc68d55f6e745d7
6 Nbcec935b88274e2aa02afe597bb7ead4
7 Nc14e3b728a38438891f356a657039332
8 Nc59b16f9349c4a818a3d496365bd352c
9 Nce300e0ec12f49cb963a3abe9f0fc1a8
10 Nf8b5d04ac114487d97d3278c72568f47
11 anzsrc-for:11
12 anzsrc-for:1103
13 schema:author N4499adc3d98449f28f5b6d4331a7c449
14 schema:citation sg:pub.10.1007/s00213-006-0399-y
15 sg:pub.10.1007/s00213-011-2180-0
16 sg:pub.10.1007/s00406-005-0578-6
17 sg:pub.10.1038/nn1510
18 sg:pub.10.1038/npp.2008.208
19 https://doi.org/10.1001/archpsyc.1993.01820140007001
20 https://doi.org/10.1001/archpsyc.1994.03950010008002
21 https://doi.org/10.1001/jama.286.19.2391
22 https://doi.org/10.1002/hup.979
23 https://doi.org/10.1006/prep.1995.1062
24 https://doi.org/10.1016/0006-8993(95)01321-0
25 https://doi.org/10.1016/j.biopsych.2008.05.005
26 https://doi.org/10.1016/j.brainresbull.2007.03.009
27 https://doi.org/10.1016/j.brainresbull.2009.06.016
28 https://doi.org/10.1016/j.euroneuro.2006.04.010
29 https://doi.org/10.1016/j.jad.2005.12.029
30 https://doi.org/10.1016/j.jad.2007.05.005
31 https://doi.org/10.1016/j.jpsychires.2007.05.007
32 https://doi.org/10.1016/j.jpsychires.2008.03.014
33 https://doi.org/10.1016/j.pnpbp.2004.11.009
34 https://doi.org/10.1016/j.pnpbp.2006.03.025
35 https://doi.org/10.1016/j.pnpbp.2007.03.001
36 https://doi.org/10.1016/j.pnpbp.2008.11.016
37 https://doi.org/10.1016/j.pnpbp.2009.03.020
38 https://doi.org/10.1016/j.pnpbp.2010.08.011
39 https://doi.org/10.1016/j.psychres.2008.06.030
40 https://doi.org/10.1016/j.psychres.2011.04.032
41 https://doi.org/10.1017/s1461145708009309
42 https://doi.org/10.1055/s-2006-931542
43 https://doi.org/10.1055/s-2007-1004594
44 https://doi.org/10.1097/yct.0b013e3181c18bbf
45 https://doi.org/10.1111/j.1440-1681.2008.05077.x
46 https://doi.org/10.1111/j.1440-1819.2010.02074.x
47 https://doi.org/10.1126/science.1100135
48 https://doi.org/10.1126/science.274.5288.740
49 https://doi.org/10.1159/000149817
50 https://doi.org/10.1159/000321804
51 https://doi.org/10.1177/0269881109105457
52 https://doi.org/10.1177/0269881109106899
53 https://doi.org/10.1523/jneurosci.10-11-03469.1990
54 https://doi.org/10.1523/jneurosci.3566-09.2009
55 https://doi.org/10.1523/jneurosci.5123-04.2005
56 https://doi.org/10.1590/s0103-507x2008000400015
57 https://doi.org/10.3109/15622971003611319
58 https://doi.org/10.4088/jcp.08m04659
59 schema:datePublished 2013-12
60 schema:datePublishedReg 2013-12-01
61 schema:description There is evidence that the brain-derived neurotrophic factor (BDNF) has implications for the pathophysiology of major depressive disorders (MDD). Measures of BDNF levels are highly dependent on the methodologies used and these vary among different studies. Therefore, the aim of this study was to carry out a descriptive analysis of the methodologies used to measure BDNF in clinical trials (CT) in patients with the diagnosis of major depression. We conducted a qualitative systematic review of CT that included samples of subjects diagnosed with major depression and evaluated the BDNF levels as an outcome. The search was performed on Pubmed, Scielo, Psychinfo and Lilacs. The selected articles were analyzed according to the CONSORT Statement and their methods of BDNF collection and analysis were described. Twenty-eight studies were included in the final analysis. Of those, 6 trials (21.4%) involved non-pharmacological interventions and only half had the MDD diagnosis based on structured interview. Trials used different methods to evaluate BDNF levels: most of them verified serum BDNF levels, 17 (60.7%) trials mentioned that measured BDNF levels in duplicate and 9 (32.1%) collected blood in fasting. A variety of methods for BDNF collection and analysis was used in the different studies, making it difficult to compare results. However, despite of the methodology, BDNF seems to increase after treatment for major depression.
62 schema:genre research_article
63 schema:inLanguage en
64 schema:isAccessibleForFree false
65 schema:isPartOf N5679ae7af1374a559f4293a266d5dc6f
66 N71d44ad2bc27499f8a4ed293adf84c94
67 sg:journal.1017895
68 schema:name Measurement Methods of BDNF Levels in Major Depression: A Qualitative Systematic Review of Clinical Trials
69 schema:pagination 485-497
70 schema:productId N8247243421e04130aa492eb5b43ac7c3
71 N88346a56d3144673900e645959d99dfc
72 Nc4e186df10ec424a863eb1362e3b0ceb
73 Ncaeaf7a877f246c683311d7fa86791bd
74 Ne810fb5136d24e96b0edf7feda54bdd5
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046000034
76 https://doi.org/10.1007/s11126-013-9261-7
77 schema:sdDatePublished 2019-04-11T01:10
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher N9300daa0dadd4023aaadac217027c924
80 schema:url http://link.springer.com/10.1007%2Fs11126-013-9261-7
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N0f21dd006fc249a296ead7b210cb8a7f rdf:first sg:person.01364021655.69
85 rdf:rest Nb9c14f68125b4fc180ab85a27f567c62
86 N3c59995698c54775a1007df43edc1863 rdf:first sg:person.0706530755.19
87 rdf:rest N9c71bc5721284acb8125751e9ba629e7
88 N4499adc3d98449f28f5b6d4331a7c449 rdf:first sg:person.0776502172.19
89 rdf:rest N71bfb7029c4e49a1a7039ebb96a6ac65
90 N466db0800fd54b09a9413ebe1d3075a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Brain-Derived Neurotrophic Factor
92 rdf:type schema:DefinedTerm
93 N5679ae7af1374a559f4293a266d5dc6f schema:volumeNumber 84
94 rdf:type schema:PublicationVolume
95 N5c197efab2e642489ad2e8ce44a284b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Qualitative Research
97 rdf:type schema:DefinedTerm
98 N6997ec8cb0774d55afbaffcefb14e447 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Treatment Outcome
100 rdf:type schema:DefinedTerm
101 N6e019c1689f34d65abab8eadd0dc4a49 rdf:first sg:person.01106551554.80
102 rdf:rest rdf:nil
103 N71bfb7029c4e49a1a7039ebb96a6ac65 rdf:first sg:person.01002062265.46
104 rdf:rest N0f21dd006fc249a296ead7b210cb8a7f
105 N71d44ad2bc27499f8a4ed293adf84c94 schema:issueNumber 4
106 rdf:type schema:PublicationIssue
107 N73a4f6397d014bcd83652968b9371c60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Humans
109 rdf:type schema:DefinedTerm
110 N8247243421e04130aa492eb5b43ac7c3 schema:name readcube_id
111 schema:value db1e34a84c64d68547bc0d04861cacd2db9c92357c432185aef246be59ac84d6
112 rdf:type schema:PropertyValue
113 N88346a56d3144673900e645959d99dfc schema:name dimensions_id
114 schema:value pub.1046000034
115 rdf:type schema:PropertyValue
116 N9300daa0dadd4023aaadac217027c924 schema:name Springer Nature - SN SciGraph project
117 rdf:type schema:Organization
118 N9c71bc5721284acb8125751e9ba629e7 rdf:first sg:person.01265523077.03
119 rdf:rest N6e019c1689f34d65abab8eadd0dc4a49
120 Na2227afcaa20425a9bc68d55f6e745d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Specimen Handling
122 rdf:type schema:DefinedTerm
123 Nb9c14f68125b4fc180ab85a27f567c62 rdf:first sg:person.0603141600.03
124 rdf:rest N3c59995698c54775a1007df43edc1863
125 Nbcec935b88274e2aa02afe597bb7ead4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Reagent Kits, Diagnostic
127 rdf:type schema:DefinedTerm
128 Nc14e3b728a38438891f356a657039332 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Clinical Trials as Topic
130 rdf:type schema:DefinedTerm
131 Nc4e186df10ec424a863eb1362e3b0ceb schema:name nlm_unique_id
132 schema:value 0376465
133 rdf:type schema:PropertyValue
134 Nc59b16f9349c4a818a3d496365bd352c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Depressive Disorder, Major
136 rdf:type schema:DefinedTerm
137 Ncaeaf7a877f246c683311d7fa86791bd schema:name pubmed_id
138 schema:value 23564563
139 rdf:type schema:PropertyValue
140 Nce300e0ec12f49cb963a3abe9f0fc1a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Antidepressive Agents
142 rdf:type schema:DefinedTerm
143 Ne810fb5136d24e96b0edf7feda54bdd5 schema:name doi
144 schema:value 10.1007/s11126-013-9261-7
145 rdf:type schema:PropertyValue
146 Nf8b5d04ac114487d97d3278c72568f47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Biomarkers
148 rdf:type schema:DefinedTerm
149 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
150 schema:name Medical and Health Sciences
151 rdf:type schema:DefinedTerm
152 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
153 schema:name Clinical Sciences
154 rdf:type schema:DefinedTerm
155 sg:journal.1017895 schema:issn 0033-2720
156 1573-6709
157 schema:name Psychiatric Quarterly
158 rdf:type schema:Periodical
159 sg:person.01002062265.46 schema:affiliation https://www.grid.ac/institutes/grid.8532.c
160 schema:familyName Nuernberg
161 schema:givenName Gabriela Lotin
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002062265.46
163 rdf:type schema:Person
164 sg:person.01106551554.80 schema:affiliation https://www.grid.ac/institutes/grid.8532.c
165 schema:familyName Rocha
166 schema:givenName Neusa Sica
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106551554.80
168 rdf:type schema:Person
169 sg:person.01265523077.03 schema:affiliation https://www.grid.ac/institutes/grid.8532.c
170 schema:familyName Ceresér
171 schema:givenName Keila Maria Mendes
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265523077.03
173 rdf:type schema:Person
174 sg:person.01364021655.69 schema:affiliation https://www.grid.ac/institutes/grid.8532.c
175 schema:familyName Sordi
176 schema:givenName Anne Orgler
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364021655.69
178 rdf:type schema:Person
179 sg:person.0603141600.03 schema:affiliation https://www.grid.ac/institutes/grid.8532.c
180 schema:familyName de Souza
181 schema:givenName Lívia Hartmann
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603141600.03
183 rdf:type schema:Person
184 sg:person.0706530755.19 schema:affiliation https://www.grid.ac/institutes/grid.8532.c
185 schema:familyName Remy
186 schema:givenName Lysa
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706530755.19
188 rdf:type schema:Person
189 sg:person.0776502172.19 schema:affiliation https://www.grid.ac/institutes/grid.8532.c
190 schema:familyName Teche
191 schema:givenName Stefania Pigatto
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776502172.19
193 rdf:type schema:Person
194 sg:pub.10.1007/s00213-006-0399-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1051019920
195 https://doi.org/10.1007/s00213-006-0399-y
196 rdf:type schema:CreativeWork
197 sg:pub.10.1007/s00213-011-2180-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000431853
198 https://doi.org/10.1007/s00213-011-2180-0
199 rdf:type schema:CreativeWork
200 sg:pub.10.1007/s00406-005-0578-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010626924
201 https://doi.org/10.1007/s00406-005-0578-6
202 rdf:type schema:CreativeWork
203 sg:pub.10.1038/nn1510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029321786
204 https://doi.org/10.1038/nn1510
205 rdf:type schema:CreativeWork
206 sg:pub.10.1038/npp.2008.208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036759990
207 https://doi.org/10.1038/npp.2008.208
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1001/archpsyc.1993.01820140007001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043130775
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1001/archpsyc.1994.03950010008002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033696748
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1001/jama.286.19.2391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017140615
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1002/hup.979 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033035585
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1006/prep.1995.1062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008075499
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/0006-8993(95)01321-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007387183
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.biopsych.2008.05.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020534397
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.brainresbull.2007.03.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024274155
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/j.brainresbull.2009.06.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032583731
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/j.euroneuro.2006.04.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032689248
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/j.jad.2005.12.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011819726
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/j.jad.2007.05.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009335079
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/j.jpsychires.2007.05.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022833342
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/j.jpsychires.2008.03.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020507411
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/j.pnpbp.2004.11.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044187693
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/j.pnpbp.2006.03.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006521859
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/j.pnpbp.2007.03.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016218051
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/j.pnpbp.2008.11.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041454046
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/j.pnpbp.2009.03.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033012668
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/j.pnpbp.2010.08.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050678733
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/j.psychres.2008.06.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019338528
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/j.psychres.2011.04.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018990522
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1017/s1461145708009309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054933309
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1055/s-2006-931542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057457290
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1055/s-2007-1004594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057479084
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1097/yct.0b013e3181c18bbf schema:sameAs https://app.dimensions.ai/details/publication/pub.1046681838
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1111/j.1440-1681.2008.05077.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030044081
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1111/j.1440-1819.2010.02074.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021591403
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1126/science.1100135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008540305
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1126/science.274.5288.740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062554657
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1159/000149817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030863385
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1159/000321804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012930584
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1177/0269881109105457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019454331
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1177/0269881109106899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034600740
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1523/jneurosci.10-11-03469.1990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078512881
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1523/jneurosci.3566-09.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034655080
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1523/jneurosci.5123-04.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026615020
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1590/s0103-507x2008000400015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011380533
284 rdf:type schema:CreativeWork
285 https://doi.org/10.3109/15622971003611319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049860392
286 rdf:type schema:CreativeWork
287 https://doi.org/10.4088/jcp.08m04659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072204387
288 rdf:type schema:CreativeWork
289 https://www.grid.ac/institutes/grid.8532.c schema:alternateName Federal University of Rio Grande do Sul
290 schema:name UFRGS, Porto Alegre, Brazil
291 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...