Possible role of a radiation-induced p53 mutation in a Nelson’s syndrome patient with a fatal outcome View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-12

AUTHORS

Emilia Modolo Pinto, Sheila A. C. Siqueira, Priscilla Cukier, Maria C. B. V. Fragoso, Chin Jia Lin, Berenice Bilharinho de Mendonca

ABSTRACT

Nelson's syndrome (NS) is characterized by the appearance and/or progression of ACTH-secreting pituitary macroadenomas in patients who had previously undergone bilateral adrenalectomy for the treatment of Cushing's disease. Such corticotroph macroadenomas respond poorly to currently available therapeutic options which include surgery, radiotherapy and chemotherapy. P53 protein accumulation may be detected by immunohistochemistry in pituitary corticotroph adenomas and it has been suggested that it might be causally related to tumor development. Wild type P53 protein plays an important role in the cellular response to ionizing radiation and other DNA damaging agents and is mutated in many human tumors. In this study we report an adult male patient with NS who underwent both transsphenoidal and transcranial pituitary surgeries, conventional and stereotaxic radiotherapy and brachytherapy. Despite of the efforts to control tumor mass and growth, this macroadenoma displayed relentless growth and aggressive behavior. DNA extracted from the first two surgical samples, as well as DNA from peripheral blood leukocytes disclosed normal p53 sequence. DNA extracted from tumor samples obtained at surgeries performed after pituitary irradiation carried a somatic heterozygous mutation, consisting of a deletion of four cytosines between nucleotides 12,144-12,149 in exon 4 of the p53 gene. This frameshift mutation creates a stop codon in exon 4 excluding the expression of a functional protein from the defective allele. These data demonstrate a possible association between the P53 protein loss of function induced by radiotherapy and the aggressive course of the disease in this patient. More... »

PAGES

400-404

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11102-009-0194-y

DOI

http://dx.doi.org/10.1007/s11102-009-0194-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032575939

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19655257


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ACTH-Secreting Pituitary Adenoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Mutational Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fatal Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, p53", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nelson Syndrome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pituitary Irradiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiation Effects", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Sao Paulo", 
          "id": "https://www.grid.ac/institutes/grid.11899.38", 
          "name": [
            "Unidade de Endocrinologia do Desenvolvimento, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular LIM/42, Disciplina de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil", 
            "Laborat\u00f3rio de Patologia Molecular, LIM22, Departamento de Patologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, Av. Dr. Arnaldo, 455, sala 1144, 01246-903, S\u00e3o Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pinto", 
        "givenName": "Emilia Modolo", 
        "id": "sg:person.01234624673.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234624673.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo", 
          "id": "https://www.grid.ac/institutes/grid.411074.7", 
          "name": [
            "Divis\u00e3o de Anatomia Patol\u00f3gica, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Siqueira", 
        "givenName": "Sheila A. C.", 
        "id": "sg:person.01306322204.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306322204.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo", 
          "id": "https://www.grid.ac/institutes/grid.411074.7", 
          "name": [
            "Unidade de Endocrinologia do Desenvolvimento, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular LIM/42, Disciplina de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cukier", 
        "givenName": "Priscilla", 
        "id": "sg:person.014336506137.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014336506137.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo", 
          "id": "https://www.grid.ac/institutes/grid.411074.7", 
          "name": [
            "Unidade de Endocrinologia do Desenvolvimento, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular LIM/42, Disciplina de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fragoso", 
        "givenName": "Maria C. B. V.", 
        "id": "sg:person.01106140077.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106140077.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sao Paulo", 
          "id": "https://www.grid.ac/institutes/grid.11899.38", 
          "name": [
            "Laborat\u00f3rio de Patologia Molecular, LIM22, Departamento de Patologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo, Av. Dr. Arnaldo, 455, sala 1144, 01246-903, S\u00e3o Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Chin Jia", 
        "id": "sg:person.01354420330.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354420330.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo", 
          "id": "https://www.grid.ac/institutes/grid.411074.7", 
          "name": [
            "Unidade de Endocrinologia do Desenvolvimento, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular LIM/42, Disciplina de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Mendonca", 
        "givenName": "Berenice Bilharinho", 
        "id": "sg:person.01267677327.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267677327.91"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1365-2265.1994.tb02797.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009970741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/s0004-27302007000800026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021721545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35042675", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023763406", 
          "https://doi.org/10.1038/35042675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35042675", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023763406", 
          "https://doi.org/10.1038/35042675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rstb.1994.0106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027721673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2265.2008.03404.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034889423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/s0100-879x2002000500008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035438039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1507/endocrj1954.39.177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035676081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03347568", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036664013", 
          "https://doi.org/10.1007/bf03347568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2265.1995.tb02697.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037778489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2265.1998.00578.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046010636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1009929704018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050905302", 
          "https://doi.org/10.1023/a:1009929704018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2006-1328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064289419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.80.2.4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064298036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.81.1.124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064298447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem.81.1.8550738", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064319743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078912673", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-12", 
    "datePublishedReg": "2011-12-01", 
    "description": "Nelson's syndrome (NS) is characterized by the appearance and/or progression of ACTH-secreting pituitary macroadenomas in patients who had previously undergone bilateral adrenalectomy for the treatment of Cushing's disease. Such corticotroph macroadenomas respond poorly to currently available therapeutic options which include surgery, radiotherapy and chemotherapy. P53 protein accumulation may be detected by immunohistochemistry in pituitary corticotroph adenomas and it has been suggested that it might be causally related to tumor development. Wild type P53 protein plays an important role in the cellular response to ionizing radiation and other DNA damaging agents and is mutated in many human tumors. In this study we report an adult male patient with NS who underwent both transsphenoidal and transcranial pituitary surgeries, conventional and stereotaxic radiotherapy and brachytherapy. Despite of the efforts to control tumor mass and growth, this macroadenoma displayed relentless growth and aggressive behavior. DNA extracted from the first two surgical samples, as well as DNA from peripheral blood leukocytes disclosed normal p53 sequence. DNA extracted from tumor samples obtained at surgeries performed after pituitary irradiation carried a somatic heterozygous mutation, consisting of a deletion of four cytosines between nucleotides 12,144-12,149 in exon 4 of the p53 gene. This frameshift mutation creates a stop codon in exon 4 excluding the expression of a functional protein from the defective allele. These data demonstrate a possible association between the P53 protein loss of function induced by radiotherapy and the aggressive course of the disease in this patient.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11102-009-0194-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1119029", 
        "issn": [
          "1386-341X", 
          "1573-7403"
        ], 
        "name": "Pituitary", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "Possible role of a radiation-induced p53 mutation in a Nelson\u2019s syndrome patient with a fatal outcome", 
    "pagination": "400-404", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9b30624940f4ac30ef56ca1c331e261f2d5a39f256eddb4942e5d46f6a6b9ff5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19655257"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9814578"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11102-009-0194-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032575939"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11102-009-0194-y", 
      "https://app.dimensions.ai/details/publication/pub.1032575939"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000522.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11102-009-0194-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11102-009-0194-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11102-009-0194-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11102-009-0194-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11102-009-0194-y'


 

This table displays all metadata directly associated to this object as RDF triples.

211 TRIPLES      21 PREDICATES      58 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11102-009-0194-y schema:about N097e825a21c14a02adf74b3e09fe15d0
2 N17d72e8365c14985be5051404db9958c
3 N3923809867794f6da790a68ac9bcc31e
4 N5b002638866c42468a15b78069955591
5 N605afe4d4eec4752a07c64e5a2daef3a
6 N6726c9c4f2d342cabb11f4f31d3d24e2
7 Na379d918aaaf46098218e26d2ce920d0
8 Nab93080206c1492ca1f8e542708fcd19
9 Nb09381a47d6241388179487c9b052f64
10 Nb7916dad22bb47009dd5c713c355295a
11 Ne87d7fee343546b4bec54f140ad8bcd4
12 Nf287229b0b7f44f29356fb2956a01576
13 Nf68eca1a62dc45d6aa35a5efd23ddf7f
14 anzsrc-for:11
15 anzsrc-for:1112
16 schema:author N26dc24e7b07c4d7da297f96b5027b900
17 schema:citation sg:pub.10.1007/bf03347568
18 sg:pub.10.1023/a:1009929704018
19 sg:pub.10.1038/35042675
20 https://app.dimensions.ai/details/publication/pub.1078912673
21 https://doi.org/10.1046/j.1365-2265.1998.00578.x
22 https://doi.org/10.1098/rstb.1994.0106
23 https://doi.org/10.1111/j.1365-2265.1994.tb02797.x
24 https://doi.org/10.1111/j.1365-2265.1995.tb02697.x
25 https://doi.org/10.1111/j.1365-2265.2008.03404.x
26 https://doi.org/10.1210/jc.2006-1328
27 https://doi.org/10.1210/jc.80.2.4
28 https://doi.org/10.1210/jc.81.1.124
29 https://doi.org/10.1210/jcem.81.1.8550738
30 https://doi.org/10.1507/endocrj1954.39.177
31 https://doi.org/10.1590/s0004-27302007000800026
32 https://doi.org/10.1590/s0100-879x2002000500008
33 schema:datePublished 2011-12
34 schema:datePublishedReg 2011-12-01
35 schema:description Nelson's syndrome (NS) is characterized by the appearance and/or progression of ACTH-secreting pituitary macroadenomas in patients who had previously undergone bilateral adrenalectomy for the treatment of Cushing's disease. Such corticotroph macroadenomas respond poorly to currently available therapeutic options which include surgery, radiotherapy and chemotherapy. P53 protein accumulation may be detected by immunohistochemistry in pituitary corticotroph adenomas and it has been suggested that it might be causally related to tumor development. Wild type P53 protein plays an important role in the cellular response to ionizing radiation and other DNA damaging agents and is mutated in many human tumors. In this study we report an adult male patient with NS who underwent both transsphenoidal and transcranial pituitary surgeries, conventional and stereotaxic radiotherapy and brachytherapy. Despite of the efforts to control tumor mass and growth, this macroadenoma displayed relentless growth and aggressive behavior. DNA extracted from the first two surgical samples, as well as DNA from peripheral blood leukocytes disclosed normal p53 sequence. DNA extracted from tumor samples obtained at surgeries performed after pituitary irradiation carried a somatic heterozygous mutation, consisting of a deletion of four cytosines between nucleotides 12,144-12,149 in exon 4 of the p53 gene. This frameshift mutation creates a stop codon in exon 4 excluding the expression of a functional protein from the defective allele. These data demonstrate a possible association between the P53 protein loss of function induced by radiotherapy and the aggressive course of the disease in this patient.
36 schema:genre research_article
37 schema:inLanguage en
38 schema:isAccessibleForFree false
39 schema:isPartOf N7ea9bbc6f6f846a1a1ab5de57b94b230
40 Na8a290e90c8b4ca58182c9175b6681a1
41 sg:journal.1119029
42 schema:name Possible role of a radiation-induced p53 mutation in a Nelson’s syndrome patient with a fatal outcome
43 schema:pagination 400-404
44 schema:productId N2ddf99db7c9a40d88bca7c63aca72615
45 N436cc0bd306045268041ed942191068e
46 N51093eef5e3047f4bc46e6bc8ad32a77
47 Nbfe69623186141ffb176531b9018896a
48 Nc11efd1af08e4e318e68f96f81f55558
49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032575939
50 https://doi.org/10.1007/s11102-009-0194-y
51 schema:sdDatePublished 2019-04-10T23:27
52 schema:sdLicense https://scigraph.springernature.com/explorer/license/
53 schema:sdPublisher N38b31d519fa04a96859e7f473e88090d
54 schema:url http://link.springer.com/10.1007%2Fs11102-009-0194-y
55 sgo:license sg:explorer/license/
56 sgo:sdDataset articles
57 rdf:type schema:ScholarlyArticle
58 N097e825a21c14a02adf74b3e09fe15d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
59 schema:name Male
60 rdf:type schema:DefinedTerm
61 N17d72e8365c14985be5051404db9958c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
62 schema:name Fatal Outcome
63 rdf:type schema:DefinedTerm
64 N26dc24e7b07c4d7da297f96b5027b900 rdf:first sg:person.01234624673.27
65 rdf:rest Nf5e981dbb15845cb93d053bc6d460dc7
66 N2ddf99db7c9a40d88bca7c63aca72615 schema:name nlm_unique_id
67 schema:value 9814578
68 rdf:type schema:PropertyValue
69 N38b31d519fa04a96859e7f473e88090d schema:name Springer Nature - SN SciGraph project
70 rdf:type schema:Organization
71 N3923809867794f6da790a68ac9bcc31e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Humans
73 rdf:type schema:DefinedTerm
74 N3a150175622448f0a25da1bd8c9bedac rdf:first sg:person.01106140077.61
75 rdf:rest Ndd8a90dfee204cb384e86fbbb4e71130
76 N436cc0bd306045268041ed942191068e schema:name doi
77 schema:value 10.1007/s11102-009-0194-y
78 rdf:type schema:PropertyValue
79 N493a70d2759940dda07bd36ff010e707 rdf:first sg:person.014336506137.14
80 rdf:rest N3a150175622448f0a25da1bd8c9bedac
81 N51093eef5e3047f4bc46e6bc8ad32a77 schema:name readcube_id
82 schema:value 9b30624940f4ac30ef56ca1c331e261f2d5a39f256eddb4942e5d46f6a6b9ff5
83 rdf:type schema:PropertyValue
84 N5b002638866c42468a15b78069955591 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name ACTH-Secreting Pituitary Adenoma
86 rdf:type schema:DefinedTerm
87 N605afe4d4eec4752a07c64e5a2daef3a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Radiation Effects
89 rdf:type schema:DefinedTerm
90 N6726c9c4f2d342cabb11f4f31d3d24e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Pituitary Irradiation
92 rdf:type schema:DefinedTerm
93 N7ea9bbc6f6f846a1a1ab5de57b94b230 schema:volumeNumber 14
94 rdf:type schema:PublicationVolume
95 Na379d918aaaf46098218e26d2ce920d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Adult
97 rdf:type schema:DefinedTerm
98 Na8a290e90c8b4ca58182c9175b6681a1 schema:issueNumber 4
99 rdf:type schema:PublicationIssue
100 Naa83e812d49f4e97adb0a88eba4ad933 rdf:first sg:person.01267677327.91
101 rdf:rest rdf:nil
102 Nab93080206c1492ca1f8e542708fcd19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Base Sequence
104 rdf:type schema:DefinedTerm
105 Nb09381a47d6241388179487c9b052f64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Mutation
107 rdf:type schema:DefinedTerm
108 Nb7916dad22bb47009dd5c713c355295a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Adenoma
110 rdf:type schema:DefinedTerm
111 Nbfe69623186141ffb176531b9018896a schema:name dimensions_id
112 schema:value pub.1032575939
113 rdf:type schema:PropertyValue
114 Nc11efd1af08e4e318e68f96f81f55558 schema:name pubmed_id
115 schema:value 19655257
116 rdf:type schema:PropertyValue
117 Ndd8a90dfee204cb384e86fbbb4e71130 rdf:first sg:person.01354420330.44
118 rdf:rest Naa83e812d49f4e97adb0a88eba4ad933
119 Ne87d7fee343546b4bec54f140ad8bcd4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name DNA Mutational Analysis
121 rdf:type schema:DefinedTerm
122 Nf287229b0b7f44f29356fb2956a01576 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Genes, p53
124 rdf:type schema:DefinedTerm
125 Nf5e981dbb15845cb93d053bc6d460dc7 rdf:first sg:person.01306322204.95
126 rdf:rest N493a70d2759940dda07bd36ff010e707
127 Nf68eca1a62dc45d6aa35a5efd23ddf7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Nelson Syndrome
129 rdf:type schema:DefinedTerm
130 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
131 schema:name Medical and Health Sciences
132 rdf:type schema:DefinedTerm
133 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
134 schema:name Oncology and Carcinogenesis
135 rdf:type schema:DefinedTerm
136 sg:journal.1119029 schema:issn 1386-341X
137 1573-7403
138 schema:name Pituitary
139 rdf:type schema:Periodical
140 sg:person.01106140077.61 schema:affiliation https://www.grid.ac/institutes/grid.411074.7
141 schema:familyName Fragoso
142 schema:givenName Maria C. B. V.
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106140077.61
144 rdf:type schema:Person
145 sg:person.01234624673.27 schema:affiliation https://www.grid.ac/institutes/grid.11899.38
146 schema:familyName Pinto
147 schema:givenName Emilia Modolo
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234624673.27
149 rdf:type schema:Person
150 sg:person.01267677327.91 schema:affiliation https://www.grid.ac/institutes/grid.411074.7
151 schema:familyName de Mendonca
152 schema:givenName Berenice Bilharinho
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267677327.91
154 rdf:type schema:Person
155 sg:person.01306322204.95 schema:affiliation https://www.grid.ac/institutes/grid.411074.7
156 schema:familyName Siqueira
157 schema:givenName Sheila A. C.
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306322204.95
159 rdf:type schema:Person
160 sg:person.01354420330.44 schema:affiliation https://www.grid.ac/institutes/grid.11899.38
161 schema:familyName Lin
162 schema:givenName Chin Jia
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354420330.44
164 rdf:type schema:Person
165 sg:person.014336506137.14 schema:affiliation https://www.grid.ac/institutes/grid.411074.7
166 schema:familyName Cukier
167 schema:givenName Priscilla
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014336506137.14
169 rdf:type schema:Person
170 sg:pub.10.1007/bf03347568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036664013
171 https://doi.org/10.1007/bf03347568
172 rdf:type schema:CreativeWork
173 sg:pub.10.1023/a:1009929704018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050905302
174 https://doi.org/10.1023/a:1009929704018
175 rdf:type schema:CreativeWork
176 sg:pub.10.1038/35042675 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023763406
177 https://doi.org/10.1038/35042675
178 rdf:type schema:CreativeWork
179 https://app.dimensions.ai/details/publication/pub.1078912673 schema:CreativeWork
180 https://doi.org/10.1046/j.1365-2265.1998.00578.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046010636
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1098/rstb.1994.0106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027721673
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1111/j.1365-2265.1994.tb02797.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009970741
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1111/j.1365-2265.1995.tb02697.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037778489
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1111/j.1365-2265.2008.03404.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034889423
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1210/jc.2006-1328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064289419
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1210/jc.80.2.4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064298036
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1210/jc.81.1.124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064298447
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1210/jcem.81.1.8550738 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064319743
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1507/endocrj1954.39.177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035676081
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1590/s0004-27302007000800026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021721545
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1590/s0100-879x2002000500008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035438039
203 rdf:type schema:CreativeWork
204 https://www.grid.ac/institutes/grid.11899.38 schema:alternateName University of Sao Paulo
205 schema:name Laboratório de Patologia Molecular, LIM22, Departamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Arnaldo, 455, sala 1144, 01246-903, São Paulo, Brazil
206 Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM/42, Disciplina de Endocrinologia e Metabologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
207 rdf:type schema:Organization
208 https://www.grid.ac/institutes/grid.411074.7 schema:alternateName Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
209 schema:name Divisão de Anatomia Patológica, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
210 Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM/42, Disciplina de Endocrinologia e Metabologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
211 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...