Creating Carotenoid Diversity in E. coli Cells using Combinatorial and Directed Evolution Strategies View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-02

AUTHORS

Claudia Schmidt-Dannert, Pyung Cheon Lee, Benjamin N. Mijts

ABSTRACT

Carotenoids represent a structurally diverse class of pigments with important biological functions and commercial applications. Biosynthesis of carotenoids has been studied on a molecular level for the core pathways and recombinant hosts have been engineered for heterologous carotenoid production. This paper summarizes our efforts on accessing novel carotenoid compounds in engineered E. coli by altering the catalytic activities of enzymes using in vitro evolution, by exploring the catalytic promiscuity of known carotenoid enzymes and by mining for novel enzymes in microbial genome sequences. More... »

PAGES

67-74

Journal

TITLE

Phytochemistry Reviews

ISSUE

1

VOLUME

5

Author Affiliations

Related Patents

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11101-005-5465-2

DOI

http://dx.doi.org/10.1007/s11101-005-5465-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042613650


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