Evaluation of medication-related problems in liver transplant recipients with and without an outpatient medication consultation by a clinical pharmacist: a ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-09-13

AUTHORS

Midas B. Mulder, B. Doga, S. D. Borgsteede, A. M. van den Burg, H. J. Metselaar, C. M. den Hoed, N. G.M. Hunfeld

ABSTRACT

BackgroundTransplant recipients undergo significant changes in their medication regimen during follow-up and are at an increased risk for medication-related problems (MRPs).AimThis study aimed to compare the prevalence and types of MRPs and interventions in liver transplant recipients with and without an outpatient medication consultation by a clinical pharmacist as well as the satisfaction with information about medicines and medication adherence.MethodWe performed a single-center, observational cohort study. A retro- and prospective cohort were used and subdivided in a group that did and did not receive a medication consultation. The prevalence and types of MRPs and interventions were identified and categorized. The satisfaction parameters were evaluated using validated questionnaires.ResultsIncluded were 291 patients. In total, 368 MRPs were identified in 197 patients in the non-medication consultation cohort (median 1; range 1–3 per patient) and 248 MRPs in 94 patients in the medication consultation cohort (median 2; range 1–4 per patient). In the medication consultation cohort, significantly fewer MRPs as unnecessary drugs (17.3% versus 58.7%, p < 0.001), suboptimal therapy (2.4% versus 9.5%, p < 0.001), untreated indication (2.8% versus 6.8%, p = 0.040) and underdosed drugs (0.4% versus 6.3%, p < 0.001) were identified. In the non-medication consultation cohort significantly more patients used unnecessary drugs (72.1% versus 39.4%, p < 0.001) compared to the medication consultation cohort. Patients in both cohorts are satisfied with the information about medicines and reported a high medication adherence.ConclusionPatients in the medication consultation cohort had significantly fewer MRPs and used significantly less unnecessary drugs. Including a clinical pharmacist to the post-transplant care has an added value. More... »

PAGES

1114-1122

References to SciGraph publications

  • 2009-12-11. Clinical pharmacy services and solid organ transplantation: a literature review in INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11096-022-01423-6

    DOI

    http://dx.doi.org/10.1007/s11096-022-01423-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1150963768

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/36100818


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