Impact of hospital pharmacist interventions on the combination of citalopram or escitalopram with other QT-prolonging drugs View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02

AUTHORS

A. Chastang, S. Renet, J. Corny, H. Beaussier, A. Petre, A. Lillo-Lelouet, T. T. Phan Thi, Y. Bézie

ABSTRACT

Background Citalopram and escitalopram can both induce dose-dependent QT prolongation. The risk of arrhythmia may be increased with concomitant use of other drugs that induce QT prolongation. Objective To evaluate the prevalence and impact of pharmacist interventions on the combination of citalopram or escitalopram with other drugs that induce QT prolongation. Setting A French hospital with 517 computerized beds. Method All cardiac adverse drug reactions (ADRs) related to citalopram or escitalopram reported to the French pharmacovigilance database (FPDB) were analyzed. Then, over a 6-month period, all computerized prescriptions including citalopram or escitalopram and drug-drug interactions (DDI) were analyzed by pharmacists using a computerized provider order entry system (DXCare®, Medasys). Results Only 27 cardiac ADRs related to citalopram or escitalopram were reported in the database. Among the 57,857 prescriptions and 2116 contraindicated DDIs (3.7 %) that were analyzed. 444 DDIs (0.8 %) were considered to be clinically relevant by pharmacists and physicians and 168 (i.e., approximately 30 %) were related to a combination including citalopram or escitalopram. Most of the prescriptions related to DDIs including citalopram or escitalopram were discontinued in response to a pharmacist intervention when initiated during the hospital stay. Conclusion A high number of hospital prescriptions including citalopram or escitalopram with another QT-prolonging drug occurred, highlighting the importance of involvement of clinical pharmacists in prevention of potential ADRs related to such contraindications. More... »

PAGES

42-48

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11096-018-0724-7

DOI

http://dx.doi.org/10.1007/s11096-018-0724-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111099843

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30610545


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Saint-Joseph", 
          "id": "https://www.grid.ac/institutes/grid.414363.7", 
          "name": [
            "Pharmacy Department, Groupe hospitalier Paris Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chastang", 
        "givenName": "A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Paris-Saclay", 
          "id": "https://www.grid.ac/institutes/grid.460789.4", 
          "name": [
            "Pharmacy Department, Groupe hospitalier Paris Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France", 
            "Clinical Pharmacy Department, University Paris Saclay, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Renet", 
        "givenName": "S.", 
        "id": "sg:person.0612021775.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612021775.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Saint-Joseph", 
          "id": "https://www.grid.ac/institutes/grid.414363.7", 
          "name": [
            "Pharmacy Department, Groupe hospitalier Paris Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Corny", 
        "givenName": "J.", 
        "id": "sg:person.01141133703.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141133703.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Saint-Joseph", 
          "id": "https://www.grid.ac/institutes/grid.414363.7", 
          "name": [
            "Clinical Research Center, Groupe hospitalier Paris Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beaussier", 
        "givenName": "H.", 
        "id": "sg:person.01116256712.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116256712.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Saint-Joseph", 
          "id": "https://www.grid.ac/institutes/grid.414363.7", 
          "name": [
            "Pharmacy Department, Groupe hospitalier Paris Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Petre", 
        "givenName": "A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Europ\u00e9en Georges-Pompidou", 
          "id": "https://www.grid.ac/institutes/grid.414093.b", 
          "name": [
            "Centre R\u00e9gional de PharmacoVigilance, H\u00f4pital Europ\u00e9en Georges Pompidou, 20 Rue Leblanc, 75015, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lillo-Lelouet", 
        "givenName": "A.", 
        "id": "sg:person.0662722437.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662722437.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Saint-Joseph", 
          "id": "https://www.grid.ac/institutes/grid.414363.7", 
          "name": [
            "Pharmacy Department, Groupe hospitalier Paris Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Phan Thi", 
        "givenName": "T. T.", 
        "id": "sg:person.014365505722.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014365505722.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Saint-Joseph", 
          "id": "https://www.grid.ac/institutes/grid.414363.7", 
          "name": [
            "Pharmacy Department, Groupe hospitalier Paris Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "B\u00e9zie", 
        "givenName": "Y.", 
        "id": "sg:person.0743167661.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743167661.40"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.4103/0976-9668.107289", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000237148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40264-015-0281-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001160740", 
          "https://doi.org/10.1007/s40264-015-0281-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40264-015-0281-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001160740", 
          "https://doi.org/10.1007/s40264-015-0281-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2296-11-65", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005124139", 
          "https://doi.org/10.1186/1471-2296-11-65"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.psym.2014.09.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007119733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.rpsm.2013.12.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011325105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.rpsm.2013.12.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011325105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00002018-200629050-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012106416", 
          "https://doi.org/10.2165/00002018-200629050-00003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.279.15.1200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018359649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.jaa.0000465221.04234.ca", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021418119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.jaa.0000465221.04234.ca", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021418119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.1p627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028848561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.1p627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028848561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00002018-200730100-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029632802", 
          "https://doi.org/10.2165/00002018-200730100-00009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pds.1836", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030316560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pds.1836", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030316560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archinte.164.7.785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031397038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/msj.20298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032739361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/heart.89.11.1363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035064438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3810/pgm.2010.11.2233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042212694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2046-4053-3-56", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045010603", 
          "https://doi.org/10.1186/2046-4053-3-56"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.1q529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045163012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.1q529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045163012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11606-009-1238-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047739491", 
          "https://doi.org/10.1007/s11606-009-1238-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11606-009-1238-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047739491", 
          "https://doi.org/10.1007/s11606-009-1238-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/0976-500x.120957", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049583980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.280.15.1311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051193375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1060028013501994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051694136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1060028013501994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051694136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pds.1155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052006513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pds.1155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052006513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40360-016-0053-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052894498", 
          "https://doi.org/10.1186/s40360-016-0053-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1995.03530010049034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053354824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1503/jpn.120256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067426716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1503/jpn.120256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067426716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1503/jpn.130055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067426730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1503/jpn.130055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067426730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076808049", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajhp/61.4.380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076808049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajhp/61.4.380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076808049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajhp/61.4.380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076808049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1090393516", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/2045125317721662", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091444876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/2045125317721662", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091444876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmjopen-2017-016627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092239553"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-02", 
    "datePublishedReg": "2019-02-01", 
    "description": "Background Citalopram and escitalopram can both induce dose-dependent QT prolongation. The risk of arrhythmia may be increased with concomitant use of other drugs that induce QT prolongation. Objective To evaluate the prevalence and impact of pharmacist interventions on the combination of citalopram or escitalopram with other drugs that induce QT prolongation. Setting A French hospital with 517 computerized beds. Method All cardiac adverse drug reactions (ADRs) related to citalopram or escitalopram reported to the French pharmacovigilance database (FPDB) were analyzed. Then, over a 6-month period, all computerized prescriptions including citalopram or escitalopram and drug-drug interactions (DDI) were analyzed by pharmacists using a computerized provider order entry system (DXCare\u00ae, Medasys). Results Only 27 cardiac ADRs related to citalopram or escitalopram were reported in the database. Among the 57,857 prescriptions and 2116 contraindicated DDIs (3.7\u00a0%) that were analyzed. 444 DDIs (0.8\u00a0%) were considered to be clinically relevant by pharmacists and physicians and 168 (i.e., approximately 30\u00a0%) were related to a combination including citalopram or escitalopram. Most of the prescriptions related to DDIs including citalopram or escitalopram were discontinued in response to a pharmacist intervention when initiated during the hospital stay. Conclusion A high number of hospital prescriptions including citalopram or escitalopram with another QT-prolonging drug occurred, highlighting the importance of involvement of clinical pharmacists in prevention of potential ADRs related to such contraindications.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11096-018-0724-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1044817", 
        "issn": [
          "2210-7703", 
          "2210-7711"
        ], 
        "name": "International Journal of Clinical Pharmacy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "41"
      }
    ], 
    "name": "Impact of hospital pharmacist interventions on the combination of citalopram or escitalopram with other QT-prolonging drugs", 
    "pagination": "42-48", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7a5b1d67463510db2a63fa476e2d72510058342187fef51d4f803834fcd98920"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30610545"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101554912"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11096-018-0724-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111099843"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11096-018-0724-7", 
      "https://app.dimensions.ai/details/publication/pub.1111099843"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000338_0000000338/records_47957_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs11096-018-0724-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11096-018-0724-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11096-018-0724-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11096-018-0724-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11096-018-0724-7'


 

This table displays all metadata directly associated to this object as RDF triples.

222 TRIPLES      21 PREDICATES      60 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11096-018-0724-7 schema:about anzsrc-for:11
2 anzsrc-for:1117
3 schema:author N7c0441e6d600404bae3d4fcf770cc3ef
4 schema:citation sg:pub.10.1007/s11606-009-1238-8
5 sg:pub.10.1007/s40264-015-0281-0
6 sg:pub.10.1186/1471-2296-11-65
7 sg:pub.10.1186/2046-4053-3-56
8 sg:pub.10.1186/s40360-016-0053-1
9 sg:pub.10.2165/00002018-200629050-00003
10 sg:pub.10.2165/00002018-200730100-00009
11 https://app.dimensions.ai/details/publication/pub.1076808049
12 https://app.dimensions.ai/details/publication/pub.1090393516
13 https://doi.org/10.1001/archinte.164.7.785
14 https://doi.org/10.1001/jama.1995.03530010049034
15 https://doi.org/10.1001/jama.279.15.1200
16 https://doi.org/10.1001/jama.280.15.1311
17 https://doi.org/10.1002/msj.20298
18 https://doi.org/10.1002/pds.1155
19 https://doi.org/10.1002/pds.1836
20 https://doi.org/10.1016/j.psym.2014.09.002
21 https://doi.org/10.1016/j.rpsm.2013.12.005
22 https://doi.org/10.1093/ajhp/61.4.380
23 https://doi.org/10.1097/01.jaa.0000465221.04234.ca
24 https://doi.org/10.1136/bmjopen-2017-016627
25 https://doi.org/10.1136/heart.89.11.1363
26 https://doi.org/10.1177/1060028013501994
27 https://doi.org/10.1177/2045125317721662
28 https://doi.org/10.1345/aph.1p627
29 https://doi.org/10.1345/aph.1q529
30 https://doi.org/10.1503/jpn.120256
31 https://doi.org/10.1503/jpn.130055
32 https://doi.org/10.3810/pgm.2010.11.2233
33 https://doi.org/10.4103/0976-500x.120957
34 https://doi.org/10.4103/0976-9668.107289
35 schema:datePublished 2019-02
36 schema:datePublishedReg 2019-02-01
37 schema:description Background Citalopram and escitalopram can both induce dose-dependent QT prolongation. The risk of arrhythmia may be increased with concomitant use of other drugs that induce QT prolongation. Objective To evaluate the prevalence and impact of pharmacist interventions on the combination of citalopram or escitalopram with other drugs that induce QT prolongation. Setting A French hospital with 517 computerized beds. Method All cardiac adverse drug reactions (ADRs) related to citalopram or escitalopram reported to the French pharmacovigilance database (FPDB) were analyzed. Then, over a 6-month period, all computerized prescriptions including citalopram or escitalopram and drug-drug interactions (DDI) were analyzed by pharmacists using a computerized provider order entry system (DXCare<sup>®</sup>, Medasys). Results Only 27 cardiac ADRs related to citalopram or escitalopram were reported in the database. Among the 57,857 prescriptions and 2116 contraindicated DDIs (3.7 %) that were analyzed. 444 DDIs (0.8 %) were considered to be clinically relevant by pharmacists and physicians and 168 (i.e., approximately 30 %) were related to a combination including citalopram or escitalopram. Most of the prescriptions related to DDIs including citalopram or escitalopram were discontinued in response to a pharmacist intervention when initiated during the hospital stay. Conclusion A high number of hospital prescriptions including citalopram or escitalopram with another QT-prolonging drug occurred, highlighting the importance of involvement of clinical pharmacists in prevention of potential ADRs related to such contraindications.
38 schema:genre research_article
39 schema:inLanguage en
40 schema:isAccessibleForFree false
41 schema:isPartOf N73b3dc2dfc154767ba4a6c43271b23aa
42 Ncaec7c5786e24425a8f0e984d08fc676
43 sg:journal.1044817
44 schema:name Impact of hospital pharmacist interventions on the combination of citalopram or escitalopram with other QT-prolonging drugs
45 schema:pagination 42-48
46 schema:productId N0c41d894bd9142c7b39943c927a16cdf
47 N41433ef8a5704174a7be16137430d82a
48 N542f4bcb16644ba6a486b6fdee276a0f
49 N5f8f3ffd1f5249df9e64bc50275d2c03
50 Na180af3944434af18a7cbeae865a4118
51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111099843
52 https://doi.org/10.1007/s11096-018-0724-7
53 schema:sdDatePublished 2019-04-11T09:08
54 schema:sdLicense https://scigraph.springernature.com/explorer/license/
55 schema:sdPublisher Nb4222b0334f842bfa3b87078db797dd6
56 schema:url https://link.springer.com/10.1007%2Fs11096-018-0724-7
57 sgo:license sg:explorer/license/
58 sgo:sdDataset articles
59 rdf:type schema:ScholarlyArticle
60 N0c41d894bd9142c7b39943c927a16cdf schema:name doi
61 schema:value 10.1007/s11096-018-0724-7
62 rdf:type schema:PropertyValue
63 N3ad923e334c74bbfb2a570b60da490b0 rdf:first sg:person.0612021775.26
64 rdf:rest N4793034c43874dce9bc1be04f6d70f18
65 N41433ef8a5704174a7be16137430d82a schema:name nlm_unique_id
66 schema:value 101554912
67 rdf:type schema:PropertyValue
68 N4793034c43874dce9bc1be04f6d70f18 rdf:first sg:person.01141133703.36
69 rdf:rest Nc19877c76b3e473c9dfbbbe6335958a8
70 N4a456492a9364b2b9d630aabbe7e2ddb rdf:first sg:person.0662722437.04
71 rdf:rest Nf704cd90102d4882963502fc9fb5e7d3
72 N542f4bcb16644ba6a486b6fdee276a0f schema:name dimensions_id
73 schema:value pub.1111099843
74 rdf:type schema:PropertyValue
75 N5f8f3ffd1f5249df9e64bc50275d2c03 schema:name readcube_id
76 schema:value 7a5b1d67463510db2a63fa476e2d72510058342187fef51d4f803834fcd98920
77 rdf:type schema:PropertyValue
78 N6a01051e02af47ce8d63e56381d15447 rdf:first Nb91de7762f31404c9bd69ae08bebdf4e
79 rdf:rest N4a456492a9364b2b9d630aabbe7e2ddb
80 N73b3dc2dfc154767ba4a6c43271b23aa schema:issueNumber 1
81 rdf:type schema:PublicationIssue
82 N7c0441e6d600404bae3d4fcf770cc3ef rdf:first Nafd7c5baf6d54eeaa2932e1b028c7d2e
83 rdf:rest N3ad923e334c74bbfb2a570b60da490b0
84 Na180af3944434af18a7cbeae865a4118 schema:name pubmed_id
85 schema:value 30610545
86 rdf:type schema:PropertyValue
87 Nafd7c5baf6d54eeaa2932e1b028c7d2e schema:affiliation https://www.grid.ac/institutes/grid.414363.7
88 schema:familyName Chastang
89 schema:givenName A.
90 rdf:type schema:Person
91 Nb4222b0334f842bfa3b87078db797dd6 schema:name Springer Nature - SN SciGraph project
92 rdf:type schema:Organization
93 Nb91de7762f31404c9bd69ae08bebdf4e schema:affiliation https://www.grid.ac/institutes/grid.414363.7
94 schema:familyName Petre
95 schema:givenName A.
96 rdf:type schema:Person
97 Nc19877c76b3e473c9dfbbbe6335958a8 rdf:first sg:person.01116256712.35
98 rdf:rest N6a01051e02af47ce8d63e56381d15447
99 Ncaec7c5786e24425a8f0e984d08fc676 schema:volumeNumber 41
100 rdf:type schema:PublicationVolume
101 Nf3881c8a3f9c47b89c0db238083b5699 rdf:first sg:person.0743167661.40
102 rdf:rest rdf:nil
103 Nf704cd90102d4882963502fc9fb5e7d3 rdf:first sg:person.014365505722.34
104 rdf:rest Nf3881c8a3f9c47b89c0db238083b5699
105 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
106 schema:name Medical and Health Sciences
107 rdf:type schema:DefinedTerm
108 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
109 schema:name Public Health and Health Services
110 rdf:type schema:DefinedTerm
111 sg:journal.1044817 schema:issn 2210-7703
112 2210-7711
113 schema:name International Journal of Clinical Pharmacy
114 rdf:type schema:Periodical
115 sg:person.01116256712.35 schema:affiliation https://www.grid.ac/institutes/grid.414363.7
116 schema:familyName Beaussier
117 schema:givenName H.
118 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116256712.35
119 rdf:type schema:Person
120 sg:person.01141133703.36 schema:affiliation https://www.grid.ac/institutes/grid.414363.7
121 schema:familyName Corny
122 schema:givenName J.
123 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141133703.36
124 rdf:type schema:Person
125 sg:person.014365505722.34 schema:affiliation https://www.grid.ac/institutes/grid.414363.7
126 schema:familyName Phan Thi
127 schema:givenName T. T.
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014365505722.34
129 rdf:type schema:Person
130 sg:person.0612021775.26 schema:affiliation https://www.grid.ac/institutes/grid.460789.4
131 schema:familyName Renet
132 schema:givenName S.
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612021775.26
134 rdf:type schema:Person
135 sg:person.0662722437.04 schema:affiliation https://www.grid.ac/institutes/grid.414093.b
136 schema:familyName Lillo-Lelouet
137 schema:givenName A.
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662722437.04
139 rdf:type schema:Person
140 sg:person.0743167661.40 schema:affiliation https://www.grid.ac/institutes/grid.414363.7
141 schema:familyName Bézie
142 schema:givenName Y.
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743167661.40
144 rdf:type schema:Person
145 sg:pub.10.1007/s11606-009-1238-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047739491
146 https://doi.org/10.1007/s11606-009-1238-8
147 rdf:type schema:CreativeWork
148 sg:pub.10.1007/s40264-015-0281-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001160740
149 https://doi.org/10.1007/s40264-015-0281-0
150 rdf:type schema:CreativeWork
151 sg:pub.10.1186/1471-2296-11-65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005124139
152 https://doi.org/10.1186/1471-2296-11-65
153 rdf:type schema:CreativeWork
154 sg:pub.10.1186/2046-4053-3-56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045010603
155 https://doi.org/10.1186/2046-4053-3-56
156 rdf:type schema:CreativeWork
157 sg:pub.10.1186/s40360-016-0053-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052894498
158 https://doi.org/10.1186/s40360-016-0053-1
159 rdf:type schema:CreativeWork
160 sg:pub.10.2165/00002018-200629050-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012106416
161 https://doi.org/10.2165/00002018-200629050-00003
162 rdf:type schema:CreativeWork
163 sg:pub.10.2165/00002018-200730100-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029632802
164 https://doi.org/10.2165/00002018-200730100-00009
165 rdf:type schema:CreativeWork
166 https://app.dimensions.ai/details/publication/pub.1076808049 schema:CreativeWork
167 https://app.dimensions.ai/details/publication/pub.1090393516 schema:CreativeWork
168 https://doi.org/10.1001/archinte.164.7.785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031397038
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1001/jama.1995.03530010049034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053354824
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1001/jama.279.15.1200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018359649
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1001/jama.280.15.1311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051193375
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1002/msj.20298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032739361
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1002/pds.1155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052006513
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1002/pds.1836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030316560
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/j.psym.2014.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007119733
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/j.rpsm.2013.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011325105
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1093/ajhp/61.4.380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076808049
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1097/01.jaa.0000465221.04234.ca schema:sameAs https://app.dimensions.ai/details/publication/pub.1021418119
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1136/bmjopen-2017-016627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092239553
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1136/heart.89.11.1363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035064438
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1177/1060028013501994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051694136
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1177/2045125317721662 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091444876
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1345/aph.1p627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028848561
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1345/aph.1q529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045163012
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1503/jpn.120256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067426716
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1503/jpn.130055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067426730
205 rdf:type schema:CreativeWork
206 https://doi.org/10.3810/pgm.2010.11.2233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042212694
207 rdf:type schema:CreativeWork
208 https://doi.org/10.4103/0976-500x.120957 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049583980
209 rdf:type schema:CreativeWork
210 https://doi.org/10.4103/0976-9668.107289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000237148
211 rdf:type schema:CreativeWork
212 https://www.grid.ac/institutes/grid.414093.b schema:alternateName Hôpital Européen Georges-Pompidou
213 schema:name Centre Régional de PharmacoVigilance, Hôpital Européen Georges Pompidou, 20 Rue Leblanc, 75015, Paris, France
214 rdf:type schema:Organization
215 https://www.grid.ac/institutes/grid.414363.7 schema:alternateName Hôpital Saint-Joseph
216 schema:name Clinical Research Center, Groupe hospitalier Paris Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France
217 Pharmacy Department, Groupe hospitalier Paris Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France
218 rdf:type schema:Organization
219 https://www.grid.ac/institutes/grid.460789.4 schema:alternateName University of Paris-Saclay
220 schema:name Clinical Pharmacy Department, University Paris Saclay, Paris, France
221 Pharmacy Department, Groupe hospitalier Paris Saint-Joseph, 185 rue Raymond Losserand, 75014, Paris, France
222 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...