Esophageal perforation: a research review of the anti-infective treatment View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-10

AUTHORS

Jennifer Gregory, Jason Hecht

ABSTRACT

Background Esophageal perforation is a complex disease state and often difficult to diagnose due to the variability in patient presentation. The chosen anti-infective treatment and duration of anti-infective therapy that patients with esophageal perforation receive has been inconsistent. Choice of anti-infective treatment and duration of therapy may also be highly variable from institution to institution, and can even vary by provider. To our knowledge, there has not been a publication reviewing esophageal perforation with a specific focus on pharmacologic management. Aim of the review The aim of this study is to summarize pertinent research articles focused on the anti-infective treatment of adult patients diagnosed with esophageal perforation. Method Pubmed electronic database was utilized to search for articles meeting pre-defined criteria. Articles were included in this review if they discussed at least 1 of the following 3 criteria: choice of anti-infective treatment regimen, duration of anti-infective therapy, or identification of organisms growing from cultures associated with the esophageal perforation. Results Seventy-seven articles included information related to our research question. No randomized-controlled trials were identified and only 7 identified articles reported all 3 criteria of interest. Conclusion Review of the literature from 1979 to 2017 reveals the need for high quality evidence related to anti-infective treatment in patients diagnosed with esophageal perforation. More... »

PAGES

953-962

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11096-018-0680-2

DOI

http://dx.doi.org/10.1007/s11096-018-0680-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105169864

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29956135


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