Tribo-Charging Behaviour of Inhalable Mannitol Blends with Salbutamol Sulphate. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-06

AUTHORS

S Zellnitz, J T Pinto, M Brunsteiner, H Schroettner, J Khinast, A Paudel

ABSTRACT

PURPOSE: The performance of carrier-based dry powder inhaler (DPI) formulations can be critically impacted by interfacial interactions driven by tribo-electrification. Therefore, the aim of the present work was to understand how distinct API particle characteristics affect the charging behaviour of blends intended for DPI delivery. METHODS: Salbutamol sulphate (SBS) particles engineered via spray-drying and jet milling were used as model APIs. D-mannitol was selected as a model carrier. The materials were characterized concerning their different particle properties and their charge was analysed alone and in blends before and after flow over a stainless-steel pipe. RESULTS: The spray-dried SBS (amorphous and spherical) charged positively and to a higher extent than jet milled SBS (crystalline and acicular) that charged negatively and to a lower extent. D-mannitol charged positively and to a higher extent than the APIs. All drug-excipient blends charged negatively and differences were found between the spray-dried and jet milled SBS blends at 2% and 5% drug loads. CONCLUSIONS: It was demonstrated how distinct solid-states, particle shape, size and morphology as well as different water contents of the different materials can affect tribo-charging. For their binary blends, the amount and nature of fines seem to govern inter-particle contacts critically impacting charge evolution. More... »

PAGES

80

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11095-019-2612-9

DOI

http://dx.doi.org/10.1007/s11095-019-2612-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113327984

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30968221


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