Antiretroviral Hydrophobic Core Graft-Copolymer Nanoparticles: The Effectiveness against Mutant HIV-1 Strains and in Vivo Distribution after Topical Application View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-05

AUTHORS

Anita Leporati, Suresh Gupta, Elijah Bolotin, Gerardo Castillo, Joshua Alfaro, Marina B. Gottikh, Alexei A. Bogdanov Jr

ABSTRACT

PURPOSE: Developing and testing of microbicides for pre-exposure prophylaxis and post-exposure protection from HIV are on the list of major HIV/AIDS research priorities. To improve solubility and bioavailability of highly potent anti-retroviral drugs, we explored the use of a nanoparticle (NP) for formulating a combination of two water-insoluble HIV inhibitors. METHODS: The combination of a non-nucleoside HIV reverse transcriptase inhibitor (NNRTI), Efavirenz (EFV), and an inhibitor of HIV integrase, Elvitegravir (ELV) was stabilized with a graft copolymer of methoxypolyethylene glycol-polylysine with a hydrophobic core (HC) composed of fatty acids (HC-PGC). Formulations were tested in TZM-bl cells infected either with wild-type HIV-1IIIB, or drug-resistant HIV-1 strains. In vivo testing of double-labeled NP formulations was performed in female rats after a topical intravaginal administration using SPECT/CT imaging and fluorescence microscopy. RESULTS: We observed a formation of stable 23-30 nm NP with very low cytotoxicity when EFV and ELV were combined with HC-PGC at a 1:10 weight ratio. For NP containing ELV and EFV (at 1:1 by weight) we observed a remarkable improvement of EC50 of EFV by 20 times in the case of A17 strain. In vivo imaging and biodistribution showed in vivo presence of NP components at 24 and 48 h after administration, respectively. CONCLUSIONS: insoluble orthogonal inhibitors of HIV-1 life cycle may be formulated into the non-aggregating ultrasmall NP which are highly efficient against NNRTI-resistant HIV-1 variant. More... »

PAGES

73

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11095-019-2604-9

DOI

http://dx.doi.org/10.1007/s11095-019-2604-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113043247

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30919089


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-HIV Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Benzoxazines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Carriers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Combinations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Liberation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Resistance, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Integrase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydrophobic and Hydrophilic Interactions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Dynamics Simulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nanoparticles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polyethylene Glycols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polylysine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quinolones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Distribution", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Massachusetts Medical School", 
          "id": "https://www.grid.ac/institutes/grid.168645.8", 
          "name": [
            "Laboratory of Molecular Imaging Probes, Department of Radiology, University of Massachusetts Medical School, S6-434, 55 Lake Ave North, 01655, Worcester, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leporati", 
        "givenName": "Anita", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Massachusetts Medical School", 
          "id": "https://www.grid.ac/institutes/grid.168645.8", 
          "name": [
            "Laboratory of Molecular Imaging Probes, Department of Radiology, University of Massachusetts Medical School, S6-434, 55 Lake Ave North, 01655, Worcester, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gupta", 
        "givenName": "Suresh", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "PharmaIN (United States)", 
          "id": "https://www.grid.ac/institutes/grid.423536.5", 
          "name": [
            "PharmaIn Corp, 11812 North Creek Parkway N. Suite 10, Bothell, Washington, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bolotin", 
        "givenName": "Elijah", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "PharmaIN (United States)", 
          "id": "https://www.grid.ac/institutes/grid.423536.5", 
          "name": [
            "PharmaIn Corp, 11812 North Creek Parkway N. Suite 10, Bothell, Washington, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Castillo", 
        "givenName": "Gerardo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "PharmaIN (United States)", 
          "id": "https://www.grid.ac/institutes/grid.423536.5", 
          "name": [
            "PharmaIn Corp, 11812 North Creek Parkway N. Suite 10, Bothell, Washington, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alfaro", 
        "givenName": "Joshua", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Moscow State University", 
          "id": "https://www.grid.ac/institutes/grid.14476.30", 
          "name": [
            "A.N. Belozersky Institute of Physico-Chemical Biology and Department of Chemistry, Moscow State University, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gottikh", 
        "givenName": "Marina B.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Russian Academy of Sciences", 
          "id": "https://www.grid.ac/institutes/grid.4886.2", 
          "name": [
            "Laboratory of Molecular Imaging Probes, Department of Radiology, University of Massachusetts Medical School, S6-434, 55 Lake Ave North, 01655, Worcester, MA, USA", 
            "Department of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russia", 
            "Laboratory of Molecular Imaging, A. N. Bach Institute of Biochemistry, Federal Research Center \u201cFundamentals of Biotechnology\u201d, Russian Academy of Sciences, Laboratory of Molecular Imaging, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bogdanov Jr", 
        "givenName": "Alexei A.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1021/bc5005087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000466388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nano.2011.01.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006390845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nano.2011.01.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006390845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0074314", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014578302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/365451a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016663177", 
          "https://doi.org/10.1038/365451a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpharm.2012.07.070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016681495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0000000000000172", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016713434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0000000000000172", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016713434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11095-008-9765-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020710738", 
          "https://doi.org/10.1007/s11095-008-9765-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejpb.2016.12.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021916822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2012.06.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022569245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2012.06.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022569245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nano.2016.07.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026059205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nano.2016.07.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026059205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/nnm.09.90", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028476889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11095-006-9132-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029273543", 
          "https://doi.org/10.1007/s11095-006-9132-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2014.10.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031433494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2014.10.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031433494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/13543780903055056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031447014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.biochem.67.1.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032641448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.addr.2015.09.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033043878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2334-9-198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033177609", 
          "https://doi.org/10.1186/1471-2334-9-198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11095-012-0904-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034306048", 
          "https://doi.org/10.1007/s11095-012-0904-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/mi.2010.2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035530579", 
          "https://doi.org/10.1038/mi.2010.2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7150/thno.4070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035584077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actbio.2016.08.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040152253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actbio.2016.08.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040152253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1163/156856201744425", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044691762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejpb.2008.09.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044805108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044805538", 
          "https://doi.org/10.1038/nature11398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpharm.2009.12.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046419605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.bi.63.070194.001025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046544253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11095-011-0542-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048786503", 
          "https://doi.org/10.1007/s11095-011-0542-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clinthera.2009.04.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049082202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2014.04.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050437019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0000000000001349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050611697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0000000000001349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050611697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.03591-14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051874284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11095-011-0646-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052689346", 
          "https://doi.org/10.1007/s11095-011-0646-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acs.molpharmaceut.5b00544", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055120105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.2009.0227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059225965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3003453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062687346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.00450-16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062708972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.01291-16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062712019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1389200043335487", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069175457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1568026043388448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069193069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077332473", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1717932115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100077594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2018.1917", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101781476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2018.03.054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101841348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2018.03.054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101841348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1071/sh18103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1110205743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1071/sh18103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1110205743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1071/sh18103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1110205743"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-05", 
    "datePublishedReg": "2019-05-01", 
    "description": "PURPOSE: Developing and testing of microbicides for pre-exposure prophylaxis and post-exposure protection from HIV are on the list of major HIV/AIDS research priorities. To improve solubility and bioavailability of highly potent anti-retroviral drugs, we explored the use of a nanoparticle (NP) for formulating a combination of two water-insoluble HIV inhibitors.\nMETHODS: The combination of a non-nucleoside HIV reverse transcriptase inhibitor (NNRTI), Efavirenz (EFV), and an inhibitor of HIV integrase, Elvitegravir (ELV) was stabilized with a graft copolymer of methoxypolyethylene glycol-polylysine with a hydrophobic core (HC) composed of fatty acids (HC-PGC). Formulations were tested in TZM-bl cells infected either with wild-type HIV-1IIIB, or drug-resistant HIV-1 strains. In vivo testing of double-labeled NP formulations was performed in female rats after a topical intravaginal administration using SPECT/CT imaging and fluorescence microscopy.\nRESULTS: We observed a formation of stable 23-30\u00a0nm NP with very low cytotoxicity when EFV and ELV were combined with HC-PGC at a 1:10 weight ratio. For NP containing ELV and EFV (at 1:1 by weight) we observed a remarkable improvement of EC50 of EFV by 20 times in the case of A17 strain. In vivo imaging and biodistribution showed in vivo presence of NP components at 24 and 48\u00a0h after administration, respectively.\nCONCLUSIONS: insoluble orthogonal inhibitors of HIV-1 life cycle may be formulated into the non-aggregating ultrasmall NP which are highly efficient against NNRTI-resistant HIV-1 variant.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11095-019-2604-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2675319", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2674233", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2501202", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3803347", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3492677", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1094644", 
        "issn": [
          "0724-8741", 
          "1573-904X"
        ], 
        "name": "Pharmaceutical Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "36"
      }
    ], 
    "name": "Antiretroviral Hydrophobic Core Graft-Copolymer Nanoparticles: The Effectiveness against Mutant HIV-1 Strains and in Vivo Distribution after Topical Application", 
    "pagination": "73", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11095-019-2604-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1113043247"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "44ee31939f8910fc37c1b0626af019c55f4f40baa7ad47730499520ee69bcbb2"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8406521"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30919089"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11095-019-2604-9", 
      "https://app.dimensions.ai/details/publication/pub.1113043247"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-16T06:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000377_0000000377/records_106828_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs11095-019-2604-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11095-019-2604-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11095-019-2604-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11095-019-2604-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11095-019-2604-9'


 

This table displays all metadata directly associated to this object as RDF triples.

353 TRIPLES      21 PREDICATES      95 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11095-019-2604-9 schema:about N1ea3b7ad2fdd4f4e9773393d834ec35c
2 N2b2aff9f381d47f18fa5a6a8594eead7
3 N2d9603be47764fb4bb6c712656048e30
4 N34fe539d15bc4f8c9daab630238aa7d4
5 N3568cd433b5e43e88b2174515e31950a
6 N47eb11345d954751919808d56730b141
7 N5a120536c58d49e199c77e84b678fca1
8 N5c8aef4d1b1a4e34b38ee44dd39c595c
9 N5d7d5a1a836b4bbd98d98fc784148846
10 N684fc3b1b35d47cdb9a4c4fadac6665e
11 N801b5d2ed9ca4cedb2a992e0c9e75795
12 N81f866fb67c240608b91524163ab4767
13 N9b9254b70db745389485ce9500995168
14 N9d16556f90f3448d869e9b6dd3371081
15 N9e21a799d2dd4568980b229571d26a17
16 Na346633f9dec41afb3a1356204085253
17 Na721bd154a7c45efbfcb83f23847719c
18 Ncfcaed68c91b4d8f891345a5522b489a
19 Ndbb6726267ee45d3998974af49e25721
20 Ndc441ecab68b43f7ae818ad8f41a7a86
21 Ne35d6e2c9cbe464ab4ba3e4ec127783f
22 Neb8be065309749be871ebac5bc37e38d
23 anzsrc-for:11
24 anzsrc-for:1108
25 schema:author N1a3b59f90a7c427e824648eaa243dd7b
26 schema:citation sg:pub.10.1007/s11095-006-9132-0
27 sg:pub.10.1007/s11095-008-9765-2
28 sg:pub.10.1007/s11095-011-0542-2
29 sg:pub.10.1007/s11095-011-0646-8
30 sg:pub.10.1007/s11095-012-0904-4
31 sg:pub.10.1038/365451a0
32 sg:pub.10.1038/mi.2010.2
33 sg:pub.10.1038/nature11398
34 sg:pub.10.1186/1471-2334-9-198
35 https://app.dimensions.ai/details/publication/pub.1077332473
36 https://doi.org/10.1001/jama.2018.1917
37 https://doi.org/10.1016/j.actbio.2016.08.018
38 https://doi.org/10.1016/j.addr.2015.09.012
39 https://doi.org/10.1016/j.biomaterials.2018.03.054
40 https://doi.org/10.1016/j.clinthera.2009.04.020
41 https://doi.org/10.1016/j.ejpb.2008.09.022
42 https://doi.org/10.1016/j.ejpb.2016.12.019
43 https://doi.org/10.1016/j.ijpharm.2009.12.013
44 https://doi.org/10.1016/j.ijpharm.2012.07.070
45 https://doi.org/10.1016/j.jconrel.2012.06.008
46 https://doi.org/10.1016/j.jconrel.2014.04.033
47 https://doi.org/10.1016/j.jconrel.2014.10.026
48 https://doi.org/10.1016/j.nano.2011.01.017
49 https://doi.org/10.1016/j.nano.2016.07.004
50 https://doi.org/10.1021/acs.molpharmaceut.5b00544
51 https://doi.org/10.1021/bc5005087
52 https://doi.org/10.1071/sh18103
53 https://doi.org/10.1073/pnas.1717932115
54 https://doi.org/10.1089/aid.2009.0227
55 https://doi.org/10.1097/qad.0000000000001349
56 https://doi.org/10.1097/qai.0000000000000172
57 https://doi.org/10.1126/scitranslmed.3003453
58 https://doi.org/10.1128/aac.00450-16
59 https://doi.org/10.1128/aac.03591-14
60 https://doi.org/10.1128/jcm.01291-16
61 https://doi.org/10.1146/annurev.bi.63.070194.001025
62 https://doi.org/10.1146/annurev.biochem.67.1.1
63 https://doi.org/10.1163/156856201744425
64 https://doi.org/10.1371/journal.pone.0074314
65 https://doi.org/10.1517/13543780903055056
66 https://doi.org/10.2174/1389200043335487
67 https://doi.org/10.2174/1568026043388448
68 https://doi.org/10.2217/nnm.09.90
69 https://doi.org/10.7150/thno.4070
70 schema:datePublished 2019-05
71 schema:datePublishedReg 2019-05-01
72 schema:description PURPOSE: Developing and testing of microbicides for pre-exposure prophylaxis and post-exposure protection from HIV are on the list of major HIV/AIDS research priorities. To improve solubility and bioavailability of highly potent anti-retroviral drugs, we explored the use of a nanoparticle (NP) for formulating a combination of two water-insoluble HIV inhibitors. METHODS: The combination of a non-nucleoside HIV reverse transcriptase inhibitor (NNRTI), Efavirenz (EFV), and an inhibitor of HIV integrase, Elvitegravir (ELV) was stabilized with a graft copolymer of methoxypolyethylene glycol-polylysine with a hydrophobic core (HC) composed of fatty acids (HC-PGC). Formulations were tested in TZM-bl cells infected either with wild-type HIV-1IIIB, or drug-resistant HIV-1 strains. In vivo testing of double-labeled NP formulations was performed in female rats after a topical intravaginal administration using SPECT/CT imaging and fluorescence microscopy. RESULTS: We observed a formation of stable 23-30 nm NP with very low cytotoxicity when EFV and ELV were combined with HC-PGC at a 1:10 weight ratio. For NP containing ELV and EFV (at 1:1 by weight) we observed a remarkable improvement of EC50 of EFV by 20 times in the case of A17 strain. In vivo imaging and biodistribution showed in vivo presence of NP components at 24 and 48 h after administration, respectively. CONCLUSIONS: insoluble orthogonal inhibitors of HIV-1 life cycle may be formulated into the non-aggregating ultrasmall NP which are highly efficient against NNRTI-resistant HIV-1 variant.
73 schema:genre research_article
74 schema:inLanguage en
75 schema:isAccessibleForFree false
76 schema:isPartOf Nf03095adbe2843eeb637a5133a34131a
77 Nf7c9af14a96c4e12a3f272ff38f11f4c
78 sg:journal.1094644
79 schema:name Antiretroviral Hydrophobic Core Graft-Copolymer Nanoparticles: The Effectiveness against Mutant HIV-1 Strains and in Vivo Distribution after Topical Application
80 schema:pagination 73
81 schema:productId N25e2471cb6be4f8ca7038cfbbe220b7a
82 N2adce92a0ca04209a6aaa1f4e5f35202
83 N65689fe42ca74f5590d04a8e8bf3819f
84 Nb44b3138126e4eb1a5c70c4bf62021b9
85 Nf1338d6b97fe40bab17589ff0baa7580
86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113043247
87 https://doi.org/10.1007/s11095-019-2604-9
88 schema:sdDatePublished 2019-04-16T06:24
89 schema:sdLicense https://scigraph.springernature.com/explorer/license/
90 schema:sdPublisher N903c1c1968984f8dbb5bfc1894049075
91 schema:url https://link.springer.com/10.1007%2Fs11095-019-2604-9
92 sgo:license sg:explorer/license/
93 sgo:sdDataset articles
94 rdf:type schema:ScholarlyArticle
95 N0193b85c2b7b4092a522d09157b826a7 rdf:first Na4db6b709b9d43b380d9ac78003aa0a7
96 rdf:rest Nf41a9ed46cd348e0a33a9ee5edad473f
97 N17656824b788414996833930056b6054 rdf:first N4da59f865a184a5fa18d4c233db4cfc7
98 rdf:rest Nfa74309cccbb43a290382cc5cb9c6a9f
99 N1a3b59f90a7c427e824648eaa243dd7b rdf:first Nde25bee9e8bd494abe2ec0323eed06f3
100 rdf:rest N0193b85c2b7b4092a522d09157b826a7
101 N1ea3b7ad2fdd4f4e9773393d834ec35c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Cell Line
103 rdf:type schema:DefinedTerm
104 N25e2471cb6be4f8ca7038cfbbe220b7a schema:name pubmed_id
105 schema:value 30919089
106 rdf:type schema:PropertyValue
107 N2adce92a0ca04209a6aaa1f4e5f35202 schema:name nlm_unique_id
108 schema:value 8406521
109 rdf:type schema:PropertyValue
110 N2b2aff9f381d47f18fa5a6a8594eead7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Drug Resistance, Viral
112 rdf:type schema:DefinedTerm
113 N2d9603be47764fb4bb6c712656048e30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Anti-HIV Agents
115 rdf:type schema:DefinedTerm
116 N34fe539d15bc4f8c9daab630238aa7d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Nanoparticles
118 rdf:type schema:DefinedTerm
119 N3568cd433b5e43e88b2174515e31950a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name HIV Integrase Inhibitors
121 rdf:type schema:DefinedTerm
122 N35ed904e7ea744d392c361b3e7630eba rdf:first N5bbf21850de24a7f96b59341ad46a4c9
123 rdf:rest N8d4cfa9e9b80427286f022388c7c5393
124 N371b1205a3724b618bf87c73699dd5c8 schema:affiliation https://www.grid.ac/institutes/grid.423536.5
125 schema:familyName Alfaro
126 schema:givenName Joshua
127 rdf:type schema:Person
128 N47eb11345d954751919808d56730b141 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Rats
130 rdf:type schema:DefinedTerm
131 N4da59f865a184a5fa18d4c233db4cfc7 schema:affiliation https://www.grid.ac/institutes/grid.423536.5
132 schema:familyName Castillo
133 schema:givenName Gerardo
134 rdf:type schema:Person
135 N5a120536c58d49e199c77e84b678fca1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Mutation
137 rdf:type schema:DefinedTerm
138 N5bbf21850de24a7f96b59341ad46a4c9 schema:affiliation https://www.grid.ac/institutes/grid.14476.30
139 schema:familyName Gottikh
140 schema:givenName Marina B.
141 rdf:type schema:Person
142 N5c8aef4d1b1a4e34b38ee44dd39c595c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Molecular Dynamics Simulation
144 rdf:type schema:DefinedTerm
145 N5d7d5a1a836b4bbd98d98fc784148846 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Polylysine
147 rdf:type schema:DefinedTerm
148 N65689fe42ca74f5590d04a8e8bf3819f schema:name readcube_id
149 schema:value 44ee31939f8910fc37c1b0626af019c55f4f40baa7ad47730499520ee69bcbb2
150 rdf:type schema:PropertyValue
151 N684fc3b1b35d47cdb9a4c4fadac6665e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Benzoxazines
153 rdf:type schema:DefinedTerm
154 N801b5d2ed9ca4cedb2a992e0c9e75795 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Female
156 rdf:type schema:DefinedTerm
157 N81f866fb67c240608b91524163ab4767 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Drug Combinations
159 rdf:type schema:DefinedTerm
160 N8d4cfa9e9b80427286f022388c7c5393 rdf:first Ndae83aceb9974146b63715e37802eaf0
161 rdf:rest rdf:nil
162 N903c1c1968984f8dbb5bfc1894049075 schema:name Springer Nature - SN SciGraph project
163 rdf:type schema:Organization
164 N9ad0b373276e4cb7bc0b68be4470f824 schema:affiliation https://www.grid.ac/institutes/grid.423536.5
165 schema:familyName Bolotin
166 schema:givenName Elijah
167 rdf:type schema:Person
168 N9b9254b70db745389485ce9500995168 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Reverse Transcriptase Inhibitors
170 rdf:type schema:DefinedTerm
171 N9d16556f90f3448d869e9b6dd3371081 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Tissue Distribution
173 rdf:type schema:DefinedTerm
174 N9e21a799d2dd4568980b229571d26a17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name HIV Infections
176 rdf:type schema:DefinedTerm
177 Na346633f9dec41afb3a1356204085253 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name HIV-1
179 rdf:type schema:DefinedTerm
180 Na4db6b709b9d43b380d9ac78003aa0a7 schema:affiliation https://www.grid.ac/institutes/grid.168645.8
181 schema:familyName Gupta
182 schema:givenName Suresh
183 rdf:type schema:Person
184 Na721bd154a7c45efbfcb83f23847719c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Hydrophobic and Hydrophilic Interactions
186 rdf:type schema:DefinedTerm
187 Nb44b3138126e4eb1a5c70c4bf62021b9 schema:name doi
188 schema:value 10.1007/s11095-019-2604-9
189 rdf:type schema:PropertyValue
190 Ncfcaed68c91b4d8f891345a5522b489a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Animals
192 rdf:type schema:DefinedTerm
193 Ndae83aceb9974146b63715e37802eaf0 schema:affiliation https://www.grid.ac/institutes/grid.4886.2
194 schema:familyName Bogdanov Jr
195 schema:givenName Alexei A.
196 rdf:type schema:Person
197 Ndbb6726267ee45d3998974af49e25721 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Drug Liberation
199 rdf:type schema:DefinedTerm
200 Ndc441ecab68b43f7ae818ad8f41a7a86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Polyethylene Glycols
202 rdf:type schema:DefinedTerm
203 Nde25bee9e8bd494abe2ec0323eed06f3 schema:affiliation https://www.grid.ac/institutes/grid.168645.8
204 schema:familyName Leporati
205 schema:givenName Anita
206 rdf:type schema:Person
207 Ne35d6e2c9cbe464ab4ba3e4ec127783f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Quinolones
209 rdf:type schema:DefinedTerm
210 Neb8be065309749be871ebac5bc37e38d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Drug Carriers
212 rdf:type schema:DefinedTerm
213 Nf03095adbe2843eeb637a5133a34131a schema:volumeNumber 36
214 rdf:type schema:PublicationVolume
215 Nf1338d6b97fe40bab17589ff0baa7580 schema:name dimensions_id
216 schema:value pub.1113043247
217 rdf:type schema:PropertyValue
218 Nf41a9ed46cd348e0a33a9ee5edad473f rdf:first N9ad0b373276e4cb7bc0b68be4470f824
219 rdf:rest N17656824b788414996833930056b6054
220 Nf7c9af14a96c4e12a3f272ff38f11f4c schema:issueNumber 5
221 rdf:type schema:PublicationIssue
222 Nfa74309cccbb43a290382cc5cb9c6a9f rdf:first N371b1205a3724b618bf87c73699dd5c8
223 rdf:rest N35ed904e7ea744d392c361b3e7630eba
224 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
225 schema:name Medical and Health Sciences
226 rdf:type schema:DefinedTerm
227 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
228 schema:name Medical Microbiology
229 rdf:type schema:DefinedTerm
230 sg:grant.2501202 http://pending.schema.org/fundedItem sg:pub.10.1007/s11095-019-2604-9
231 rdf:type schema:MonetaryGrant
232 sg:grant.2674233 http://pending.schema.org/fundedItem sg:pub.10.1007/s11095-019-2604-9
233 rdf:type schema:MonetaryGrant
234 sg:grant.2675319 http://pending.schema.org/fundedItem sg:pub.10.1007/s11095-019-2604-9
235 rdf:type schema:MonetaryGrant
236 sg:grant.3492677 http://pending.schema.org/fundedItem sg:pub.10.1007/s11095-019-2604-9
237 rdf:type schema:MonetaryGrant
238 sg:grant.3803347 http://pending.schema.org/fundedItem sg:pub.10.1007/s11095-019-2604-9
239 rdf:type schema:MonetaryGrant
240 sg:journal.1094644 schema:issn 0724-8741
241 1573-904X
242 schema:name Pharmaceutical Research
243 rdf:type schema:Periodical
244 sg:pub.10.1007/s11095-006-9132-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029273543
245 https://doi.org/10.1007/s11095-006-9132-0
246 rdf:type schema:CreativeWork
247 sg:pub.10.1007/s11095-008-9765-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020710738
248 https://doi.org/10.1007/s11095-008-9765-2
249 rdf:type schema:CreativeWork
250 sg:pub.10.1007/s11095-011-0542-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048786503
251 https://doi.org/10.1007/s11095-011-0542-2
252 rdf:type schema:CreativeWork
253 sg:pub.10.1007/s11095-011-0646-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052689346
254 https://doi.org/10.1007/s11095-011-0646-8
255 rdf:type schema:CreativeWork
256 sg:pub.10.1007/s11095-012-0904-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034306048
257 https://doi.org/10.1007/s11095-012-0904-4
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/365451a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016663177
260 https://doi.org/10.1038/365451a0
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/mi.2010.2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035530579
263 https://doi.org/10.1038/mi.2010.2
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/nature11398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044805538
266 https://doi.org/10.1038/nature11398
267 rdf:type schema:CreativeWork
268 sg:pub.10.1186/1471-2334-9-198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033177609
269 https://doi.org/10.1186/1471-2334-9-198
270 rdf:type schema:CreativeWork
271 https://app.dimensions.ai/details/publication/pub.1077332473 schema:CreativeWork
272 https://doi.org/10.1001/jama.2018.1917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101781476
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/j.actbio.2016.08.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040152253
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/j.addr.2015.09.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033043878
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/j.biomaterials.2018.03.054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101841348
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/j.clinthera.2009.04.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049082202
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/j.ejpb.2008.09.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044805108
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/j.ejpb.2016.12.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021916822
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/j.ijpharm.2009.12.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046419605
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/j.ijpharm.2012.07.070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016681495
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/j.jconrel.2012.06.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022569245
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/j.jconrel.2014.04.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050437019
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/j.jconrel.2014.10.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031433494
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/j.nano.2011.01.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006390845
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/j.nano.2016.07.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026059205
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1021/acs.molpharmaceut.5b00544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055120105
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1021/bc5005087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000466388
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1071/sh18103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110205743
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1073/pnas.1717932115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100077594
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1089/aid.2009.0227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059225965
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1097/qad.0000000000001349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050611697
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1097/qai.0000000000000172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016713434
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1126/scitranslmed.3003453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062687346
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1128/aac.00450-16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062708972
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1128/aac.03591-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051874284
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1128/jcm.01291-16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062712019
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1146/annurev.bi.63.070194.001025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046544253
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1146/annurev.biochem.67.1.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032641448
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1163/156856201744425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044691762
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1371/journal.pone.0074314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014578302
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1517/13543780903055056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031447014
331 rdf:type schema:CreativeWork
332 https://doi.org/10.2174/1389200043335487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069175457
333 rdf:type schema:CreativeWork
334 https://doi.org/10.2174/1568026043388448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069193069
335 rdf:type schema:CreativeWork
336 https://doi.org/10.2217/nnm.09.90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028476889
337 rdf:type schema:CreativeWork
338 https://doi.org/10.7150/thno.4070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035584077
339 rdf:type schema:CreativeWork
340 https://www.grid.ac/institutes/grid.14476.30 schema:alternateName Moscow State University
341 schema:name A.N. Belozersky Institute of Physico-Chemical Biology and Department of Chemistry, Moscow State University, Moscow, Russia
342 rdf:type schema:Organization
343 https://www.grid.ac/institutes/grid.168645.8 schema:alternateName University of Massachusetts Medical School
344 schema:name Laboratory of Molecular Imaging Probes, Department of Radiology, University of Massachusetts Medical School, S6-434, 55 Lake Ave North, 01655, Worcester, MA, USA
345 rdf:type schema:Organization
346 https://www.grid.ac/institutes/grid.423536.5 schema:alternateName PharmaIN (United States)
347 schema:name PharmaIn Corp, 11812 North Creek Parkway N. Suite 10, Bothell, Washington, USA
348 rdf:type schema:Organization
349 https://www.grid.ac/institutes/grid.4886.2 schema:alternateName Russian Academy of Sciences
350 schema:name Department of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russia
351 Laboratory of Molecular Imaging Probes, Department of Radiology, University of Massachusetts Medical School, S6-434, 55 Lake Ave North, 01655, Worcester, MA, USA
352 Laboratory of Molecular Imaging, A. N. Bach Institute of Biochemistry, Federal Research Center “Fundamentals of Biotechnology”, Russian Academy of Sciences, Laboratory of Molecular Imaging, Moscow, Russia
353 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...