Increasing the Bile Acid Sequestration Performance of Cationic Hydrogels by Using an Advanced/Controlled Polymerization Technique View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-06-16

AUTHORS

Patrícia V. Mendonça, André Matos, Andreia F. Sousa, Arménio C. Serra, Sérgio Simões, Jorge F. J. Coelho

ABSTRACT

PurposeTo investigate the influence of the polymerization technique and the content of hydroxyl groups on the performance of new bile acid sequestrants based on PAMPMTA-co-PHEA (PAMPTMA: poly((3-acrylamidopropyl)trimethylammonium chloride); PHEA: poly(2-hydroxyethyl acrylate)) hydrogels.MethodsPAMPMTA-co-PHEA hydrogels were prepared using either free radical polymerization or supplemental activator and reducing agent atom transfer radical polymerization. The chemical structure and composition of the hydrogels was confirmed by both FTIR and ssNMR. The binding of sodium cholate as the model bile salt was evaluated in simulated intestinal fluid using HPLC. The degradation of the polymers was evaluated in vitro in solutions mimicking the gastrointestinal tract environment.ResultsThe binding showed that an increase of the amount of HEA in the hydrogel lead to a decrease of the binding capacity. In addition, it was demonstrated for the first time that the hydrogels produced by SARA ATRP presented a higher binding capacity than similar ones produced by FRP. Finally, it was observed that copolymers of PAMPTMA-co-PHEA showed no sign of degradation in solutions mimicking both the stomach and the intestine environment.ConclusionsThe use of an advanced polymerization technique, such as the SARA ATRP, could be beneficial for the preparation of BAS with enhanced performance. More... »

PAGES

1934-1943

References to SciGraph publications

  • 2001. Pancreatic Lipase in INTESTINAL LIPID METABOLISM
  • 1991-01. Bile acid sequestrants: Mechanisms of action on bile acid and cholesterol metabolism in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 1991-01. Bile acid sequestrants: mechanisms of action on bile acid and cholesterol metabolism in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11095-017-2204-5

    DOI

    http://dx.doi.org/10.1007/s11095-017-2204-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1086044520

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28623473


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Pharmacology and Pharmaceutical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bile Acids and Salts", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Binding Sites", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hydrogels", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oxidation-Reduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polyhydroxyethyl Methacrylate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymerization", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Quaternary Ammonium Compounds", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sodium Cholate", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "CEMUC, Department of Chemical Engineering, University of Coimbra, 3030-790, Coimbra, Portugal", 
              "id": "http://www.grid.ac/institutes/grid.8051.c", 
              "name": [
                "CEMUC, Department of Chemical Engineering, University of Coimbra, 3030-790, Coimbra, Portugal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mendon\u00e7a", 
            "givenName": "Patr\u00edcia V.", 
            "id": "sg:person.012105015606.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012105015606.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CEMUC, Department of Chemical Engineering, University of Coimbra, 3030-790, Coimbra, Portugal", 
              "id": "http://www.grid.ac/institutes/grid.8051.c", 
              "name": [
                "CEMUC, Department of Chemical Engineering, University of Coimbra, 3030-790, Coimbra, Portugal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matos", 
            "givenName": "Andr\u00e9", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CICECO - Aveiro Institute of Materials and Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal", 
              "id": "http://www.grid.ac/institutes/grid.7311.4", 
              "name": [
                "CICECO - Aveiro Institute of Materials and Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sousa", 
            "givenName": "Andreia F.", 
            "id": "sg:person.01257674762.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257674762.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CEMUC, Department of Chemical Engineering, University of Coimbra, 3030-790, Coimbra, Portugal", 
              "id": "http://www.grid.ac/institutes/grid.8051.c", 
              "name": [
                "CEMUC, Department of Chemical Engineering, University of Coimbra, 3030-790, Coimbra, Portugal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Serra", 
            "givenName": "Arm\u00e9nio C.", 
            "id": "sg:person.0743417201.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743417201.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Bluepharma, Ind\u00fastria Farmac\u00eautica, SA, S\u00e3o Martinho do Bispo, 3045-016, Coimbra, Portugal", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Bluepharma, Ind\u00fastria Farmac\u00eautica, SA, S\u00e3o Martinho do Bispo, 3045-016, Coimbra, Portugal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sim\u00f5es", 
            "givenName": "S\u00e9rgio", 
            "id": "sg:person.01011715045.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011715045.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CEMUC, Department of Chemical Engineering, University of Coimbra, 3030-790, Coimbra, Portugal", 
              "id": "http://www.grid.ac/institutes/grid.8051.c", 
              "name": [
                "CEMUC, Department of Chemical Engineering, University of Coimbra, 3030-790, Coimbra, Portugal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Coelho", 
            "givenName": "Jorge F. J.", 
            "id": "sg:person.01010137046.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010137046.07"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/bf03216291", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025227221", 
              "https://doi.org/10.1007/bf03216291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4615-1195-3_4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000070293", 
              "https://doi.org/10.1007/978-1-4615-1195-3_4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01409410", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007795274", 
              "https://doi.org/10.1007/bf01409410"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-06-16", 
        "datePublishedReg": "2017-06-16", 
        "description": "PurposeTo investigate the influence of the polymerization technique and the content of hydroxyl groups on the performance of new bile acid sequestrants based on PAMPMTA-co-PHEA (PAMPTMA: poly((3-acrylamidopropyl)trimethylammonium chloride); PHEA: poly(2-hydroxyethyl acrylate)) hydrogels.MethodsPAMPMTA-co-PHEA hydrogels were prepared using either free radical polymerization or supplemental activator and reducing agent atom transfer radical polymerization. The chemical structure and composition of the hydrogels was confirmed by both FTIR and ssNMR. The binding of sodium cholate as the model bile salt was evaluated in simulated intestinal fluid using HPLC. The degradation of the polymers was evaluated in vitro in solutions mimicking the gastrointestinal tract environment.ResultsThe binding showed that an increase of the amount of HEA in the hydrogel lead to a decrease of the binding capacity. In addition, it was demonstrated for the first time that the hydrogels produced by SARA ATRP presented a higher binding capacity than similar ones produced by FRP. Finally, it was observed that copolymers of PAMPTMA-co-PHEA showed no sign of degradation in solutions mimicking both the stomach and the intestine environment.ConclusionsThe use of an advanced polymerization technique, such as the SARA ATRP, could be beneficial for the preparation of BAS with enhanced performance.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s11095-017-2204-5", 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.9586194", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3767877", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3532345", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1094644", 
            "issn": [
              "0724-8741", 
              "1573-904X"
            ], 
            "name": "Pharmaceutical Research", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "9", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "34"
          }
        ], 
        "keywords": [
          "polymerization technique", 
          "radical polymerization", 
          "SARA ATRP", 
          "agent atom transfer radical polymerization", 
          "atom transfer radical polymerization", 
          "transfer radical polymerization", 
          "free radical polymerization", 
          "advanced polymerization techniques", 
          "amount of HEA", 
          "high binding capacity", 
          "model bile salt", 
          "supplemental activator", 
          "chemical structure", 
          "hydroxyl groups", 
          "cationic hydrogels", 
          "intestinal fluid", 
          "hydrogel lead", 
          "hydrogels", 
          "ATRP", 
          "polymerization", 
          "intestine environment", 
          "sequestration performance", 
          "signs of degradation", 
          "sodium cholate", 
          "enhanced performance", 
          "gastrointestinal tract environment", 
          "binding capacity", 
          "copolymers", 
          "FTIR", 
          "polymers", 
          "new bile acid sequestrant", 
          "PHEA", 
          "first time", 
          "salt", 
          "degradation", 
          "solution", 
          "bile salts", 
          "binding", 
          "preparation", 
          "HPLC", 
          "cholate", 
          "capacity", 
          "structure", 
          "composition", 
          "technique", 
          "HEA", 
          "lead", 
          "performance", 
          "amount", 
          "sequestrants", 
          "BAS", 
          "addition", 
          "environment", 
          "content", 
          "influence", 
          "bile acid sequestrants", 
          "similar ones", 
          "group", 
          "acid sequestrants", 
          "fluid", 
          "decrease", 
          "increase", 
          "time", 
          "one", 
          "use", 
          "activator", 
          "ConclusionsThe use", 
          "stomach", 
          "FRP", 
          "signs", 
          "PurposeTo"
        ], 
        "name": "Increasing the Bile Acid Sequestration Performance of Cationic Hydrogels by Using an Advanced/Controlled Polymerization Technique", 
        "pagination": "1934-1943", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1086044520"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s11095-017-2204-5"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28623473"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s11095-017-2204-5", 
          "https://app.dimensions.ai/details/publication/pub.1086044520"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-12-01T06:35", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_723.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s11095-017-2204-5"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11095-017-2204-5'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11095-017-2204-5'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11095-017-2204-5'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11095-017-2204-5'


     

    This table displays all metadata directly associated to this object as RDF triples.

    226 TRIPLES      21 PREDICATES      108 URIs      97 LITERALS      16 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s11095-017-2204-5 schema:about N2a2642df7a394700a4b8b9fa63be7f76
    2 N37b1490ae4454af88e2d7b40a1800df2
    3 N3c5986254d164e31bae2a7b119b5b89d
    4 N5085d41e900d4a86b536710d77d28b6f
    5 N5bf8813345f34aca9ac51f901730a1f4
    6 N9dca3d3aab4e4c87aabbf8cee5b1e9b6
    7 Ndcd1b804c7374737883736847cf0454e
    8 Ne5f1193f80e8485eb3f706b61c224d33
    9 Nf16ef321d78e4883b305e0d00dde1d14
    10 anzsrc-for:11
    11 anzsrc-for:1115
    12 schema:author N478057deaf8643dd9950317d381b09cf
    13 schema:citation sg:pub.10.1007/978-1-4615-1195-3_4
    14 sg:pub.10.1007/bf01409410
    15 sg:pub.10.1007/bf03216291
    16 schema:datePublished 2017-06-16
    17 schema:datePublishedReg 2017-06-16
    18 schema:description PurposeTo investigate the influence of the polymerization technique and the content of hydroxyl groups on the performance of new bile acid sequestrants based on PAMPMTA-co-PHEA (PAMPTMA: poly((3-acrylamidopropyl)trimethylammonium chloride); PHEA: poly(2-hydroxyethyl acrylate)) hydrogels.MethodsPAMPMTA-co-PHEA hydrogels were prepared using either free radical polymerization or supplemental activator and reducing agent atom transfer radical polymerization. The chemical structure and composition of the hydrogels was confirmed by both FTIR and ssNMR. The binding of sodium cholate as the model bile salt was evaluated in simulated intestinal fluid using HPLC. The degradation of the polymers was evaluated in vitro in solutions mimicking the gastrointestinal tract environment.ResultsThe binding showed that an increase of the amount of HEA in the hydrogel lead to a decrease of the binding capacity. In addition, it was demonstrated for the first time that the hydrogels produced by SARA ATRP presented a higher binding capacity than similar ones produced by FRP. Finally, it was observed that copolymers of PAMPTMA-co-PHEA showed no sign of degradation in solutions mimicking both the stomach and the intestine environment.ConclusionsThe use of an advanced polymerization technique, such as the SARA ATRP, could be beneficial for the preparation of BAS with enhanced performance.
    19 schema:genre article
    20 schema:isAccessibleForFree false
    21 schema:isPartOf Na1139dfc33a14caab453207a0a7d2735
    22 Nb8b200f979594f02bba5f797cd4a43b6
    23 sg:journal.1094644
    24 schema:keywords ATRP
    25 BAS
    26 ConclusionsThe use
    27 FRP
    28 FTIR
    29 HEA
    30 HPLC
    31 PHEA
    32 PurposeTo
    33 SARA ATRP
    34 acid sequestrants
    35 activator
    36 addition
    37 advanced polymerization techniques
    38 agent atom transfer radical polymerization
    39 amount
    40 amount of HEA
    41 atom transfer radical polymerization
    42 bile acid sequestrants
    43 bile salts
    44 binding
    45 binding capacity
    46 capacity
    47 cationic hydrogels
    48 chemical structure
    49 cholate
    50 composition
    51 content
    52 copolymers
    53 decrease
    54 degradation
    55 enhanced performance
    56 environment
    57 first time
    58 fluid
    59 free radical polymerization
    60 gastrointestinal tract environment
    61 group
    62 high binding capacity
    63 hydrogel lead
    64 hydrogels
    65 hydroxyl groups
    66 increase
    67 influence
    68 intestinal fluid
    69 intestine environment
    70 lead
    71 model bile salt
    72 new bile acid sequestrant
    73 one
    74 performance
    75 polymerization
    76 polymerization technique
    77 polymers
    78 preparation
    79 radical polymerization
    80 salt
    81 sequestrants
    82 sequestration performance
    83 signs
    84 signs of degradation
    85 similar ones
    86 sodium cholate
    87 solution
    88 stomach
    89 structure
    90 supplemental activator
    91 technique
    92 time
    93 transfer radical polymerization
    94 use
    95 schema:name Increasing the Bile Acid Sequestration Performance of Cationic Hydrogels by Using an Advanced/Controlled Polymerization Technique
    96 schema:pagination 1934-1943
    97 schema:productId N86ac8918bc684f38922a7f12c7d3b831
    98 N91ef3997c9e74661a34d7aec5c2af02d
    99 Nca09b09d01574485b488bc4ee98bf61c
    100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086044520
    101 https://doi.org/10.1007/s11095-017-2204-5
    102 schema:sdDatePublished 2022-12-01T06:35
    103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    104 schema:sdPublisher Nd46bcf99d1504802a1ee7138ff7f4433
    105 schema:url https://doi.org/10.1007/s11095-017-2204-5
    106 sgo:license sg:explorer/license/
    107 sgo:sdDataset articles
    108 rdf:type schema:ScholarlyArticle
    109 N2a2642df7a394700a4b8b9fa63be7f76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    110 schema:name Polyhydroxyethyl Methacrylate
    111 rdf:type schema:DefinedTerm
    112 N32e7dda5c2ad4eb09b0788f8d96f9e78 rdf:first sg:person.01010137046.07
    113 rdf:rest rdf:nil
    114 N37b1490ae4454af88e2d7b40a1800df2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Binding Sites
    116 rdf:type schema:DefinedTerm
    117 N3c5986254d164e31bae2a7b119b5b89d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Bile Acids and Salts
    119 rdf:type schema:DefinedTerm
    120 N478057deaf8643dd9950317d381b09cf rdf:first sg:person.012105015606.04
    121 rdf:rest Nc6182c7eec404e9faaa03df96bf57bc0
    122 N5085d41e900d4a86b536710d77d28b6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Oxidation-Reduction
    124 rdf:type schema:DefinedTerm
    125 N5bf8813345f34aca9ac51f901730a1f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Hydrogels
    127 rdf:type schema:DefinedTerm
    128 N86ac8918bc684f38922a7f12c7d3b831 schema:name dimensions_id
    129 schema:value pub.1086044520
    130 rdf:type schema:PropertyValue
    131 N8d3a0413c3fd4ce698439b8f11c210e7 rdf:first sg:person.01257674762.74
    132 rdf:rest Ne2593c55003c49279898f38f84101f70
    133 N91ef3997c9e74661a34d7aec5c2af02d schema:name doi
    134 schema:value 10.1007/s11095-017-2204-5
    135 rdf:type schema:PropertyValue
    136 N9dca3d3aab4e4c87aabbf8cee5b1e9b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Quaternary Ammonium Compounds
    138 rdf:type schema:DefinedTerm
    139 Na1139dfc33a14caab453207a0a7d2735 schema:issueNumber 9
    140 rdf:type schema:PublicationIssue
    141 Nb8b200f979594f02bba5f797cd4a43b6 schema:volumeNumber 34
    142 rdf:type schema:PublicationVolume
    143 Nc6182c7eec404e9faaa03df96bf57bc0 rdf:first Nf5a2baa2367740668954586c0d7bfca3
    144 rdf:rest N8d3a0413c3fd4ce698439b8f11c210e7
    145 Nca09b09d01574485b488bc4ee98bf61c schema:name pubmed_id
    146 schema:value 28623473
    147 rdf:type schema:PropertyValue
    148 Nd46bcf99d1504802a1ee7138ff7f4433 schema:name Springer Nature - SN SciGraph project
    149 rdf:type schema:Organization
    150 Ndcd1b804c7374737883736847cf0454e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Sodium Cholate
    152 rdf:type schema:DefinedTerm
    153 Ne2593c55003c49279898f38f84101f70 rdf:first sg:person.0743417201.03
    154 rdf:rest Neae6900840944be790a185bd4365d6e0
    155 Ne5f1193f80e8485eb3f706b61c224d33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Humans
    157 rdf:type schema:DefinedTerm
    158 Neae6900840944be790a185bd4365d6e0 rdf:first sg:person.01011715045.75
    159 rdf:rest N32e7dda5c2ad4eb09b0788f8d96f9e78
    160 Nf16ef321d78e4883b305e0d00dde1d14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Polymerization
    162 rdf:type schema:DefinedTerm
    163 Nf5a2baa2367740668954586c0d7bfca3 schema:affiliation grid-institutes:grid.8051.c
    164 schema:familyName Matos
    165 schema:givenName André
    166 rdf:type schema:Person
    167 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    168 schema:name Medical and Health Sciences
    169 rdf:type schema:DefinedTerm
    170 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
    171 schema:name Pharmacology and Pharmaceutical Sciences
    172 rdf:type schema:DefinedTerm
    173 sg:grant.3532345 http://pending.schema.org/fundedItem sg:pub.10.1007/s11095-017-2204-5
    174 rdf:type schema:MonetaryGrant
    175 sg:grant.3767877 http://pending.schema.org/fundedItem sg:pub.10.1007/s11095-017-2204-5
    176 rdf:type schema:MonetaryGrant
    177 sg:grant.9586194 http://pending.schema.org/fundedItem sg:pub.10.1007/s11095-017-2204-5
    178 rdf:type schema:MonetaryGrant
    179 sg:journal.1094644 schema:issn 0724-8741
    180 1573-904X
    181 schema:name Pharmaceutical Research
    182 schema:publisher Springer Nature
    183 rdf:type schema:Periodical
    184 sg:person.01010137046.07 schema:affiliation grid-institutes:grid.8051.c
    185 schema:familyName Coelho
    186 schema:givenName Jorge F. J.
    187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010137046.07
    188 rdf:type schema:Person
    189 sg:person.01011715045.75 schema:affiliation grid-institutes:None
    190 schema:familyName Simões
    191 schema:givenName Sérgio
    192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011715045.75
    193 rdf:type schema:Person
    194 sg:person.012105015606.04 schema:affiliation grid-institutes:grid.8051.c
    195 schema:familyName Mendonça
    196 schema:givenName Patrícia V.
    197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012105015606.04
    198 rdf:type schema:Person
    199 sg:person.01257674762.74 schema:affiliation grid-institutes:grid.7311.4
    200 schema:familyName Sousa
    201 schema:givenName Andreia F.
    202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257674762.74
    203 rdf:type schema:Person
    204 sg:person.0743417201.03 schema:affiliation grid-institutes:grid.8051.c
    205 schema:familyName Serra
    206 schema:givenName Arménio C.
    207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743417201.03
    208 rdf:type schema:Person
    209 sg:pub.10.1007/978-1-4615-1195-3_4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000070293
    210 https://doi.org/10.1007/978-1-4615-1195-3_4
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1007/bf01409410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007795274
    213 https://doi.org/10.1007/bf01409410
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1007/bf03216291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025227221
    216 https://doi.org/10.1007/bf03216291
    217 rdf:type schema:CreativeWork
    218 grid-institutes:None schema:alternateName Bluepharma, Indústria Farmacêutica, SA, São Martinho do Bispo, 3045-016, Coimbra, Portugal
    219 schema:name Bluepharma, Indústria Farmacêutica, SA, São Martinho do Bispo, 3045-016, Coimbra, Portugal
    220 rdf:type schema:Organization
    221 grid-institutes:grid.7311.4 schema:alternateName CICECO - Aveiro Institute of Materials and Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal
    222 schema:name CICECO - Aveiro Institute of Materials and Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal
    223 rdf:type schema:Organization
    224 grid-institutes:grid.8051.c schema:alternateName CEMUC, Department of Chemical Engineering, University of Coimbra, 3030-790, Coimbra, Portugal
    225 schema:name CEMUC, Department of Chemical Engineering, University of Coimbra, 3030-790, Coimbra, Portugal
    226 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...