Biodegradable Poly(ester-urethane) Carriers Exhibiting Controlled Release of Epirubicin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-01-24

AUTHORS

Karolina Żółtowska, Urszula Piotrowska, Ewa Oledzka, Marzena Kuras, Anna Zgadzaj, Marcin Sobczak

ABSTRACT

PurposeThe purpose of this study was to develop the perspective biodegradable poly(ester-urethane) (PUR) carriers based on “predominantly isotactic” and atactic polylactides (PLAs), and poly(ε-caprolactone) (PCL), for the controlled release of epirubicin (EPI).MethodsThe biodegradable PURs containing different soft segments as new and effective carriers of EPI have been obtained. The preliminary studies on toxicity and degradation of obtained polymers, and the release of the EPI from PUR carriers were carried out.ResultsWe found that the kinetic release of EPI from the obtained PUR carriers tested in vitro at 37°C and pH 7.4 was strongly dependent on the kind of the polyesters, used as the soft segment in PURs synthesis. Furthermore, we demonstrated that the EPI was released from various synthesized carriers in a rather regular manner, according to the diffusion-degradation and degradation mechanisms. Importantly, in some cases, the kinetics of the EPI release was nearly zero-order.ConclusionThe results show that the obtained PURs are very effective and perspective carriers and might be potentially applied in the technology of high controlled EPI delivery systems. More... »

PAGES

780-792

References to SciGraph publications

  • 2007-04-25. Role of anthracyclines in the era of targeted therapy in CARDIOVASCULAR TOXICOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11095-017-2105-7

    DOI

    http://dx.doi.org/10.1007/s11095-017-2105-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1074211210

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28120174


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