Rifampicin Loaded Mannosylated Cationic Nanostructured Lipid Carriers for Alveolar Macrophage-specific Delivery View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-05

AUTHORS

Xu Song, Qing Lin, Ling Guo, Yao Fu, Jianfeng Han, Huan Ke, Xun Sun, Tao Gong, Zhirong Zhang

ABSTRACT

PURPOSE: In this study, cationic mannosylated nanostructured lipid carriers (Man-NLCs) were developed for the targeted delivery of rifampicin to alveolar macrophages. METHODS: Rifampicin loaded Man-NLCs (RFP-Man-NLCs) and rifampicin loaded unmodified nanostructured lipid carriers (REP-NLCs) were prepared using thin film homogenization method and characterized by particle size, polydispersity index, zeta potential, transmission electron microscopy, encapsulation efficiency, pharmacokinetics, biodistribution, cell specific targeting, cytotoxicity and inflammatory response. RESULTS: RFP-Man-NLCs and REP-NLCs obtained displayed a size distribution around 160 nm (PDI <0.30) with positive charges of approximately 30 mV. The encapsulation efficiency of RFP was above 90%. In the biodistribution study, both RFP-Man-NLCs and RFP-NLCs, compared with the commercially available rifampicin solution, displayed superior lung-targeting ability. Compared to REP-NLCs, RFP-Man-NLCs exhibited significantly higher uptake efficiency in NR8383 cells and alveolar macrophages, which achieved cell-specific targeting. In addition, RFP-Man-NLCs were demonstrated to be a safe formulation with minimum toxicity and no inflammatory response. CONCLUSIONS: RFP-Man-NLCs provided an alternative strategy for selectively delivering rifampicin to alveolar macrophages. More... »

PAGES

1741-1751

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11095-014-1572-3

DOI

http://dx.doi.org/10.1007/s11095-014-1572-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024512482

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25407545


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibiotics, Antitubercular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Carriers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Delivery Systems", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macrophages, Alveolar", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mannose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nanostructures", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Particle Size", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Wistar", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rifampin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Distribution", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Sichuan University", 
          "id": "https://www.grid.ac/institutes/grid.13291.38", 
          "name": [
            "Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, Sichuan University, Chengdu, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Song", 
        "givenName": "Xu", 
        "id": "sg:person.015635362715.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015635362715.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sichuan University", 
          "id": "https://www.grid.ac/institutes/grid.13291.38", 
          "name": [
            "Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, Sichuan University, Chengdu, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Qing", 
        "id": "sg:person.01133407155.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133407155.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sichuan University", 
          "id": "https://www.grid.ac/institutes/grid.13291.38", 
          "name": [
            "Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, Sichuan University, Chengdu, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guo", 
        "givenName": "Ling", 
        "id": "sg:person.0716240702.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716240702.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sichuan University", 
          "id": "https://www.grid.ac/institutes/grid.13291.38", 
          "name": [
            "Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, Sichuan University, Chengdu, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fu", 
        "givenName": "Yao", 
        "id": "sg:person.01276274543.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276274543.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sichuan University", 
          "id": "https://www.grid.ac/institutes/grid.13291.38", 
          "name": [
            "Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, Sichuan University, Chengdu, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Han", 
        "givenName": "Jianfeng", 
        "id": "sg:person.01346530047.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346530047.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sichuan University", 
          "id": "https://www.grid.ac/institutes/grid.13291.38", 
          "name": [
            "Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, Sichuan University, Chengdu, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ke", 
        "givenName": "Huan", 
        "id": "sg:person.012715574115.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012715574115.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sichuan University", 
          "id": "https://www.grid.ac/institutes/grid.13291.38", 
          "name": [
            "Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, Sichuan University, Chengdu, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sun", 
        "givenName": "Xun", 
        "id": "sg:person.01306201417.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306201417.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sichuan University", 
          "id": "https://www.grid.ac/institutes/grid.13291.38", 
          "name": [
            "Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, Sichuan University, Chengdu, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gong", 
        "givenName": "Tao", 
        "id": "sg:person.01206560212.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206560212.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sichuan University", 
          "id": "https://www.grid.ac/institutes/grid.13291.38", 
          "name": [
            "Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, Sichuan University, Chengdu, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Zhirong", 
        "id": "sg:person.01354266507.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354266507.69"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1211/002235702320266217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003050576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35021074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004001592", 
          "https://doi.org/10.1038/35021074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2009.12.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010696566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7150/thno.4525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011571982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/aps.2013.43", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011954397", 
          "https://doi.org/10.1038/aps.2013.43"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.201208077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013928763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpharm.2012.07.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014318488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-3659(00)00293-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015239656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ange.201208077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015786027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tube.2011.04.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016140779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/b:pham.0000029292.66792.4f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016548291", 
          "https://doi.org/10.1023/b:pham.0000029292.66792.4f"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3300865", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022831969", 
          "https://doi.org/10.1038/sj.gt.3300865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3300865", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022831969", 
          "https://doi.org/10.1038/sj.gt.3300865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2007.10.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023666748"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2012.09.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024834212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tube.2010.12.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025219027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jgm.910", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027358903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jchromb.2011.06.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028399198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2007.01.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029165479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ptr.3522", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032042121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nano.2010.09.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032044670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpharm.2005.06.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032157588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpharm.2005.06.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032157588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2011.10.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034686060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1286-4579(02)00083-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034739343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1286-4579(02)00083-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034739343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1088/0957-4484/24/29/295101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036118728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0171-2985(11)80465-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036463937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-5173(02)00180-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038245310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-5173(02)00180-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038245310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.200206-626oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040163774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/319235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042025418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3126/saarctb.v10i1.8677", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043980266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3126/saarctb.v10i1.8677", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043980266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2005.05.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045134057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2005.05.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045134057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2009.08.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045248678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1592/phco.2005.25.10.1303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046632459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1592/phco.2005.25.10.1303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046632459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2007.10.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048626242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpharm.2008.10.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048627630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11051-013-1634-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052359360", 
          "https://doi.org/10.1007/s11051-013-1634-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/smll.201301992", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052554517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpharm.2003.08.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052932357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/nl103264u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056218257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/nl103264u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056218257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1191/0960327106ht601oa", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064153583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1191/0960327106ht601oa", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064153583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074399694", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077245959", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081465548", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081908536", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082093488", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082186567", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082305205", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-05", 
    "datePublishedReg": "2015-05-01", 
    "description": "PURPOSE: In this study, cationic mannosylated nanostructured lipid carriers (Man-NLCs) were developed for the targeted delivery of rifampicin to alveolar macrophages.\nMETHODS: Rifampicin loaded Man-NLCs (RFP-Man-NLCs) and rifampicin loaded unmodified nanostructured lipid carriers (REP-NLCs) were prepared using thin film homogenization method and characterized by particle size, polydispersity index, zeta potential, transmission electron microscopy, encapsulation efficiency, pharmacokinetics, biodistribution, cell specific targeting, cytotoxicity and inflammatory response.\nRESULTS: RFP-Man-NLCs and REP-NLCs obtained displayed a size distribution around 160 nm (PDI <0.30) with positive charges of approximately 30 mV. The encapsulation efficiency of RFP was above 90%. In the biodistribution study, both RFP-Man-NLCs and RFP-NLCs, compared with the commercially available rifampicin solution, displayed superior lung-targeting ability. Compared to REP-NLCs, RFP-Man-NLCs exhibited significantly higher uptake efficiency in NR8383 cells and alveolar macrophages, which achieved cell-specific targeting. In addition, RFP-Man-NLCs were demonstrated to be a safe formulation with minimum toxicity and no inflammatory response.\nCONCLUSIONS: RFP-Man-NLCs provided an alternative strategy for selectively delivering rifampicin to alveolar macrophages.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11095-014-1572-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1094644", 
        "issn": [
          "0724-8741", 
          "1573-904X"
        ], 
        "name": "Pharmaceutical Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "32"
      }
    ], 
    "name": "Rifampicin Loaded Mannosylated Cationic Nanostructured Lipid Carriers for Alveolar Macrophage-specific Delivery", 
    "pagination": "1741-1751", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "74c75aa8cfbe94714ab14366545f965ed89dee75f0b80cd0970d328bfe88e6cf"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25407545"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8406521"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11095-014-1572-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1024512482"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11095-014-1572-3", 
      "https://app.dimensions.ai/details/publication/pub.1024512482"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:12", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000522.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11095-014-1572-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11095-014-1572-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11095-014-1572-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11095-014-1572-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11095-014-1572-3'


 

This table displays all metadata directly associated to this object as RDF triples.

325 TRIPLES      21 PREDICATES      91 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11095-014-1572-3 schema:about N01d0c076a4634f27b5cbc78883927bfc
2 N11f76139af54484fb328e0f4dcd884a1
3 N34301e8164d1414fad24ed8e0df52e7f
4 N4f1315ee2eda4751aa9b45032a5a27d3
5 N5fbedae37b8e4f99a026fe4b0b10f653
6 N625fe02d7a894b0f8179326a3f281c26
7 N7a994601e8a9400f8eb9f369e50c60a3
8 N9b3f0a5b21ea4d6b8f8b6e0524d9ac03
9 Na836304050a24f889ce395a26b99dacf
10 Nb469c9cb786d47e1987692dcbf106865
11 Nbb2cada1f67341a2be44a272a2740f75
12 Nbc1d46647763416c96a994d571fa5be5
13 Nd31cb8c65c7d45c6b67913813af2ac7d
14 Nee0536c7616c48239839ccbc11a12b6f
15 Nf394b928cad64be1bd9f22036f7d00ee
16 Nf409c3e826964fc1a37e3759af1da546
17 anzsrc-for:06
18 anzsrc-for:0601
19 schema:author Ne4ad38ece9374ed19f7d2859dcad0f4f
20 schema:citation sg:pub.10.1007/s11051-013-1634-1
21 sg:pub.10.1023/b:pham.0000029292.66792.4f
22 sg:pub.10.1038/35021074
23 sg:pub.10.1038/aps.2013.43
24 sg:pub.10.1038/sj.gt.3300865
25 https://app.dimensions.ai/details/publication/pub.1074399694
26 https://app.dimensions.ai/details/publication/pub.1077245959
27 https://app.dimensions.ai/details/publication/pub.1081465548
28 https://app.dimensions.ai/details/publication/pub.1081908536
29 https://app.dimensions.ai/details/publication/pub.1082093488
30 https://app.dimensions.ai/details/publication/pub.1082186567
31 https://app.dimensions.ai/details/publication/pub.1082305205
32 https://doi.org/10.1002/ange.201208077
33 https://doi.org/10.1002/anie.201208077
34 https://doi.org/10.1002/jgm.910
35 https://doi.org/10.1002/ptr.3522
36 https://doi.org/10.1002/smll.201301992
37 https://doi.org/10.1016/j.biomaterials.2005.05.044
38 https://doi.org/10.1016/j.ijpharm.2003.08.017
39 https://doi.org/10.1016/j.ijpharm.2005.06.025
40 https://doi.org/10.1016/j.ijpharm.2008.10.003
41 https://doi.org/10.1016/j.ijpharm.2012.07.036
42 https://doi.org/10.1016/j.jchromb.2011.06.041
43 https://doi.org/10.1016/j.jconrel.2007.01.013
44 https://doi.org/10.1016/j.jconrel.2007.10.011
45 https://doi.org/10.1016/j.jconrel.2007.10.027
46 https://doi.org/10.1016/j.jconrel.2009.08.026
47 https://doi.org/10.1016/j.jconrel.2009.12.019
48 https://doi.org/10.1016/j.jconrel.2011.10.009
49 https://doi.org/10.1016/j.jconrel.2012.09.011
50 https://doi.org/10.1016/j.nano.2010.09.001
51 https://doi.org/10.1016/j.tube.2010.12.001
52 https://doi.org/10.1016/j.tube.2011.04.003
53 https://doi.org/10.1016/s0168-3659(00)00293-5
54 https://doi.org/10.1016/s0171-2985(11)80465-1
55 https://doi.org/10.1016/s0378-5173(02)00180-1
56 https://doi.org/10.1016/s1286-4579(02)00083-7
57 https://doi.org/10.1021/nl103264u
58 https://doi.org/10.1086/319235
59 https://doi.org/10.1088/0957-4484/24/29/295101
60 https://doi.org/10.1164/rccm.200206-626oc
61 https://doi.org/10.1191/0960327106ht601oa
62 https://doi.org/10.1211/002235702320266217
63 https://doi.org/10.1592/phco.2005.25.10.1303
64 https://doi.org/10.3126/saarctb.v10i1.8677
65 https://doi.org/10.7150/thno.4525
66 schema:datePublished 2015-05
67 schema:datePublishedReg 2015-05-01
68 schema:description PURPOSE: In this study, cationic mannosylated nanostructured lipid carriers (Man-NLCs) were developed for the targeted delivery of rifampicin to alveolar macrophages. METHODS: Rifampicin loaded Man-NLCs (RFP-Man-NLCs) and rifampicin loaded unmodified nanostructured lipid carriers (REP-NLCs) were prepared using thin film homogenization method and characterized by particle size, polydispersity index, zeta potential, transmission electron microscopy, encapsulation efficiency, pharmacokinetics, biodistribution, cell specific targeting, cytotoxicity and inflammatory response. RESULTS: RFP-Man-NLCs and REP-NLCs obtained displayed a size distribution around 160 nm (PDI <0.30) with positive charges of approximately 30 mV. The encapsulation efficiency of RFP was above 90%. In the biodistribution study, both RFP-Man-NLCs and RFP-NLCs, compared with the commercially available rifampicin solution, displayed superior lung-targeting ability. Compared to REP-NLCs, RFP-Man-NLCs exhibited significantly higher uptake efficiency in NR8383 cells and alveolar macrophages, which achieved cell-specific targeting. In addition, RFP-Man-NLCs were demonstrated to be a safe formulation with minimum toxicity and no inflammatory response. CONCLUSIONS: RFP-Man-NLCs provided an alternative strategy for selectively delivering rifampicin to alveolar macrophages.
69 schema:genre research_article
70 schema:inLanguage en
71 schema:isAccessibleForFree false
72 schema:isPartOf N73c1fd9a87274908aaff95c7d9468e43
73 N7d47c589e2ff48879626ec7b3f2e6ed5
74 sg:journal.1094644
75 schema:name Rifampicin Loaded Mannosylated Cationic Nanostructured Lipid Carriers for Alveolar Macrophage-specific Delivery
76 schema:pagination 1741-1751
77 schema:productId N95842fe9d9a04035aa04bf68230cc078
78 Nd62ddfa98e244171bae9edc486b7641d
79 Ne982868e9ac94519841b59b70de67981
80 Nf8b0c71da9754f6895ae056b75ca3e6c
81 Nfe46e8f5722b44eda85ae6c6c7cdd442
82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024512482
83 https://doi.org/10.1007/s11095-014-1572-3
84 schema:sdDatePublished 2019-04-10T14:12
85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
86 schema:sdPublisher N7e3d37f4a826430e8464cea7a3801583
87 schema:url http://link.springer.com/10.1007%2Fs11095-014-1572-3
88 sgo:license sg:explorer/license/
89 sgo:sdDataset articles
90 rdf:type schema:ScholarlyArticle
91 N01d0c076a4634f27b5cbc78883927bfc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Cell Line
93 rdf:type schema:DefinedTerm
94 N11f76139af54484fb328e0f4dcd884a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Rats, Wistar
96 rdf:type schema:DefinedTerm
97 N1a09fa56fcf147d1b37b0ec42ef4b8dd rdf:first sg:person.01306201417.51
98 rdf:rest N9dbe94b36f1c4eb1a3dccbb1541d38dc
99 N34301e8164d1414fad24ed8e0df52e7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Male
101 rdf:type schema:DefinedTerm
102 N4153abc515a546709956a7c2794554c2 rdf:first sg:person.01276274543.60
103 rdf:rest N8511df98d31f41409adfdcf12d3e8c5a
104 N4f1315ee2eda4751aa9b45032a5a27d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Mannose
106 rdf:type schema:DefinedTerm
107 N5fbedae37b8e4f99a026fe4b0b10f653 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Particle Size
109 rdf:type schema:DefinedTerm
110 N625fe02d7a894b0f8179326a3f281c26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Rifampin
112 rdf:type schema:DefinedTerm
113 N73c1fd9a87274908aaff95c7d9468e43 schema:issueNumber 5
114 rdf:type schema:PublicationIssue
115 N7a994601e8a9400f8eb9f369e50c60a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Drug Carriers
117 rdf:type schema:DefinedTerm
118 N7d47c589e2ff48879626ec7b3f2e6ed5 schema:volumeNumber 32
119 rdf:type schema:PublicationVolume
120 N7e3d37f4a826430e8464cea7a3801583 schema:name Springer Nature - SN SciGraph project
121 rdf:type schema:Organization
122 N8511df98d31f41409adfdcf12d3e8c5a rdf:first sg:person.01346530047.61
123 rdf:rest Ncb930d9f11764588bdabbb033dec6d5a
124 N9439127d2c7147569a085cb02cfe195c rdf:first sg:person.0716240702.42
125 rdf:rest N4153abc515a546709956a7c2794554c2
126 N95842fe9d9a04035aa04bf68230cc078 schema:name pubmed_id
127 schema:value 25407545
128 rdf:type schema:PropertyValue
129 N9b3f0a5b21ea4d6b8f8b6e0524d9ac03 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Tissue Distribution
131 rdf:type schema:DefinedTerm
132 N9dbe94b36f1c4eb1a3dccbb1541d38dc rdf:first sg:person.01206560212.35
133 rdf:rest Nb9c121f1c26d463fbef4281e3c16a3f7
134 Na836304050a24f889ce395a26b99dacf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Drug Delivery Systems
136 rdf:type schema:DefinedTerm
137 Nb469c9cb786d47e1987692dcbf106865 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Macrophages, Alveolar
139 rdf:type schema:DefinedTerm
140 Nb9c121f1c26d463fbef4281e3c16a3f7 rdf:first sg:person.01354266507.69
141 rdf:rest rdf:nil
142 Nba68c6b0d91d4ba38bd244cb8d07f6c4 rdf:first sg:person.01133407155.16
143 rdf:rest N9439127d2c7147569a085cb02cfe195c
144 Nbb2cada1f67341a2be44a272a2740f75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Humans
146 rdf:type schema:DefinedTerm
147 Nbc1d46647763416c96a994d571fa5be5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Lipids
149 rdf:type schema:DefinedTerm
150 Ncb930d9f11764588bdabbb033dec6d5a rdf:first sg:person.012715574115.00
151 rdf:rest N1a09fa56fcf147d1b37b0ec42ef4b8dd
152 Nd31cb8c65c7d45c6b67913813af2ac7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Mice
154 rdf:type schema:DefinedTerm
155 Nd62ddfa98e244171bae9edc486b7641d schema:name readcube_id
156 schema:value 74c75aa8cfbe94714ab14366545f965ed89dee75f0b80cd0970d328bfe88e6cf
157 rdf:type schema:PropertyValue
158 Ne4ad38ece9374ed19f7d2859dcad0f4f rdf:first sg:person.015635362715.39
159 rdf:rest Nba68c6b0d91d4ba38bd244cb8d07f6c4
160 Ne982868e9ac94519841b59b70de67981 schema:name doi
161 schema:value 10.1007/s11095-014-1572-3
162 rdf:type schema:PropertyValue
163 Nee0536c7616c48239839ccbc11a12b6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Nanostructures
165 rdf:type schema:DefinedTerm
166 Nf394b928cad64be1bd9f22036f7d00ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Animals
168 rdf:type schema:DefinedTerm
169 Nf409c3e826964fc1a37e3759af1da546 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Antibiotics, Antitubercular
171 rdf:type schema:DefinedTerm
172 Nf8b0c71da9754f6895ae056b75ca3e6c schema:name dimensions_id
173 schema:value pub.1024512482
174 rdf:type schema:PropertyValue
175 Nfe46e8f5722b44eda85ae6c6c7cdd442 schema:name nlm_unique_id
176 schema:value 8406521
177 rdf:type schema:PropertyValue
178 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
179 schema:name Biological Sciences
180 rdf:type schema:DefinedTerm
181 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
182 schema:name Biochemistry and Cell Biology
183 rdf:type schema:DefinedTerm
184 sg:journal.1094644 schema:issn 0724-8741
185 1573-904X
186 schema:name Pharmaceutical Research
187 rdf:type schema:Periodical
188 sg:person.01133407155.16 schema:affiliation https://www.grid.ac/institutes/grid.13291.38
189 schema:familyName Lin
190 schema:givenName Qing
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133407155.16
192 rdf:type schema:Person
193 sg:person.01206560212.35 schema:affiliation https://www.grid.ac/institutes/grid.13291.38
194 schema:familyName Gong
195 schema:givenName Tao
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206560212.35
197 rdf:type schema:Person
198 sg:person.012715574115.00 schema:affiliation https://www.grid.ac/institutes/grid.13291.38
199 schema:familyName Ke
200 schema:givenName Huan
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012715574115.00
202 rdf:type schema:Person
203 sg:person.01276274543.60 schema:affiliation https://www.grid.ac/institutes/grid.13291.38
204 schema:familyName Fu
205 schema:givenName Yao
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276274543.60
207 rdf:type schema:Person
208 sg:person.01306201417.51 schema:affiliation https://www.grid.ac/institutes/grid.13291.38
209 schema:familyName Sun
210 schema:givenName Xun
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306201417.51
212 rdf:type schema:Person
213 sg:person.01346530047.61 schema:affiliation https://www.grid.ac/institutes/grid.13291.38
214 schema:familyName Han
215 schema:givenName Jianfeng
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346530047.61
217 rdf:type schema:Person
218 sg:person.01354266507.69 schema:affiliation https://www.grid.ac/institutes/grid.13291.38
219 schema:familyName Zhang
220 schema:givenName Zhirong
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354266507.69
222 rdf:type schema:Person
223 sg:person.015635362715.39 schema:affiliation https://www.grid.ac/institutes/grid.13291.38
224 schema:familyName Song
225 schema:givenName Xu
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015635362715.39
227 rdf:type schema:Person
228 sg:person.0716240702.42 schema:affiliation https://www.grid.ac/institutes/grid.13291.38
229 schema:familyName Guo
230 schema:givenName Ling
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716240702.42
232 rdf:type schema:Person
233 sg:pub.10.1007/s11051-013-1634-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052359360
234 https://doi.org/10.1007/s11051-013-1634-1
235 rdf:type schema:CreativeWork
236 sg:pub.10.1023/b:pham.0000029292.66792.4f schema:sameAs https://app.dimensions.ai/details/publication/pub.1016548291
237 https://doi.org/10.1023/b:pham.0000029292.66792.4f
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/35021074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004001592
240 https://doi.org/10.1038/35021074
241 rdf:type schema:CreativeWork
242 sg:pub.10.1038/aps.2013.43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011954397
243 https://doi.org/10.1038/aps.2013.43
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/sj.gt.3300865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022831969
246 https://doi.org/10.1038/sj.gt.3300865
247 rdf:type schema:CreativeWork
248 https://app.dimensions.ai/details/publication/pub.1074399694 schema:CreativeWork
249 https://app.dimensions.ai/details/publication/pub.1077245959 schema:CreativeWork
250 https://app.dimensions.ai/details/publication/pub.1081465548 schema:CreativeWork
251 https://app.dimensions.ai/details/publication/pub.1081908536 schema:CreativeWork
252 https://app.dimensions.ai/details/publication/pub.1082093488 schema:CreativeWork
253 https://app.dimensions.ai/details/publication/pub.1082186567 schema:CreativeWork
254 https://app.dimensions.ai/details/publication/pub.1082305205 schema:CreativeWork
255 https://doi.org/10.1002/ange.201208077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015786027
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1002/anie.201208077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013928763
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1002/jgm.910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027358903
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1002/ptr.3522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032042121
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1002/smll.201301992 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052554517
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/j.biomaterials.2005.05.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045134057
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/j.ijpharm.2003.08.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052932357
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/j.ijpharm.2005.06.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032157588
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.ijpharm.2008.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048627630
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.ijpharm.2012.07.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014318488
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.jchromb.2011.06.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028399198
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.jconrel.2007.01.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029165479
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.jconrel.2007.10.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048626242
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.jconrel.2007.10.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023666748
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.jconrel.2009.08.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045248678
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.jconrel.2009.12.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010696566
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.jconrel.2011.10.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034686060
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.jconrel.2012.09.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024834212
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.nano.2010.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032044670
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.tube.2010.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025219027
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/j.tube.2011.04.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016140779
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/s0168-3659(00)00293-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015239656
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/s0171-2985(11)80465-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036463937
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/s0378-5173(02)00180-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038245310
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/s1286-4579(02)00083-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034739343
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1021/nl103264u schema:sameAs https://app.dimensions.ai/details/publication/pub.1056218257
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1086/319235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042025418
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1088/0957-4484/24/29/295101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036118728
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1164/rccm.200206-626oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1040163774
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1191/0960327106ht601oa schema:sameAs https://app.dimensions.ai/details/publication/pub.1064153583
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1211/002235702320266217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003050576
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1592/phco.2005.25.10.1303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046632459
318 rdf:type schema:CreativeWork
319 https://doi.org/10.3126/saarctb.v10i1.8677 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043980266
320 rdf:type schema:CreativeWork
321 https://doi.org/10.7150/thno.4525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011571982
322 rdf:type schema:CreativeWork
323 https://www.grid.ac/institutes/grid.13291.38 schema:alternateName Sichuan University
324 schema:name Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, Sichuan University, Chengdu, People’s Republic of China
325 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...